Dr. S.M. Hermans MSc PhD publications


Publications Dr. S.M. Hermans MSc PhD

Scientific staff member (UD)
Main activities
Research, Patient care
Infectious Diseases Epidemiology
Focus of research

My research interests include the epidemiology of HIV and tuberculosis co-infection, in particular recurrent tuberculosis, and operational research into the implementation of optimal strategies of health care delivery in sub-Saharan Africa.

My current research projects include epidemiological analyses of a decade of data on tuberculosis in the City of Cape Town, South Africa, and Kampala, Uganda. My particular interest is to determine the burden of recurrent TB using deterministic linkage techniques. I also investigate the impact of public health interventions such as antiretroviral therapy and Xpert MTB/RIF on population level TB notification rates. I am the principal investigator of a TB case finding study in rural Tanzania funded by TB Reach (WHO Stop TB department), and am the lead clinical investigator on a universal HIV test & treat programme in the same area.

I am involved in the mentorship of students at various levels: bachelorthesis BSc Medicine (AMC) and the Global Health Elective course (VUMc). I am the co-supervisor of two PhD students undertaking research into TB epidemiology in South Africa and Mozambique.


  • Burnett SM, Zawedde-Muyanja S, Hermans SM, Weaver MR, Colebunders R, Manabe YC, Effect of TB/HIV Integration on TB and HIV Indicators in Rural Ugandan Health Facilities. JAIDS-J ACQ IMM DEF 2018;79 (5):605-611 [PubMed]
  • Kaplan R, Hermans S, Caldwell J, Jennings K, Bekker LG, Wood R, HIV and TB co-infection in the ART era: CD4 count distributions and TB case fatality in Cape Town. BMC INFECT DIS 2018;18 (1):356 [PubMed]
  • Tedijanto C, Hermans S, Cobelens F, Wood R, Andrews JR, Drivers of Seasonal Variation in Tuberculosis Incidence: Insights from a Systematic Review and Mathematical Model. EPIDEMIOLOGY 2018;29 (6):857-866 [PubMed]
  • Verma S, Du P, Nakanjako D, Hermans S, Briggs J, Nakiyingi L, Ellner JJ, Manabe YC, Salgame P, Tuberculosis in advanced HIV infection is associated with increased expression of IFN gamma and its downstream targets. BMC INFECT DIS 2018;18 (1):220 [PubMed]


  • Hermans S, Caldwell J, Kaplan R, Cobelens F, Wood R, The impact of the roll-out of rapid molecular diagnostic testing for tuberculosis on empirical treatment in Cape Town, South Africa. B WORLD HEALTH ORGAN 2017;95 (8):554-563 [PubMed]
  • Hermans SM, Babirye JA, Mbabazi O, Kakooza F, Colebunders R, Castelnuovo B, Sekaggya-Wiltshire C, Parkes-Ratanshi R, Manabe YC, Treatment decisions and mortality in HIV-positive presumptive smear-negative TB in the Xpert™ MTB/RIF era: a cohort study. BMC INFECT DIS 2017;17 (1):433 [PubMed]
  • Hermans SM, Elbireer S, Tibakabikoba H, Hoefman BJ, Manabe YC, Text messaging to decrease tuberculosis treatment attrition in TB-HIV coinfection in Uganda. PATIENT PREFER ADHER 2017;11:1479-1487 [PubMed]


  • Blaser N, Zahnd C, Hermans S, Salazar-Vizcaya L, Estill J, Morrow C, Egger M, Keiser O, Wood R, Tuberculosis in Cape Town: An age-structured transmission model. EPIDEMICS-NETH 2016;14:54-61 [PubMed]
  • Ford N, Matteelli A, Shubber Z, Hermans S, Meintjes G, Grinsztejn B, Waldrop G, Kranzer K, Doherty M, Getahun H, TB as a cause of hospitalization and in-hospital mortality among people living with HIV worldwide: a systematic review and meta-analysis. J INT AIDS SOC 2016;19 (1):20714 [PubMed]
  • Hermans SM, Andrews JR, Bekker LG, Wood R, The mass miniature chest radiography programme in Cape Town, South Africa, 1948-1994: The impact of active tuberculosis case finding. SAMJ S AFR MED J 2016;106 (12):60-1269 [PubMed]
  • Hermans SM, Grant AD, Chihota V, Lewis JJ, Vynnycky E, Churchyard GJ, Fielding KL, The timing of tuberculosis after isoniazid preventive therapy among gold miners in South Africa: a prospective cohort study. BMC MED 2016;14 (1):45 [PubMed]


  • Hermans S, Boulle A, Caldwell J, Pienaar D, Wood R, Temporal trends in TB notification rates during ART scale-up in Cape Town: an ecological analysis. J INT AIDS SOC 2015;18 (1):20240 [PubMed]
  • Hermans S, Horsburgh CR Jr, Wood R, A Century of Tuberculosis Epidemiology in the Northern and Southern Hemisphere: The Differential Impact of Control Interventions. PLOS ONE 2015;10 (8):e0135179 [PubMed]
  • Hermans S, Manabe Y, Population-level tuberculosis incidence in the ART era. LANCET INFECT DIS 2015;15 (9):997-998 [PubMed]
  • Hermans S, Middelkoop K, Wood R, Shared locations of TB cases: places of acquisition or transmission of infection?. TROP MED INT HEALTH 2015;20 (7):965 [PubMed]
  • Janssen S, Hermans S, Knap M, Moekotte A, Rossatanga EG, Adegnika AA, Bélard S, Hänscheid T, Grobusch MP, Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambaréné, Gabon. PLOS NEGLECT TROP D 2015;9 (5):e0003769 [PubMed]


