foto

V. de Waard PhD

Position
Scientific staff member (UD)
Main activities
Research, Teaching
Specialisation
aneurysm development
Focus of research

Develop therapeutics that can reduce vessel wall degradation and thus decrease the growth (rate) of aortic aneurysms.

Key publications
  • Hibender S, Franken R, van Roomen C, ter Braake A, van der Made I, Schermer EE, Gunst Q, van den Hoff MJ, Lutgens E, Pinto YM, Groenink M, Zwinderman AH, Mulder BJM, de Vries CJM, de Waard V, Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G/+ Marfan Mouse Model. ARTERIOSCL THROM VAS 2016;36 (8):1618-1626 [PubMed]
  • Medzikovic L, Schumacher CA, Verkerk AO, van Deel ED, Wolswinkel R, van der Made I, Bleeker N, Cakici D, van den Hoogenhof MMG, Meggouh F, Creemers EE, Remme CA, Baartscheer A, de Winter RJ, de Vries CJM, Arkenbout EK, de Waard V, Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling. SCI REP-UK 2015;5:15404 [PubMed]
  • Franken R, den Hartog AW, Radonic T, Micha D, Maugeri A, van Dijk FS, Meijers-Heijboer HE, Timmermans J, Scholte AJ, van den Berg MP, Groenink M, Mulder BJM, Zwinderman AH, de Waard V, Pals G, Beneficial Outcome of Losartan Therapy Depends on Type of FBN1 Mutation in Marfan Syndrome. CIRC-CARDIOVASC GENE 2015;8 (2):383-388 [PubMed]
  • Groenink M, den Hartog AW, Franken R, Radonic T, de Waard V, Timmermans J, Scholte AJ, van den Berg MP, Spijkerboer AM, Marquering HA, Zwinderman AH, Mulder BJM, Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial. EUR HEART J 2013;34 (45):3491-3500 [PubMed]
  • Marinkovic G, Hibender S, Hoogenboezem M, van Broekhoven A, Girigorie AF, Bleeker N, Hamers AAJ, Stap J, van Buul JD, de Vries CJM, de Waard V, Immunosuppressive drug azathioprine reduces aneurysm progression through inhibition of Rac1 and c-Jun-terminal-N-kinase in endothelial cells. ARTERIOSCL THROM VAS 2013;33 (10):2380-2388 [PubMed]
All Publications
Curriculum Vitae
1989-1995 Studying Medical Biology, Biology Faculty, University of Amsterdam

1996-1997 Research Scientist at Dept Vascular Biology of The Scripps Research Institute, La Jolla, CA, USA

1997-2002 PhD Student at the Medical Biochemistry Dept, AMC, University of Amsterdam

2002-2004 Post doc at the Medical Biochemistry Dept, AMC, University of Amsterdam

2004-2008 Post doc at the Div. of Biopharmaceutics, Leiden/ Amsterdam Center for Drug Research, Leiden University

2008-present Assistant Professor at the Medical Biochemistry Dept, AMC, University of Amsterdam

Research programmes

Understanding aortic aneurysm progression

Faculty
V. de Waard PhD

PhD Students
M.M. van Andel
M.P. Clemente MSc
V.H. Kremer
L. Schimmel
M.K. Tran
S.A. Wanga

Prof. dr. C.J.M. de Vries (Regulation of Vascular Homeostasis and Metabolism)

Other research related activities
  • Co-organizer of Dutch Heart Foundation Papendal PhD student course, NHS
  • National and international grant reviewer in the field of Vascular Biology, NHS and other (inter)national organisations
  • Reviewer for a number of vascular, international IF journals
  • Teach Science in Society to highschool girls to promote science, VHTO
  • co-organiser 4th Benelux Nuclear Receptor Meeting Amsterdam, 2011, Benelux Nuclear Receptor Research Network
  • Co-inventor on a patent concerning the development of novel drug-eluting stents, AMC
Current research funding
  • Life Sciences Health TKI
  • Stichting AMC Foundation (Vrijgesteld)