Prof. dr. E.C. de Jong PhD publications


Publications Prof. dr. E.C. de Jong PhD

Main activities
Research, Teaching
Focus of research

Our immune system is critically important in eliminating pathogens that invade our body, including bacteria, viruses and parasites. To effectively challenge various classes of pathogens, the development of specific types of antigen-specific T cells is required, which activate different pathogen-tailored effector mechanisms. Protection against endosomal pathogens requires type 1 T helper (Th1) cells, protection against helminths Th2 cells, protection against bacteria Th17 cells and protection against viruses cytotoxic T (Tc) cells. Importantly, the function of these effector T cells is inhibited by T regulatory (Tr) cells, that prevent in this way excessive host tissue damage, autoimmunity and allergy. These different effector T cells develop from multipotent naive T cells. Our work has contributed to the concept that dendritic cells (DCs) are specialized antigen-presenting cells that orchestrate the development of protective type of effector T cell responses by their ability to sense different pathogen classes. An important research theme in my group is the question to what extent there are specialized DC subsets and by what mechanism DCs promote the development of Th1, Th2, Th17 or Treg cells. Secondly, this knowledge is applied in the development of novel therapies for immunological, inflammatory diseases such as allergic disorders.


  • Balraadjsing PP, de Jong EC, Grijpma DW, Tanck MW, Zaat SA, Poly(trimethylene carbonate) and poly(D,L-lactic acid) modify human dendritic cell responses to staphylococci but do not affect Th1 and Th2 cell development. EUR CELLS MATER 2018;35:103-116 [PubMed]
  • Groot Kormelink T, Mol S, de Jong EC, Wauben MHM, The role of extracellular vesicles when innate meets adaptive. SEMIN IMMUNOPATHOL 2018;40 (5):439-452 [PubMed]
  • Hansen IS, Krabbendam L, Bernink JH, Loayza-Puch F, Hoepel W, van Burgsteden JA, Kuijper EC, Buskens CJ, Bemelman WA, Zaat SAJ, Agami R, Vidarsson G, van den Brink GR, de Jong EC, Wildenberg ME, Baeten DLP , Everts B, den Dunnen J, + dendritic cells into pro-inflammatory cells through glycolytic reprogramming. NAT COMMUN 2018;9 (1):863 [PubMed]
  • Souwer Y, Groot Kormelink T, Taanman-Kueter EW, Muller FJ, van Capel TMM, Varga DV, Bar-Ephraim YE, Teunissen MBM, van Ham SM, Kuijpers TW, Wouters D, Meyaard L, de Jong EC, Human T(H)17 cell development requires processing of dendritic cell-derived CXCL8 by neutrophil elastase. J ALLERGY CLIN IMMUN 2018;141 (6):2286-2289 [PubMed]
  • Winkel BMF, Dalenberg MR, de Korne CM, Feijt C, Langenberg MCC, Pelgrom L, Ganesh MS, Yazdanbakhsh M, Smits HH, de Jong EC, Everts B, van Leeuwen FWB, Hokke CH, Roestenberg M, Early Induction of Human Regulatory Dermal Antigen Presenting Cells by Skin-Penetrating Schistosoma Mansoni Cercariae. FRONT IMMUNOL 2018;9:2510 [PubMed]


  • Breedveld A, Groot Kormelink T, van Egmond M, de Jong EC, Granulocytes as modulators of dendritic cell function. J LEUKOCYTE BIOL 2017;102 (4):1003-1016 [PubMed]


  • Dhawan S, de Palma G, Willemze RA, Hilbers FW, Verseijden C, Luyer MD, Nuding S, Wehkamp J, Souwer Y, de Jong EC, Seppen J, van den Wijngaard RM, Wehner S, Verdu E, Bercik P, de Jonge WJ, Acetylcholine-producing T cells in the intestine regulate antimicrobial peptide expression and microbial diversity. AM J PHYSIOL-GASTR L 2016;311 (5):G920-G933 [PubMed]
  • Mouser EEIM. Parasitic helminths and HIV-1 infection: the effect of immunomodulatory antigens. S.l.: s.n.; 2016. 152p. ISBN 978-94-6182-579-7 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Berkhout B, Paxton WA; copromotor(s): de Jong EC, Pollakis G)
  • Mouser EEIM, Pollakis G, Yazdanbakhsh M, Harnett W, de Jong EC, Paxton WA, Brugia malayi Antigen (BmA) Inhibits HIV-1 Trans-Infection but Neither BmA nor ES-62 Alter HIV-1 Infectivity of DC Induced CD4+ Th-Cells. PLOS ONE 2016;11 (1):e0146527 [PubMed]
  • Smits HH, Hiemstra PS, Prazeres da Costa C, Ege M, Edwards M, Garn H, Howarth PH, Jartti T, de Jong EC, Maizels RM, Marsland BJ, McSorley HJ, Müller A, Pfefferle PI, Savelkoul H, Schwarze J, Unger WWJ, von Mutius E, Yazdanbakhsh M, Taube C, Microbes and asthma: Opportunities for intervention. J ALLERGY CLIN IMMUN 2016;137 (3):690-697 [PubMed]


