Prof. dr. A.K. Groen

Main activities
Research, Teaching
Systems Medicine
Focus of research

An integrated approach to study cardiometabolism

Key publications
  • van der Velde AE, Vrins CLJ, van den Oever K, Kunne C, Elferink RPJO, Kljipers F, Groen AK, Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice. GASTROENTEROLOGY 2007;133 (3):967-975 [PubMed]
  • Kuipers F, Bloks VW, Groen AK, Beyond intestinal soap-bile acids in metabolic control. NAT REV ENDOCRINOL 2014;10 (8):488-498 [PubMed]
  • Out C, Hageman J, Bloks VW, Gerrits H, Sollewijn Gelpke MD, Bos T, Havinga R, Smit MJ, Kuipers F, Groen AK, Liver Receptor Homolog-1 Is Critical for Adequate Up-regulation of Cyp7a1 Gene Transcription and Bile Salt Synthesis During Bile Salt Sequestration. HEPATOLOGY 2011;53 (6):2075-2085 [PubMed]
  • Jakulj L, van Dijk TH, de Boer JF, Kootte RS, Schonewille M, Paalvast Y, Boer T, Bloks VW, Boverhof R, Nieuwdorp M, Beuers UHW, Stroes ESG, Groen AK, Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion. CELL METAB 2016;24 (6):783-794 [PubMed]
  • de Boer JF, Schonewille M, Boesjes M, Wolters H, Bloks VW, Bos T, van Dijk TH, Jurdzinski A, Boverhof R, Wolters JC, Kuivenhoven JA, van Deursen JM, Oude Elferink RPJ, Moschetta A, Kremoser C, Verkade HJ, Kuipers F, Groen AK, Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice. GASTROENTEROLOGY 2017;152 (5):1126-1138.e6 [PubMed]
All Publications
Research programmes

A systems biology approach to unravel the etiology of the Metabolic Syndrome

Metabolic Syndrome  is defined as the clustering of abdominal obesity, elevated blood pressure, impaired glucose tolerance, high triglycerides  and low HDL-cholesterol and is widely used as simple clinical definition of overweight individuals at increased morbidity risk. The complexity of the interrelations between the different symptoms in Metabolic Syndrome has led to the need for the application of systems biology approaches to obtain a deep understanding of the mechanisms underlying the comorbidities.  To gather mechanistic insight in the etiology and interdependence of the different components of the Metabolic Syndrome we are developing a multiscale systems biology approach  using both dynamic and genomewide metabolic modelling approaches. We aim to obtain a  comprehensive genomic and metabolic map of healthy humans and  metabolic syndrome patients including their microbiome. This will generate detailed insight in the metabolic network dysregulation in Metabolic Syndrome patients and will suggest novel therapeutic strategies to rebalance the metabolic networks.



Prof. dr. A.K. Groen

PhD Students
O. Aydin
Drs. G.J. Bakker MD (DOCTOR)
D. Goncalves
Drs. A.V. Hartstra MD
A.M. Koopen
A.S. Meijnikman
Drs. C.C. van Olden
J.J. Witjes
X. Zhang
Drs. S.A.J. van der AA (University of Groningen)
Drs. T. Paalvast (University of Groningen)
Drs. M. van der Stee (University of Groningen)
Drs. X. Zhang (University of Groningen)

Prof. dr. M. Nieuwdorp MD PhD (Gutmicrobiota as novel diagnostic and therapeutic targets in cardiometabolism)

Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • ZonMw