Dr. M.W. Langendam PhD publications


Publications Dr. M.W. Langendam PhD

Scientific staff member (UD)
Main activities
Research, Teaching
Evidence synthesis methodology
Focus of research

Miranda Langendam joined the AMC in 2008, as staff member of the Dutch Cochrane Centre. After the Centre, hosted by the department of Clinical Epidemiology, Biostatistics and Bioinformatics, moved to UMC Utrecht in January 2014 she had the opportunity to stay at AMC to develop an evidence synthesis research line.

The aim of her research is to help patients, health care providers and policy makers making evidence-based health care decisions. Trained as epidemiologist/methodologist she is interested in developing, applying and teaching methods to summarize and present the best available evidence to support health (care) decisions. The research topics she is working address a wide range of health care quations and reach from PICO formulation (e.g. defining the clinical pathway and developing core outcome sets) to guideline implementation strategies. Key words: clinical epidemiology, evidence-based medicine, systematic reviews, meta-analysis, GRADE, guideline development, research & teaching.



  • Hooijmans CR, de Vries RBM, Ritskes-Hoitinga M, Rovers MM, Leeflang MM, IntHout J, Wever KE, Hooft L, de Beer H, Kuijpers T, Macleod MR, Sena ES, ter Riet G, Morgan RL, Thayer KA, Rooney AA, Guyatt GH, Schünemann HJ, Langendam MW, Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies. PLOS ONE 2018;13 (1):e0187271 [PubMed]
  • Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, Gupta S, Langendam M, Staiano A, Thapar N, Tipnis N, Tabbers M, Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J PEDIATR GASTR NUTR 2018;66 (3):516-554 [PubMed]
  • Singendonk MMJ, Tabbers MM, Benninga MA, Langendam MW, Pediatric Gastroesophageal Reflux Disease: Systematic Review on Prognosis and Prognostic Factors. J PEDIATR GASTR NUTR 2018;66 (2):239-243 [PubMed]
  • Steutel NF, Langendam MW, Benninga MA, Jansen MEP, Tabbers MM, A Multifaceted Intervention to Reduce Pediatric Acid-Suppressant Prescriptions for Gastroesophageal Reflux: What Have We Learned?. J PEDIATR GASTR NUTR 2018;67 (5):605-609 [PubMed]
  • Swaen GMH, Langendam M, Weyler J, Burger H, Siesling S, Atsma WJ, Bouter L, Responsible Epidemiologic Research Practice: a guideline developed by a working group of the Netherlands Epidemiological Society. J CLIN EPIDEMIOL 2018;100:111-119 [PubMed]
  • van Aalst M, Lötsch F, Spijker R, van der Meer JTM, Langendam MW, Goorhuis A, Grobusch MP, de Bree GJ, Incidence of invasive pneumococcal disease in immunocompromised patients: A systematic review and meta-analysis. TRAVEL MED INFECT DI 2018;24:89-100 [PubMed]
  • Vrolijk-Bosschaart TF, Verlinden E , Langendam MW, de Smet V, Teeuw AH, Brilleslijper-Kater SN, Benninga MA, Lindauer RJL, The Diagnostic Utility of the Child Sexual Behavior Inventory for Sexual Abuse: A Systematic Review. J CHILD SEX ABUS 2018;27 (7):729-751 [PubMed]


  • Steutel NF, Benninga MA, Langendam MW, Korterink JJ, Indrio F, Szajewska H, Tabbers MM, Developing a core outcome set for infant colic for primary, secondary and tertiary care settings: a prospective study. BMJ OPEN 2017;7 (5):e015418 [PubMed]


