foto

Prof. PhD M.A. Boermeester

Position
Full Professor
Main activities
Patient care, Research
Specialisation
gastrointestinal surgery, surgery of abdominal infections
Focus of research


Focus: clinical and preclinical aspects of abdominal infections and intestinal failure

1a. peritonitis (diagnostics, surgical treatment, emergency surgery, intestinal failure surgery, complex abdominal wall reconstruction)

1b. acute and chronic pancreatitis

1c. inflammatory responses in abdominal sepsis and anastomotic leakage

Optimal diagnostic imaging in patients with acute abdominal pain, patients with suspected appendicitis, patients with suspected diverticulitis, patients with suspected postoperative infectious complications.

The role of the genetic make-up in the disease course, several single nucleotide polymorphisms (SNPs) are investigated in acute (necrotizing) pancreatitis.

Logistic regression modelling searches for a clinical score to select patients who will benefit from a relaparotomy; a decision tool is developed and prospectively evaluated and modified for triage for imaging (ZonMW).

Cost-effectiveness of antibiotic treatment compared to non-antibiotic treatment in diverticulitis: a randomized pragmatic trial (DIABOLO trial; ZonMW, CZ). Long-term follow-up Diabolo. Individual patient data meta-analysis of two RCT on antibiotics in diverticulitis (international collaboration)

Surgical and medical treatment of pancreatitis. For chronic pancreatis, treatment of pain is evaluated (CARE prospective registry, Mylan grant). ESCAPE trial within the Dutch Pancreatitis Study Group evaluates optimal intervention strategy for painful chronic pancreatitis (ZonMW, MLDS).

SECURE trial: Adequate selection for cholecystectomy in patients with gallbladder stones and pain (ZonMW;www.amc.nl/web/CRU/Secure/Home.htm).

Complex abdominal wall reconstruction (CAWR) and intestinal failure: LIFE study to reduce enterocutaneous fistula output (Ipsen). CLOSE-UP study for biomesh closure of acute open abdomen (LifeCell). Management and surgical therapy of intestinal failure is being investigated. AWARE I and II studies evaluate long-term outcome of CAWR.

The EPOCH trial (ZonMW, ZN, J&J/Ethicon) evaluates various perioperative interventions for the prevention of surgical site infections. The Pressure trial is an RCT on the effect of closed incision negative pressure treatment (iNPWT) to prevent surigcal site occurrences. The mechanisms that underlie this protective NPWT are being evaluated in animal models.

Research plans (2017‑2019):

Research in intestinal failure and complex abdominal wall reconstructions.

Preclinical research in closed incision negative pressure wound therapy and in biofilm research (coated meshes) to reduce the risk of surgical site infections.

Clinical interventions to reduce the risk for surgical site infections (normoglycemia, normothermia, hyperoxygenation, normovolemia, surgical site handling).

Targeting diagnostics and treatment of abdominal infections (diverticulitis, appendicitis).

Genomics and microbiome in abdominal infections. Next generation sequencing in acute necrotizing pancreatitis, microbiome assessment in acute diverticulitis, microbiome in patients with early MOF in acute pancreatitis, intestinal micro-environment in relation to anastomotic healing / leakage
 

 

Key publications
  • Issa Yama, Bruno Marco J., Bakker Olaf J., Besselink Marc G., Schepers Nicolien J., van Santvoort Hjalmar C., Gooszen Hein G., Boermeester Marja A. Treatment options for chronic pancreatitis Nature reviews. Gastroenterology & hepatology 2014;11 (9):556-564 [PubMed]
  • Kiewiet Jordy J. S., Leeuwenburgh Marjolein M. N., Bipat Shandra, Bossuyt Patrick M. M., Stoker Jaap, Boermeester Marja A. A Systematic Review and Meta-Analysis of Diagnostic Performance of Imaging in Acute Cholecystitis Radiology 2012;264 (3):708-720 [PubMed]
  • Ahmed Ali Usama, Issa Yama, Hagenaars Julia C., Bakker Olaf J., van Goor Harry, Nieuwenhuijs Vincent B., Bollen Thomas L., van Ramshorst Bert, Witteman Ben J., Brink Menno A., Schaapherder Alexander F., Dejong Cornelis H., Spanier B. W. Marcel, Heisterkamp Joos, van der Harst Erwin, van Eijck Casper H., Besselink Marc G., Gooszen Hein G., van Santvoort Hjalmar C., Boermeester Marja A. Risk of Recurrent Pancreatitis and Progression to Chronic Pancreatitis After a First Episode of Acute Pancreatitis Clinical gastroenterology and hepatology 2016;14 (5):738-746 [PubMed]
  • de Vries Eefje N., Eikens-Jansen Manon P., Hamersma Alice M., Smorenburg Susanne M., Gouma Dirk J., Boermeester Marja A. Prevention of Surgical Malpractice Claims by Use of a Surgical Safety Checklist Annals of surgery 2011;253 (3):624-628 [PubMed]
  • van der Gaag Niels A., van Gulik Thomas M., Busch Olivier R. C., Sprangers Mirjam A., Bruno Marco J., Zevenbergen Chantal, Gouma Dirk J., Boermeester Marja A. Functional and Medical Outcomes After Tailored Surgery for Pain Due to Chronic Pancreatitis Annals of surgery 2012;255 (4):763-770 [PubMed]
All Publications
Curriculum Vitae

