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Prof. A.C. van der Wal MD PhD

Position
Professor
Main activities
Patient care, Research, Teaching
Specialisation
Cardiovascular Pathology
Focus of research

atherosclerosis and thrombosis

sudden cardiac death

vascular tumours

Key publications
  • Castellani C, Angelini A, de Boer OJ, van der Loos CM, Fedrigo M, Frigo AC, Meijer-Jorna LB, Li X, Ploegmakers HJP, Tona F, Feltrin G, Gerosa G, Valente M, Thiene G, van der Wal AC, Intraplaque hemorrhage in cardiac allograft vasculopathy. AM J TRANSPLANT 2014;14 (1):184-192 [PubMed]
  • de Boer OJ, Li X, Teeling P, Mackaay C, Ploegmakers HJ, van der Loos CM, Daemen MJ, de Winter RJ, van der Wal AC, Neutrophils, neutrophil extracellular traps and interleukin-17 associate with the organisation of thrombi in acute myocardial infarction. THROMB HAEMOSTASIS 2013;109 (2):290-297 [PubMed]
  • Halushka MK, Angelini A, Bartoloni G, Basso C, Batoroeva L, Bruneval P, Buja LM, Butany J, d'Amati G, Fallon JT, Gallagher PJ, Gittenberger-de Groot AC, Gouveia RH, Kholova I, Kelly KL, Leone O, Litovsky SH, Maleszewski JJ, Miller DV, Mitchell RN, Preston SD, Pucci A, Radio SJ, Rodriguez ER, Sheppard MN, Stone JR, Suvarna SK, Tan CD, Thiene G, Veinot JP, van der Wal AC, Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association For European Cardiovascular Pathology: II. Noninflammatory degenerative diseases - nomenclature and diagnostic criteria. CARDIOVASC PATHOL 2016;25 (3):247-257 [PubMed]
  • Grundeken MJ, Li X, Kurpershoek CE, Kramer MC, Vink A, Piek JJ, Tijssen JGP, Koch KT, Wykrzykowska JJ, de Winter RJ, van der Wal AC, Distal embolization of hydrophilic-coating material from coronary guidewires after percutaneous coronary interventions. CIRC-CARDIOVASC INTE 2015;8 (2):e001816 [PubMed]
  • Li X, de Boer OJ, Ploegmaker H, Teeling P, Daemen MJ, de Winter RJ, van der Wal AC, Granulocytes in coronary thrombus evolution after myocardial infarction--time-dependent changes in expression of matrix metalloproteinases. CARDIOVASC PATHOL 2016;25 (1):40-46 [PubMed]
All Publications
Research programmes

Cardiovascular Pathology

1. From plaque instabilty towards thrombus instability. Clinicopathological correlations, mainly features of plaque inflammation) of patients with various ischemic coronary syndromes were investigated, prior to treatment (de novo plaques) or after coronary intervention (restenosis plaques, stented arteries) which is longlasting and succesful collaboration with AMC department of Cardiology (Prof RJ de Winter). Present focus is on coronary thrombectomy specimens which have been histologically graded with opportunities for combined pathological and epidemiological work. Results gave new insights in thrombus organization and propagation after plaque rupture / erosion.; research focus has shifted from plaque towards the coronary trombus, with focus on neutrophils and their secretory proteins, Apoptosis and Netosis in thrombus and interaction with coagulation and plaque inflammation and processes of tissue repair (angiogenesis and fibrogenesis). Large tissue bank of >2500 thrombectomy samples and coronary arteries  obtained at autopsy are instrumental for these  studies

2. Coronary Allograft Vasculopathy (CAV) is studied together with pathologists of University of Padua (Prof Angelini): various mechanisms of vascular rejection and their implications for lesional angiogensis, hemorrhage and thrombosis.

3. Angiomas and vascular Malformations. Mechanisms of angiogenesis and vessel maturation have been studied in a large cohort of patients with archived materials (>250, representing unique series of vascular anomlies) by in situ investigations on growth factors for vascular wall cells, expression of cell cycle specific proteins, and association with clinical parameters and follow up; This resulted in PhD thesis of Dr Meijer-Jorna. We will further evaluate implications of these novel findings for the current classifications of vascular anomalies, and investigate angiogenesis as possible target for therapies in symptomatic vascular malformations.

4. Pathology collaboration and support of clinical research groups in AMC and UMC Utrecht and of Association for European Cardiovascular Pathology (AECVP): on diversity of topics in cardiovascular pathology

Faculty
Prof. A.C. van der Wal MD PhD
Dr. O.J. de Boer PhD
Prof. dr. M.J.A.P. Daemen

Postdocs
Drs. D.R. Pabittei

PhD Students
Drs. N.P. Denswil
K.R. Pertiwi
O.C.G. Stam
A.M. Utami

Other research related activities
  • Contribution to guidelines and protocols, endomyocardial biopsy, autopsy investigation of suddden cardiac death
  • Board of directors / Trustees / Supervisory board, Association European Cardiovascular Pathology (AECVP)