  • Bakdash G, Vogelpoel LTC, van Capel TMM, Kapsenberg ML, de Jong EC, Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells. MUCOSAL IMMUNOL 2015;8 (2):265-278 [PubMed]
  • Bernink JH, Krabbendam L, Germar K, de Jong E, Gronke K, Kofoed-Nielsen M, Munneke JM, Hazenberg MD, Villaudy J, Buskens CJ, Bemelman WA, Diefenbach A, Blom B, Spits H, Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria. IMMUNITY 2015;43 (1):146-160 [PubMed]
  • de Groot R. On human dendritic cell subsets harnessing cytotoxic T-cell responses. S.l.: s.n.; 2015. 128p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): de Jong EC, Kapsenberg ML; copromotor(s): )
  • de Jong EC, Samsom JN, 50(th) Anniversary Congress of the Dutch Society of Immunology. EUR J IMMUNOL 2015;45 (2):331-332 [PubMed]
  • van der Sluis RM, van Capel TMM, Speijer D, Sanders RW, Berkhout B, de Jong EC, Jeeninga RE, van Montfort T, Dendritic cell type-specific HIV-1 activation in effector T cells: implications for latent HIV-1 reservoir establishment. AIDS 2015;29 (9):1003-1014 [PubMed]
  • van Tongeren J, Röschmann KIL, Reinartz SM, Luiten S, Fokkens WJ, de Jong EC, van Drunen CM, Expression profiling and functional analysis of Toll-like receptors in primary healthy human nasal epithelial cells shows no correlation and a refractory LPS response. CLIN TRANSL ALLERGY 2015;5:42 [PubMed]
  • Vogelpoel LTC. FcγRIIa, a novel director of cytokine production in infection and autoimmunity. S.l.: s.n.; 2015. 176p. ISBN 978-94-6233-077-1 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): de Jong EC, Kapsenberg ML; copromotor(s): den Dunnen J)
  • Vogelpoel LTC, Baeten DLP , de Jong EC, den Dunnen J, Control of cytokine production by human Fc gamma receptors: implications for pathogen defense and autoimmunity. FRONT IMMUNOL 2015;6:79 [PubMed]
  • Vogelpoel LTC, Hansen IS, Visser MW, Nagelkerke SQ, Kuijpers TW, Kapsenberg ML, de Jong EC, den Dunnen J, FcγRIIa cross-talk with TLRs, IL-1R, and IFNγR selectively modulates cytokine production in human myeloid cells. IMMUNOBIOLOGY 2015;220 (2):193-199 [PubMed]


  • Bakdash G, van Capel TMM, Mason LMK, Kapsenberg ML, de Jong EC, Vitamin D3 metabolite calcidiol primes human dendritic cells to promote the development of immunomodulatory IL-10-producing T cells. VACCINE 2014;32 (47):6294-6302 [PubMed]
  • Germeraad WTV, de Jong EC, Trouw LA, Five decades of Dutch immunology. IMMUNOL LETT 2014;162 (2 B):83-84 [PubMed]
  • Vogelpoel LTC, Hansen IS, Rispens T, Muller FJM, van Capel TMM, Turina MC, Vos JB, Baeten DLP , Kapsenberg ML, de Jong EC, den Dunnen J, Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages. NAT COMMUN 2014;5:5444 [PubMed]