  • Gopalakrishna G. Interpreting the evidence-base for making recommendations on medical tests. S.l.: s.n.; 2016. 241p. ISBN 978-94-028-0312-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Bossuyt PMM, Scholten RJPM; copromotor(s): Leeflang MMG, Langendam MW)
  • Gopalakrishna G, Langendam MW, Scholten RJPM, Bossuyt PMM, Leeflang MMG, Defining the clinical pathway in cochrane diagnostic test accuracy reviews. BMC MED RES METHODOL 2016;16 (1):153 [PubMed]
  • Gopalakrishna G, Leeflang MMG, Davenport C, Sanabria AJ, Alonso-Coello P, McCaffery K, Bossuyt P, Langendam MW, Barriers to making recommendations about medical tests: a qualitative study of European guideline developers. BMJ OPEN 2016;6 (9):e010549 [PubMed]
  • Langendam M, Carrasco-Labra A, Santesso N, Mustafa RA, Brignardello-Petersen R, Ventresca M, Heus P , Lasserson T, Moustgaard R, Brozek J, Schünemann HJ, Improving GRADE evidence tables part 2: a systematic survey of explanatory notes shows more guidance is needed. J CLIN EPIDEMIOL 2016;74:19-27 [PubMed]
  • Morgan RL, Thayer KA, Bero L, Bruce N, Falck-Ytter Y, Ghersi D, Guyatt G, Hooijmans C, Langendam M, Mandrioli D, Mustafa RA, Rehfuess EA, Rooney AA, Shea B, Silbergeld EK, Sutton P, Wolfe MS, Woodruff TJ, Verbeek JH, Holloway AC, Santesso N, Schünemann HJ, GRADE: Assessing the quality of evidence in environmental and occupational health. ENVIRON INT 2016;92-93:611-616 [PubMed]
  • Morroy G, Keijmel SP, Delsing CE, Bleijenberg G, Langendam M, Timen A, Bleeker-Rovers CP, Fatigue following Acute Q-Fever: A Systematic Literature Review. PLOS ONE 2016;11 (5):e0155884 [PubMed]
  • Santesso N, Carrasco-Labra A, Langendam M, Brignardello-Petersen R, Mustafa RA, Heus P , Lasserson T, Opiyo N, Kunnamo I, Sinclair D, Garner P, Treweek S, Tovey D, Akl EA, Tugwell P, Brozek JL, Guyatt G, Schünemann HJ, Improving GRADE evidence tables part 3: detailed guidance for explanatory footnotes supports creating and understanding GRADE certainty in the evidence judgments. J CLIN EPIDEMIOL 2016;74:28-39 [PubMed]
  • Schünemann HJ, Mustafa R, Brozek J, Santesso N, Alonso-Coello P, Guyatt G, Scholten R, Langendam M, Leeflang MM, Akl EA, Singh JA, Meerpohl J, Hultcrantz M, Bossuyt P, Oxman AD [Contributors: Schünemann HJ, Mustafa R, Brozek J, Santesso N, Alonso-Coello P, Scholten R, Langendam M, Bossuyt P, Leeflang MM, Akl EA, Singh J, Meerpohl J, Hultcrantz M, Guyatt G, Oxman AD, Lange S, Parmelli E, Moberg J, Rosenbaum S, Brignardello-Petersen R, Wiercioch W, Davoli M, Nowak A, Dietl B]] , GRADE Guidelines: 16. GRADE evidence to decision frameworks for tests in clinical practice and public health. J CLIN EPIDEMIOL 2016;76:89-98 [PubMed]


  • Weber MA, Kleijn MH, Langendam M, Limpens J, Heineman MJ, Roovers JP, Local Oestrogen for Pelvic Floor Disorders: A Systematic Review. PLOS ONE 2015;10 (9):e0136265 [PubMed]


