foto

Prof. PhD J. Booij

Position
Full Professor
Main activities
Patient care, Research
Specialisation
neuroreceptor imaging
Focus of research

Our research is focussed on neuroreceptor imaging with SPECT and PET, with special interests in Parkinson's disease, dementia with Lewy bodies, schizophrenia, addiction, major depression, and neurotoxicity of XTC. In addiction, preclinial research is focussed on the development of new SPECT and PET tracers, and SPECT imaging in small laboratory animals

Key publications
  • Joling Merijn, Vriend Chris, van den Heuvel Odile A., Raijmakers Pieter G. H. M., Jones Paul A., Berendse Henk W., Booij Jan Analysis of Extrastriatal I-123-FP-CIT Binding Contributes to the Differential Diagnosis of Parkinsonian Diseases Journal of nuclear medicine 2017;58 (7):1117-1123 [PubMed]
  • Bakker Geor, Vingerhoets Wilhelmina A., van Wieringen Jan-Peter, de Bruin Kora, Eersels Jos, de Jong Jan, Chahid Youssef, Rutten Bart P., Dubois Susan, Watson Megan, Mogg Adrian J., Xiao Hongling, Crabtree Michael, Collier David A., Felder Christian C., Barth Vanessa N., Broad Lisa M., Bloemen Oswald J., van Amelsvoort Thérèse A., Booij Jan I-123-Iododexetimide Preferentially Binds to the Muscarinic Receptor Subtype M-1 In Vivo Journal of nuclear medicine 2015;56 (2):317-322 [PubMed]
  • Crunelle Cleo L., van den Brink Wim, Dom Geert, Booij Jan Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD British journal of psychiatry 2014;204 (6):486-487 [PubMed]
  • Doppler Kathrin, Jentschke Hanna-Maria, Schulmeyer Lena, Vadasz David, Janzen Annette, Luster Markus, Höffken Helmut, Mayer Geert, Brumberg Joachim, Booij Jan, Musacchio Thomas, Klebe Stephan, Sittig-Wiegand Elisabeth, Volkmann Jens, Sommer Claudia, Oertel Wolfgang H. Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease Acta neuropathologica 2017;133 (4):535-545 [PubMed]
  • Gevonden Martin, Booij Jan, van den Brink Wim, Heijtel Dennis, van Os Jim, Selten Jean-Paul Increased release of dopamine in the striata of young adults with hearing impairment and its relevance for the social defeat hypothesis of schizophrenia JAMA psychiatry 2014;71 (12):1364-1372 [PubMed]
All Publications
Research programmes

Prof. PhD J. Booij (Neuroreceptor imaging in addiction and neuropsychiatric disorders)

  • The role of dopamine in PKU
  • Imaging of dopamine transporters to differentiate dementia with Lewy bodies from Alzheimer’s disease
  • Serotonin transporter imaging in depression, and the occupancy of the serotonin transporter by the SSRI paroxetine
  • Assessment of loss of serotonin transporters in Ecstasy users
  • Detection of loss of dopamine D2 receptor binding in heroin and cocaine users
  • Effects of methylphenidaat in ADHD patients with comorbid cocaine addiction
  • Effects of varenicline on dopamine D2 receptors and craving
  • Imaging of the occupancy of D2 receptors by endogenous dopamine (acute dopamine depletion paradigm) in healthy controls and VCFS patients
  • The role of the dopaminergic and serotonergic system in focal dystonia
  • Dopamine D2 receptors and its role in obesity

Theme: Neurological and Psychiatric Disorders

Postdocs
PhD S.M. Adriaanse
PhD J.L.H. Eersels

PhD Students
I.M. Bakker
MSc M.J. Gevonden
M. Joling
R. Schalbroeck
E.D.A. van Duin

Current research funding
  • AMC (Vrijgesteld)
  • GE Healthcare BV
  • GE Healthcare Limited
  • Siemens Healthcare Nederland B.V.
  • ZonMw (Vrijgesteld)