  • Bakdash G. Harnessing dendritic cells to promote immune tolerance. Opportunities for allergen-specific immunotherapy. s.l.: s.n.; 2013. 168p. ISBN 9789461822789 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kapsenberg ML; copromotor(s): de Jong EC)
  • Bakdash G, Schneider LP, van Capel TMM, Kapsenberg ML, Teunissen MBM, de Jong EC, Intradermal application of vitamin D3 increases migration of CD14+ dermal dendritic cells and promotes the development of Foxp3+ regulatory T cells. HUM VACC IMMUNOTHER 2013;9 (2):250-258 [PubMed]
  • Karrich JJ, Jachimowski LCM, Libouban M, Iyer A, Brandwijk K, Taanman-Kueter EW, Nagasawa M, de Jong EC, Uittenbogaart CH, Blom B, MicroRNA-146a regulates survival and maturation of human plasmacytoid dendritic cells. BLOOD 2013;122 (17):3001-3009 [PubMed]
  • van der Aar AMG, Picavet DI, Muller FJ, de Boer L, van Capel TMM, Zaat SAJ, Bos JD, Janssen H, George TC, Kapsenberg ML, van Ham SM, Teunissen MBM, de Jong EC, Langerhans cells favor skin flora tolerance through limited presentation of bacterial antigens and induction of regulatory T cells. J INVEST DERMATOL 2013;133 (5):1240-1249 [PubMed]
  • van Spriel AB, de Jong EC, Dendritic cell science: more than 40 years of history. J LEUKOCYTE BIOL 2013;93 (1):33-38 [PubMed]


  • de Groot R, van Beelen AJ, Bakdash G, Taanman-Kueter EWM, de Jong EC, Kapsenberg ML, Viral dsRNA-activated human dendritic cells produce IL-27, which selectively promotes cytotoxicity in naive CD8(+) T cells. J LEUKOCYTE BIOL 2012;92 (3):605-610 [PubMed]
  • den Dunnen J, Vogelpoel LTC, Wypych T, Muller FJM, de Boer L, Kuijpers TW, Zaat SAJ, Kapsenberg ML, de Jong EC, IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and Fc gamma RIIa in human dendritic cells. BLOOD 2012;120 (1):112-121 [PubMed]
  • Schneider LP, Schoonderwoerd AJ, Moutaftsi M, Howard RF, Reed SG, de Jong EC, Teunissen MBM, Intradermally administered TLR4 agonist GLA-SE enhances the capacity of human skin DCs to activate T cells and promotes emigration of Langerhans cells. VACCINE 2012;30 (28):4216-4224 [PubMed]
  • Souwer Y, de Wit J, Muller FJM, Bos HK, Jorritsma T, Kapsenberg ML, de Jong EC, van Ham SM, Response Priming of human naive CD4(+) T cells via CD5 costimulation requires IL-6 for optimal Th17 development. BLOOD 2012;119 (20):4812-4813
  • van Thuijl AOJ. Exploring immunological mechanisms in cow’s milk allergy. s.l.: s.n.; 2012. 154p. ISBN 9789461820884 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Aalderen WMC, Prakken BJ; copromotor(s): Sprikkelman AB, de Jong EC)


  • de Wit J, Souwer Y, van Beelen AJ, de Groot R, Muller FJM, Klaasse Bos H, Jorritsma T, Kapsenberg ML, de Jong EC, van Ham SM, CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation. BLOOD 2011;118 (23):6107-6114 [PubMed]
  • Gringhuis SI, Wevers BA, Kaptein TM, van Capel TMM, Theelen B, Boekhout T, de Jong EC, Geijtenbeek TBH, Selective C-Rel Activation via Malt1 Controls Anti-Fungal T-H-17 Immunity by Dectin-1 and Dectin-2. PLOS PATHOG 2011;7 (1):e1001259 [PubMed]
  • van der Aar AMG, de Groot R, Sanchez-Hernandez M, Taanman EWM, van Lier RAW, Teunissen MBM, de Jong EC, Kapsenberg ML, Cutting Edge: Virus Selectively Primes Human Langerhans Cells for CD70 Expression Promoting CD8(+) T Cell Responses. J IMMUNOL 2011;187 (7):3488-3492 [PubMed]
  • van der Aar AMG, Sibiryak DS, Bakdash G, van Capel TMM, van der Kleij HPM, Opstelten DJE, Teunissen MBM, Kapsenberg ML, de Jong EC, Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory T cells. J ALLERGY CLIN IMMUN 2011;127 (6):1532-U334 [PubMed]


