Dr. A. Beqqali publications


Publications Dr. A. Beqqali

Main activities
Molecular biology of the heart
Focus of research

 RNA related molecular mechanisms of heart failure


  • Al-Saaidi RA, Rasmussen TB, Birkler RID, Palmfeldt J, Beqqali A, Pinto YM, Nissen PH, Baandrup U, Mølgaard H, Hey TM, Eiskjaer H, Bross P, Mogensen J, The clinical outcome of LMNA missense mutations can be associated with the amount of mutated protein in the nuclear envelope. EUR J HEART FAIL 2018;20 (10):1404-1412 [PubMed]
  • Aufiero S, van den Hoogenhof MMG, Reckman YJ, Beqqali A, van der Made I, Kluin J, Khan MAF, Pinto YM, Creemers EE, Cardiac circRNAs arise mainly from constitutive exons rather than alternatively spliced exons. RNA 2018;24 (6):815-827 [PubMed]
  • Damanafshan A, Elzenaar I, Samson-Couterie B, van der Made I, Bourajjaj M, van den Hoogenhof MM, van Veen HA, Picavet DI, Beqqali A, Ehler E, de Windt LJ, Pinto YM, van Oort RJ, The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy. CARDIOVASC RES 2018;114 (11):1474-1486 [PubMed]
  • van den Hoogenhof MMG, Beqqali A, Amin AS, van der Made I, Aufiero S, Khan MAF, Schumacher CA, Jansweijer JA , van Spaendonck-Zwarts KY, Remme CA, Backs J, Verkerk AO, Baartscheer A, Pinto YM, Creemers EE, RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling. CIRCULATION 2018;138 (13):1330-1342 [PubMed]


  • van den Hoogenhof MMG, van der Made I, Beqqali A, de Groot NE, Damanafshan A, van Oort RJ, Pinto YM, Creemers EE, The RNA-binding protein Rbm38 is dispensable during pressure overload-induced cardiac remodeling in mice. PLOS ONE 2017;12 (8):e0184093 [PubMed]
  • van Eldik W, den Adel B, Monshouwer-Kloots J, Salvatori D, Maas S, van der Made I, Creemers EE, Frank D, Frey N, Boontje N, van der Velden J, Steendijk P, Mummery C, Passier R, Beqqali A, Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart. PLOS ONE 2017;12 (12):e0189139 [PubMed]


  • Beqqali A, Bollen IAE, Rasmussen TB, van den Hoogenhof MM, van Deutekom HWM, Schafer S, Haas J, Meder B, Sørensen KE, van Oort RJ, Mogensen J, Hubner N, Creemers EE, van der Velden J, Pinto YM, A mutation in the glutamate-rich region of RNA-binding motif protein 20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank-Starling mechanism. CARDIOVASC RES 2016;112 (1):452-463 [PubMed]
  • Devalla HD, Gélinas R, Aburawi EH, Beqqali A, Goyette P, Freund C, Chaix MA, Tadros R, Jiang H, Le Béchec A, Monshouwer-Kloots JJ, Zwetsloot T, Kosmidis G, Latour F, Alikashani A, Hoekstra M , Schlaepfer J, Mummery CL, Stevenson B, Kutalik Z, de Vries AA, Rivard L, Wilde AA, Talajic M, Verkerk AO, Al-Gazali L, Rioux JD, Bhuiyan ZA, Passier R, TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT. EMBO MOL MED 2016;8 (12):1390-1408 [PubMed]
  • Khan MAF, Reckman YJ, Aufiero S, van den Hoogenhof MMG, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM, RBM20 Regulates Circular RNA Production From the Titin Gene. CIRC RES 2016;119 (9):996-1003 [PubMed]
  • Peters T, Hermans-Beijnsberger S, Beqqali A, Bitsch N, Nakagawa S, Prasanth KV, de Windt LJ, van Oort RJ, Heymans S, Schroen B, Long Non-Coding RNA Malat-1 Is Dispensable during Pressure Overload-Induced Cardiac Remodeling and Failure in Mice. PLOS ONE 2016;11 (2):e0150236 [PubMed]
  • West JA, Beqqali A, Ament Z, Elliott P, Pinto YM, Arbustini E, Griffin JL, A targeted metabolomics assay for cardiac metabolism and demonstration using a mouse model of dilated cardiomyopathy. METABOLOMICS 2016;12:59 [PubMed]


  • Weeland CJ, van den Hoogenhof MM, Beqqali A, Creemers EE, Insights into alternative splicing of sarcomeric genes in the heart. J MOL CELL CARDIOL 2015;81:107-113 [PubMed]


  • Al-Saaidi R, Rasmussen TB, Palmfeldt J, Nissen PH, Beqqali A, Hansen J, Pinto YM, Boesen T, Mogensen J, Bross P, The LMNA mutation p.Arg321Ter associated with dilated cardiomyopathy leads to reduced expression and a skewed ratio of lamin A and lamin C proteins. EXP CELL RES 2013;319 (19):3010-3019 [PubMed]


  • Du Puy L, Beqqali A, van Tol HTA, Monshouwer-Kloots J, Passier R, Haagsman HP, Roelen BAJ, Sarcosin (Krp1) in skeletal muscle differentiation: gene expression profiling and knockdown experiments. INT J DEV BIOL 2012;56 (4):301-309 [PubMed]


  • van Eldik W, Beqqali A, Monshouwer-Kloots J, Mummery C, Passier R, Cytoskeletal heart-enriched actin-associated protein (CHAP) is expressed in striated and smooth muscle cells in chick and mouse during embryonic and adult stages. INT J DEV BIOL 2011;55 (6):649-655 [PubMed]


  • Beqqali A, Monshouwer-Kloots J, Monteiro R, Welling M, Bakkers J, Ehler E, Verkleij A, Mummery C, Passier R, CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. J CELL SCI 2010;123 (Part 7):1141-1150 [PubMed]


  • Beqqali A, van Eldik W, Mummery C, Passier R, Human stem cells as a model for cardiac differentiation and disease. CELL MOL LIFE SCI 2009;66 (5):800-813 [PubMed]
  • Du Puy L, Beqqali A, Monshouwer-Kloots J, Haagsman HP, Roelen BAJ, Passier R, CAZIP, a novel protein expressed in the developing heart and nervous system. DEV DYNAM 2009;238 (11):2903-2911 [PubMed]


  • Beqqali A, Kloots J, Ward-van Oostwaard D, Mummery C, Passier R, Genome-wide transcriptional profiling of human embryonic stem cells differentiating to cardiomyocytes. STEM CELLS 2006;24 (8):1956-1967 [PubMed]