foto

MSc PhD H. Peters Sengers

Positions
Other Academic Staff, Research Associate
Main activities
Research
Specialisation
Clinical Epidemiology
Focus of research

Since September 2017, I started to work as a postdoctoral clinical epidemiologist in the group of prof. dr. Tom van der Poll. My project will entail data analyses linking clinical and molecular data including validation of already discovered RNA biomarkers for sepsis in independent patient groups, and discovery of new sepsis biomarkers focusing on messenger RNA’s. I intend to use the Molecular Diagnosis and Risk Stratification of Sepsis (MARS) database, a prospective cohort study including 8113 patients admitted to the intensive care units (ICUs) of two Dutch tertiary teaching hospitals. My key projects include:

1) To predict key variables associated with organ dysfunction 24-48 hours ahead of time in critically ill patients admitted to the ICU. Being able to predict organ dysfunction ahead of time will assist physicians in preempting severe organ dysfunction, and thereby aiding in the clinical decision process earlier in the course of ICU treatment.

2) Finding a molecular host response assay for sepsis. This could aid phycisians in tailoring antibiotic treatment to critically ill patients admitted to the ICU.

 

Key publications
  • Peters-Sengers Hessel, Berger Stefan P., Heemskerk Martin B. A., Al Arashi Doaa, Homan van der Heide Jaap J., Hemke Aline C., ten Berge Ineke J. M., Idu Mirza M., Betjes Michiel G. H., van Zuilen Arjan D., Hilbrands Luuk B., de Vries Aiko P. J., Nurmohamed Azam S., Christiaans Maarten H., Ernest van Heurn L. W., de Fijter Johan W., Bemelman Frederike J. Stretching the Limits of Renal Transplantation in Elderly Recipients of Grafts from Elderly Deceased Donors Journal of the American Society of Nephrology 2017;28 (2):621-631 [PubMed]
  • Olde Engberink Rik H. G., van den Hoek Thomas C., van Noordenne Nicky D., van den Born Bert-Jan H., Peters-Sengers Hessel, Vogt Liffert Use of a Single Baseline Versus Multiyear 24-Hour Urine Collection for Estimation of Long-Term Sodium Intake and Associated Cardiovascular and Renal Risk Circulation 2017;136 (10):917-926 [PubMed]
  • Peters-Sengers H., Houtzager J. H. E., Heemskerk M. B. A., Idu M. M., Minnee R. C., Klaasen R. W., Joor S. E., Hagenaars J. A. M., Rebers P. M., Homan van der Heide J. J., Roodnat J. I., Bemelman F. J. DCD Donor Hemodynamics as Predictor of Outcome After Kidney Transplantation American journal of transplantation 2018;18 (8):1966-1976 [PubMed]
  • Kers Jesper, Peters-Sengers Hessel, Heemskerk Martin B. A., Berger Stefan P., Betjes Michiel G. H., van Zuilen Arjan D., Hilbrands Luuk B., de Fijter Johan W., Nurmohamed Azam S., Christiaans Maarten H., Homan van der Heide Jaap J., Debray Thomas P. A., Bemelman Fréderike J. Predicition models for delayed graft function: external validation on The Dutch Prospective Renal Transplantation Registry Nephrology, dialysis, transplantation 2018;33 (7):1259-1268 [PubMed]
All Publications