Prof. R.A.A. Mathot PhD

Other Academic Staff, Full Professor
Main activities
Research, Other
Clinical Pharmacology
Focus of research
- Population pharmacokinetics and pharmacodynamics (population PK-PD modelling)
- Therapeutic drug monitoring
- Analytical chemistry
Therapeutic fields:
- Blood clotting factor concentrates
- Monoclonal antibodies in inflammatory disease
- Neonatal/pediatric drug therapy
- Antibiotics


Key publications
  • Bijleveld Yuma A., de Haan Timo R., van der Lee Johanna H., Groenendaal Floris, Dijk Peter H., van Heijst Arno, de Jonge Rogier C. J., Dijkman Koen P., van Straaten Henrica L. M., Rijken Monique, Zonnenberg Inge A., Cools Filip, Zecic Alexandra, Nuytemans Debbie H. G. M., van Kaam Anton H., Mathôt Ron A. A. Evaluation of a System-specific Function to Describe the Pharmacokinetics of Benzylpenicillin in Term Neonates Undergoing Moderate Hypothermia Antimicrobial agents and chemotherapy 2018;62 (4):e02311-17 [PubMed]
  • Schütte L. M., van Hest R. M., Stoof S. C. M., Leebeek F. W. G., Cnossen M. H., Kruip M. J. H. A., Mathôt R. A. A. Pharmacokinetic Modelling to Predict FVIII:C Response to Desmopressin and Its Reproducibility in Nonsevere Haemophilia A Patients Thrombosis and haemostasis 2018;118 (04):621-629 [PubMed]
  • Lammers Laureen A., Achterbergh Roos, van Schaik Ron H. N., Romijn Johannes A., Mathôt Ron A. A. Effect of Short-Term Fasting on Systemic Cytochrome P450-Mediated Drug Metabolism in Healthy Subjects: A Randomized, Controlled, Crossover Study Using a Cocktail Approach Clinical pharmacokinetics 2017;56 (10):1231-1244 [PubMed]
  • Hazendonk Hendrika, Fijnvandraat Karin, Lock Janske, Driessens Mariëtte, van der Meer Felix, Meijer Karina, Kruip Marieke, Gorkom Britta Laros-van, Peters Marjolein, de Wildt Saskia, Leebeek Frank, Cnossen Marjon, Mathôt Ron A population pharmacokinetic model for perioperative dosing of factor VIII in hemophilia A patients Haematologica 2016;101 (10):1159-1169 [PubMed]
  • Franken Linda G., Masman Anniek D., de Winter Brenda C. M., Koch Birgit C. P., Baar Frans P. M., Tibboel Dick, van Gelder Teun, Mathot Ron A. A. Pharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult Patients Clinical pharmacokinetics 2016;55 (6):697-709 [PubMed]
All Publications
Curriculum Vitae

Academic education, degrees and specialization
1981-1988: MSc Pharmacy (cum laude), University of Leiden
1989-1990: PharmD, University of Utrecht
1991-1995: PhD, Leiden Amsterdam Center for Drug Research, University of Leiden. Thesis: Preclinical pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of adenosine receptor ligands.
1995-1998: Specializiation Hospital Pharmacy, Central Pharmacy of The Hague Hospitals, The Hague
2007         : Specialization Clinical Pharmacology, Leiden University Medical Center

Research and position
1991-1995: PhD student. Leiden Amsterdam Center for Drug Research, University of Leiden
1995-1998: Hospital Pharmacy resident, Central Pharmacy of The Hague Hospitals, The Hague
1999-2002: Clinical Investigator – Staff Hospital Pharmacist, Department of Hospital Pharmacy, Slotervaart Hospital and The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam
2002-2010: Clinical Investigator – Staff Hospital Pharmacist, Head Clinical Pharmacy Laboratory, Department of Hospital Pharmacy, ErasmusMC - University Medical Center Rotterdam
2010-2014: Co-chair of the Department of Hospital Pharmacy, Academic Medical Center - University of Amsterdam
2011-        : Professor of Clinical Pharmacology, Academic Medical Center - University of Amsterdam
2012-        : Principal Investigator, Academic Medical Center - University of Amsterdam  



Research programmes

Prof. R.A.A. Mathot PhD (Population pharmacokinetic-pharmacodynamic (PK-PD) research)

1. Pharmacokinetic guided dosing of blood clotting factors in hemophilia and Van Willebrands Disease (collaboration prof. dr. C. Fijnvandraat / dr. M. Cnossen / prof. dr. F. Leebeek (ErasmusMC))

2. Pharmacokinetics and -dynamics of monoclonal antibodies in inflammatory bowel disease ((collaboration prof. dr. G. d'Haens / dr. M. Lowenberg)

3. Pharmacokinetics and pharmacodynamics of medication in neonates (collaboration dr. T. de Haan)

4. Nutritional conditioning of drug metabolism (collaboration dr. HJ Klumpen / prof. dr. H. Romijn)

5. Individualized dosing of antibiotic agents in critically ill patients (dr. P. Elbers / dr. R. van Hest)

Y.A. Bijleveld
G.J.H. Dumont
A.E. Gerards
M.E.P. Jansen
E.M. Kemper PhD
P.F.M. Kuks PhD
I.M. Rigter
A.M. Schimmel
R.M. van Hest PhD
P.C. van Rijn-Bikker
M.L. Voll

PhD Students
T. Guo
S. Sassen
L.M. Schutte
A.S. Strik
A.K. van den Broek
I. van Moort
S.E.M. Vonk MSc

M.H. Cnossen MD PhD
T.R. de Haan MD PhD
Prof. G.R.A.M. D'Haens PhD
P.W.G. Elbers PhD
Prof. C.J. Fijnvandraat PhD
H. Klumpen MD PhD
M.J.H.A. Kruip PhD
Prof. F.W.G. Leebeek
M. Lowenberg MD PhD
Prof. J.A. Romijn PhD

Current research funding
  • AMC
  • Bispebjerg Hospitals
  • Erasmus MC Sophia Kinderziekenhuis
  • NWO
  • Stichting AMC Foundation
  • Stichting MITIALTO
  • Swedish Orphan Biovitrum BVBA/SPRL