  • Busard C, Zweegers J, Limpens J, Langendam M, Spuls PI, Combined use of systemic agents for psoriasis: a systematic review. JAMA DERMATOL 2014;150 (11):1213-1220 [PubMed]
  • Gopalakrishna G, Mustafa RA, Davenport C, Scholten RJPM, Hyde C, Brozek J, Schünemann HJ, Bossuyt PMM, Leeflang MMG, Langendam MW, Applying Grading of Recommendations Assessment, Development and Evaluation (GRADE) to diagnostic tests was challenging but doable. J CLIN EPIDEMIOL 2014;67 (7):760-768 [PubMed]
  • Hooijmans CR, Rovers MM, de Vries RBM, Leenaars M, Ritskes-Hoitinga M, Langendam MW, SYRCLE's risk of bias tool for animal studies. BMC MED RES METHODOL 2014;14:43 [PubMed]
  • Kuijpers T, Niël-Weise B, Langendam M, Scholten RJPM. Beoordelen en graderen van wetenschappelijk bewijs in: van Everdingen JJE, Dreesens DHH, Burgers JS, Swinkels JA , van Barneveld TA, van der Weijden T, editors. Handboek evidence-based richtlijnontwikkeling, een leidraad voor de praktijk, 2e druk. Houten: Bohn Stafleu van Loghum; 2013., p. 111-124
  • Smits MJ, van Wijk MP, Langendam MW, Benninga MA, Tabbers MM, Association between gastroesophageal reflux and pathologic apneas in infants: a systematic review. NEUROGASTROENT MOTIL 2014;26 (11):1527-1538 [PubMed]
  • Steutel NF, Benninga MA, Langendam MW, de Kruijff I, Tabbers MM, Reporting outcome measures in trials of infant colic. J PEDIATR GASTR NUTR 2014;59 (3):341-346 [PubMed]
  • Tabbers MM, Benninga MA, Di Lorenzo C, Langendam MW, Authors' response. J PEDIATR GASTR NUTR 2014;59 (3):e34-e35 [PubMed]
  • Tabbers MM, Dilorenzo C, Berger MY, Faure C, Langendam MW, Nurko S, Staiano A, Vandenplas Y, Benninga MA, Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN. J PEDIATR GASTR NUTR 2014;58 (2):258-274 [PubMed]
  • van der Pol R, Langendam M, Benninga M, van Wijk M, Tabbers M, Efficacy and safety of histamine-2 receptor antagonists. JAMA PEDIATR 2014;168 (10):947-954 [PubMed]
  • Zuure FR, Urbanus AT, Langendam MW, Helsper CW, van den Berg CHSB, Davidovich U, Prins M, Outcomes of hepatitis C screening programs targeted at risk groups hidden in the general population: a systematic review. BMC PUBLIC HEALTH 2014;14 (1):66 [PubMed]


  • Gopalakrishna G, Langendam MW, Scholten RJPM, Bossuyt PMM, Leeflang MMG, Guidelines for guideline developers: a systematic review of grading systems for medical tests. IMPLEMENT SCI 2013;8 (1):78 [PubMed]
  • Langendam MW, Akl EA, Dahm P, Glasziou P, Guyatt G, Schünemann HJ, Assessing and presenting summaries of evidence in Cochrane Reviews. SYST REV 2013;2:81 [PubMed]
  • Langendam MW, Daams JG, Wetering FT, Hoving JL, Smits PBA, Evidence-based medicine in de bedrijfs- en verzekeringsgeneeskunde, deel 2. QUINTESSE 2013;2:42-47
  • Langendam MW, Tiemersma EW, van der Werf MJ, Sandgren A, Adverse events in healthy individuals and MDR-TB contacts treated with anti-tuberculosis drugs potentially effective for preventing development of MDR-TB: a systematic review. PLOS ONE 2013;8 (1):e53599 [PubMed]
  • Treweek S, Oxman AD, Alderson P, Bossuyt PM, Brandt L, Brożek J, Davoli M, Flottorp S, Harbour R, Hill S, Liberati A, Liira H, Schünemann HJ, Rosenbaum S, Thornton J, Vandvik PO, Alonso-Coello P [Contributors: Hartley C, Loudon K, Slater W, Stewart N, Treweek S, Brandt L, Flottorp S, Glenton C, Kristiansen A, Lewin S, Moberg J, Morelli A, Oxman A, Rosenbaum S, Vandvik PO, Ødgaard-Jensen J, Alonso-Coello P, Martinez-García L, Rigau D, Solà I, Sanabria AJ, Amato L, Brunetti M, Davoli M, Magrini N, Parmelli E, Nonino F, de Palma R, Papini D, Pregno S, Saitto C, Bossuyt P, Gopalakrishna G, Langendam M, Leeflang M, Scholten R, Gülmezoglu M, Permanand G, Weerasuriyak K, Antes G, Meerpohl J, Schünemann H, Alderson P, McFarlane E, Thornton J, Callaghan M, Graham K, Harbour R, Ritchie K, Service D, Kunnamo I, Liira H, Guyatt G, Mustafa R, Neumann I, Santesso N, Spencer F, Falck-Ytter Y, Brignardello-Petersen R, Carrasco- Labra A, Kunz R, Akl E]] , Developing and Evaluating Communication Strategies to Support Informed Decisions and Practice Based on Evidence (DECIDE): protocol and preliminary results. IMPLEMENT SCI 2013;8 (1):6 [PubMed]