Education, training, degrees, employment

 

1973 - 1979 Atheneum B, Marnix College, Ede
1979 - 1980 Freshman year Physical Education, Free University, Amsterdam
1980(6) - 1984(5) Clinical Neurophysiology, Diakonessenhuis, Utrecht
1983 - 1987 Medicine, Faculty of Medicine, University of Amsterdam
Nov 27, 1987 Masters degree in Medicine, Faculty of Medicine, University of Amsterdam
1984 - 1990(6) Clinical Neurophysiology, Diakonessenhuis Utrecht and St. Elisabeth Hospital
Amersfoort
1989 - 1991(7) Medical trainee/intern, University of Amsterdam
1991(8) - 1992(3) Surgical resident, Hospital Hilversum, Hilversum
1992(3) - 1994(7) PhD-research, Dept. of Surgery, Free University Hospital, Amsterdam
December 7, 1994 PhD degree in Medicine, Free University Amsterdam
Title thesis: “Pathogenesis and modulation of the systemic inflammatory response in endotoxemia and sepsis”.
1994(7) - 1997(6) Surgical resident, Medical Specialist Training, Dept. of Surgery, Academic
Medical Center, Amsterdam
1997(6) - 1999(6) Surgical Resident, Medical Specialist Training, Dept. of Surgery, St. Lucas
Hospital
1999(6) - 2000(6) Surgical Resident, Medical Specialist Training, Dept. of Surgery, Academic
Medical Center, Amsterdam
July 1, 2000 Registration as surgeon
2000(7) - 2002(6) Surgeon, Fellow GI surgery, Dept. of Surgery, Academic Medical Center, Amsterdam
July 2002 Registration as gastrointestinal surgeon
2002(7) - present Consultant surgeon, Dept. of Surgery, Academic Medical Center, Amsterdam
Specialty: Gastrointestinal surgery, HPB and GI infection, Patient safety
June 19, 2007 MSc degree in Clinical Epidemiology, NIHES Erasmus University, Rotterdam;
Clinical epidemiologist
Nov 2007 - present Principal Investigator (PI) at the AMC
2008 Certificate Basic Qualification Education (Basis Kwalificatie Onderwijs (BKO))
2009 - 2011 Editor of the British Journal of Surgery (BJS)
Mch 2012 - present Professor of Surgery, Academic Medical Center Amsterdam
http://www.oratiereeks.nl/upload/pdf/PDF-6672weboratie-Boermeester.pdf

 

Thesis, other educations, courses

 

1994 (7/12/94) PhD-thesis, Faculty of Medicine, Free University Amsterdam
Title thesis: “Pathogenesis and modulation of the systemic inflammatory response in endotoxemia and sepsis”.
Promotor: Prof.dr R.I.C. Wesdorp;
Co-promotores: Prof.dr C.E. Hack, Dr. P.A.M. van Leeuwen
1994 Postdoctoral Specialisation Course “Advanced Immunology”
1995(9) - 1997(9) Curriculum Specialisation (course) “Intensive Care Medicine”,
Gemeenschappelijke Intensivisten Commissie (GIC)
1999 Evidence Based Surgery course, AMC Amsterdam
2004(8) - 2004(9) Summer course ‘Clinical Epidemiology’, Masters Program Clinical
Epidemiology, Erasmus University Rotterdam/NIHES
2004(9) - 2004(10) Classical methods in statistical analysis, Masters Program Clinical
Epidemiology, Erasmus University Rotterdam/NIHES
2005(3) Advanced Diagnostic Research, Masters Program Clinical Epidemiology,
Erasmus University Rotterdam/NIHES and University of Utrecht
2005(9) Study design, Masters Program Clinical Epidemiology, Erasmus University
Rotterdam/NIHES
2005(11) Modern statistical methods, Masters Program Clinical Epidemiology, Erasmus University Rotterdam/NIHES
2006 (10-11) Clinical Epidemiology, Masters Program Clinical Epidemiology, NIHES Rotterdam/Julius Center Utrecht
2007 (3) Prognostic Research, Masters Program Clinical Epidemiology, NIHES Rotterdam/Julius Center Utrecht
2007 (4) Clinical trials, Masters Program Clinical Epidemiology, NIHES Rotterdam/Julius Center Utrecht