  • de Jong E, Suddason T, Lord GM, Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells. CLIN EXP IMMUNOL 2010;159 (2):148-158 [PubMed]
  • Smole U, Balazs N, Hoffmann-Sommergruber K, Radauer C, Hafner C, Wallner M, Ferreira F, Grössinger R, de Jong EC, Wagner S, Breiteneder H, Differential T-cell responses and allergen uptake after exposure of dendritic cells to the birch pollen allergens Bet v 1.0101, Bet v 1.0401 and Bet v 1.1001. IMMUNOBIOLOGY 2010;215 (11):903-909 [PubMed]
  • Souwer Y, Szegedi K, Kapsenberg ML, de Jong EC, IL-17 and IL-22 in atopic allergic disease. CURR OPIN IMMUNOL 2010;22 (6):821-826 [PubMed]
  • van der Aar AMG. Functional specialization of human skin dendritic cell subsets in immunity to different slasses of pathogens. s.l.: s.n.; 2010. 160p. ISBN 9789490371104 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Bos JD, Kapsenberg ML; copromotor(s): Teunissen MBM, de Jong EC)


  • Huibregtse IL. Antigen-specific oral tolerance for the treatment of imflammatory and allergic diseases. s.l.: s.n.; 2009. 219p. ISBN 978909024163 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Bartelsman JFWM; copromotor(s): de Jong EC)
  • Moreno M, Mol BM, von Mensdorff-Pouilly S, Verheijen RHM, de Jong EC, von Blomberg BME, van den Eertwegh AJM, Scheper RJ, Bontkes HJ, Differential indirect activation of human invariant natural killer T cells by Toll-like receptor agonists. IMMUNOTHERAPY-UK 2009;1 (4):557-570 [PubMed]
  • Smits HH, Gloudemans AK, van Nimwegen M, Willart MA, Soullié T, Muskens F, de Jong EC, Boon L, Pilette C, Johansen FE, Hoogsteden HC, Hammad H, Lambrecht BN, Cholera toxin B suppresses allergic inflammation through induction of secretory IgA. MUCOSAL IMMUNOL 2009;2 (4):331-339 [PubMed]
  • van Beelen AJ. Control of T cell immunity by dendritic cell-derived IL-12 cytokine family members. s.l.: s.n.; 2009. 159p. ISBN 9789085704294 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kapsenberg ML; copromotor(s): de Jong EC)


  • Lebre MC, van Capel TMM, Bos JD, Knol EF, Kapsenberg ML, de Jong EC, Aberrant function of peripheral blood myeloid and plasmacytoid dendritic cells in atopic dermatitis patients. J ALLERGY CLIN IMMUN 2008;122 (5):969-976 [PubMed]
  • van Tongeren J, Reinartz SM, Fokkens WJ, de Jong EC, van Drunen CM, Interactions between epithelial cells and dendritic cells in airway immune responses: lessons from allergic airway disease. ALLERGY 2008;63 (9):1124-1135 [PubMed]
  • Zelinkova Z, van Beelen AJ, de Kort F, Moerland PD, van Themaat EVL, te Velde AA, van Deventer SJ, de Jong EC, Hommes DW, Muramyl dipeptide-induced differential gene expression in NOD2 mutant and wild-type Crohn's disease patient-derived dendritic cells. INFLAMM BOWEL DIS 2008;14 (2):186-194 [PubMed]