  • Boluyt N, Rottier BL, Langendam MW, Richtlijnen worden transparanter met de GRADE-methode: nieuwe methode maakt overwegingen bij aanbevelingen expliciet. NED TIJDSCHR GENEESKD 2012;156 (25):A4379 [PubMed]
  • Langendam M, Luijf YM, Hooft L, DeVries JH, Mudde AH, Scholten RJPM, Continuous glucose monitoring systems for type 1 diabetes mellitus. COCHRANE DB SYST REV 2012;2012 (1):CD008101 [PubMed]
  • Langendam MW, van der Werf MJ, Huitric E, Manissero D, SERIES "RATIONAL USE OF ANTI-TUBERCULOSIS DRUGS" Edited by G. B Migliori and D. Manissero Number 1 in this Series Prevalence of inappropriate tuberculosis treatment regimens: a systematic review. EUR RESPIR J 2012;39 (4):1012-1020 [PubMed]
  • Migliori GB, Langendam MW, D'Ambrosio L, Centis R, Blasi F, Huitric E, Manissero D, van der Werf MJ, Protecting the tuberculosis drug pipeline: stating the case for the rational use of fluoroquinolones. EUR RESPIR J 2012;40 (4):814-822 [PubMed]
  • van der Werf MJ, Langendam MW, Huitric E, Manissero D, Knowledge of tuberculosis-treatment prescription of health workers: a systematic review. EUR RESPIR J 2012;39 (5):1248-1255 [PubMed]
  • van der Werf MJ, Langendam MW, Huitric E, Manissero D, Multidrug resistance after inappropriate tuberculosis treatment: a meta-analysis. EUR RESPIR J 2012;39 (6):1511-1519 [PubMed]
  • van der Werf MJ, Langendam MW, Sandgren A, Manissero D, Lack of evidence to support policy development for management of contacts of multidrug-resistant tuberculosis patients: two systematic reviews. INT J TUBERC LUNG D 2012;16 (3):288-296 [PubMed]


  • Langendam M, Pijnenburg MWH, de Jongste JC, Hooft L, Scholten RJPM, Boluyt N, Behandeling kinderen met astma op geleide van stikstofmonoxide in de uitademingslucht: meerwaarde stikstofmonoxidemeting nog niet aangetoond. NED TIJDSCHR GENEESKD 2010;154 (18):A1804 [PubMed]


  • Langendam MW, Hooijkaas C, Piepenbrink JF, Toenemend gebruik van geneesmiddelen voor diabetes mellitus in Nederland, 1998-2003. NED TIJDSCHR GENEESKD 2006;150 (25):1396-1401 [PubMed]


  • van de Laar TJW, Langendam MW, Bruisten SM, Welp EAE, Verhaest I, van Ameijden EJC, Coutinho RA, Prins M, Changes in risk behavior and dynamics of hepatitis C virus infections among young drug users in Amsterdam, the Netherlands. J MED VIROL 2005;77 (4):509-518 [PubMed]


