Dr. M. van Dijk PhD publications


Publications Dr. M. van Dijk PhD

Scientific staff member (UD)
Main activities
molecular biology
Focus of research

We study the functional genomics and epigenetics in embryonic and placental development. Research is focussed on investigating genes involved in developmental processes occurring in the first trimester of pregnancy. Events leading to identical twinning or dysfunctional placentation causing pre-eclampsia and intra-uterine growth restriction are simulated to provide key insight into the origins of these events.  


  • Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GHY, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B, ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. SCIENCE 2017;357 (6352):707-713 [PubMed]


  • Jain CV, Kadam L, van Dijk M, Kohan-Ghadr HR, Kilburn BA, Hartman C, Mazzorana V, Visser A, Hertz M, Bolnick AD, Fritz R, Armant DR, Drewlo S, Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal. SCI TRANSL MED 2016;8 (363):363re4 [PubMed]
  • Oudejans CBM, Poutsma A, Michel OJ, Thulluru HK, Mulders J, van de Vrugt HJ, Sistermans EA, van Dijk M, Noncoding RNA-regulated gain-of-function of STOX2 in Finnish pre-eclamptic families. SCI REP-UK 2016;6:32129 [PubMed]
  • Oudejans C, Poutsma A, Michel O, Mulders J, Visser A, van Dijk M, Nauta T, Bokslag A, Paulus W, de Haas A, Koolwijk P, de Groot CJM, Genome-Wide Identification of Epigenetic Hotspots Potentially Related to Cardiovascular Risk in Adult Women after a Complicated Pregnancy. PLOS ONE 2016;11 (2):e0148313 [PubMed]
  • Zhang C, Ji Z, Wang M, Zhang W, Yang R, An H, Yang R, van Abel D, van Dijk M, Yang X, Ou G, Zhu HH, Gao WQ, Stox1 as a novel transcriptional suppressor of Math1 during cerebellar granule neurogenesis and medulloblastoma formation. CELL DEATH DIFFER 2016;23 (12):2042-2053 [PubMed]


  • Oudejans CBM, Michel OJ, Janssen R, Habets R, Poutsma A, Sistermans EA, Weiss MM, Incarnato D, Oliviero S, Kleiverda G, van Dijk M, Arngrímsson R, Susceptibility allele-specific loss of miR-1324-mediated silencing of the INO80B chromatin-assembly complex gene in pre-eclampsia. HUM MOL GENET 2015;24 (1):118-127 [PubMed]
  • Thulluru HK, Michel OJ, Oudejans CBM, van Dijk M., ACVR2A promoter polymorphism rs1424954 in the Activin-A signaling pathway in trophoblasts. PLACENTA 2015;36 (4):345-349 [PubMed]
  • van Dijk M, Visser A, Buabeng KML, Poutsma A, van der Schors RC, Oudejans CBM, Mutations within the LINC-HELLP non-coding RNA differentially bind ribosomal and RNA splicing complexes and negatively affect trophoblast differentiation. HUM MOL GENET 2015;24 (19):5475-5485 [PubMed]


  • van Dijk M, Oudejans C, (Epi)genetic control of human trophoblast invasion. FRONT GENET 2014;5:38 [PubMed]


  • Thulluru HK, Park C, Dufort D, Kleiverda G, Oudejans C, van Dijk M, Maternal Nodal inversely affects NODAL and STOX1 expression in the fetal placenta. FRONT GENET 2013;4:170 [PubMed]
  • van Dijk M, Oudejans C, (Epi)genetics of pregnancy-associated diseases. FRONT GENET 2013;4:180 [PubMed]


  • van Abel D, Abdulhamid O, Scheper W, van Dijk M, Oudejans CBM, STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease. NEUROSCI LETT 2012;528 (2):104-109 [PubMed]
  • van Abel D, Abdul-Hamid O, van Dijk M, Oudejans CBM, Transcription factor STOX1A promotes mitotic entry by binding to the CCNB1 promotor. PLOS ONE 2012;7 (1):e29769 [PubMed]
  • van Abel D, Michel O, Veerhuis R, Jacobs M, van Dijk M, Oudejans CBM, Direct downregulation of CNTNAP2 by STOX1A is associated with Alzheimer's disease. J ALZHEIMERS DIS 2012;31 (4):793-800 [PubMed]
  • van Dijk M, Thulluru HK, Mulders J, Michel OJ, Poutsma A, Windhorst S, Kleiverda G, Sie D, Lachmeijer AMA, Oudejans CBM, HELLP babies link a novel lincRNA to the trophoblast cell cycle. J CLIN INVEST 2012;122 (11):4003-4011 [PubMed]
  • van Dijk M, Visser A, Posthuma J, Poutsma A, Oudejans CBM, Naturally occurring variation in trophoblast invasion as a source of novel (epigenetic) biomarkers. FRONT GENET 2012;3:22 [PubMed]


