foto

Prof. D. van de Beek MD PhD

Position
Professor
Main activities
Patient care, Research
Specialisation
Neurological infection and inflammatory diseases
Focus of research

The Department of Neurology performs clinical and translational research within three research themes: infection & inflammation, cerebrovasculair disorders, and movement disorders. The themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.

We perform clinical translational research in the field of neurological infections & inflammation. We perform prospective clinical cohort studies, randomized clinical trials, and experimental research, combining our clinical expertise with groundbreaking, translational approaches using clinical data, human samples, next generation sequencing, in vitro techniques, and mouse models in the erea's of bacterial meningitis & encephalitis, infections after stroke, septic encephalopathy, and inflammatory diseases of peripheral nerves and muscles.

 

Key publications
  • van de Beek D, Brouwer MC, Thwaites GE, Tunkel AR, Advances in treatment of bacterial meningitis. LANCET 2012;380 (9854):1693-1702 [PubMed]
  • McIntyre PB, O'Brien KL, Greenwood B, van de Beek D, Effect of vaccines on bacterial meningitis worldwide. LANCET 2012;380 (9854):1703-1711 [PubMed]
  • Brouwer MC, Tunkel AR, McKhann GM 2nd, van de Beek D, Brain Abscess. NEW ENGL J MED 2014;371 (5):447-456 [PubMed]
  • Westendorp WF, Vermeij JD, Zock E, Hooijenga IJ, Kruyt ND, Bosboom HJLW, Kwa VIH, Weisfelt M, Remmers MJM, ten Houten R, Schreuder AHCMT, Vermeer SE, van Dijk EJ, Dippel DWJ, Dijkgraaf MGW, Spanjaard L, Vermeulen M, van der Poll T, Prins JM, Vermeij FH, Roos YBWEM, Kleyweg RP, Kerkhoff H, Brouwer MC, Zwinderman AH, van de Beek D, Nederkoorn PJ [Contributors: van de Beek D, Nederkoorn PJ, Westendorp WF , Vermeij JD, Kerkhoff H, Zock E, Kleyweg RP, Bosboom JLW, Kwa VIH, Weisfelt M, Kruyt ND, Remmers MJM, van Dijk EJ, Vermeij F, Schreuder A, Vermeer SE, ten Houten R, Dippel DWJ, Kappelle LJ, van der Worp HB, Merkies ISJ, de Bruijn SFTM, de Laat KF, Haag D, Jellema K, Keizer K, de Rijk MC, Vermeij AJ, Visser MC, Aerden LAM, Schut ES, Reichman LJA, de Gans K, van den Berg-Vos RM, van Goor MPJ, Wijnhoud AD, van der Ree TC, Janmaat M, van Orshoven N, Manschot SM, Dijkgraaf MGW, van der Poll T, Prins JM, Spanjaard L, Vermeij FH]] , The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial. LANCET 2015;385 (9977):1519-1526 [PubMed]
  • Bijlsma MW, Brouwer MC, Kasanmoentalib ES, Kloek AT, Lucas MJ, Tanck MW, van der Ende A, van de Beek D, Community-acquired bacterial meningitis in adults in the Netherlands, 2006-14: a prospective cohort study. LANCET INFECT DIS 2016;16 (3):339-347 [PubMed]
All Publications
Curriculum Vitae
2012- Professor of neurology
2007- Neurologist, Group leader neurological infection and inflammation, Department of Neurology, Center for Infection and Immunity, University of Amsterdam
2006-2007Neurologist, Mayo Clinic, Rochester, USA
2000-2006 Board Certification Neurology, Academic Medical Center, Amsterdam
1998-2004 Doctorate (Ph.D.), “Bacterial meningitis in adults”, University of Amsterdam
1992-1999 Medical Degree (M.D.) 
Faculty of Medicine, University of Amsterdam
Research programmes

Neuroinfection and Inflammation

Bacterial meningitis. In 2002, we completed a study on the life-saving effect of adjunctive dexamethasone therapy in bacterial meningitis. Subsequently, we identified defining factors in the prognosis of this devastating disease in the largest cohort study to date. We translated research results to clinical practice in papers on the management of meningitis. MeninGene is a nationwide project on genetic traits that may support the susceptibility to severe forms of bacterial meningitis. 

Encephalitis. Recently, we completed the PACEM study. In this prospective cohort study we aim to systematically determine the causes of meningitis and encephalitis in children and adults with suspected bacterial meningitis, and describe clinical and laboratory findings in these patients.