  • Gelderblom HC, Nijhuis LEJ, de Jong EC, te Velde AA, Pajkrt D, Reesink HW, Beld MGHM, van Deventer SJH, Jansen PLM, Monocyte-derived dendritic cells from chronic HCV patients are not infected but show an immature phenotype and aberrant cytokine profile. LIVER INT 2007;27 (7):944-953 [PubMed]
  • Huibregtse IL, Snoeck V, de Creus A, Braat H, de Jong EC, van Deventer SJH, Rottiers P, Induction of ovalbumin-specific tolerance by oral administration of Lactococcus lactis secreting ovalbumin. GASTROENTEROLOGY 2007;133 (2):517-528 [PubMed]
  • Lebre MC, van der Aar AMG, van Baarsen L, van Capel TMM, Schuitemaker JHN, Kapsenberg ML, de Jong EC, Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J INVEST DERMATOL 2007;127 (2):331-341 [PubMed]
  • Tas SW, Vervoordeldonk MJ, Hajji N, Schuitemaker JHN, van der Sluijs KF, May MJ, Ghosh S, Kapsenberg ML, Tak PP, de Jong EC, Noncanonical NF-kappa B signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation. BLOOD 2007;110 (5):1540-1549 [PubMed]
  • van Beelen AJ, Teunissen MBM, Kapsenberg ML, de Jong EC, Interleukin-17 in inflammatory skin disorders. CURR OPIN ALLERGY CL 2007;7 (5):374-381 [PubMed]
  • van Beelen AJ, Zelinkova Z, Taanman-Kueter EW, Muller FJ, Hommes DW, Zaat SAJ, Kapsenberg ML, de Jong EC, Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. IMMUNITY 2007;27 (4):660-669 [PubMed]
  • van der Aar AMG, Sylva-Steenland RMR, Bos JD, Kapsenberg ML, de Jong EC, Teunissen MBM, Cutting edge: Loss of TLR2, TLR4, and TLR5 on Langerhans cells abolishes bacterial recognition. J IMMUNOL 2007;178 (4):1986-1990 [PubMed]


  • Braat H. From bug to drug in Crohn's disease. Immunomodulation of dendritic cells. S.l.: s.n.; 2006. 160p. ISBN 90-9020379-6 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): van Deventer SJH, Peppelenbosch MP; copromotor(s): de Jong EC, Hommes DW)
  • Calder PC, Krauss-Etschmann S, de Jong EC, Dupont C, Frick JS, Frokiaer H, Heinrich J, Garn H, Koletzko S, Lack G, Mattelio G, Renz H, Sangild PT, Schrezenmeir J, Stulnig TM, Thymann T, Wold AE, Koletzko B, Early nutrition and immunity - progress and perspectives. BRIT J NUTR 2006;96 (4):774-790 [PubMed]
  • de Jong EC, Kapsenberg ML, Future perspectives of novel immunomodulating substances in immunotherapy. ARB PAUL EHRLICH INST BUNDESAMT SERA IMPFSTOFFE FRANKF A M 2006;ahead of print [PubMed]
  • de Jong EC, Kapsenberg ML. Future perspectives of novel immunomodulation substances in immunotherapy in: Löwer J, Vieths S, editors. Regulatory Control and Standardization of Allergenic Extracts: 11th International Paul-Ehrlich-Seminar September 29 - October 1, 2005, Hotel Steigenberger, Bad Homburg. Wiesbaden: Chmielorz; 2005., p. 207-210
  • de Jong EC, Smits HH, Wierenga EA, Kapsenberg ML. Microbial instruction of dendritic cells in: Lutz MB, Romani N, Steinkasserer Null, editors. Handbook of dendritic cells, biology, diseases, and therapies. Weinheim: Wiley-VCH Verlag; 2006., p. 405-426
  • Groot F. Dendritic cell-mediated HIV-1 transmission. S.l.: s.n.; 2006. 171p. ISBN 90-8559-192-9 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Berkhout B, Kapsenberg ML; copromotor(s): de Jong EC)
  • Groot F, Kuijpers TW, Berkhout B, de Jong EC, Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1. RETROVIROLOGY 2006;3:75 [PubMed]
  • Groot F, van Capel TMM, Kapsenberg ML, Berkhout B, de Jong EC, Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: transmission facilitation versus replication inhibition. BLOOD 2006;108 (6):1957-1964 [PubMed]
  • Groot F, van Capel TMM, Schuitemaker J, Berkhout B, de Jong EC, Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission. RETROVIROLOGY 2006;3:52 [PubMed]