 

Committees and working parties
Internal (AMC):
- AMC Research Council member
- Antibiotics Committee
- Infection Committee
- Bachelor Committee Medical Curriculum
- Chair of AMC support group for applicants of the Netherlands Organisation for Health Research and Development (ZonMW) grants (KF / AGIKO)
- Coordinator medical Masters Program, module 2.4, HPB and GI diseases
- Bachelor revision committee

 

External (national and international), present and past:
- steering committee Global Guidelines of Surgical Site Infections, WHO (World Health Organisation), Geneva
- Sectieredacteur, Nederlands Tijdschrift voor Geneeskunde (Neth J of Med)
- past Editor of British Journal of Surgery
- reviewer for several international journals
- past Council member (Recorder) of the Surgical Infection Society Europe (SIS-E)
- presently Councillor-at-large of the Surgical Infection Society Europe (SIS-E)
- Dutch Guideline Committee Antibiotics, sepsis guideline (SWAB, Stichting Werkgroep Antibiotica Beleid)
- Steering committee of the Dutch Acute Pancreatitis Study Group (DAPSG)
- past Medium Care GuidelineCommittee, Dutch Society of Intensive Care (NVIC)
- Clinical Guidelines Committee, Dutch Society of Surgeons (NVvH)
- Patient Safety Committee, Dutch Society of Surgeons (NVvH)
- Safety Management System, chair of theme ‘safety checks – errors in patients (Veiligheidsmanagement systeem, Orde van Ned specialisten; voorzitter van thema “verwisseling van en bij patienten”)
- past member of the Research Committee Netherlands Organisation for Health Research and Development (ZonMW) grants (KF / AGIKO)
- Klankbordgroep Richtlijn acute appendicitis, NVvH
- klankbordgroep Dutch Guideline Committee richtlijn TOP 1 (Toezicht operatief process, pre-operatief), CBO
- member Dutch Guideline Committee TOP2 (Toezicht operatief proces, peroperatief), Orde van Medisch Specialisten
- member Dutch Guideline Committee TOP3 (Toezicht operatief proces, postoperatief), Orde van Medisch Specialisten
- member Dutch Guideline Committee Diverticulitis, Orde van Medisch Specialisten
- chair Dutch Guideline Committee Acute Abdominal Pain, Orde van Medisch Specialisten

 

Teaching experience

 

2008 Certificaat Basis Kwalificatie Onderwijs (BKO)
2000 - present medical intern teaching (bedside teaching, fysical diagnostics, theoretical education,
medical documentation discussion meetings)
2000 - present training surgical residents, local (practical, theoretical)
2002(6) Tutor in course ‘Evidence Based Surgery’, AMC Amsterdam
2003(6) Tutor in course ‘Evidence Based Surgery’, AMC Amsterdam
2004(6) Tutor in course ‘Evidence Based Surgery’, AMC Amsterdam
2003 - 2004 case-driven theoretical clinical teaching (‘kleinschalig theoretisch klinisch lijnonderwijs’ (3rd and 4th year medical students))
2004(6) national training program surgical residents (peritonitis, fistula)
2005(6) Tutor in course ‘Evidence Based Surgery’, AMC Amsterdam
2005 - 2013 coordinator common trunk course surgical specialities: ‘the critically ill patient’
2006(6) Tutor in course ‘Evidence Based Surgery’, AMC Amsterdam
2006 - present Coordinator medical Bachelors Program, module 2.4, HPB and GI diseases, University of Amsterdam
2007(6) national training program surgical residents (peritonitis, fistula)
2007(6) Tutor in course ‘Evidence Based Surgery’, AMC Amsterdam
2008 (2) How to review a clinical paper – BJS workshop, Schiphol, Amsterdam
2008 (10) How to write a clinical paper – BJS workshop, Malta
2009 (11) How to review a clinical paper – BJS workshop, Schiphol, Amsterdam
2009 (11) How to write a clinical paper – BJS workshop, Ede

2016-present theme coordinator Regulatie&Afweer, Epicurus, new Bachelor program, University of Amsterdam

 

 

 

Awards (2009-2016)

 

Professor Goris award for research achievements in surgical infections, Nijmegen, 2009.

