Prof. dr. S.T. Pals MD PhD publications

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Publications Prof. dr. S.T. Pals MD PhD

Position
Professor
Main activities
Patient care, Research, Teaching
Specialisation
Pathology
Focus of research

“We are exploring the interactions between malignant B cells and their microenvironment since these represent the Achilles’ heel of these cancers”

 

Professor dr S.T. Pals (Steven) MD, PhD

 

KEY KNOWLEDGE AREAS:
Malignant lymphoma, Multiple Myeloma (Kahler's disease), Lymphocyte homing, Adhesion molecules, Intracellular signalling.

 

RESEARCH FOCUS:
The research themes of the Immuno- and Hematopathology laboratory are “B-cell development and neoplasia” and “Cell adhesion and migration in inflammation and cancer”. Our mission is: i) to advance the insight into the fundamental biological processes underlying B cell development and cell migration; ii) to acquire knowledge required to improve the diagnosis and treatment of B cell malignancies and to control inflammation and cancer metastasis.

 

CLINICAL AND INDUSTRY RELEVANCE:
Malignant Lymphoma and Multiple Myeloma are common cancers with a high patient morbidity and mortality. Genetic defects in concert with cues from the tumor microenvironment activate signalling pathways that drive tumor growth, survival, and dissemination. Targeting these pathways by small-molecule drugs and antibodies has recently been shown to be highly effective in Lymphoma and Myeloma treatment. In our laboratory, new targets are being explored by in vitro studies as well as in by employing mouse models.

 

RESEARCHER'S BRIEF:
“In the past, workers in a Pathology department like ours would visually inspect patient tissue for signs of disease. Now we are actually delving into the molecular details of pathologies, lymphoma and multiple myeloma in our case. Some very complex and highly interesting details are coming to light. We know now that both normal and malignant B cells require 'homing receptors' to direct them to specific tissues or organs, where they recognize ‘address molecules’. Once arrived, the B cells are highly dependent on the microenvironment for their growth and survival; we are exploring which environmental cues are crucial.  We thusfar discovered that WNTs and hepatocyte growth factor (HGF) support Multiple Myeloma growth, and also promote the bone damage typically seen in this disease. Moreover, recent studies from our laboratory have shown that interfering with the homing and retention of malignant B cells is a highly effective treatment for patients with several types of non-Hodgkin's lymphoma, including chronic  lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and Waldestrom Macroglobilinemia. Specifically, we demonstrated that the impressive therapeutic effect of the  "break through" Bruton's tyrosine kinase (BTK) inhibitor ibrutinib and the PI3Kd inhibitor idelalisib is largely based on induction of cell death by anoikis (homelessness). 

 

RESEARCHER'S QUALIFICATIONS, EXPERIENCE:
Professor of Immuno- and Hematopathology. MD, PhD, Head Molecular Immuno- and Hematopathology laboratory. STP is member of the Scientific Board of the Dutch Cancer Society, and the Scientific Advisory Board for the Fight against Cancer of the Royal Dutch Academy of Science.

 

