Prof. M.A. Benninga PhD

Full Professor
Main activities
Education, Patient care, Research
Functional Gastrointestinal Disorders, IBD, Parenteral Nutrition
Focus of research
  • Functional gastrointestinal disorders
  • Gastro-oesophageal reflux disease
  • Abdominal pain
  • Constipation and fecal incontinence in childhood
  • Inflammatory bowel disease
Key publications
  • Bongers Marloes E. J., van Wijk Michiel P., Reitsma Johannes B., Benninga Marc A. Long-Term Prognosis for Childhood Constipation: Clinical Outcomes in Adulthood Pediatrics 2010;126 (1):E156-E162 [PubMed]
  • van den Berg Maartje M., Bongers Marloes E. J., Voskuijl Wieger P., Benninga Marc A. No role for increased rectal compliance in pediatric functional constipation Gastroenterology 2009;137 (6):1963-1969 [PubMed]
  • Bekkali Noor-L.-Houda, van den Berg Maartje-Maria, Dijkgraaf Marcel G. W., van Wijk Michiel P., Bongers Marloes E. J., Liem Olivia, Benninga Marc A. Rectal Fecal Impaction Treatment in Childhood Constipation: Enemas Versus High Doses Oral PEG Pediatrics 2009;124 (6):E1108-E1115 [PubMed]
  • Vlieger Arine M., Menko-Frankenhuis Carla, Wolfkamp Simone C. S., Tromp Ellen, Benninga Marc A. Hypnotherapy for children with functional abdominal pain or irritable bowel syndrome: a randomized controlled trial Gastroenterology 2007;133 (5):1430-1436 [PubMed]
  • van der Plas R. N., Benninga M. A., Büller H. A., Bossuyt P. M., Akkermans L. M., Redekop W. K., Taminiau J. A. Biofeedback training in treatment of childhood constipation: a randomised controlled study Lancet 1996;348 (9030):776-780 [PubMed]
All Publications
Research programmes

Prof. M.A. Benninga PhD (Functional Gastro-intestinal Disorders in Childhood)

Reflux disease: Using combined manometry-impedance assembly we showed that minute amounts of feed trigger transient lower esophageal sphincter relaxations (TLESRs) in the right lateral position, but not in the left lateral position.These findings provide clear evidence for the presence of mechanisms for luminal sensing of gastric contents at the level of esophago-gastric junction which regulate the threshold for triggering of the TLESRs by gastric distension. Abdominal pain: We compared the effect of Hypnotherapy in the treatment of 53 children with long lasting complaints of functional abdominal pain and irritable bowel syndrome with that of standard medical therapy (SMT), consisting of education, dietary interventions and intervention on stress factors.  Hypnotherapy was highly superior with a significantly greater reduction in pain scores compared to SMT (p<0.001). At one year follow up, successful treatment was accomplished in 85% of the HT group and 25% of the SMT group (p <0.001) Constipation: Distensability (compliance) of the rectum was higher in children with functional constipation when compared to healthy children. This means that the rectum is stretched and larger stool volumes are needed to trigger rectal sensation. While this parameter of rectal function is abnormal in the majority of children with severe constipation, the clinical relevance of rectal compliance is not yet investigated.

This research group participates in MLDS

A. Kindermann PhD
B.G.P. Koot MD PhD
M.M. Tabbers MD PhD
M.P. van Wijk MD PhD
A.M. Vlieger

PhD Students
T. de Meij
M.L. van Engelenburg-van Lonkhuyzen

I. de Kruijff PhD
A. Lei
H.W. Voogt

Current research funding
  • ALLERGAN Limited
  • AMC
  • BGP Products Operations GmBH
  • Baxter Healthcare Corporation
  • Inventia
  • Janssen Biologics B.V.
  • Janssen Cilag B.V.
  • MAPI S.A.S. - RWE
  • MC Haaglanden
  • St.Steun EKZ AMC Fonds Motiliteitslaboratorium
  • St.Steun Emma Kinderzkh. AMC, Fonds Motiliteitslaboratorium
  • StatFinn Oy
  • Stichting AMC Foundation
  • Stichting Vermeer 14
  • Stichting Virtutis Opus
  • Stichting tot Steun EKZ-AMC
  • UMCG