Prof. dr. A.J.P.M. Smout

Main activities
Neurogastroenterology and Motility
Focus of research

Pathophysiology, diagnosis and treatment of gastrointestinal motility disorders and functional GI disorders

Key publications
  • Bredenoord AJ, Pandolfino JE, Smout AJPM, Gastro-oesophageal reflux disease. LANCET 2013;381 (9881):1933-1942 [PubMed]
  • Bredenoord AJ, Fox M, Kahrilas PJ, Pandolfino JE, Schwizer W, Smout AJPM [Contributors: Conklin JL, Cook IJ, Gyawali CP, Hebbard G, Holloway RH, Ke M, Keller J, Mittal RK, Peters J, Richter J, Roman S, Rommel N, Sifrim D, Tutuian R, Valdovinos M, Vela MF, Zerbib F]] , Chicago classification criteria of esophageal motility disorders defined in high resolution esophageal pressure topography. NEUROGASTROENT MOTIL 2012;24 (1):57-65 [PubMed]
  • Hemmink GJM, Bredenoord AJ, Weusten BLAM, Monkelbaan JF, Timmer R, Smout AJPM, Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: 'on' or 'off' proton pump inhibitor?. AM J GASTROENTEROL 2008;103 (10):2446-2453 [PubMed]
  • van Herwaarden MA, Samsom M, Smout AJ, Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanisms other than transient LES relaxations. GASTROENTEROLOGY 2000;119 (6):1439-1446 [PubMed]
  • Weusten BL, Roelofs JM, Akkermans LM, van Berge-Henegouwen GP, Smout AJ, The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data. GASTROENTEROLOGY 1994;107 (6):1741-1745 [PubMed]
All Publications
Research programmes

Clinical Neurogastroenterology and Motility


Contractions and tone of the muscle in the wall of the digestive canal (from mouth to anus), constantly contribute to the complex functions of the canal. The regulation of these complex motor acitivities is partly hormonal, but largely neuronal. A dense neuronal network in the wall of the alimentary tract acts in conjuction with extrinsic autonomic nerves and the central nervous system.  In a large proportion of patients who present with symptoms suggestive of malfunctioning of the digestive tract, motor abnormalities appear to be the cause of the symptoms. In addition, increased perception of stimuli from the gastrointestinal canal plays an important  role in the genesis of symptoms, with abnormal functioning of receptors and the intrinsic neuronal plexuses in the gut wall, the neuronal pathways to the brain and the central nervous system.

The research programme Clinical Neurogastroenterology and Motility aims to provide better understanding of gastrointestinal motor disorders and  to improve diagnostic techniques and therapy. The focus is on disorders of the proximal part of the digestive tract, such as gastro-oesophageal reflux disease, oesophageal motor disorders and functional dyspepsia.

Prof. dr. A.J.P.M. Smout
Prof. dr. A.J. Bredenoord

PhD Students
M.L. Haasnoot
R.A.B. Oude Nijhuis MD
Drs. F.A.M. Ponds
W.E. de Rooij
J.M. Schuitenmaker
Drs. A. Bogte (Universiteit Utrecht)
C.E. Flik (Universiteit Utrecht)

Prof. dr. A.J. Bredenoord (Neurogastroenterology and Motility: Esophageal diseases)

Other research related activities
  • Contribution to guidelines and protocols, NVMDL richtlijn Gastro-oesofageale refluxziekte
  • Contribution to guidelines and protocols, Multidisciplinaire richtlijn Prikkelbaar Darm Syndroom