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PhD J. den Dunnen

Position
Assistant Professor
Main activities
Research
Specialisation
Immunology
Focus of research

Investigating the role of Fc receptors on myeloid cells during bacterial infections, rheumatoid arthritis, and inflammatory bowel disease.

Key publications
  • Golebski K., Hoepel W., van Egmond D., de Groot E. J., Amatngalim G. D., Beekman J. M., Fokkens W. J., van Drunen C. M., den Dunnen J. FcγRIII stimulation breaks the tolerance of human nasal epithelial cells to bacteria through cross-talk with TLR4 Mucosal immunology 2019;12 (2):425-433 [PubMed]
  • Hansen Ivo S., Krabbendam Lisette, Bernink Jochem H., Loayza-Puch Fabricio, Hoepel Willianne, van Burgsteden Johan A., Kuijper Elsa C., Buskens Christianne J., Bemelman Willem A., Zaat Sebastiaan A. J., Agami Reuven, Vidarsson Gestur, van den Brink Gijs R., de Jong Esther C., Wildenberg Manon E., Baeten Dominique L. P., Everts Bart, den Dunnen Jeroen FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming Nature communications 2018;9 (1):863 [PubMed]
  • Hansen Ivo S., Hoepel Willianne, Zaat Sebastiaan A. J., Baeten Dominique L. P., den Dunnen Jeroen Serum IgA Immune Complexes Promote Proinflammatory Cytokine Production by Human Macrophages, Monocytes, and Kupffer Cells through FcαRI-TLR Cross-Talk Journal of immunology (Baltimore, Md. 2017;199 (12):4124-4131 [PubMed]
  • Vogelpoel Lisa T. C., Hansen Ivo S., Rispens Theo, Muller Femke J. M., van Capel Toni M. M., Turina Maureen C., Vos Joost B., Baeten Dominique L. P., Kapsenberg Martien L., de Jong Esther C., den Dunnen Jeroen Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages Nature communications 2014;5:5444 [PubMed]
  • den Dunnen Jeroen, Vogelpoel Lisa T. C., Wypych Tomasz, Muller Femke J. M., de Boer Leonie, Kuijpers Taco W., Zaat Sebastiaan A. J., Kapsenberg Martien L., de Jong Esther C. IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and Fc gamma RIIa in human dendritic cells Blood 2012;120 (1):112-121 [PubMed]
All Publications
Research programmes

PhD J. den Dunnen (Fc receptor induced inflammation)

 My group studies the induction of inflammation by Fc receptors during bacterial infections, rheumatoid arthritis, and inflammatory bowel disease, with the aim to identify new targets for therapy of these diseases.

Prof. PhD D.L.P. Baeten (Immunopathology of chronic inflammatory arthritis)

Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Europese Unie