Y. Pannekoek PhD

Assistant Professor
Main activities
Education, Research
Molecular Microbiology of Bacterial Meningitis and Chlamydia infections.
Focus of research

We study the molecular epidemiology and population structure of the main pathogens causing meningitis, Neisseria meningitidis and Streptococcus pneumoniae, and of Chlamydia species causing respiratory infections and sexual transmitted disease. In addition, we study the pathogenesis of meningococcal and invasive pneumococcal disease. We are particularly interested in the bacterial stress response and its regulation by small RNAs (ribo-regulation) in conjunction with alternative sigma factors like sigmaE.
In collaborative studies with Dr. D. van de Beek (Department of Neurology, AMC) we investigate clinical aspects of bacterial meningitis as well correlation between clinical features, outcome and host and bacterial factors.

Key publications
  • Pannekoek Yvonne, Huis In 't Veld Robert A. G., Schipper Kim, Bovenkerk Sandra, Kramer Gertjan, Brouwer Matthijs C., van de Beek Diederik, Speijer Dave, van der Ende Arie Neisseria meningitidis Uses Sibling Small Regulatory RNAs To Switch from Cataplerotic to Anaplerotic Metabolism mBio 2017;8 (2):e02293-16 [PubMed]
  • Huis In 't Veld Robert Antonius Gerhardus, Willemsen Antonius Marcellinus, van Kampen Antonius Hubertus Cornelis, Bradley Edward John, Baas Frank, Pannekoek Yvonne, van der Ende Arie Deep sequencing whole transcriptome exploration of the σE regulon in Neisseria meningitidis PLoS ONE 2011;6 (12):e29002 [PubMed]
  • Versteeg Bart, Bruisten Sylvia M., Pannekoek Yvonne, Jolley Keith A., Maiden Martin C. J., van der Ende Arie, Harrison Odile B. Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease BMC genomics 2018;19 (1):130 [PubMed]
  • Pannekoek Yvonne, Huis In 't Veld Robert, Schipper Kim, Bovenkerk Sandra, Kramer Gertjan, Speijer Dave, van der Ende Arie Regulation of Neisseria meningitidis cytochrome bc1 components by NrrF, a Fur-controlled small noncoding RNA FEBS open bio 2017;7 (9):1302-1315 [PubMed]
  • Pannekoek Yvonne, Qi-Long Qin, Zhang Yu-Zhong, van der Ende Arie Genus delineation of Chlamydiales by analysis of the percentage of conserved proteins justifies the reunifying of the genera Chlamydia and Chlamydophila into one single genus Chlamydia Pathogens and disease 2016;74 (6):ftw071 [PubMed]
All Publications
Research programmes

A. van der Ende PhD (Epidemiology and pathogenesis of bacterial meningitis)

Y. Pannekoek PhD (Promoties)