 

Max Siurala Award, the XI Gastrodays in Finland, Helsinki, 2009.

 

Health Care Efficacy Research ZonMW, National Pearl Award 2009 for OPTIMA study, best cost-effectiveness study

 

National Patient Safety Award 2011 (IGZ) for SURPASS checklist

 

Nominatie Nationale Zorg Jaarprijs 2011/ runner-up beste ZonMW Parel laatste 10 jaar, voor OPTIMA studie (optimale beeldvorming bij acute buikpijn)

 

ESGAR award, best publication in Eur Radiology in 2011. “A comparison of the Accuracy of Ultrasound and Computed Tomography in common diagnoses causing acute abdominal pain”
written by you, Adrienne van Randen, Wytze Laméris, H. Wouter van Es, Hans P. M. van Heesewijk, Bert van Ramshorst, Wim ten Hove, Willem H. Bouma, Maarten S. van Leeuwen, Esteban M. van Keulen, Patrick M. Bossuyt, Jaap Stoker and Marja A. Boermeester, on behalf of the OPTIMA study group

Honorary member of the german Society of Visceral Surgery, 2015

Research programmes

Prof. PhD M.A. Boermeester (Abdominal infections in surgery)

Focus: clinical and preclinical aspects of abdominal infections and intestinal failure

1a. peritonitis (diagnostics, surgical treatment, emergency surgery, intestinal failure surgery, complex abdominal wall reconstruction)

1b. acute and chronic pancreatitis

1c. inflammatory responses in abdominal sepsis and anastomotic leakage

Optimal diagnostic imaging in patients with acute abdominal pain, patients with suspected appendicitis, patients with suspected diverticulitis, patients with suspected postoperative infectious complications.

The role of the genetic make-up in the disease course, several single nucleotide polymorphisms (SNPs) are investigated in acute (necrotizing) pancreatitis.

Logistic regression modelling searches for a clinical score to select patients who will benefit from a relaparotomy; a decision tool is developed and prospectively evaluated and modified for triage for imaging (ZonMW).

Cost-effectiveness of antibiotic treatment compared to non-antibiotic treatment in diverticulitis: a randomized pragmatic trial (DIABOLO trial; ZonMW, CZ). Long-term follow-up Diabolo. Individual patient data meta-analysis of two RCT on antibiotics in diverticulitis (international collaboration)

Surgical and medical treatment of pancreatitis. For chronic pancreatis, treatment of pain is evaluated (CARE prospective registry, Mylan grant). ESCAPE trial within the Dutch Pancreatitis Study Group evaluates optimal intervention strategy for painful chronic pancreatitis (ZonMW, MLDS).

SECURE trial: Adequate selection for cholecystectomy in patients with gallbladder stones and pain (ZonMW;www.amc.nl/web/CRU/Secure/Home.htm).

Complex abdominal wall reconstruction (CAWR) and intestinal failure: LIFE study to reduce enterocutaneous fistula output (Ipsen). CLOSE-UP study for biomesh closure of acute open abdomen (LifeCell). Management and surgical therapy of intestinal failure is being investigated. AWARE I and II studies evaluate long-term outcome of CAWR.

The EPOCH trial (ZonMW, ZN, J&J/Ethicon) evaluates various perioperative interventions for the prevention of surgical site infections. The Pressure trial is an RCT on the effect of closed incision negative pressure treatment (iNPWT) to prevent surigcal site occurrences. The mechanisms that underlie this protective NPWT are being evaluated in animal models.


Research plans (2017‑2019):

Research in intestinal failure and complex abdominal wall reconstructions.

Preclinical research in closed incision negative pressure wound therapy and in biofilm research (coated meshes) to reduce the risk of surgical site infections.

Clinical interventions to reduce the risk for surgical site infections (normoglycemia, normothermia, hyperoxygenation, normovolemia, surgical site handling).

Targeting diagnostics and treatment of abdominal infections (diverticulitis, appendicitis).