2018

  • Mulder CL, Catsburg LAE, Zheng Y, de Winter-Korver CM, van Daalen SKM, van Wely M, Pals S, Repping S, van Pelt AMM, Long-term health in recipients of transplanted in vitro propagated spermatogonial stem cells. HUM REPROD 2018;33 (1):81-90 [PubMed]
  • Nijland ML, Koens L , Pals ST, ten Berge IJM, Bemelman FJ, Kersten MJ, Clinicopathological characteristics of T-cell non-Hodgkin lymphoma arising in patients with immunodeficiencies: a single-center case series of 25 patients and a review of the literature. HAEMATOLOGICA 2018;103 (3):486-496 [PubMed]
  • Ren Z, van Andel H, de Lau W, Hartholt RB, Maurice MM, Clevers H, Kersten MJ, Spaargaren M, Pals ST, Syndecan-1 promotes Wnt/beta-catenin signaling in multiple myeloma by presenting Wnts and R-spondins. BLOOD 2018;131 (9):982-994 [PubMed]
  • Schrader AMR, Jansen PM, Willemze R, Vermeer MH, Cleton-Jansen AM, Somers SF, Veelken H, van Eijk R, Kraan W, Kersten MJ, van den Brand M, Stevens WBC, de Jong D, Abdul Hamid M, Tanis BC, Posthuma EFM, Nijland M, Diepstra A, Pals ST, Cleven AHG, Vermaat JSP, High prevalence of MYD88 and CD79B mutations in intravascular large B-cell lymphoma. BLOOD 2018;131 (18):2086-2089 [PubMed]
  • Vlijm-Kievit A, Jorna NGE, Moll E, Pajkrt E, Pals ST, Middeldorp S, Biemond BJ, Zeerleder SS, Tio MA, Kemper EM, Hazenberg MD, Acute lymphoblastic leukemia during the third trimester of pregnancy. LEUKEMIA LYMPHOMA 2018;59 (5):1274-1276 [PubMed]
  • Vos JM, Notermans NC, D'Sa S, Lunn MP, van der Pol WL, Kraan W, Reilly MM, Chalker J, Gupta R, Kersten MJ, Pals ST, Minnema MC, High prevalence of the MYD88 L265P mutation in IgM anti-MAG paraprotein-associated peripheral neuropathy. J NEUROL NEUROSUR PS 2018;89 (9):1007-+ [PubMed]

2017

  • de Rooij MFM. Targeting the BCR signalosome in B cell malignancies. S.l.: s.n.; 2017. 209p. ISBN 978-94-6299-746-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Pals ST; copromotor(s): Spaargaren M)
  • Joosten SPJ, Zeilstra J, van Andel H, Mijnals RC, Zaunbrecher J, Duivenvoorden AAM, van de Wetering M, Clevers H, Spaargaren M, Pals ST, MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms. GASTROENTEROLOGY 2017;153 (4):1040-+ [PubMed]
  • Kuijpers TW, Tool ATJ, van der Bijl I, de Boer M, van Houdt M, de Cuyper IM, Roos D, van Alphen F, van Leeuwen K, Cambridge EL, Arends MJ, Dougan G, Clare S, Ramirez-Solis R, Pals ST, Adams DJ, Meijer AB, van den Berg TK, Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency. J ALLERGY CLIN IMMUN 2017;140 (1):273-+ [PubMed]
  • Oud MM, Tuijnenburg P, Hempel M, van Vlies N, Ren Z, Ferdinandusse S, Jansen MH, Santer R, Johannsen J, Bacchelli C, Alders M, Li R, Davies R, Dupuis L, Cale CM, Wanders RJA, Pals ST, Ocaka L, James C, Müller I, Lehmberg K, Strom T, Engels H, Williams HJ, Beales P, Roepman R, Dias P, Brunner HG, Cobben JM, Hall C, Hartley T, Le Quesne Stabej P, Mendoza-Londono R, Davies EG, de Sousa SB, Lessel D, Arts HH, Kuijpers TW, Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome. AM J HUM GENET 2017;100 (2):281-296 [PubMed]
  • van Andel H, Kocemba KA, de Haan-Kramer A, Mellink CH, Piwowar M, Broijl A, van Duin M, Sonneveld P, Maurice MM, Kersten MJ , Spaargaren M, Pals ST, Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease. ONCOGENE 2017;36 (15):2105-2115 [PubMed]
  • van Andel H, Ren Z, Koopmans I, Joosten SPJ, Kocemba KA, de Lau W, Kersten MJ, de Bruin AM, Guikema JEJ, Clevers H, Spaargaren M, Pals ST, Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins. P NATL ACAD SCI USA 2017;114 (2):376-381 [PubMed]
  • van Keimpema M, Grüneberg LJ, Schilder-Tol EJM, Oud MECM, Beuling EA, Hensbergen PJ, de Jong J, Pals ST, Spaargaren M, The small FOXP1 isoform predominantly expressed in activated B cell-like diffuse large B-cell lymphoma and full-length FOXP1 exert similar oncogenic and transcriptional activity in human B cells. HAEMATOLOGICA 2017;102 (3):573-583 [PubMed]
  • Vos JM, Tsakmaklis N, Patterson CJ, Meid K, Castillo JJ, Brodsky P, Ganz T, Pals ST, Kersten MJ, Xu L, Yang G, Treon SP, Hunter ZR, CXCL13 levels are elevated in patients with Waldenström macroglobulinemia, and are predictive of major response to ibrutinib. HAEMATOLOGICA 2017;102 (11):e452-e455 [PubMed]