  • Boor PPC, Ijzermans JNM, van der Molen RG, Binda R, Mancham S, Metselaar HJ, Kusters JG, de Jong E, Drexhage HA, Kwekkeboom J, Immunomagnetic selection of functional dendritic cells from human lymph nodes. IMMUNOL LETT 2005;99 (2):162-168 [PubMed]
  • de Graaff PMA, de Jong EC, van Capel TM, van Dijk MEA, Roholl PJM, Boes J, Luytjes W, Kimpen JLL, van Bleek GM, Respiratory syncytial virus infection of monocyte-derived dendritic cells decreases their capacity to activate CD4 T cells. J IMMUNOL 2005;175 (9):5904-5911 [PubMed]
  • de Jong EC, Smits HH, Kapsenberg ML, Dendritic cell-mediated T cell polarization. SPRINGER SEMIN IMMUN 2005;26 (3):289-307 [PubMed]
  • Groot F, Geijtenbeek TBH, Sanders RW, Baldwin CE, Sanchez-Hernandez M, Floris R, van Kooyk Y, de Jong EC, Berkhout B, Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN--gp120 interaction. J VIROL 2005;79 (5):3009-3015 [PubMed]
  • Grundmeijer HGLM , Hochheimer EH, de Jong E, den Heeten GJ. Knobbel in de borst in: de Jongh TOH, de Vries H, Grundmeijer HGLM, editors. Diagnostiek van alledaagse klachten. Bouwstenen voor rationeel probleemoplossen (2e dr.). Houten: Bohn Stafleu Van Loghum; 2005., p. 375-384
  • Kwekkeboom J, Boor PPC, Sen E, Kusters JG, Drexhage HA, de Jong EC, Tilanus HW, Ijzermans JNM, Metselaar HJ, Human liver myeloid dendritic cells maturate in vivo into effector DC with a poor allogeneic T-cell stimulatory capacity. TRANSPL P 2005;37 (1):15-16 [PubMed]
  • Lebre MC, Burwell T, Vieira PL, Lora J, Coyle AJ, Kapsenberg ML, Clausen BE, de Jong EC, Differential expression of inflammatory chemokines by Th1- and Th2-cell promoting dendritic cells: a role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of inflammation. IMMUNOL CELL BIOL 2005;83 (5):525-535 [PubMed]
  • Skowera A, de Jong EC, Schuitemaker JHN, Allen JS, Wessely SC, Griffiths G, Kapsenberg M, Peakman M, Analysis of anthrax and plague biowarfare vaccine interactions with human monocyte-derived dendritic cells. J IMMUNOL 2005;175 (11):7235-7243 [PubMed]
  • Smits HH, de Jong EC, Wierenga EA, Kapsenberg ML, Different faces of regulatory DCs in homeostasis and immunity. TRENDS IMMUNOL 2005;26 (3):123-129 [PubMed]
  • Smits HH, Engering A, van der Kleij D, de Jong EC, Schipper K, van Capel TMM, Zaat BAJ, Yazdanbakhsh M, Wierenga EA, van Kooyk Y, Kapsenberg ML, Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. J ALLERGY CLIN IMMUN 2005;115 (6):1260-1267 [PubMed]
  • Taams LS, van Amelsfort JMR, Tiemessen MM, Jacobs KMG, de Jong EC, Akbar AN, Bijlsma JWJ, Lafeber FPJG, Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells. HUM IMMUNOL 2005;66 (3):222-230 [PubMed]
  • Tas SW, de Jong EC, Hajji N, May MJ, Ghosh S, Vervoordeldonk MJ, Tak PP, Selective inhibition of NF-kappaB in dendritic cells by the NEMO-binding domain peptide blocks maturation and prevents T cell proliferation and polarization. EUR J IMMUNOL 2005;35 (4):1164-1174 [PubMed]


  • Braat H, de Jong EC, van den Brande JMH, Kapsenberg ML, Peppelenbosch MP, van Tol EAF, van Deventer SJH, Dichotomy between Lactobacillus rhamnosus and Klebsiella pneumoniae on dendritic cell phenotype and function. J MOL MED-JMM 2004;82 (3):197-205 [PubMed]
  • Hijnen D, de Bruin-Weller M, Oosting B, Lebre C, de Jong E, Bruijnzeel-Koomen C, Knol E, Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis. J ALLERGY CLIN IMMUN 2004;113 (2):334-340 [PubMed]
  • Smits HH, van Beelen AJ, Hessle C, Westland R, de Jong E, Soeteman E, Wold A, Wierenga EA, Kapsenberg ML, Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. EUR J IMMUNOL 2004;34 (5):1371-1380 [PubMed]
  • van der Molen RG, Sprengers D, Binda RS, de Jong EC, Niesters HGM, Kusters JG, Kwekkeboom J, Janssen HLA, Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B. HEPATOLOGY 2004;40 (3):738-746 [PubMed]