Genomics and microbiome in abdominal infections. Next generation sequencing in acute necrotizing pancreatitis, microbiome assessment in acute diverticulitis, microbiome in patients with early MOF in acute pancreatitis, intestinal micro-environment in relation to anastomotic healing / leakage

National grants:

 

  1. ZonMW Health Care Efficiency Research Program 2002 ‘Planned versus on demand relaparotomy in secondary peritonitis: a multicenter randomized trial’. (RELAP trial) (project number 945-02-028).
  2. ZonMW Health Care Efficiency Research Program 2004 ‘Optimization of diagnostic imaging use in patients with acute abdominal pain: cost-effectiveness analysis of imaging strategies (OPTIMA trial) (project number 945-04-308). The OPTIMA trial has received the ZonMW Health Care Efficiency Research Program Parel Award 2009 and has received further funding for implementation of results. The OPTIMA trial enrolled more than 1000 consecutive patients with abdominal pain >2 hours and <5 days.
  3. ZonMW Patient Safety Research Program 2005 ‘Evaluation and optimization of a safety checklist covering critical safety risks in surgical patients. (project number 80-81600-98-011; SURPASS checklist)
  4. Dutch Digestive Diseases Foundation (MLDS) grant 2001-2003 ‘Planned versus on demand relaparotomy in secondary peritonitis: compartimentalized inflammatory responses’ (project number WS 00-54).
  5. ZonMW Health Care Efficiency Research Program 2008. ‘The clinical and economic impact of a clinical pharmacy team on surgical patients; a randomized cost-effectiveness study’ (project number 80-00702298; SUREPILL)).
  6. ZonMW. Dutch Health Care and Efficacy Research Program 2008, Implementation (VIP) grant for “Planned relaparotomy verus relaparotomy on demand in abdominal sepsis: a randomized, multicenter, clinical trial (RELAP)”.
  7. Dutch Digestive Diseases Foundation (MLDS) grant 2009-2011. A randomized clinical trial on the effectiveness of antibiotics in uncomplicated acute diverticulitis (DIABOLO).
  8. ZonMW Health Care and Efficiency Research Program 2010-2012 (ZonMW VEMI). Magnetic resonance imaging in acute appendicitis.
  9. ZonMW Health Care and Efficiency Research 2010-2012 (ZonMW). Effectiveness of antibiotics in uncomplicated acute diverticulitis (DIABOLO).
  10. ZonMW Health Care and Efficiency Research 2011-2015. ESCAPE trial: Early Surgery versus Optimal Current Step-up Practice for Chronic Pancreatitis.
  11. Project grant 2011-2013. MLDS grant. ESCAPE trial: Early Surgery versus Optimal Current Step-up Practice for Chronic Pancreatitis.
  12. ZonMW Health Care and Efficacy Research 2011 (ZonMW Implementation). A systematic analysis of factors hindering and supporting implementation of the ‘relaparotomy on demand’ strategy in patients with secondary peritonitis.
  13. ZonMW Health Care and Efficacy Research 2013. SECURE trial: Adequate selection for cholecystectomy in patients with gallbladder stones and pain (ZonMW;www.amc.nl/web/CRU/Secure/Home.htm).
  14. Co-financing sponsor: CZ Zorgverzekering. The SECURE trial: Scrutinizing (in)efficient use of cholecystectomy: a randomized trial concerning variation in practice.
  15. Project grant 2012-2013. Dutch Health Care and Efficacy Research (ZonMW), Implementation for “Surgical Patient Safety System (SURPASS)”.
  16. Project grant 2011-2013. Dutch Health Care and Efficacy Research (ZonMW) for “ Guideline for diagnostic imaging in patients with acute abdominal pain”.
  17. Project grant 2013-2014. Dutch Health Care and Efficacy Research (ZonMW) for 'Implementation decision tool for relaparotomy (SEPAR study)'.
  18. LIFE study to reduce enterocutaneous fistula output (Ipsen).
  19. CLOSE-UP study for biomesh closure of acute open abdomen (LifeCell).
  20. Project grant 2016-2019. Dutch Health Care and Efficacy Research (ZonMW) for 'Perioperative enhancement program to reduce surgical site infections'. EPOCH trial

Other grants:

 

- CARE programme (Chronic Pancreatitis Registry), sponsored by grants the Dutch Patient Platform of Pancreatic Diseases (www.alvleeskliervereniging.nl) and by Abbott Healthcare bv (Weesp, the Netherlands).
Themes: Infection and Immunity and Gastro-intestinal diseases

 

Faculty
PhD E.J.M. Nieveen van Dijkum

Others
V. Mathura

Current research funding
  • AMC (Vrijgesteld)
  • Abbott B.V.
  • Johnson & Johnson Medical BV
  • KCI UK Holdings Ltd.
  • Maag, Lever, Darm Stichting
  • Middletree B.V.
  • NewCompliance Group B.V.
  • ZonMw