2016

  • de Rooij MFM, Kuil A, Kraan W, Kersten MJ, Treon SP, Pals ST, Spaargaren M, Ibrutinib and idelalisib target B cell receptor- but not CXCL12/CXCR4-controlled integrin-mediated adhesion in Waldenström macroglobulinemia. HAEMATOLOGICA 2016;101 (3):e111-e115 [PubMed]
  • Gillissen MA, de Jong G, Levie SE, Yasuda E, Bakker AQ, Evers LM, Pals ST, Huisman C, van Helden PM, Spits H, Hazenberg MD, AML relapse after rituximab treatment for GvHD: crucial role for B cells in GvL responses. BONE MARROW TRANSPL 2016;51 (9):1245-1248 [PubMed]
  • Nijland ML, Kersten MJ, Pals ST, Bemelman FJ, ten Berge IJM, Epstein-Barr Virus-Positive Posttransplant Lymphoproliferative Disease After Solid Organ Transplantation: Pathogenesis, Clinical Manifestations, Diagnosis, and Management. TRANSPLANT DIRECT 2016;2 (1):e48 [PubMed]
  • Pals ST, Kersten MJ, Spaargaren M, Targeting cell adhesion and homing as strategy to cure Waldenström's macroglobulinemia. BEST PRACT RES CL HA 2016;29 (2):161-168 [PubMed]
  • Vos JMI, Kersten MJ, Kraan W, Groeneveld ON, Linn C, Pals ST, Minnema MC, Effective treatment of Bing-Neel Syndrome with oral fludarabine: a case series of four consecutive patients. BRIT J HAEMATOL 2016;172 (3):461-464 [PubMed]

2015

  • de Rooij MFM, Kuil A, Kater AP, Kersten MJ, Pals ST, Spaargaren M, Ibrutinib and idelalisib synergistically target BCR-controlled adhesion in MCL and CLL: a rationale for combination therapy. BLOOD 2015;125 (14):2306-2309 [PubMed]
  • Montgomery M, van Santen MM, Biemond BJ, Diamond RH, Pals ST, Hepatosplenic T-Cell Lymphoma: A Population-Based Study Assessing Incidence and Association With Immune-Mediated Disease. GASTROENTEROL HEPATOL (N Y) 2015;11 (3):160-163 [PubMed]
  • Nieuwenhuis MBB, van der Salm SMA, Verhoeff JJC, van der Kooi AJ, Slavujecvic-Letic I, Pals ST, Vos JMI, A 43-Year-Old Female with Multifocal Cerebral Lesions. Histiocytic Sarcoma. BRAIN PATHOL 2015;25 (3):371-372 [PubMed]
  • van Keimpema M. The FOX and the mutants in mature human B cells and DLBCL: The role of FOXP1 in mature human B cell biology and lymphomagenesis & prevalence of oncogenic MyD88 and CD79B mutations in diffuse large B cell lymphoma. S.l.: s.n.; 2015. 213p. ISBN 978-94-6299-186-6 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Pals ST; copromotor(s): Spaargaren M)
  • van Keimpema M, Grüneberg LJ, Mokry M, van Boxtel R, van Zelm MC, Coffer P, Pals ST, Spaargaren M, The forkhead transcription factor FOXP1 represses human plasma cell differentiation. BLOOD 2015;126 (18):2098-2109 [PubMed]
  • Vermaat JS, Pals ST, Younes A, Dreyling M, Federico M, Aurer I, Radford J, Kersten MJ, Precision medicine in diffuse large B-cell lymphoma: hitting the target. HAEMATOLOGICA 2015;100 (8):989-993 [PubMed]

