Prof. dr. N. Zelcer PhD

Associate professor (UHD)
Main activities
Transcriptional regulation of metabolism
Focus of research

* Contribution of the LXR-IDOL-LDLR axis to cholesterol metabolism

* Identification of novel metabolic genes

* Studying the contribution of the UPS system to metabolism

Key publications
  • Sorrentino V, Fouchier SW, Motazacker MM, Nelson JK, Defesche JC, Dallinga-Thie GM, Kastelein JJP, Kees Hovingh G, Zelcer N, Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein. EUR HEART J 2013;34 (17):1292-1297 [PubMed]
  • Nelson JK, Sorrentino V, Avagliano Trezza R, Heride C, Urbe S, Distel B, Zelcer N, The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL. CIRC RES 2016;118 (3):410-419 [PubMed]
  • Lu X, Meima ME, Nelson JK, Sorrentino V, Loregger A, Scheij S, Dekkers DHW, Mulder MT, Demmers JAA, M-Dallinga-Thie G, Zelcer N, Danser AHJ, Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism. CIRC RES 2016;118 (2):222-229 [PubMed]
  • Zelcer N, Sharpe LJ, Loregger A, Kristiana I, Cook ECL, Phan L, Stevenson J, Brown AJ, The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway. MOL CELL BIOL 2014;34 (7):1262-1270 [PubMed]
  • Zelcer N, Hong C, Boyadjian R, Tontonoz P, LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. SCIENCE 2009;325 (5936):100-104 [PubMed]
All Publications
Research programmes

Transcriptional regulation of metabolism

 Research program:


Prof. dr. N. Zelcer PhD

Dr. A. Loregger
Dr. L. Martinelli
Dr. F. Mortensen

PhD Students
J.E. Hakonen
N.M. van Loon
J.M.E. Tan
S.A.E. van Wouw MSc

Ing. M. van den Berg
Dr. M. Moeton
Ing. R. Ottenhoff
Ing. S. Scheij

Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Europese Unie
  • Nederlandse Hartstichting
  • NWO
  • Stichting AMC Foundation (Vrijgesteld)
  • University of Notre Dame