  • van Leth F, Wit FWNM, Hermans SM, Antiretroviral therapy and tuberculosis: does the regimen matter?. EXPERT REV ANTI-INFE 2014;12 (1):5-7 [PubMed]


  • Hermans SM, Manabe YC, Kiragga AN, Hoepelman AIM, Lange JMA, van Leth F, Risk of tuberculosis after antiretroviral treatment initiation: a comparison between efavirenz and nevirapine using inverse probability weighting. ANTIVIR THER 2013;18 (4):615-622 [PubMed]


  • Hermans SM. HIV and tuberculosis co-infection in Uganda. Clinical management, immune reconstitution and health service delivery. Utrecht: Optima Grafische Communicatie, Rotterdam; 2012. 120p. ISBN 978-94-6169-258-0 Proefschrift Universiteit Utrecht, Interne Geneeskunde i.h.b. de infectieziekten, onderzoek in AMC-UvA. (Promotor(s): Hoepelman AIM, Lange JMA; copromotor(s): Manabe YC, van Leth F)
  • Hermans SM, Castelnuovo B, Katabira C, Mbidde P, Lange JMA, Hoepelman AIM, Coutinho A, Manabe YC, Integration of HIV and TB Services Results in Improved TB Treatment Outcomes and Earlier Prioritized ART Initiation in a Large Urban HIV Clinic in Uganda. JAIDS-J ACQ IMM DEF 2012;60 (2):E29-E35 [PubMed]
  • Hermans SM, Sempa J, Castelnuovo B, Manabe YC, van Leth F, Comment on: Predictors of immune recovery and the association with late mortality while on antiretroviral treatment in Cambodia. T ROY SOC TROP MED H 2012;106 (5):328-329 [PubMed]
  • Hermans SM, van Leth F, Kiragga AN, Hoepelman AIM, Lange JMA, Manabe YC, Unrecognised tuberculosis at antiretroviral therapy initiation is associated with lower CD4+ T cell recovery. TROP MED INT HEALTH 2012;17 (12):1527-1533 [PubMed]
  • Hermans SM, van Leth F, Manabe YC, Hoepelman AIM, Lange JMA, Kambugu A, Earlier initiation of antiretroviral therapy, increased tuberculosis case finding and reduced mortality in a setting of improved HIV care: a retrospective cohort study. HIV MED 2012;13 (6):337-344 [PubMed]
  • Hermans S, Nasuuna E, van Leth F, Byhoff E, Schwarz M, Hoepelman A, Lange J, Manabe YC, Implementation and effect of intensified case finding on diagnosis of tuberculosis in a large urban HIV clinic in Uganda: a retrospective cohort study. BMC PUBLIC HEALTH 2012;12:674 [PubMed]
  • Kuznik A, Lamorde M, Hermans S, Castelnuovo B, Auerbach B, Semeere A, Sempa J, Ssennono M, Ssewankambo F, Manabe YC, Evaluating the cost-effectiveness of combination antiretroviral therapy for the prevention of mother-to-child transmission of HIV in Uganda. B WORLD HEALTH ORGAN 2012;90 (8):595-603 [PubMed]
  • Manabe YC, Hermans SM, Lamorde M, Castelnuovo B, Mullins CD, Kuznik A, Rifampicin for Continuation Phase Tuberculosis Treatment in Uganda: A Cost-Effectiveness Analysis. PLOS ONE 2012;7 (6):e39187 [PubMed]
  • Sempa J, Ssennono M, Kuznik A, Lamorde M, Sowinski S, Semeere A, Hermans S, Castelnuovo B, Manabe YC, Cost-effectiveness of early initiation of first-line combination antiretroviral therapy in Uganda. BMC PUBLIC HEALTH 2012;12:736 [PubMed]


  • Hermans SM, Buys EM, Cardiogenic shock. NETH HEART J 2010;18 (7-8):384 [PubMed]
  • Hermans SM, Kiragga AN, Schaefer P, Kambugu A, Hoepelman AIM, Manabe YC, Incident Tuberculosis during Antiretroviral Therapy Contributes to Suboptimal Immune Reconstitution in a Large Urban HIV Clinic in Sub-Saharan Africa. PLOS ONE 2010;5 (5):e10527 [PubMed]


  • Hermans SM, Schouten WEM, Faber TE, Hoepelman IM, Andriesse GI, Een subcutane zwelling met een maligne presentatie, maar met een infectieuze oorzaak. NED TIJDSCHR GENEESKD 2004;148 (33):1636-1641 [PubMed]


  • Busari OJ, Vervoort M, Hermans SM, Blom JR, Medical education in the new millennium--a Caribbean perspective. MED EDUC 2001;35 (7):703-706 [PubMed]