2014

  • Kersten MJ , Kraan W, Doorduijn J, Bromberg J, Lam K, Kluin PM, van der Holt BJ, Spaargaren M, Pals ST, Diffuse large B cell lymphomas relapsing in the CNS lack oncogenic MYD88 and CD79B mutations. BLOOD CANCER J 2014;4:e266 [PubMed]
  • Kocemba KA. The bone marrow niche in the pathogenesis of multiple myeloma: A role for Wnt signaling and adrenomedullin. s.l.: s.n.; 2014. 223p. ISBN 9788363861162 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Pals ST; copromotor(s): Spaargaren M)
  • Kraan W, van Keimpema M, Horlings HM, Schilder-Tol EJM, Oud MECM, Noorduyn LA, Kluin PM, Kersten MJ , Spaargaren M, Pals ST, High prevalence of oncogenic MYD88 and CD79B mutations in primary testicular diffuse large B-cell lymphoma. LEUKEMIA 2014;28 (3):719-720 [PubMed]
  • Rampanelli E, Rouschop KMA, Claessen N, Teske GJD, Pals ST, Leemans JC, Florquin S, Opposite role of CD44-standard and CD44-variant-3 in tubular injury and development of renal fibrosis during chronic obstructive nephropathy. KIDNEY INT 2014;86 (3):558-569 [PubMed]
  • van Keimpema M, Grüneberg LJ, Mokry M, van Boxtel R, Koster J, Coffer PJ, Pals ST, Spaargaren M, FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells. BLOOD 2014;124 (23):3431-3440 [PubMed]
  • Zeilstra J, Joosten SPJ, van Andel H, Tolg C, Berns A, Snoek M, van de Wetering M, Spaargaren M, Clevers H, Pals ST, Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling. ONCOGENE 2014;33 (5):665-670 [PubMed]

2013

  • Aan de Kerk DJ, van Leeuwen EMM, Jansen MH, van den Berg JM, Alders M, Vermont CL, van Lier RAW, Pals ST, Kuijpers TW, Aberrant humoral immune reactivity in DOCK8 deficiency with follicular hyperplasia and nodal plasmacytosis. CLIN IMMUNOL 2013;149 (1):25-31 [PubMed]
  • Bot PT, Grundmann S, van Royen N, Joosten SPJ, Schirmer SH, de kleijn DPV, Pals ST, Pasterkamp G, Piek JJ, Hoefer IE, Distinct CD44 splice variants differentially affect collateral artery growth. CURR VASC PHARMACOL 2013;11 (1):13-20 [PubMed]
  • Chang BY, Francesco M, de Rooij MFM, Magadala P, Steggerda SM, Huang MM, Kuil A, Herman SEM, Chang S, Pals ST, Wilson W, Wiestner A, Spaargaren M, Buggy JJ, Elias L, Egress of CD19(+)CD5(+) cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients. BLOOD 2013;122 (14):2412-2424 [PubMed]
  • Hovius JWR, de Wever B, Sohne M, Brouwer MC, Coumou J, Wagemakers A, Oei A, Knol H, Narasimhan S, Hodiamont CJ, Jahfari S, Pals ST, Horlings HM, Fikrig E, Sprong H, van Oers MHJ, A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. LANCET 2013;382 (9892):658 [PubMed]
  • Kocemba KA, van Andel H, de Haan-Kramer A, Mahtouk K, Versteeg R, Kersten MJ , Spaargaren M, Pals ST, The hypoxia target adrenomedullin is aberrantly expressed in multiple myeloma and promotes angiogenesis. LEUKEMIA 2013;27 (8):1729-1737 [PubMed]
  • Kraan W, Horlings HM, van Keimpema M, Schilder-Tol EJM, Oud MECM, Scheepstra C, Kluin PM, Kersten MJ , Spaargaren M, Pals ST, High prevalence of oncogenic MYD88 and CD79B mutations in diffuse large B-cell lymphomas presenting at immune-privileged sites. BLOOD CANCER J 2013;3:e139 [PubMed]
  • Lascano V, Guadagnoli M, Schot JG, Luijks DM, Guikema JEJ, Cameron K, Hahne M, Pals S, Slinger E, Kipps TJ, van Oers MHJ, Eldering E, Medema JP, Kater AP, Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model. BLOOD 2013;122 (24):3960-3963 [PubMed]
  • Pascutti MF, Jak M, Tromp JM, Derks IAM, Remmerswaal EBM, Thijssen R, van Attekum MHA, van Bochove GG, Luijks DM, Pals ST, van Lier RAW, Kater AP, van Oers MHJ, Eldering E, IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells. BLOOD 2013;122 (17):3010-3019 [PubMed]
  • Rampanelli E, Dessing MC, Claessen N, Teske GJD, Joosten SPJ, Pals ST, Leemans JC, Florquin S, CD44-deficiency attenuates the immunologic responses to LPS and delays the onset of endotoxic shock-induced renal inflammation and dysfunction. PLOS ONE 2013;8 (12):e84479 [PubMed]
  • Reijmers RM, Spaargaren M, Pals ST, Heparan sulfate proteoglycans in the control of B cell development and the pathogenesis of multiple myeloma. FEBS J 2013;280 (10):2180-2193 [PubMed]
  • Vos JMI, Minnema MC, Wijermans PW, Croockewit S, Chamuleau MED, Pals ST, Klein SK, Delforge M, van Imhoff GW, Kersten MJ, Guideline for diagnosis and treatment of Waldenström's macroglobulinaemia. NETH J MED 2013;71 (2):54-62 [PubMed]
  • Zeilstra J, Joosten SPJ, Vermeulen L, Koster J, Medema JP, Versteeg R, Spaargaren M, Pals ST, CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status. PLOS ONE 2013;8 (8):e72849 [PubMed]

