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Prof. MD PhD A.C. van der Wal

Position
Full Professor
Main activities
Education, Patient care, Research
Specialisation
Cardiovascular Pathology
Focus of research

atherosclerosis and thrombosis

sudden cardiac death

vascular tumours

Key publications
  • Castellani C., Angelini A., de Boer O. J., van der Loos C. M., Fedrigo M., Frigo A. C., Meijer-Jorna L. B., Li X., Ploegmakers H. J. P., Tona F., Feltrin G., Gerosa G., Valente M., Thiene G., van der Wal A. C. Intraplaque hemorrhage in cardiac allograft vasculopathy American journal of transplantation 2014;14 (1):184-192 [PubMed]
  • de Boer Onno J., Li Xiaofei, Teeling Peter, Mackaay Claire, Ploegmakers Hanneke J., van der Loos Chris M., Daemen Mat J., de Winter Robbert J., van der Wal Allard C. Neutrophils, neutrophil extracellular traps and interleukin-17 associate with the organisation of thrombi in acute myocardial infarction Thrombosis and haemostasis 2013;109 (2):290-297 [PubMed]
  • Halushka Marc K., Angelini Annalisa, Bartoloni Giovanni, Basso Cristina, Batoroeva Lubov, Bruneval Patrick, Buja L. Maximilian, Butany Jagdish, d'Amati Giulia, Fallon John T., Gallagher Patrick J., Gittenberger-de Groot Adriana C., Gouveia Rosa H., Kholova Ivana, Kelly Karen L., Leone Ornella, Litovsky Silvio H., Maleszewski Joseph J., Miller Dylan V., Mitchell Richard N., Preston Stephen D., Pucci Angela, Radio Stanley J., Rodriguez E. Rene, Sheppard Mary N., Stone James R., Suvarna S. Kim, Tan Carmela D., Thiene Gaetano, Veinot John P., van der Wal Allard C. Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association For European Cardiovascular Pathology: II. Noninflammatory degenerative diseases - nomenclature and diagnostic criteria Cardiovascular pathology 2016;25 (3):247-257 [PubMed]
  • Grundeken Maik J., Li Xiaofei, Kurpershoek C. Eline, Kramer Miranda C., Vink Aryan, Piek Jan J., Tijssen Jan G. P., Koch Karel T., Wykrzykowska Joanna J., de Winter Robbert J., van der Wal Allard C. Distal embolization of hydrophilic-coating material from coronary guidewires after percutaneous coronary interventions Circulation. Cardiovascular interventions 2015;8 (2):e001816 [PubMed]
  • Li Xiaofei, de Boer Onno J., Ploegmaker Hanneke, Teeling Peter, Daemen Mat Jap, de Winter Robbert J., van der Wal Allard C. Granulocytes in coronary thrombus evolution after myocardial infarction--time-dependent changes in expression of matrix metalloproteinases Cardiovascular pathology 2016;25 (1):40-46 [PubMed]
All Publications
Research programmes

Prof. MD PhD A.C. van der Wal (Cardiovascular Pathology)

1. From plaque instabilty towards thrombus instability. Clinicopathological correlations, mainly features of plaque inflammation) of patients with various ischemic coronary syndromes were investigated, prior to treatment (de novo plaques) or after coronary intervention (restenosis plaques, stented arteries) which is longlasting and succesful collaboration with AMC department of Cardiology (Prof RJ de Winter). Present focus is on coronary thrombectomy specimens which have been histologically graded with opportunities for combined pathological and epidemiological work. Results gave new insights in thrombus organization and propagation after plaque rupture / erosion.; research focus has shifted from plaque towards the coronary trombus, with focus on neutrophils and their secretory proteins, Apoptosis and Netosis in thrombus and interaction with coagulation and plaque inflammation and processes of tissue repair (angiogenesis and fibrogenesis). Large tissue bank of >2500 thrombectomy samples and coronary arteries  obtained at autopsy are instrumental for these  studies

2. Coronary Allograft Vasculopathy (CAV) is studied together with pathologists of University of Padua (Prof Angelini): various mechanisms of vascular rejection and their implications for lesional angiogensis, hemorrhage and thrombosis.

3. Angiomas and vascular Malformations. Mechanisms of angiogenesis and vessel maturation have been studied in a large cohort of patients with archived materials (>250, representing unique series of vascular anomlies) by in situ investigations on growth factors for vascular wall cells, expression of cell cycle specific proteins, and association with clinical parameters and follow up; This resulted in PhD thesis of Dr Meijer-Jorna. We will further evaluate implications of these novel findings for the current classifications of vascular anomalies, and investigate angiogenesis as possible target for therapies in symptomatic vascular malformations.

4. Pathology collaboration and support of clinical research groups in AMC and UMC Utrecht and of Association for European Cardiovascular Pathology (AECVP): on diversity of topics in cardiovascular pathology

Faculty
Prof. PhD M.J.A.P. Daemen
PhD O.J. de Boer

Postdocs
D. Dara Rosmailina Pabittei