Ing. I.A.M. Derks publications


Publications Ing. I.A.M. Derks

Laboratory technician
Main activities
Apoptosis signaling in immunity
Focus of research

Apoptosis in the immunesystem


  • Thijssen R, ter Burg J, Garrick B, van Bochove GGW, Brown JR, Fernandes SM, Rodríguez MS, Michot JM, Hallek M, Eichhorst B, Reinhardt HC, Bendell J, Derks IAM, van Kampen RJW, Hege K, Kersten MJ, Trowe T, Filvaroff EH, Eldering E, Kater AP, Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia. BLOOD 2016;128 (4):574-583 [PubMed]


  • te Raa GD, Derks IAM, Navrkalova V, Skowronska A, Moerland PD, van Laar J, Oldreive C, Monsuur H, Trbusek M, Malcikova J, Lodén M, Geisler CH, Hüllein J, Jethwa A, Zenz T, Pospisilova S, Stankovic T, van Oers MHJ, Kater AP , Eldering E, The impact of SF3B1 mutations in CLL on the DNA-damage response. LEUKEMIA 2015;29 (5):1133-1142 [PubMed]
  • te Raa GD, Moerland PD, Leeksma AC, Derks IA, Yigittop H, Laddach N, Loden-van Straaten M, Navrkalova V, Trbusek M, Luijks DM, Zenz T, Skowronska A, Hoogendoorn M, Stankovic T, van Oers MH, Eldering E, Kater AP, Assessment of p53 and ATM functionality in chronic lymphocytic leukemia by multiplex ligation-dependent probe amplification. CELL DEATH DIS 2015;6:e1852 [PubMed]
  • Tonino SH, Mulkens CE, van Laar J, Derks IAM, Suo G, Croon-de Boer F, van Oers MHJ, Eldering E, Wang JY, Kater AP, Induction of TAp73 by platinum-based compounds to overcome drug resistance in p53 dysfunctional chronic lymphocytic leukemia. LEUKEMIA LYMPHOMA 2015;56 (8):2439-2447 [PubMed]
  • Vieira Braga FA, Hertoghs KML, Kragten NAM, Doody GM, Barnes NA, Remmerswaal EBM, Hsiao CC, Moerland PD, Wouters D, Derks IAM, van Stijn A, Demkes M, Hamann J, Eldering E, Nolte MA, Tooze RM, ten Berge IJM, van Gisbergen KPJM, van Lier RAW, Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans. EUR J IMMUNOL 2015;45 (10):2945-2958 [PubMed]


  • Pascutti MF, Jak M, Tromp JM, Derks IAM, Remmerswaal EBM, Thijssen R, van Attekum MHA, van Bochove GG, Luijks DM, Pals ST, van Lier RAW, Kater AP, van Oers MHJ, Eldering E, IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells. BLOOD 2013;122 (17):3010-3019 [PubMed]
  • Wensveen FM, Geest CR, Libregts SFWM, Derks IAM, Ekert PG, Labi V, Villunger A, Nolte MA, Eldering E, BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis. APOPTOSIS 2013;18 (11):1306-1318 [PubMed]
  • Wensveen FM, Klarenbeek PL, van Gisbergen KPJM, Pascutti MF, Derks IAM, van Schaik BDC, ten Brinke A, de Vries N, Cekinovic D, Jonjic S, van Lier RAW, Eldering E, Pro-apoptotic protein Noxa regulates memory T cell population size and protects against lethal immunopathology. J IMMUNOL 2013;190 (3):1180-1191 [PubMed]


  • Helbig C, Gentek R, Backer RA, de Souza Y, Derks IAM, Eldering E, Wagner K, Jankovic D, Gridley T, Moerland PD, Flavell RA, Amsen D, Notch controls the magnitude of T helper cell responses by promoting cellular longevity. P NATL ACAD SCI USA 2012;109 (23):9041-9046 [PubMed]
  • Wensveen FM, Derks IAM, van Gisbergen KPJM, de Bruin AM, Meijers JCM, Yigittop H, Nolte MA, Eldering E, van Lier RAW, BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation. BLOOD 2012;119 (6):1440-1449 [PubMed]
  • Wensveen FM, Unger PPA, Kragten NAM, Derks IAM, ten Brinke A, Arens R, van Lier RAW, Eldering E, van Gisbergen KPJM, CD70-Driven Costimulation Induces Survival or Fas-Mediated Apoptosis of T Cells Depending on Antigenic Load. J IMMUNOL 2012;188 (9):4256-4267 [PubMed]


  • Kuijpers TW, Baars PA, Aan de Kerk DJ, Jansen MH, Derks IAM, Bredius RGM, Sanders EAM, van der Burg M, Alders M, van Lier RAW, A novel mutation in CD132 causes X-CID with defective T-cell activation and impaired humoral reactivity. J ALLERGY CLIN IMMUN 2011;128 (6):1360-1363.e4 [PubMed]
  • Wensveen FM, Alves NL, Derks IAM, Reedquist KA, Eldering E, Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1. APOPTOSIS 2011;16 (7):708-721 [PubMed]


  • Kuijpers TW, Bende RJ, Baars PA, Grummels A, Derks IAM, Dolman KM, Beaumont T, Tedder TF, van Noesel CJM, Eldering E, van Lier RAW, CD20 deficiency in humans results in impaired T cell-independent antibody responses. J CLIN INVEST 2010;120 (1):214-222 [PubMed]
  • Wensveen FM, van Gisbergen KPJM, Derks IAM, Gerlach C, Schumacher TN, van Lier RAW, Eldering E, Apoptosis Threshold Set by Noxa and Mcl-1 after T Cell Activation Regulates Competitive Selection of High-Affinity Clones. IMMUNITY 2010;32 (6):754-765 [PubMed]


  • Alves NL, van Leeuwen EMM, Derks IAM, van Lier RAW, Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling. J IMMUNOL 2008;180 (8):5201-5210 [PubMed]


  • Hallaert DYH, Spijker R, Jak M, Derks IAM, Alves NL, Wensveen FM, de Boer JP, de Jong D, Green SR, van Oers MHJ, Eldering E, Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection. CELL DEATH DIFFER 2007;14 (11):1958-1967 [PubMed]


  • Alves NL, Derks IAM, Berk E, Spijker R, van Lier RAW, Eldering E, The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells. IMMUNITY 2006;24 (6):703-716 [PubMed]


  • Eldering E, Mackus WJM, Derks IAM, Evers LM, Beuling E, Teeling P, Lens SMA, van Oers MHJ, van Lier RAW, Apoptosis via the B cell antigen receptor requires Bax translocation and involves mitochondrial depolarization, cytochrome C release, and caspase-9 activation. EUR J IMMUNOL 2004;34 (7):1950-1960 [PubMed]


  • Eldering E, Spek CA, Aberson HL, Grummels A, Derks IA, de Vos AF, McElgunn CJ, Schouten JP, Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways. NUCLEIC ACIDS RES 2003;31 (23):e153 [PubMed]