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Prof. PhD C.J.F. van Noorden

Position
Full Professor
Main activities
Education, Research
Specialisation
Histology and Cell Biology
Focus of research

Cancer  Metabolism

Key publications
  • Molenaar Remco J., Botman Dennis, Smits Myrthe A., Hira Vashendriya V., van Lith Sanne A., Stap Jan, Henneman Peter, Khurshed Mohammed, Lenting Krissie, Mul Adri N., Dimitrakopoulou Dionysia, van Drunen Cornelis M., Hoebe Ron A., Radivoyevitch Tomas, Wilmink Johanna W., Maciejewski Jaroslaw P., Vandertop W. Peter, Leenders William P., Bleeker Fonnet E., van Noorden Cornelis J. Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198 Cancer research 2015;75 (22):4790-4802 [PubMed]
  • Molenaar Remco J., van Noorden Cornelis J. Type 2 diabetes and cancer as redox diseases? Lancet 2014;384 (9946):853 [PubMed]
  • Chieco Pasquale, Jonker Ard, de Boer Bouke A., Ruijter Jan M., van Noorden Cornelis J. F. Image cytometry: protocols for 2D and 3D quantification in microscopic images Progress in histochemistry and cytochemistry 2013;47 (4):211-333 [PubMed]
  • Hira Vashendriya V. V., Ploegmakers Kimberley J., Grevers Frederieke, Verbovšek Urška, Silvestre-Roig Carlos, Aronica Eleonora, Tigchelaar Wikky, Turnšek Tamara Lah, Molenaar Remco J., van Noorden Cornelis J. F. CD133+ and Nestin+ Glioma Stem-Like Cells Reside Around CD31+ Arterioles in Niches that Express SDF-1α, CXCR4, Osteopontin and Cathepsin K journal of histochemistry and cytochemistry 2015;63 (7):481-493 [PubMed]
  • Verma Jyoti, Lal Sumit, van Noorden Cornelis J. F. Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma International journal of nanomedicine 2014;9:2863-2877 [PubMed]
All Publications
Research programmes

Prof. PhD C.J.F. van Noorden (Cancer metabolism)

Glioblastoma research is focussed on energy metabolism because we have strong indications that the Warburg effect does not apply to glioblastoma. Mitochondrial glutamine/glutamate catabolism seems to be important as energy source in cancer cells. Furthermore, the mutation in the genes of the metabolic enzymes NADP-dependent isocitrate dehydrogenase (IDH) 1 and 2 was found to be linked with prolonged survival of secondary glioblastoma patients. With the use of quantitative histochemical means, we investigate molecular mechanisms of the prolonged survival.