Neurosarcoidosis. Neurosarcoidosis a condition of unknown cause featuring granulomas in various tissues, involving the central nervous system (brain and spinal cord). In a prospective cohort study we evaluate clinical characteristics, genetic background, treatment and outcome of this disease. 

Infections after stroke. Stroke is a leading cause of death worldwide. Fever after stroke is a strong predictor of a poor outcome. Infections occur in up to 40% of patients with stroke and have also been associated with poor outcomes. In 2015, results were published of the Preventive Antibiotics in Stroke Study (PASS) on preventive use of the antibiotic ceftriaxone iin patients with acute stroke. Currently, we are particpating in the PRECIOUS project.

Septic encephalopathy. Experimental findings and neuropathological observations suggest that activation of microglia is pivotal for mediation of the behavioural effects of systemic infections. The microglial response is usually regulated tightly, but defensive features could turn neurotoxic once microglial cells escape from cholinergic inhibition. In a prospective autopsy study and animals models we evaluate the role of microglial activation in sepsis associated encephalopathy.

Inflammatory diseases of peripheral nerves and muscles. The immune mediated neuropathies (e.g. GBS, CIDP, MMN) and myopathies (e.g. dermatomysositis, IBM) and critical illness neuropathy and myopathy are the specific diseases of interest. Clinical trials, cohort studies and studies investigating immunological and genomic characterization of nerve and muscle inflammation are performed. From these studies we try to arrive at clinically relevant biomarkers of disease activity and predictors of response. 

Faculty
Prof. D. van de Beek MD PhD
Dr. M.C. Brouwer MD PhD
Dr. F. Eftimov MD PhD
Dr. A.J. van der Kooi MD
Prof. dr. I.N. van Schaik
Dr. C. Verhamme MD
Prof. dr. M. de Visser

Postdocs
Dr. M.W. Bijlsma MD PhD
Dr. E.B. Ferwerda PhD
Dr. M. Valls Serón
Dr. L. Wieske MD PhD

PhD Students
S. Dias
Drs. K.R.I.S. Dorresteijn MD
Drs. J.Y. Engelen-Lee MD
C.N. van Ettekoven
D. Fritz
Drs. I.C.M. Hoogland
L. ter Horst
K.K. Jim MD
Drs. E.S. Kasanmoentalib MD
M.N. van Kassel
H.N. Khan MSc
Drs. A.T. Kloek MD
Drs. D.L.H. Koelman MD
Drs. M.M. Koopmans MD
P.H.C. Kremer MD
Drs. J.D. Vermeij MD
Drs. D. Westhoff MD
I.E. van Zeggeren
E. Zock MSc (Albert Schweitzer ziekenhuis)
Drs. M.E. Adrichem
Drs. E. Beeldman MD PhD
Drs. B.W. van Paassen
Drs. S.M. Schade van Westrum MD (Martini Ziekenhuis Groningen)
Drs. E.S. Schut MD (Martini Ziekenhuis)

Others
J. Gibson
S. Gouda BA
Ing. V. Jaspers
Drs. W.K. Man MSc

Other research related activities
  • Contribution to guidelines and protocols, Dutch Bacterial Meningitis Guidelines
  • Contribution to guidelines and protocols, Dutch Lyme Disease Guidelines
  • Contribution to guidelines and protocols, Dutch Antibiotic Guidelines in Neurological Disorders
  • Membership of editorial board / Editorship, BMC INFECTIOUS DISEASES
  • Membership of editorial board / Editorship, COCHRANE DATABASE OF SYSTEMATIC REVIEWS
  • Contribution to guidelines and protocols, IDSA guideline - Nosocomial Meningitis
  • Coordinator Clinical Series Meningitis, Lancet
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Biogen Limited
  • Crediteurenadm. VUmc, p/a Profource Service Center
  • CSL Behring LLC
  • Eli Lilly and Company
  • ESCMID
  • Europese Unie
  • GBS/CIDP Foundation International
  • GlaxoSmithKline Biologicals SA
  • InFlectis BioScience
  • IQVIA RDS Netherlands B.V.
  • Life Sciences Health TKI
  • Medical Research BV
  • Nederlands Herseninstituut
  • Peripheral Nerve Society
  • PHARNEXT
  • Premier Research Group Ltd
  • Prinses Beatrix Spierfonds
  • ProPhase, LLC.
  • Stichting AMC Foundation
  • Stichting Het Remmert Adriaan Laan Fonds
  • Stichting tot Steun EKZ-AMC
  • ZonMw