Prof. PhD A.J.P.M. Smout

Medical Specialist, Full Professor
Main activities
Neurogastroenterology and Motility
Focus of research

Pathophysiology, diagnosis and treatment of gastrointestinal motility disorders and functional GI disorders

Key publications
  • Bredenoord Albert J., Pandolfino John E., Smout André J. P. M. Gastro-oesophageal reflux disease Lancet 2013;381 (9881):1933-1942 [PubMed]
  • Bredenoord A. J., Fox M., Kahrilas P. J., Pandolfino J. E., Schwizer W., Smout A. J. P. M., Conklin Jeffrey L., Cook Ian J., Gyawali C. Prakash, Hebbard Geoffrey, Holloway Richard H., Ke Meiyun, Keller Jutta, Mittal Ravinder K., Peters Jeff, Richter Joel, Roman Sabine, Rommel Nathalie, Sifrim Daniel, Tutuian Radu, Valdovinos Miguel, Vela Marcelo F., Zerbib Frank Chicago classification criteria of esophageal motility disorders defined in high resolution esophageal pressure topography Neurogastroenterology and motility 2012;24 (1):57-65 [PubMed]
  • Hemmink Gerrit J. M., Bredenoord Albert J., Weusten Bas L. A. M., Monkelbaan Jan F., Timmer Robin, Smout André J. P. M. Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: 'on' or 'off' proton pump inhibitor? American journal of gastroenterology 2008;103 (10):2446-2453 [PubMed]
  • van Herwaarden M. A., Samsom M., Smout A. J. Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanisms other than transient LES relaxations Gastroenterology 2000;119 (6):1439-1446 [PubMed]
  • Weusten B. L., Roelofs J. M., Akkermans L. M., van Berge-Henegouwen G. P., Smout A. J. The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data Gastroenterology 1994;107 (6):1741-1745 [PubMed]
All Publications
Research programmes

Prof. PhD A.J.P.M. Smout (Clinical Neurogastroenterology and Motility)


Contractions and tone of the muscle in the wall of the digestive canal (from mouth to anus), constantly contribute to the complex functions of the canal. The regulation of these complex motor acitivities is partly hormonal, but largely neuronal. A dense neuronal network in the wall of the alimentary tract acts in conjuction with extrinsic autonomic nerves and the central nervous system.  In a large proportion of patients who present with symptoms suggestive of malfunctioning of the digestive tract, motor abnormalities appear to be the cause of the symptoms. In addition, increased perception of stimuli from the gastrointestinal canal plays an important  role in the genesis of symptoms, with abnormal functioning of receptors and the intrinsic neuronal plexuses in the gut wall, the neuronal pathways to the brain and the central nervous system.

The research programme Clinical Neurogastroenterology and Motility aims to provide better understanding of gastrointestinal motor disorders and  to improve diagnostic techniques and therapy. The focus is on disorders of the proximal part of the digestive tract, such as gastro-oesophageal reflux disease, oesophageal motor disorders and functional dyspepsia.

Prof. PhD A.J. Bredenoord

PhD Students
A. Bogte
C.E. Flik

Medewerkers buiten research programmes van afdeling Maag-Darm-Leverziekten

Prof. PhD A.J. Bredenoord (Neurogastroenterology and Motility: Esophageal diseases)