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Prof. dr. M. Nieuwdorp MD PhD

Position
Professor
Main activities
Research, Patient care
Specialisation
Internal medicine/Endocrinology-Vascular Medicine
Focus of research

 

- role of gutmicrobiota in development of human obesity, insulin resistance and dyslipidemia
 

 

Key publications
  • Vrieze A , van Nood E, Holleman F, Salojärvi J, Kootte RS, Bartelsman JFWM, Dallinga-Thie GM, Ackermans MT, Serlie MJ, Oozeer R, Derrien M, Druesne A, van Hylckama Vlieg JET, Bloks VW, Groen AK, Heilig HGHJ, Zoetendal EG, Stroes ES, de Vos WM, Hoekstra JBL, Nieuwdorp M, Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome. GASTROENTEROLOGY 2012;143 (4):913-+ [PubMed]
  • van Nood E, Vrieze A , Nieuwdorp M, Fuentes S, Zoetendal EG, de Vos WM, Visser CE, Kuijper EJ, Bartelsman JFWM, Tijssen JGP, Speelman P, Dijkgraaf MGW, Keller JJ, Duodenal infusion of donor feces for recurrent Clostridium difficile. NEW ENGL J MED 2013;368 (5):407-415 [PubMed]
  • Li SS, Zhu A, Benes V, Costea PI, Hercog R, Hildebrand F, Huerta-Cepas J, Nieuwdorp M, Salojärvi J, Voigt AY, Zeller G, Sunagawa S, de Vos WM, Bork P, Durable coexistence of donor and recipient strains after fecal microbiota transplantation. SCIENCE 2016;352 (6285):586-589 [PubMed]
  • Kootte RS, Levin E , Salojärvi J, Smits LP, Hartstra AV, Udayappan SD, Hermes G, Bouter KE, Koopen AM, Holst JJ, Knop FK, Blaak EE, Zhao J, Smidt H, Harms AC, Hankemeijer T, Bergman JJGHM, Romijn HA, Schaap FG, Olde Damink SWM, Ackermans MT, Dallinga-Thie GM, Zoetendal E, de Vos WM, Serlie MJ, Stroes ESG, Groen AK, Nieuwdorp M, Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition. CELL METAB 2017;26 (4):611-619.e6 [PubMed]
  • Deschasaux M, Bouter KE, Prodan A, Levin E , Groen AK, Herrema H, Tremaroli V, Bakker GJ, Attaye I, Pinto-Sietsma SJ, van Raalte DH, Snijder MB, Nicolaou M, Peters R, Zwinderman AH, Bäckhed F, Nieuwdorp M, Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography. NAT MED 2018;24 (10):1526-+ [PubMed]
All Publications
Curriculum Vitae

2002 MD (Utrecht University)

 

2007 PhD (AMC-Univerisity of Amsterdam,promotor: Prof J.J.P. Kastelein)

 

2007-2008 Postdoctoral fellow University of California San Diego (Glycobiology research center, prof J. Esko)

2008 VENI-ZONMW grant

2012 Registration Internist-Endocrinologist

 

2012-  Associate professor Vascular Medicine

 

2013-2018 Visiting Professor Sahlgrenska University Hospital, Gothenborg University (Prof F. Backhed)

 

2014- Chief Laboratory of Experimental Vascular Medicine, AMC-UvA

 

2014 VIDI-ZONMW grant

2015 Professor Internal Medicine  AMC-UvA

 

Research programmes

Gutmicrobiota as novel diagnostic and therapeutic targets in cardiometabolism

Our group focuses on the role of intestinal microbiota in chronic inflammation and human cardiometabolism in a translational fashion. We aim to find novel pathophysiological pathways driving cardiovascular disease, dyslipidemia and diabetes mellitus studying the role of baceria in adipose tissue, liver (NASH) and macrovascular inflammation. In line, we will try to identify novel therapeutic targets via identifying bacterial ligands or developing novel probiotic bacterial strains and vaccination leads to treat these diseases.

Faculty
Prof. dr. M. Nieuwdorp MD PhD
Dr. ir. G.M. Dallinga-Thie PhD
Prof. dr. A.K. Groen
Dr. J.H.M. Levels PhD
E. Levin PhD
Prof. dr. N.A.W. van Riel (Eindhoven University of Technology)
Prof. dr. E.S.G. Stroes MD PhD

Postdocs
Dr. M. Davids
H.J. Herrema PhD
Dr. ir. S.K. Imangaliyev
A. Prodan PhD

PhD Students
I. Attaye MD
O. Aydin
Drs. A.C.G. van Baar
Drs. G.J. Bakker MD (DOCTOR)
U. Boulund
Drs. K.E.C. Bouter
N.C. de Clercq
Drs. P.W. Gilijamse
D. Goncalves
Drs. P.F. de Groot
J.J. Habibe
Drs. A.V. Hartstra MD
V.A.T. Houttu
A.M. Koopen
A.W.J.M. van de Laar
A.S. Meijnikman
C.M. Mosterd
Drs. C.C. van Olden
P. Smeele
J. van Son
Drs. R.P. Surendran
M. Wijdeveld
J.J. Witjes
Drs. K. Wortelboer MSc
Drs. M.J.B. van Baar MD (VUMC)
K. Fluitman (VUMC)
L. van Ruiten MD (VUmC)
T. Scheithauer MSc (VUmc)

Others
J.C. Borger BSc
Ir. S.R. Havik
Ing. J.P. Jansen
R. Schmitz
Ing. M. Versloot
Ing. M. Winkelmeijer
D. Zwirs BSc

Prof. dr. E.S.G. Stroes MD PhD (Novel anti-atherogenic strategies targeting the vessel wall)

Other research related activities
  • Membership of advisory board / Consultant, Caelus Health
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • AstraZeneca BV
  • Caelus Pharmaceuticals B.V.
  • Europese Unie
  • Fondation Leducq
  • Nederlandse Hartstichting
  • Novo Nordisk B.V.
  • Stichting AMC Foundation (Vrijgesteld)
  • Technical University of Denmark
  • The Novo Nordisk Foundation Center
  • ZonMw