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PhD N.T.P. Bakker

Position
Assistant Professor
Main activities
Education, Research
Specialisation
Vascular Biology
Focus of research

Experimental work on vascular remodeling associated with altered blood flow, hypertension and atherosclerosis. Role of vascular tone, inflammation and transglutaminases in arterial remodeling.

Currently I focus on the role of the brain vasculature in cognitive function. In particular, I am interested in the perivascular pathway of amyloid beta removal. The characteristics, its driving force, and impact of vascular pathology on this transport pathway are currently unknown and of great potential importance in the development of dementia.

Key publications
  • Bedussi Beatrice, Naessens Daphne M. P., de Vos Judith, Olde Engberink Rik, Wilhelmus Micha M. M., Richard Edo, ten Hove Malyssa, VanBavel Ed, Bakker Erik N. T. P. Enhanced interstitial fluid drainage in the hippocampus of spontaneously hypertensive rats Scientific reports 2017;7 (1):744 [PubMed]
  • Bedussi Beatrice, van der Wel Nicole N., de Vos Judith, van Veen Henk, Siebes Maria, VanBavel Ed, Bakker Erik N. T. P. Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways Journal of cerebral blood flow and metabolism 2017;37 (4):1374-1385 [PubMed]
  • Bedussi Beatrice, Almasian Mitra, de Vos Judith, VanBavel Ed, Bakker Erik N. T. P. Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow Journal of cerebral blood flow and metabolism 2018;38 (4):719-726 [PubMed]
  • Palao Teresa, Rippe Catarina, van Veen Henk, VanBavel Ed, Swärd Karl, Bakker Erik N. T. P. Thrombospondin-4 knockout in hypertension protects small-artery endothelial function but induces aortic aneurysms American journal of physiology. Heart and circulatory physiology 2016;310 (11):H1486-H1493 [PubMed]
  • Palao Teresa, Swärd Karl, Jongejan Aldo, Moerland Perry D., de Vos Judith, van Weert Angela, Arribas Silvia M., Groma Gergely, VanBavel Ed, Bakker Erik N. T. P. Gene Expression and MicroRNA Expression Analysis in Small Arteries of Spontaneously Hypertensive Rats. Evidence for ER Stress PLoS ONE 2015;10 (9):e0137027 [PubMed]
All Publications
Curriculum Vitae

1988-93 Biology University of Leiden. Masters degree: 10-8-93
1993-98 PhD project Dept. of Physiology, VUMC. Thesis: Regulation of vascular tone by endothelial factors in isolated arterioles. PhD degree: 9-6-98
1998-2001 Post-doc Medical Physics, AMC. Topic: structural and functional adaptation of arterioles.
2001-2002 Marie Curie Fellowship, European Union. Dept. Of Pharmacology, University of Aarhus, Aarhus, Denmark. Title: Microvascular remodeling: structure follows function?
2002-2006 Dekker Fellowship Netherlands Heart Foundation. Dept. Medical Physics, AMC. Topic: Mechanisms of coronary microvascular remodeling.
2006-2008 Dekker Fellowship Netherlands Heart Foundation, continuation and extension with PhD project: “The role of transglutaminases in the progression of atherosclerosis”.
2008- Assistant Professor, Dept. of Biomedical Engineering and Physics, AMC.
 

Current research funding
  • Stichting Alzheimer Nederland