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Prof. dr. F. Baas

Position
Professor
Main activities
Research, Patient care
Specialisation
Human Genetics
Focus of research
  • Genetics
  • DNA diagnostics
  • Neurological disorders
Key publications
  • Schaffer AE, Eggens VRC, Caglayan AO, Reuter MS, Scott E, Coufal NG, Silhavy JL, Xue Y, Kayserili H, Yasuno K, Rosti RO, Abdellateef M, Caglar C, Kasher PR, Cazemier JL, Weterman MA, Cantagrel V, Cai N, Zweier C, Altunoglu U, Satkin NB, Aktar F, Tuysuz B, Yalcinkaya C, Caksen H, Bilguvar K, Fu XD, Trotta CR, Gabriel S, Reis A, Gunel M, Baas F, Gleeson JG, CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration. CELL 2014;157 (3):651-663 [PubMed]
  • Weterman MAJ, Barth PG, van Spaendonck-Zwarts KY, Aronica E, Poll-The BT, Brouwer OF, van Tintelen JP, Qahar Z, Bradley EJ, de Wissel M, Salviati L, Angelini C, van den Heuvel L, Thomasse YEM, Backx AP, Nürnberg G, Nürnberg P, Baas F, Recessive MYL2 mutations cause infantile type I muscle fibre disease and cardiomyopathy. BRAIN 2013;136 (1):282-293 [PubMed]
  • Weterman MAJ, Sorrentino V, Kasher PR, Jakobs ME, van Engelen BGM, Fluiter K, de Wissel MB, Sizarov A, Nürnberg G, Nürnberg P, Zelcer N, Schelhaas HJ, Baas F, A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy. HUM MOL GENET 2012;21 (2):358-370 [PubMed]
  • Namavar Y, Barth PG, Kasher PR, van Ruissen F, Brockmann K, Bernert G, Writzl K, Ventura K, Cheng EY, Ferriero DM, Basel-Vanagaite L, Eggens VRC, Krägeloh-Mann I, de Meirleir L, King M, Graham JM Jr, von Moers A, Knoers N, Sztriha L, Korinthenberg R, Dobyns WB, Baas F, Poll-The BT [Contributors: van der Aa N, Arts WFM, Ades LC, Bahi-Buisson N, Battini R, Bodamer O, Boltshauser E, Boycott K, Brueton L, Brussel W, Chandler KE, Cowan FM, Crow Y, Debus O, Demir E, Hastanesi G, Eason J, Ferrie CD, Fisher RB, Foulds N, Freeman JL, Gooskens R, Haeussler M, Hageman G, Hammersen G, Horn D, Isidor B, van der Knaap MS, Kress W, Kroisel PM, Kyllerman M, Lachmeijer AMA, Lunsing RJ, McGillivray G, Möllmann S, Muntoni F, Nemeth AH, Neufeld-Kaiser W, van Nieuwenhuizen O, Ouvrier R, Pálmafy B, Peeters EAJ, Phillips JJ, Price S, Rankin J, Régal L, de Rijk-van Andel JF, Roelens F, Rutledge JC, Ryan MM, Seidl R, Sellerer NC, Shannon NL, Sival DA, Snoeck IN, Straussberg R, Tijssen MAJ, Verloo P, de Vries LS, Wargowski D, Williams AN, Windpassinger C]] , Clinical, neuroradiological and genetic findings in pontocerebellar hypoplasia. BRAIN 2011;134 (Part 1):143-156 [PubMed]
  • Bahia El Idrissi N, Das PK, Fluiter K, Rosa PS, Vreijling J, Troost D, Morgan BP, Baas F, Ramaglia V, M. leprae components induce nerve damage by complement activation: identification of lipoarabinomannan as the dominant complement activator. ACTA NEUROPATHOL 2015;129 (5):653-667 [PubMed]
All Publications
Curriculum Vitae

 

Professor Frank Baas (male) obtained his MD (1982) and his PhD (1986) at the University of Amsterdam. In 1996 he became head of the Neurogenetics laboratory and in 2002 professor of Neurogenetics at the AMC, University of Amsterdam. In 2006 he became Head of the Genome Analysis facility AMC. He is a board certified Clinical Molecular geneticist. Prof. Baas is a leading scientist in the field of neurogenetics. He has published over 250 peer reviewed papers and has patents on neuroregeneration and cancer therapy.

 

CURRENT POSITIONS
Visiting scientist Koch Institute, Massachusetts Institute of Technology
Head Genome Analysis facility AMC
Professor of Neurogenetics at AMC/ University of Amsterdam
Head of the Neurogenetics laboratory, AMC/ University of Amsterdam

President of the Dutch Society of Human Genetics


PREVIOUS POSITIONS
2010-2016 CSO Regenesance BV www.regenesance-pharma.com

1991-1996 Honorary Staff member, The Netherlands Cancer Institute
1991 Assistant Professor Department of Neurology, University of Amsterdam to specialise in human molecular (neuro) genetics
1989-1991 Visiting scientist at The Netherlands Cancer Institute, Division of Molecular Biology, establishing a research group on the regulation of gene expression and the identification of new mechanisms for multidrug resistance
1987-1988 Visiting scientist at the Massachusetts Institute of Technology, Cancer Center, Prof. Dr. D.E. Housman and Harvard Medical School, Dana Farber Cancer Institute, Prof. R.J. Arceci. Topic: Regulation and expression of mammalian P-glycoprotein genes

FELLOWSHIPS AND AWARDS
2009 Amsterdam Inventor Award 2nd price 2009
1986 Stipend from the Netherlands Organization for Research (NWO) to visit Prof. Dr. T. Maniatis’ Laboratory at Harvard University
1987-1992 Constantijn and Christiaan Huygens Fellowship form the Netherlands Organization for Research.
 

Research programmes

Prof. dr. F. Baas (Genome analysis / Neurogenetics)

Faculty
Prof. dr. F. Baas
Dr. ir. A.L.M.A. ten Asbroek
Dr. K. Fluiter
Dr. ir. F. van Ruissen
M.A.J. Weterman PhD

Postdocs
V. Ramaglia PhD

PhD Students
B. Appelhof
J.E. Hakonen
Drs. B.W. van Paassen

Others
M.E. Jakobs
Drs. S.B. Kenter
R. Zwart BSc

Other research related activities
  • Membership of advisory board / Consultant, NWO: Netherlands Organisation
  • Board of directors / Trustees / Supervisory board, Dutch Society of Human Genetics
  • Board of directors / Trustees / Supervisory board, Regenesance
  • Membership of advisory board / Consultant, Charcot Marie Tooth Association USA
  • Membership of advisory board / Consultant, Stichting MS Research
  • Membership of advisory board / Consultant, Nederlands Elpilepsie fonds
  • Stock / Shareholder, Regenesance BV
Current research funding
  • AFMTELETHON
  • Prinses Beatrix Spierfonds