  • van Deutekom H, Hoijng SP, de Haas PEW, Langendam MW, Horsman A, van Soolingen D, Coutinho RA, Clustered tuberculosis cases - Do they represent recent transmission and can they be detected earlier?. AM J RESP CRIT CARE 2004;169 (7):806-810 [PubMed]


  • Baars MJH, de Smit DJ, Langendam MW, Adèr HJ, ten Kate LP, Comparison of activities and attitudes of general practitioners concerning genetic counseling over a 10-year time-span. PATIENT EDUC COUNS 2003;50 (2):145-149 [PubMed]
  • Poppelaars FAM, van der Wal G, Braspenning JCC, Cornel MC, Henneman L, Langendam MW, ten Kate LP, Possibilities and barriers in the implementation of a preconceptional screening programme for cystic fibrosis carriers: a focus group study. PUBLIC HEALTH 2003;117 (6):396-403 [PubMed]
  • van Asten L, Langendam M, Zangerle R, Hernández Aguado I, Boufassa F, Schiffer V, Brettle RP, Robertson JR, Fontanet A, Coutinho RA, Prins M, Tuberculosis risk varies with the duration of HIV infection: a prospective study of European drug users with known date of HIV seroconversion. AIDS 2003;17 (8):1201-1208 [PubMed]
  • Welp EAE, Bosman I, Langendam MW, Totté M, Maes RAA, van Ameijden EJC, Amount of self-reported illicit drug use compared to quantitative hair test results in community-recruited young drug users in Amsterdam. ADDICTION 2003;98 (7):987-994 [PubMed]


  • Lindenburg CEA, Stolte I, Langendam MW, Miedema F, Williams IG, Colebunders R, Weber JN, Fisher M, Coutinho RA, Long-term follow-up: no effect of therapeutic vaccination with HIV-1 p17/p24:Ty virus-like particles on HIV-1 disease progression. VACCINE 2002;20 (17-18):2343-2347 [PubMed]
  • Welp EAE, Lodder AC, Langendam MW, Coutinho RA, van Ameijden EJC, HIV prevalence and risk behaviour in young drug users in Amsterdam. AIDS 2002;16 (9):1279-1284 [PubMed]


  • Henneman L, Langendam MW, ten Kate LP, Community Genetics and Its Evaluation: A European Science Foundation Workshop. COMMUNITY GENET 2001;4 (1):56-59 [PubMed]
  • Langendam MW, van Brussel GH, Coutinho RA, van Ameijden EJ, The impact of harm-reduction-based methadone treatment on mortality among heroin users. AM J PUBLIC HEALTH 2001;91 (5):774-780 [PubMed]
  • Lindenburg CE, Langendam MW, Benthem BH, Miedema F, Coutinho RA, No evidence that vaccination with a polysaccharide pneumococcal vaccine protects drug users against all-cause pneumonia. AIDS 2001;15 (10):1315-1317 [PubMed]


  • Keizer ST, Langendam MM, van Deutekom H, Coutinho RA, van Ameijden EJ, How does tuberculosis relate to HIV positive and HIV negative drug users?. J EPIDEMIOL COMMUN H 2000;54 (1):64-68 [PubMed]
  • Langendam MW, van Brussel GH, Coutinho RA, van Ameijden EJ, Methadone maintenance and cessation of injecting drug use: results from the Amsterdam Cohort Study. ADDICTION 2000;95 (4):591-600 [PubMed]
  • Langendam MW, van Brussel GH, Coutinho RA, van Ameijden EJ, Trends in HIV risk behaviour and methadone dosage among HIV-negative drug users: an ecological study. AIDS 2000;14 (12):1870-1872 [PubMed]
  • Lindenburg K, Langendam MW, Veenstra J, Miedema F, Coutinho R, Long-term effects of therapeutic vaccination with rgp 120. AIDS 2000;14 (2):203-204 [PubMed]
  • Vermaak MP, Langendam MW, van den Hoek JA, Peerbooms PG, Coutinho RA, Shigellose in Amsterdam, 1991-1998: vóórkomen en resultaten van contactonderzoek. NED TIJDSCHR GENEESKD 2000;144 (35):1688-1692 [PubMed]


