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Prof. M. Nieuwdorp MD PhD

Position
Full Professor
Main activities
Patient care, Research
Specialisation
Internal medicine/Endocrinology-Vascular Medicine
Focus of research

 

- role of gutmicrobiota in development of human obesity, insulin resistance and dyslipidemia
 

 

Key publications
  • de Groot Pieter, Scheithauer Torsten, Bakker Guido J., Prodan Andrei, Levin Evgeni, Khan Muhammad Tanweer, Herrema Hilde, Ackermans Mariette, Serlie Mireille J. M., de Brauw Maurits, Levels Johannes H. M., Sales Amber, Gerdes Victor E., Ståhlman Marcus, Schimmel Alinda W. M., Dallinga-Thie Geesje, Bergman Jacques Jghm, Holleman Frits, Hoekstra Joost B. L., Groen Albert, Bäckhed Fredrik, Nieuwdorp Max Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time Gut 2019 [PubMed]
  • Deschasaux M. lanie, Bouter Kristien E., Prodan Andrei, Levin Evgeni, Groen Albert K., Herrema Hilde, Tremaroli Valentina, Bakker Guido J., Attaye Ilias, Pinto-Sietsma Sara-Joan, van Raalte Daniel H., Snijder Marieke B., Nicolaou Mary, Peters Ron, Zwinderman Aeilko H., Bäckhed Fredrik, Nieuwdorp Max Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography Nature medicine 2018;24 (10):1526-1531 [PubMed]
  • Kootte Ruud S., Levin Evgeni, Salojärvi Jarkko, Smits Loek P., Hartstra Annick V., Udayappan Shanti D., Hermes Gerben, Bouter Kristien E., Koopen Annefleur M., Holst Jens J., Knop Filip K., Blaak Ellen E., Zhao Jing, Smidt Hauke, Harms Amy C., Hankemeijer Thomas, Bergman Jacques J. G. H. M., Romijn Hans A., Schaap Frank G., Olde Damink Steven W. M., Ackermans Mariette T., Dallinga-Thie Geesje M., Zoetendal Erwin, de Vos Willem M., Serlie Mireille J., Stroes Erik S. G., Groen Albert K., Nieuwdorp Max Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition Cell metabolism 2017;26 (4):611-+ [PubMed]
  • Nieuwdorp Max Looking for the start of metabolic disease in the gut Nature medicine 2019;25 (5):709 [PubMed]
  • Bouter Kristien E., van Raalte Daniël H., Groen Albert K., Nieuwdorp Max Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction Gastroenterology 2017;152 (7):1671-1678 [PubMed]
All Publications
Curriculum Vitae

2002 MD (Utrecht University)

 

2007 PhD (AMC-Univerisity of Amsterdam,promotor: Prof J.J.P. Kastelein)

 

2007-2008 Postdoctoral fellow University of California San Diego (Glycobiology research center, prof J. Esko)

2008 VENI-ZONMW grant

2012 Registration Internist-Endocrinologist/Vascular Medicine specialist

 

2012-  Associate professor Vascular Medicine

 

2013-2018 Visiting Professor Sahlgrenska University Hospital, Gothenborg University (Prof F. Backhed)

 

2014- Chair department of Experimental Vascular Medicine,  Amsterdam UMC 

 

2014 VIDI-ZONMW grant

 

2015 Professor Internal Medicine  AMC-UvA

 

2019 Chief division of Vascular Medicine, department of Internal Medicine, Amsterdam UMC 

 

Research programmes

Prof. M. Nieuwdorp MD PhD (Gutmicrobiota as novel diagnostic and therapeutic targets in cardiometabolism)

Our group focuses on the role of intestinal microbiota in chronic inflammation and human cardiometabolism in a translational fashion. We aim to find novel pathophysiological pathways driving cardiovascular disease, dyslipidemia and diabetes mellitus studying the role of baceria in adipose tissue, liver (NAFLD-NASH) and macrovascular inflammation. To thus end we use microbiota data derived from both fecal transplantation studies as well as the large prospective multiethnic HELIUS cohort.  In line, we will try to identify novel therapeutic targets via identifying bacterial ligands or developing novel probiotic bacterial strains and vaccination leads to treat these diseases.

Faculty
G.M. Dallinga-Thie MEng PhD
Prof. A.K. Groen PhD
J.H.M. Levels PhD
E. Levin PhD
Prof. E.S.G. Stroes MD PhD
Prof. N.A.W. van Riel PhD

Postdocs
M. Davids PhD
H.J. Herrema PhD
S.K. Imangaliyev MEng PhD
A. Prodan PhD

PhD Students
K. Fluitman
T. Scheithauer MSc
M.J.B. van Baar MD
L. van Ruiten MD

Others
J.C. Borger BSc
S.R. Havik MEng
J.P. Jansen BEng
R. Schmitz
M. Versloot BEng
M. Winkelmeijer BEng
D. Zwirs BSc

Prof. E.S.G. Stroes MD PhD (Novel anti-atherogenic strategies targeting the vessel wall)

Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Amsterdam Gastroenterology and Metabolism Res. Institute
  • BioCryst Pharmaceuticals, Inc.
  • CSL Behring LLC
  • Crediteurenadm. VUmc, p/a Profource Service Center
  • Diabetes Fonds Nederland
  • Eli Lilly Nederland BV
  • Europese Unie
  • Fondation Leducq
  • Gilead Sciences
  • Life Sciences Health TKI
  • Nederlandse Hartstichting
  • Novo Nordisk B.V.
  • Orion Clinical Services Limited
  • Technical University of Denmark
  • The Novo Nordisk Foundation Center
  • UMC Utrecht
  • Vascular Research Network BV
  • ZonMw