Drs. B.A. Wevers MSc publications

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Publications Drs. B.A. Wevers MSc

Position
PhD student
Main activities
Research
Specialisation
Molecular biology, signal transduction, innate immunology
Focus of research

Antifungal immunity. Opportunistic fungi represent a serious health problem by causing systemic life-threatening infections in individuals who are immune compromised, including HIV-1/AIDS and cancer patients. Effective phagocytic clearance of fungal pathogens requires intact Th-17 and Th1 immune responses, for mobilization and activation of neutrophils, respectively. Recognition of fungal cell wall carbohydrates by C-type lectins on human dendritic cells and subsequent cytokine production is crucial for the orchestration of protective T helper cell polarization. We are identifying C-type lectins that interact with different fungal species and how these C-type lectins induce adaptive immunity. In particular we are investigating signaling by C-type lectins such as dectin-1 and dectin-2.

2014

  • Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TBH, Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKε- and CYLD-dependent Bcl3 activation. NAT COMMUN 2014;5:3898 [PubMed]
  • Gringhuis SI, Kaptein TM, Wevers BA, van der Vlist M, Klaver EJ, van Die I, Vriend LEM, de Jong MAWP, Geijtenbeek TBH, Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production. NAT COMMUN 2014;5:5074 [PubMed]
  • Wevers BA. C-type lectin signaling in dendritic cells. Molecular control of antifungal inflammation. s.l.: s.n.; 2014. -p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Geijtenbeek TBH; copromotor(s): Gringhuis SI)
  • Wevers BA, Kaptein TM, Zijlstra-Willems EM, Theelen B, Boekhout T, Geijtenbeek TBH, Gringhuis SI, Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity. CELL HOST MICROBE 2014;15 (4):494-505 [PubMed]

2013

  • Wevers BA, Geijtenbeek TBH, Gringhuis SI, C-type lectin receptors orchestrate antifungal immunity. FUTURE MICROBIOL 2013;8 (7):839-854 [PubMed]

2012

  • Gringhuis SI, Kaptein TM, Wevers BA, Theelen B, van der Vlist M, Boekhout T, Geijtenbeek TBH, Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1 beta via a noncanonical caspase-8 inflammasome. NAT IMMUNOL 2012;13 (3):246-U63 [PubMed]

2011

  • Gringhuis SI, Wevers BA, Kaptein TM, van Capel TMM, Theelen B, Boekhout T, de Jong EC, Geijtenbeek TBH, Selective C-Rel Activation via Malt1 Controls Anti-Fungal T-H-17 Immunity by Dectin-1 and Dectin-2. PLOS PATHOG 2011;7 (1):e1001259 [PubMed]

2010

  • Wevers BA, van der Hoek L, Renin-angiotensin system in human coronavirus pathogenesis. FUTURE VIROL 2010;5 (2):145-161

2009

  • Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SCM, Geijtenbeek TBH, Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. NAT IMMUNOL 2009;10 (2):203-213 [PubMed]
  • Wevers BA, van der Hoek L, Recently Discovered Human Coronaviruses. CLIN LAB MED 2009;29 (4):715-+ [PubMed]