2012

  • Bunders MJ, van der Loos CM, Klarenbeek PL, van Hamme JL, Boer K, Wilde JCH, de Vries N, van Lier RAW, Kootstra N, Pals ST, Kuijpers TW, Memory CD4(+)CCR5(+) T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1. BLOOD 2012;120 (22):4383-4390 [PubMed]
  • de Rooij MFM, Kuil A, Geest CR, Eldering E, Chang BY, Buggy JJ, Pals ST, Spaargaren M, The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia. BLOOD 2012;119 (11):2590-2594 [PubMed]
  • Kocemba KA, Groen RWJ, van Andel H, Kersten MJ, Mahtouk K, Spaargaren M, Pals ST, Transcriptional Silencing of the Wnt-Antagonist DKK1 by Promoter Methylation Is Associated with Enhanced Wnt Signaling in Advanced Multiple Myeloma. PLOS ONE 2012;7 (2):e30359 [PubMed]
  • van Maldegem F, Wormhoudt TAM, Mulder MMS, Oud MECM, Schilder-Tol E, Musler AR, Aten J, Saeed P, Kersten MJ , Pals ST, van Noesel CJM, Bende RJ, Chlamydia psittaci-negative ocular adnexal marginal zone B-cell lymphomas have biased V(H)4-34 immunoglobulin gene expression and proliferate in a distinct inflammatory environment. LEUKEMIA 2012;26 (7):1647-1653 [PubMed]
  • Vos JM, Minnema MC, Wijermans PW, Croockewit S, Chamuleau ME, Pals ST, Klein SK, Delforge M, van Imhoff GW, Kersten MJ, Richtlijn voor diagnostiek en behandeling van de ziekte van Waldenström. NED TIJDSCHR HEMATOL 2012;9:219

