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Prof. PhD J.H. Ravesloot

Position
Full Professor
Main activities
Education
Specialisation
Educational management
Focus of research

Investigation of ion transport processes across the plasma membrane of mammalian cardiac cells.  Patch-clamp technology and quantitative fluorescence microscopy are employed to answer the scientific questions.  The type of research questions we address pertain to the physiology and pathophysiology of cardiac disease.  In particular, arrhythmias, ischemic heart disease and heart failure.   

Key publications
  • van Borren Marcel M. G. J., Verkerk Arie O., Wilders Ronald, Hajji Najat, Zegers Jan G., Bourier Jan, Tan Hanno L., Verheijck Etienne E., Peters Stephan L. M., Alewijnse Astrid E., Ravesloot Jan-Hindrik Effects of muscarinic receptor stimulation on Ca2+ transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells Basic research in cardiology 2010;105 (1):73-87 [PubMed]
  • Jansen Ineke D. C., Mardones Pablo, Lecanda Fernando, de Vries Teun J., Recalde Sergio, Hoeben Kees A., Schoenmaker Ton, Ravesloot Jan-Hindrik, van Borren Marcel M. G. J., van Eijden Theo M., Bronckers Antonius L. J. J., Kellokumpu Sakari, Medina Juan F., Everts Vincent, Oude Elferink Ronald P. J. Ae2(a,b)-Deficient mice exhibit osteopetrosis of long bones but not of calvaria FASEB journal 2009;23 (10):3470-3481 [PubMed]
  • Snoeckx L. H. E. H., Ivanics T., Peltonen L., Decking U., Ravesloot J. H. Teaching workshop on 'Implications of the Bologna Declaration for Teaching Physiology in Medical Education' at the joint meeting of the German Physiological Society and the Federation of European Physiological Societies, Cologne, 2-5 March 2008 Acta physiologica (Oxford, England) 2008;194 (2):171-173 [PubMed]
  • van Borren Marcel M. G. J., Baartscheer Antonius, Wilders Ronald, Ravesloot Jan H. NHE-1 and NBC during pseudo-ischemia/reperfusion in rabbit ventricular myocytes Journal of molecular and cellular cardiology 2004;37 (2):567-577 [PubMed]
  • Verkerk A. O., Tan H. L., Kirkels J. H., Ravesloot J. H. Role of Ca2+-activated Cl- current during proarrhythmic early after depolarizations in sheep and human ventricular myocytes Acta physiologica Scandinavica 2003;179 (2):143-148 [PubMed]
  • van Borren Marcel M. G. J., Verkerk Arie O., Vanharanta Sakari K., Baartscheer Antonius, Coronel Ruben, Ravesloot Jan H. Reduced swelling-activated Cl- current densities in hypertrophied ventricular myocytes of rabbits with heart failure Cardiovascular research 2002;53 (4):869-878 [PubMed]
  • van Borren Marcel M. G. J., Zegers Jan G., Baartscheer Antonius, Ravesloot Jan H. Contribution of NHE-1 to cell length shortening of normal and failing rabbit cardiac myocytes Journal of molecular and cellular cardiology 2006;41 (4):706-715 [PubMed]
  • Verkerk A. O., Veldkamp M. W., Baartscheer A., Schumacher C. A., Klöpping C., van Ginneken A. C., Ravesloot J. H. Ionic mechanism of delayed afterdepolarizations in ventricular cells isolated from human end-stage failing hearts Circulation 2001;104 (22):2728-2733 [PubMed]
  • Verkerk A. O., Wilders R., Ravesloot J. H. Identification of swelling-activated Cl- current in rabbit cardiac Purkinje cells Cellular and molecular life sciences 2004;61 (9):1106-1113 [PubMed]
  • Verkerk Arie O., Wilders Ronald, Coronel Ruben, Ravesloot Jan H., Verheijck E. Etienne Ionic remodeling of sinoatrial node cells by heart failure Circulation 2003;108 (6):760-766 [PubMed]
  • Role of Na-H exchangers and vacuolar H+ pumps in intracellular pH regulation in neonatal rat osteoclasts Journal of general physiology 1995;105 (2):177-208 [PubMed]
  • 2,4-dinitrophenol acutely inhibits rabbit atrial Ca2+ -sensitive Cl- current (I(TO2)) Canadian journal of physiology and pharmacology 2000;78 (10):766-773 [PubMed]
  • Voltage-activated K+ conductances in freshly isolated embryonic chicken osteoclasts Proceedings of the National Academy of Sciences of the United States of America 1989;86 (17):6821-6825 [PubMed]
All Publications
Curriculum Vitae

Jan Hindrik Ravesloot (Amsterdam 1961) studied medicine (Leiden University, doctoraal examen 1986) and did his Ph.D work at Leiden University (1991). After a three-year post-doctoral period at Yale University (New Haven, CT, USA) he became assistant-professor at the Academic Medical Center-University of Amsterdam (AMC-UvA) Department of Physiology in 1993 and was promoted to full professor in 2001. He and his staff conduct research in ion transport processes in cardiac cells. He is actively involved in advancing (bio)medical (physiology) higher education. Since september 2008 he holds the director position of the Master School Life and Earth Sciences of the UvA Faculty of Science (FNWI).