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Prof. dr. G.R. van den Brink MD PhD

Position
Professor
Main activities
Research, Patient care
Specialisation
Gastroenterology & Hepatology, Oncology, Immunology
Focus of research

The research in my group focusses on two research lines:

1. Understanding of the mechanisms that maintain a healthy colonic epithelium and the way these are deregulated during development of colorectal cancer.  

2. Mechanism of action of drugs used in patients with inflammatory bowel disease and the adaptation of existing successful therapies to achieve reduced side effects and enhanced efficacy. 

Key publications
  • Amos-Landgraf JM, Heijmans J, Wielenga MCB, Dunkin E, Krentz KJ, Clipson L, Ederveen AG, Groothuis PG, Mosselman S, Muncan V , Hommes DW, Shedlovsky A, Dove WF, van den Brink GR, Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones. P NATL ACAD SCI USA 2014;111 (46):16514-16519 [PubMed]
  • Büller NVJA, Rosekrans SL, Metcalfe C, Heijmans J, van Dop WA, Fessler E, Jansen M, Ahn C, Vermeulen JLM, Westendorp BF, Robanus-Maandag EC, Offerhaus GJ, Medema JP, D'Haens GRAM, Wildenberg ME, de Sauvage FJ, Muncan V , van den Brink GR, Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice. GASTROENTEROLOGY 2015;148 (1):170-180.e6 [PubMed]
  • Heijmans J, van Lidth de Jeude JF, Koo BK, Rosekrans SL, Wielenga MCB, van de Wetering M, Ferrante M, Lee AS, Onderwater JJM, Paton JC, Paton AW, Mommaas AM, Kodach LL, Hardwick JC, Hommes DW, Clevers H, Muncan V , van den Brink GR, ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. CELL REP 2013;3 (4):1128-1139 [PubMed]
  • Wildenberg ME, Vos ACW, Wolfkamp SCS, Duijvestein M, Verhaar AP, te Velde AA, van den Brink GR, Hommes DW, Autophagy Attenuates the Adaptive Immune Response by Destabilizing the Immunologic Synapse. GASTROENTEROLOGY 2012;142 (7):1493-+ [PubMed]
  • Muncan V , Heijmans J, Krasinski SD, Büller NV, Wildenberg ME, Meisner S, Radonjic M, Stapleton KA, Lamers WH, Biemond I, van den Bergh Weerman MA, O'Carroll D, Hardwick JC, Hommes DW, van den Brink GR, Blimp1 regulates the transition of neonatal to adult intestinal epithelium. NAT COMMUN 2011;2:452 [PubMed]
All Publications
Curriculum Vitae

See: http://nl.linkedin.com/pub/gijs-van-den-brink/4/897/890

Research programmes

Prof. dr. G.R. van den Brink MD PhD (Intestinal mucosal homeostasis and it's deregulation in inflammatory bowel disease and during oncogenesis)

Faculty
Prof. dr. G.R. van den Brink MD PhD
Dr. T.B.M. Hakvoort
Dr. V. Muncan

Postdocs
Dr. B. Baan
Dr. O. Karpus MSc
Dr. P.J. Koelink
P.S.M. Miranda
Dr. G.S. Tjabringa
Dr. L. Westera
Dr. M.E. Wildenberg

PhD Students
Drs. M.C.S van der Heijden
Drs. F.M. Houttuijn Bloemendaal MD
T. Martins Garcia
J.H.M. van der Meer
B.J. Meijer MD
M. Navis
M.M.C. Prins
W.L. Smit
C.N. Spaan
Drs. B.F. Westendorp

Others
S. Meisner BSc
J.L. Vermeulen BSc
Ing. E.W.M. Vogels

Prof. dr. G.R.A.M. D'Haens PhD (CHRONIC INFLAMMATORY BOWEL DISEASES)

Other research related activities
  • Membership of editorial board / Editorship, JOURNAL OF CROHNS & COLITIS
  • Membership of editorial board / Editorship, GASTROENTEROLOGY
  • Membership of editorial board / Editorship, GUT
  • Membership of medical or scientific committee, European Crohn's and Colitis Organisation (ECCO), Scientific committee
  • Membership of medical or scientific committee, United European Gastroenterology (UEG), Educational committee
  • Membership of medical or scientific committee, UEG, Course director UEG Summer School
  • Membership of medical or scientific committee, UEG, Course director UEG Young Investigator Meeting