  • Dekker N, Vintges MMQ, de Jong E, den Heeten GJ, ten Kate FJW, van Tienhoven G, Verwijsindicatie en snelheid van diagnostiek op de mammapoli voor sneldiagnostiek in het AMC. NED TIJDSCHR HEELKD 2003;12 (6):185-189
  • Hamann J, Kwakkenbos MJ, de Jong EC, Heus H, Olsen AS, van Lier RAW, Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence. EUR J IMMUNOL 2003;33 (5):1365-1371 [PubMed]
  • Heystek HC, den Drijver B, Kapsenberg ML, van Lier RAW, de Jong EC, Type I IFNs differentially modulate IL-12p70 production by human dendritic cells depending on the maturation status of the cells and counteract IFN-gamma-mediated signaling. CLIN IMMUNOL 2003;107 (3):170-177 [PubMed]
  • Kalinski P, Lebre MC, Kramer D, de Jong EC, van Schijndel JWPM, Kapsenberg ML, Analysis of the CD4(+) T cell responses to house dust mite allergoid. ALLERGY 2003;58 (7):648-656 [PubMed]
  • Kapsenberg ML, Wierenga EA, Kalinski P, de Jong EC. Polarization of T-Helper Cells (chptr 10) in: Lambrecht BN, Hoogsteden HC, Diamant Z, editors. The immunological basis of asthma. New York: Marcel Dekker; 2003., p. 261-280
  • Lebre MC, Antons JC, Kalinski P, Schuitemaker JHN, van Capel TMM, Kapsenberg ML, de Jong EC, Double-stranded RNA-exposed human keratinocytes promote Th1 responses by inducing a type-1 polarized phenotype in dendritic cells: Role of keratinocyte-derived tumor necrosis factor alpha, type I interferons, and interleukin-18. J INVEST DERMATOL 2003;120 (6):990-997 [PubMed]
  • Lebre MCGM. Initiation and regulation of specific immune responses by keratinocytes and dendritic cells. Role of cytokines and chemokines linking innate and specific immunity. S.l.: s.n.; 2003. 168p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kapsenberg ML, Bos JD; copromotor(s): de Jong EC)


  • de Jong EC, Vieira PL, Kalinski P, Schuitemaker JHN, Tanaka Y, Wierenga EA, Yazdanbakhsh M, Kapsenberg ML, Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals. J IMMUNOL 2002;168 (4):1704-1709 [PubMed]
  • Heijstek HC. Modulation of human dendritic cell function by therapeutic agents. S.l.: s.n.; 2002. 127p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kapsenberg ML; copromotor(s): de Jong EC)
  • Hochheimer EH, Grundmeijer HGLM , de Jong E, den Heeten GJ. Knobbel in de borst in: de Jongh TOH, de Vries H, Grundmeijer HGLM, editors. Diagnostiek van alledaagse klachten I. Bouwstenen voor rationeel probleemoplossen. Houten / Diegem: Bohn Stafleu Van Loghum; 2002., p. 145-154
  • Hochheimer EH, Grundmeijer HGLM , de Jong E, den Heeten GJ, Knobbel in de borst. HUISARTS WET 2002;45 (04):194-198
  • Kwakkenbos MJ, Chang GW, Lin HH, Pouwels W, de Jong EC, van Lier RAW, Gordon S, Hamann J, The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells. J LEUKOCYTE BIOL 2002;71 (5):854-862 [PubMed]
  • Sanders RW, de Jong EC, Baldwin CE, Schuitemaker JHN, Kapsenberg ML, Berkhout B, Differential transmission of human immunodeficiency virus type 1 by distinct subsets of effector dendritic cells. J VIROL 2002;76 (15):7812-7821 [PubMed]
  • Schuitemaker JHN, de Jong EC. Detection of cytokines by flow cytometry in: Nunez R, editor. The role of cytometry and cell sorting in research and patient care. An e-book in cytometry. S.l.: Multimedia knowledge Inc.; 2002.
  • Smits HH, de Jong EC, Schuitemaker JHN, Geijtenbeek TBH, van Kooyk Y, Kapsenberg ML, Wierenga EA, Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development. J IMMUNOL 2002;168 (4):1710-1716 [PubMed]
  • van der Kleij D, Latz E, Brouwers JFHM, Kruize YCM, Schmitz M, Kurt-Jones EA, Espevik T, de Jong EC, Kapsenberg ML, Golenbock DT, Tielens AGM, Yazdanbakhsh M, A novel host-parasite lipid cross-talk - Schistosomal lyso-phosphatidylserine activates Toll-like receptor 2 and affects immune polarization. J BIOL CHEM 2002;277 (50):48122-48129 [PubMed]
  • van Halteren AGS, van Etten E, de Jong EC, Bouillon R, Roep BO, Mathieu C, Redirection of human autoreactive T-cells upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D-3. DIABETES 2002;51 (7):2119-2125 [PubMed]
  • van Montfrans C, Hooijberg E, Rodriguez Pena MS, de Jong EC, Spits H, te Velde AA, van Deventer SJH, Generation of regulatory gut-homing human T lymphocytes using ex vivo interleukin 10 gene transfer. GASTROENTEROLOGY 2002;123 (6):1877-1888 [PubMed]


