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Prof. J.J.G.H.M. Bergman MD PhD

Main activities
Patient care, Research
Focus of research

Endoscopic detection and treatment of early neoplasia in the digestive tract.

Key publications
  • Phoa KN, van Vilsteren FGI, Weusten BLAM, Bisschops R, Schoon EJ, Ragunath K, Fullarton G, Di Pietro M, Ravi N, Visser M , Offerhaus GJ, Seldenrijk CA, Meijer SL, ten Kate FJW, Tijssen JGP, Bergman JJGHM, Radiofrequency Ablation vs Endoscopic Surveillance for Patients With Barrett Esophagus and Low-Grade Dysplasia A Randomized Clinical Trial. JAMA-J AM MED ASSOC 2014;311 (12):1209-1217 [PubMed]
  • Wani S, Rubenstein JH, Vieth M, Bergman J, Diagnosis and Management of Low-Grade Dysplasia in Barrett's Esophagus: Expert Review From the Clinical Practice Updates Committee of the American Gastroenterological Association. GASTROENTEROLOGY 2016;151 (5):822-835 [PubMed]
  • Duits LC, van der Wel MJ, Cotton CC, Phoa KN, ten Kate FJW, Seldenrijk CA, Offerhaus GJA, Visser M , Meijer SL, Mallant-Hent RC, Krishnadath KK, Pouw RE, Tijssen JGP, Shaheen NJ, Bergman JJGHM, Patients With Barrett's Esophagus and Confirmed Persistent Low-Grade Dysplasia Are at Increased Risk for Progression to Neoplasia. GASTROENTEROLOGY 2017;152 (5):993-1001.e1 [PubMed]
  • Boerwinkel DF, Swager AF, Curvers WL, Bergman JJGHM, The clinical consequences of advanced imaging techniques in Barrett's esophagus. GASTROENTEROLOGY 2014;146 (3):622-629.e4 [PubMed]
  • Phoa KN, Pouw RE, Bisschops R, Pech O, Ragunath K, Weusten BLAM, Schumacher B, Rembacken B, Meining A, Messmann H, Schoon EJ, Gossner L, Mannath J, Seldenrijk CA, Visser M , Lerut T, Seewald S, ten Kate FJ, Ell C, Neuhaus H, Bergman JJGHM, Multimodality endoscopic eradication for neoplastic Barrett oesophagus: results of an European multicentre study (EURO-II). GUT 2016;65 (4):555-562 [PubMed]
All Publications
Curriculum Vitae

Jacques Bergman was born in 1965 and qualified from the University of Utrecht in 1991. He undertook his PhD-training, dedicated to the endoscopic management of gallstone disease, in Amsterdam. He was trained in Gastroenterology in Den Bosch and Amsterdam and was appointed Consultant Gastroenterologist, at Academic Medical Center in Amsterdam in 2001 as Associate Professor in 2005, and was appointed as Head of department of Endoscopy and Professor of Gastrointestinal Endoscopy in 2011.

Dr. Bergman is the head of the AMC esophageal research team, which conducts endoscopic studies into endoscopic detection and treatment of early neoplasia in the upper digestive tract.
His research team currently consists of four physicians/endoscopists, ten research fellows, five research nurses, a database manager, and 2 physician assistants. The group has extensive experience with multicenter clinical trials and coordinates international studies in Europe, the United States and China.

Dr Bergman is member of the International Editorial board of “Gastrintestinal Endoscopy” and member of the International Editorial board of “Endoscopy”.

Dr. Bergman is a permanent member of International Working Group on Classification of Oesophagitis and is the secretary of the Dutch Society of Gastrointestinal Endoscopy.

Dr. Bergman has authored and co-authored on over 200 peer reviewed publications and text book chapters and has lectured at many national and international meetings.

Research programmes

Detection and treatment of upper gastrointestinal cancer

 

Jacques Bergman leads a variety imaging studies on detection of early neoplasia in the upper GI tract. Techniques that are currently under investigation include high resolution endoscopy, optical chromoscopy, volumetric laser endomicroscopy, and spectroscopy techniques. His group also investigates computer assisted endoscopic detection of early neoplasia as part of a consortium with the Technical University Eindhoven, the Catharina Hospital Eindhoven and the University Hospital in Leuven.