  • van Abel D, Hölzel DR, Jain S, Lun FMF, Zheng YWL, Chen EZ, Sun H, Chiu RWK, Lo YMD, van Dijk M, Oudejans CBM, SFRS7-mediated splicing of tau exon 10 is directly regulated by STOX1A in glial cells. PLOS ONE 2011;6 (7):e21994 [PubMed]
  • van Dijk M, Oudejans CBM, STOX1: Key player in trophoblast dysfunction underlying early onset preeclampsia with growth retardation. J PREGNANCY 2011;2011:521826 [PubMed]


  • van Dijk M, Drewlo S, Oudejans CBM, Differential methylation of STOX1 in human placenta. EPIGENETICS 2010;5 (8):736-742 [PubMed]
  • van Dijk M, van Bezu J, Poutsma A, Veerhuis R, Rozemuller AJ, Scheper W, Blankenstein MA, Oudejans CB, The Pre-Eclampsia Gene STOX1 Controls a Conserved Pathway in Placenta and Brain Upregulated in Late-Onset Alzheimer's Disease. J ALZHEIMERS DIS 2010;19 (2):673-679 [PubMed]
  • van Dijk M, van Bezu J, van Abel D, Dunk C, Blankenstein MA, Oudejans CBM, Lye SJ, The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation. HUM MOL GENET 2010;19 (13):2658-2667 [PubMed]


  • Go ATJJ, Visser A, van Dijk M, Mulders MAM, Eijk P, Ylstra B, Blankenstein MA, van Vugt JMG, Oudejans CBM, A novel method to identify syncytiotrophoblast-derived RNA products representative of trisomy 21 placental RNA in maternal plasma. METHODS MOL BIOL 2008;444:291-302 [PubMed]
  • Oudejans CBM, van Dijk M., Placental gene expression and pre-eclampsia. PLACENTA 2008;29 (Suppl. A):S78-S82 [PubMed]


  • Oudejans CBM, van Dijk M, Oosterkamp M, Lachmeijer A, Blankenstein MA, Genetics of preeclampsia: paradigm shifts. HUM GENET 2007;120 (5):607-612 [PubMed]


  • Verzijl D, Pardo L, van Dijk M, Gruijthuijsen YK, Jongejan A, Timmerman H, Nicholas J, Schwarz M, Murphy PM, Leurs R, Smit MJ, Helix 8 of the viral chemokine receptor ORF74 directs chemokine binding. J BIOL CHEM 2006;281 (46):35327-35335 [PubMed]


  • van Dijk M, Mulders J, Poutsma A, Könst AAM, Lachmeijer AMA, Dekker GA, Blankenstein MA, Oudejans CBM, Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family. NAT GENET 2005;37 (5):514-519 [PubMed]


  • Oudejans CBM, Mulders J, Lachmeijer AMA, van Dijk M, Könst AAM, Westerman BA, van Wijk IJ, Leegwater PAJ, Kato HD, Matsuda T, Wake N, Dekker GA, Pals G, ten Kate LP, Blankenstein MA, The parent-of-origin effect of 10q22 in pre-eclamptic females coincides with two regions clustered for genes with down-regulated expression in androgenetic placentas. MOL HUM REPROD 2004;10 (8):589-598 [PubMed]
  • van Dijk M, Mulders J, Könst A, Janssens B, van Roy F, Blankenstein M, Oudejans C, Differential downregulation of alphaT-catenin expression in placenta: trophoblast cell type-dependent imprinting of the CTNNA3 gene. GENE EXPR PATTERNS 2004;5 (1):61-65 [PubMed]
  • Verzijl D, Fitzsimons CP, van Dijk M, Stewart JP, Timmerman H, Smit MJ, Leurs R, Differential activation of murine herpesvirus 68- and Kaposi's sarcoma-associated herpesvirus-encoded ORF74 G protein-coupled receptors by human and murine chemokines. J VIROL 2004;78 (7):3343-3351 [PubMed]


  • Faber AW, van Dijk M, Raué HA, Vos JC, Ngl2p is a Ccr4p-like RNA nuclease essential for the final step in 3'-end processing of 5.8S rRNA in Saccharomyces cerevisiae. RNA 2002;8 (9):1095-1101 [PubMed]