  • Kaliński P, Vieira PL, Schuitemaker JH, de Jong EC, Kapsenberg ML, Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer. BLOOD 2001;97 (11):3466-3469 [PubMed]


  • Kaliński P, Smits HH, Schuitemaker JH, Vieira PL, van Eijk M, de Jong EC, Wierenga EA, Kapsenberg ML, IL-4 is a mediator of IL-12p70 induction by human Th2 cells: reversal of polarized Th2 phenotype by dendritic cells. J IMMUNOL 2000;165 (4):1877-1881 [PubMed]
  • Vieira PL, de Jong EC, Wierenga EA, Kapsenberg ML, Kaliński P, Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. J IMMUNOL 2000;164 (9):4507-4512 [PubMed]


  • de Jong EC, Vieira PL, Kalinski P, Kapsenberg ML, Corticosteroids inhibit the production of inflammatory mediators in immature monocyte-derived DC and induce the development of tolerogenic DC3. J LEUKOCYTE BIOL 1999;66 (2):201-204 [PubMed]
  • van der Veen MJ, van Neerven RJ, de Jong EC, Aalberse RC, Jansen HM, van der Zee JS, The late asthmatic response is associated with baseline allergen-specific proliferative responsiveness of peripheral T lymphocytes in vitro and serum interleukin-5. CLIN EXP ALLERGY 1999;29 (2):217-227 [PubMed]


  • de Jong E, Mulder W, Nooitgedacht E, Taat CW, Bras J, Carney's triad. EJSO-EUR J SURG ONC 1998;24 (2):147-149 [PubMed]
  • van Dullemen HM, de Jong E, Slors F, Tytgat GN, van Deventer SJ, Treatment of therapy-resistant perineal metastatic Crohn's disease after proctectomy using anti-tumor necrosis factor chimeric monoclonal antibody, cA2: report of two cases. DIS COLON RECTUM 1998;41 (1):98-102 [PubMed]
  • Vieira PL, Kaliński P, Wierenga EA, Kapsenberg ML, de Jong EC, Glucocorticoids inhibit bioactive IL-12p70 production by in vitro-generated human dendritic cells without affecting their T cell stimulatory potential. J IMMUNOL 1998;161 (10):5245-5251 [PubMed]


  • de Jong E, van Dullemen HM, Slors JF, Dekkers P, van Deventer SJ, Tytgat GN, Correlation between early recurrence and reoperation after ileocolonic resection in Crohn's disease: a prospective study. J AM COLL SURGEONS 1996;182 (6):503-508 [PubMed]


  • de Jong E, Knot EA, Piket D, Iburg AH, Rijken DC, Veenhof KH, Dooijewaard G, ten Cate JW, Increased plasminogen activator inhibition levels in malignancy. THROMB HAEMOSTASIS 1987;57 (2):140-143 [PubMed]
  • Knot EA, de Jong E, ten Cate JW, Gie LK, van Royen EA, Antithrombin III: biodistribution in healthy volunteers. THROMB HAEMOSTASIS 1987;58 (4):1008-1011 [PubMed]


  • Knot EA, de Jong E, ten Cate JW, Iburg AH, Henny CP, Bruin T, Stibbe J, Purified radiolabeled antithrombin III metabolism in three families with hereditary AT III deficiency: application of a three-compartment model. BLOOD 1986;67 (1):93-98 [PubMed]


  • Knot EA, Drijfhout HR, ten Cate JW, de Jong E, Iburg AH, Kahlé LH, Grijm R, alpha 2-Plasmin inhibitor metabolism in patients with liver cirrhosis. J LAB CLIN MED 1985;105 (3):353-358 [PubMed]