In addition, his group has a strong focus on the endoscopic treatment of early neoplasia using endoscopic resection and endoscopic ablation techniques as well as in organizing training programs in this field (www.barrett.nl and www.best-academia.eu).

The group also facilitates basic research on biomarkers in Barrett’s esophagus; epithelial differentiation, morphogenesis and pathogenesis in Barrett’s esophagus; gene therapy and dendritic cell therapy for esophageal cancer; and proteomics in Barrett’s esophagus. This part is led by Dr. Sheila Krishnadth, gastroenterologist at the same department.

Jacques Bergman leads ReBus: a large tissue bank project that incorporates clinical data and tissue samples of 1,000 patients treated for early Barrett's neoplasia; 3,500 Barrett's surveillance patients in the Amsterdam region; 1,500 proscpectively followed Barrett's patients in the Amsterdam Prospective Barrett's Registration Project; and 750 Barrett's patients with low-grade dysplasia.

Jacques Bergman is also involved in studies investigating the use of duodenal mucosal ablation for metabolic regulation (diabetes mellitus and NAFLD/NASH) in which he collaborates with endocrinologists and hepatologists at the AMC and a number of European institutes. He is the PI of two clinical trials in this field.

The team currently consists of two physicians/endoscopists, twelve clinical research fellows, three research nurses, and 2 physician assistants. The group has extensive experience with clinical trials and is trained according to GCP standards. The team coordinates several international multi-center studies.  

 

Faculty
Prof. J.J.G.H.M. Bergman MD PhD

Postdocs
Dr. R.E. Pouw MD PhD

PhD Students
Drs. A.C.G. van Baar
Drs. K. Belghazi
L.C. Duits MD
K.N. Fockens
A.J. de Groof
E. Klaver
K. Konte
S. Meiring
Drs. S.N. van Munster
Drs. E.A. Nieuwenhuis
Drs. W.D. Rosmolen
P. Smeele
M.R. Struyvenberg
Drs. M. van der Wel
J. van der Putten (Technical University Eindhoven)
C. Stingl (Erasmus MC)

Others
C. 't Hoen
P.S. de Koning
D. Meens-van Maris
C.M. Sondermeijer

Other research related activities
  • Membership of editorial board / Editorship, GASTROENTEROLOGY
  • Membership of editorial board / Editorship, GASTROINTESTINAL ENDOSCOPY
  • Membership of editorial board / Editorship, ENDOSCOPY
  • Membership of medical or scientific committee, Endoscopy section of Dutch Society of Gastroenterology
  • Membership of medical or scientific committee, International Working Group on Classification of Oesophagitis
  • Contribution to guidelines and protocols, ESGE Guideline for Barrett's Esophagus
  • Contribution to guidelines and protocols, CBO Guideline Oesophageal Cancer
  • Contribution to guidelines and protocols, NVMDL Guideline for Barrett's esophagus
  • Contribution to guidelines and protocols, IKC Guideline Gastric Cancer
  • Contribution to training of professionals, European EMR and RFA training program
  • Contribution to training of professionals, Dutch EMR training program
  • Board of directors / Trustees / Supervisory board, Esophageal Research Foundation Amsterdam
  • Board of directors / Trustees / Supervisory board, Dutch Barrett's registration Foundation
Current research funding
  • Aqua Medical Inc.
  • C2 Therapeutics, Inc.
  • CDx Diagnotics
  • ERBE Elektromedizin GmbH
  • Fractyl Laboratories Inc.
  • FUJIFILM Europe GmbH
  • Haga Ziekenhuis
  • Integraal Kankercentrum A'dam
  • Interpace Diagnostics Corporation
  • KWF Kankerbestrijding
  • Life Sciences Health TKI
  • Maag-Darm Stichting
  • Medtronic/MITG/GI Solutions
  • NinePoint Medical Inc.
  • Stichting AMC Foundation (Vrijgesteld)
  • Technologiestichting STW