Prof. dr. N.F. de Keizer

Main activities
Teaching, Research
Medical Informatics
Focus of research
  • Evaluation of quality of health care
  • Evaluation of health care information systems
  • Semantic interoperability and Terminological systems
Key publications
  • Karakus A, Haas LEM, Brinkman S, de Lange DW, de Keizer NF, Trends in short-term and 1-year mortality in very elderly intensive care patients in the Netherlands: a retrospective study from 2008 to 2014. INTENS CARE MED 2017;43 (10):1476-1484 [PubMed]
  • van de Klundert N, Holman R, Dongelmans DA, de Keizer NF, Data Resource Profile: the Dutch National Intensive Care Evaluation (NICE) Registry of Admissions to Adult Intensive Care Units. INT J EPIDEMIOL 2015;44 (6):1850-1850h [PubMed]
  • van der Veer SN, de Vos MLG, van der Voort PHJ, Peek N, Abu-Hanna A, Westert GP, Graafmans WC, Jager KJ, de Keizer NF, Effect of a Multifaceted Performance Feedback Strategy on Length of Stay Compared With Benchmark Reports Alone: A Cluster Randomized Trial in Intensive Care. CRIT CARE MED 2013;41 (8):1893-1904 [PubMed]
  • Oluoch T, Katana A, Ssempijja V, Kwaro D, Langat P, Kimanga D, Okeyo N, Abu-Hanna A, de Keizer N, Electronic medical record systems are associated with appropriate placement of HIV patients on antiretroviral therapy in rural health facilities in Kenya: a retrospective pre-post study. J AM MED INFORM ASSN 2014;21 (6):1009-1014 [PubMed]
  • Dentler K, Numans ME, ten Teije A, Cornet R, de Keizer NF, Formalization and computation of quality measures based on electronic medical records. J AM MED INFORM ASSN 2014;21 (2):285-291 [PubMed]
All Publications
Research programmes

Evaluation of health care and health care information

Within my research group 3 research lines can be distinguished:

1) Evaluation of quality of health care

2) Evaluation of health care information systems

3) Terminological systems

Ad 1) Most of my research is related to the Nationale Intensive Care Evaluation (NICE) registry. This registry contains case mix and outcome data of more than 80 Dutch ICUs. The goal of NICE is to assess and improve the quality of Dutch ICUs and to perform epidemiological research. Institutional comparison based on case-mix adjusted outcome plays an important role. All aspect that are important to continuously monitor quality of care by a national registry are part of this research line. Case-mix correction, prognostic models, benchmarking, quality indicators, feedback, quality of data are subjects of investigation.

Ad 2) This research line has an local, national and an international part. Within the AMC several evaluation projects of new information technologies have been running, e.g. evaluation of  the (cost) effectiveness of Teledermatology, evaluation of decision support systems in the intensive care for tidal volume, glucose regulation and medication prescription. On a national level a decision support system for cardiac rehabilitation has been evaluated on adherence to a national guideline. As a follow up a multifaceted intervention including feedback and educational outreach visits next to the decision support is evaluated. As the chair of the International Medical Informatics Association working group on health technology assessment I am involved in the development of guidelines for planning, developing and reporting evaluation studies in health informatics. Furthermore, I supervise evaluation projects of EMRs implemented in Kenya.

Ad 3) More and more health institutions are implementing electronic patient records. Ultimately data recorded in the electronic patient record can be reused for research, management information, decision support, financial and quality assessment. This is only possible when data is recorded in a detailled but also structured and standardized way. To enable standardized data entry terminological systems are essential. This research line cooperates with the Dutch ICT Institute in health care (NICTIZ) and the International Health Terminology Standard Development Organisation (IHTSDO) to investigate how end users can easily work with a terminologicalsystem, to what extend detailled and standardized data recording can be mapped to existing classifications such as ICD10 and DBC to reused the data for multiple puposes such as calculation of quality indicators, financial reimbursement, research. In this line we participate in the NFU program  "Eenmalige registratie bij de bron".


Prof. dr. N.F. de Keizer
Dr. ir. R. Cornet PhD

Dr. F. Bakhshi-Raiez PhD
Dr. S. Brinkman PhD
Dr. F. Termorshuizen

PhD Students
T. Bakker MSc
Drs. I. van Beusekom MSc
G.T.N. Burger
P. van Damme BSc
W.T. Gude MSc
M.E. Hoogendoorn
E. Joukes MSc
J.K. Kabukye
M. Knijff
C.C. Margadant MSc
H.J.T. van Mens MSc
M. Roos-Blom MSc
S.A. Wortel MSc

R. Minne MSc
Ir. W.G. Tjon Sjoe-Sjoe
E.P. van der Zwan

Other research related activities
  • Membership of editorial board / Editorship, INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
  • Board of directors / Trustees / Supervisory board, National Intensive Care Evaluation
  • Membership of medical or scientific committee, European Federation Medical Informatics, Medical informatics Europe conference SPC
  • Other, Ver. v. Informatieverwerking in de Zorg (VMBI)
Current research funding
  • AMC
  • Europese Unie
  • KNMG
  • Ministerie van VWS
  • RIVM
  • Stichting NICE