  • Gras MJ, Weide JF, Langendam MW, Coutinho RA, van den Hoek A, HIV prevalence, sexual risk behaviour and sexual mixing patterns among migrants in Amsterdam, The Netherlands. AIDS 1999;13 (14):1953-1962 [PubMed]
  • Langendam MW, van Brussel GH, Coutinho RA, van Ameijden EJ, Methadone maintenance treatment modalities in relation to incidence of HIV: results of the Amsterdam cohort study. AIDS 1999;13 (13):1711-1716 [PubMed]
  • Langendam MW, van Haastrecht HJ, van Ameijden EJ, The validity of drug users' self-reports in a non-treatment setting: prevalence and predictors of incorrect reporting methadone treatment modalities. INT J EPIDEMIOL 1999;28 (3):514-520 [PubMed]
  • Schinkel J, Langendam MW, Coutinho RA, Krol A, Brouwer M, Schuitemaker H, No evidence for an effect of the CCR5 delta32/+ and CCR2b 64I/+ mutations on human immunodeficiency virus (HIV)-1 disease progression among HIV-1-infected injecting drug users. J INFECT DIS 1999;179 (4):825-831 [PubMed]
  • van Ameijden EJ, Langendam MW, Coutinho RA, Dose-effect relationship between overdose mortality and prescribed methadone dosage in low-threshold maintenance programs. ADDICT BEHAV 1999;24 (4):559-563 [PubMed]
  • van Ameijden EJ, Langendam MW, Notenboom J, Coutinho RA, Continuing injecting risk behaviour: results from the Amsterdam Cohort Study of drug users. ADDICTION 1999;94 (7):1051-1061 [PubMed]


  • Keizer ST, Langendam MW, van Deutekom H, Coutinho RA, van Ameijden FJ, Tuberculose bij HIV-positieve en HIV-negatieve drugsgebruikers in Amsterdam. NED TIJDSCHR GENEESKD 1998;142 (4):184-189 [PubMed]
  • Langendam MW, van Haastrecht HJ, van Brussel GH, Reurs H, van den Hoek AA, Coutinho RA, van Ameijden EJ, Differentiation in the Amsterdam methadone dispensing circuit: determinants of methadone dosage and site of methadone prescription. ADDICTION 1998;93 (1):61-72 [PubMed]
  • Spijkerman I, de Wolf F, Langendam M, Schuitemaker H, Coutinho R, Emergence of syncytium-inducing human immunodeficiency virus type 1 variants coincides with a transient increase in viral RNA level and is an independent predictor for progression to AIDS. J INFECT DIS 1998;178 (2):397-403 [PubMed]
  • Spijkerman IJ, Langendam MW, van Ameijden EJ, Coutinho RA, van den Hoek A, Gender differences in clinical manifestations before AIDS diagnosis among injecting drug users. EUR J EPIDEMIOL 1998;14 (3):213-218 [PubMed]


  • de Wolf F, Spijkerman I, Schellekens PT, Langendam M, Kuiken C, Bakker M, Roos M, Coutinho R, Miedema F, Goudsmit J, AIDS prognosis based on HIV-1 RNA, CD4+ T-cell count and function: markers with reciprocal predictive value over time after seroconversion. AIDS 1997;11 (15):1799-1806 [PubMed]


  • Spijkerman IJ, Langendam MW, Veugelers PJ, van Ameijden EJ, Keet IP, Geskus RB, van den Hoek A, Coutinho RA, Differences in progression to AIDS between injection drug users and homosexual men with documented dates of seroconversion. EPIDEMIOLOGY 1996;7 (6):571-577 [PubMed]