- Koopman K. E., Roefs A., Elbers D. C. E., Fliers E., Booij J., Serlie M. J., La Fleur S. E. Brain dopamine and serotonin transporter binding are associated with visual attention bias for food in lean men Psychological medicine 2016;46 (8):1707-1717 [PubMed]
- van den Heuvel José K., Furman Kara, Gumbs Myrtille C. R., Eggels Leslie, Opland Darren M., Land Benjamin B., Kolk Sharon M., S Narayanan Nandakumar, Fliers Eric, Kalsbeek Andries, DiLeone Ralph J., la Fleur Susanne E. Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity Biological psychiatry 2015;77 (7):633-641 [PubMed]
- La Fleur S. E., Luijendijk M. C. M., van der Zwaal E. M., Brans M. A. D., Adan R. A. H. The snacking rat as model of human obesity: effects of a free-choice high-fat high-sugar diet on meal patterns International journal of obesity (2005) 2014;38 (5):643-649 [PubMed]
- Koopman Karin E., Caan Matthan W. A., Nederveen Aart J., Pels Anouk, Ackermans Mariette T., Fliers Eric, la Fleur Susanne E., Serlie Mireille J. Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: a randomized controlled trial Hepatology (Baltimore, Md.) 2014;60 (2):545-553 [PubMed]
- Koopman Karin Eva, Booij Jan, Fliers Eric, Serlie Mireille Johanna, la Fleur Susanne Eva Diet-induced changes in the Lean Brain: Hypercaloric high-fat-high-sugar snacking decreases serotonin transporters in the human hypothalamic region Molecular metabolism 2013;2 (4):417-422 [PubMed]
Grants and Honors (selection)
2016 NWO-VICI grant "To be ready or not for glucose challenges; a critical role for the brain's reward center"
2012 STW open competition grant 'Nutrients to modulate obesity-associated brain inflammation'
2012 STW perspective grant 'Enlightened Meals'
2008 ZonMW-VIDI grant “Brain mediators in obesity and insulin resistance”
2008 Alan N. Epstein Research Award, Society for the Study of Ingestive Behavior
2004 ZonMW-VENI grant “The hepatic vagus and the melanocortin system in diet-induced obesity”
2002 Novo Nordisk Award for Endocrinology
Professor, Dept Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
Honorary group leader, Metabolism and Reward Group, Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, Amsterdam, the Netherlands
Visiting Professor, Unit of Functional and Adaptive Biology, CNRS-UNiversite Paris Diderot-Paris 7, Paris, France
Associate Professor, Dept Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
Group leader/Scientific Staff Member, Dept Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
Postdoc/Assistant Professor, Dept. Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Postdoctoral fellow, Dept. Physiology, University of California San Francisco, San Francisco, USA. supervisor: Prof. dr. Mary F Dallman
3/1997 – 8/2001
PhD student (OIO), Netherlands Institute for Brain Research, Amsterdam, the Netherlands. Supervisors: dr. A Kalsbeek & Prof. dr. RM Buijs
PhD degree in Neuroscience. Thesis title: “The Suprachiasmatic Nucleus Generated Rhythm in Blood Glucose; a Role for the Autonomic Nervous System” Supervisors: Dr. A. Kalsbeek & Prof. dr. R.M. Buijs (Netherlands Institute for Brain Research, Amsterdam, the Netherlands) Thesis defense: 14/06/2001, University of Amsterdam, the Netherlands
Master’s degree (‘doctoraal’) in (Medical) Biology, University of Groningen, The Netherlands
Prof. PhD S.E. la Fleur (Brain mediators in diet-induced obesity and diabetes)
Type 2 Diabetes Mellitus is a rapidly growing epidemic. Obesity has been identified as one of the main risks for this disease and increased intake of saturated fat and sugar increases the risk to develop Obesity and Type 2 Diabetes Mellitus. Our first interest is to understand how nutrients affect the brain and how these changes mediate the overeating as observed in (most) obese people. Secondly, although peripheral actions of both fat and sugar will affect glucose metabolism, it does not explain why some obese individuals become diabetic and why others do not. We therefore focus on the effects of nutrients on the brain as an alternative route via which high caloric diets might mediate the development of diabetes.
We study these research questions with a translational approach using both diet-induced obese animals and human experimental studies. This translational approach is possible because of a close collaboration with the group of dr MJ Serlie within the Department of Endocrinology and Metabolism and the group of Prof dr J Booij from the Department of Nuclear Medicine.
PhD C. Diepenbroek
PhD J.D. Mul
MSc A. Joshi
MSc M. Ugur
BSc L. Eggels
BSc U.A. Unmehopa
- AMC (Vrijgesteld)