2011

  • de Sousa E Melo F, Colak S, Buikhuisen J, Koster J, Cameron K, de Jong JH, Tuynman JB, Prasetyanti PR, Fessler E, van den Bergh SP, Rodermond H, Dekker E, van der Loos CM, Pals ST, van de Vijver MJ, Versteeg R, Richel DJ, Vermeulen L, Medema JP, Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. CELL STEM CELL 2011;9 (5):476-485 [PubMed]
  • Groen RWJ, de Rooij MFM, Kocemba KA, Reijmers RM, de Haan-Kramer A, Overdijk MB, Aalders L, Rozemuller H, Martens ACM, Bergsagel PL, Kersten MJ, Pals ST, Spaargaren M, N-cadherin-mediated interaction with multiple myeloma cells inhibits osteoblast differentiation. HAEMATOLOGICA 2011;96 (11):1653-1661 [PubMed]
  • Hazenberg MD, Biemond BJ, Pals ST, Zumpolle CM, Schinkel CJ, Linthorst GE, Hoekstra JBL, Vos JMI, Clinical pathological conference: a non-Hodgkin's lymphoma patient with persistent anaemia after chemotherapy. NETH J MED 2011;69 (10):469-473 [PubMed]
  • Kuijpers TW, Baars PA, Aan de Kerk DJ, Jansen MH, Dors N , van Lier RAW, Pals ST, Common variable immunodeficiency and hemophagocytic features associated with a FAS gene mutation. J ALLERGY CLIN IMMUN 2011;127 (6):1411-1414 [PubMed]
  • Reijmers RM, Groen RWJ, Kuil A, Weijer K, Kimberley FC, Medema JP, van Kuppevelt TH, Li JP, Spaargaren M, Pals ST, Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival. BLOOD 2011;117 (23):6162-6171 [PubMed]
  • Tonino SH, Rijssenbeek AL, Oud ME, Pals ST, van Oers MH, Kater AP, Intracerebral Infiltration As the Unique Cause of the Clinical Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia. J CLIN ONCOL 2011;29 (34):E837-E839 [PubMed]
  • Vos JMI, Bordbar A, Vet R, Pals ST, Kater AP, Waxing and waning intravascular large cell lymphoma with widespread organ infiltration. LEUKEMIA LYMPHOMA 2011;52 (4):705-708 [PubMed]
  • Zeilstra J, Joosten SPJ, Wensveen FM, Dessing MC, Schütze DM, Eldering E, Spaargaren M, Pals ST, WNT signaling controls expression of pro-apoptotic BOK and BAX in intestinal cancer. BIOCHEM BIOPH RES CO 2011;406 (1):1-6 [PubMed]

2010

  • Bot PT, Pasterkamp G, Goumans MJ, Strijder C, Moll FL, de Vries JP, Pals ST, de Kleijn DP, Piek JJ, Hoefer IE, Hyaluronic acid metabolism is increased in unstable plaques. EUR J CLIN INVEST 2010;40 (9):818-827 [PubMed]
  • Groen RWJ. Microenvironmental regulation of multiple myeloma and malignant lymphoma. The role of HGF, Wnts, heparan sulfate proteoglycans, and N-cadherin. s.l.: s.n.; 2010. 199p. ISBN 9789090257686 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Pals ST; copromotor(s): Spaargaren M)
  • Kemper K, Sprick MR, de Bree M, Scopelliti A, Vermeulen L, Hoek M, Zeilstra J, Pals ST, Mehmet H, Stassi G, Medema JP, The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation. CANCER RES 2010;70 (2):719-729 [PubMed]
  • Mahtouk K , Moreaux J, Hose D, Reme T, Meissner T, Jourdan M, Rossi JF, Pals ST, Goldschmidt H, Klein B, Growth factors in multiple myeloma: a comprehensive analysis of their expression in tumor cells and bone marrow environment using Affymetrix microarrays. BMC CANCER 2010;10 (1):198 [PubMed]
  • Mahtouk K, Tjin EPM, Spaargaren M, Pals ST, The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas. BBA-REV CANCER 2010;1806 (2):208-219 [PubMed]
  • Reijmers RM. Heparan sulfate proteoglycans in B cell maturation and myeloma plasma cell survival. s.l.: s.n.; 2010. 165p. ISBN 9789090256450 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Pals ST; copromotor(s): Spaargaren M)
  • Reijmers RM, Groen RWJ, Rozemuller H, Kuil A, de Haan-Kramer A, Csikós T, Martens ACM, Spaargaren M, Pals ST, Targeting EXT1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma. BLOOD 2010;115 (3):601-604 [PubMed]
  • Reijmers RM, Vondenhoff MFR, Roozendaal R, Kuil A, Li JP, Spaargaren M, Pals ST, Mebius RE, Impaired Lymphoid Organ Development in Mice Lacking the Heparan Sulfate Modifying Enzyme Glucuronyl C5-Epimerase. J IMMUNOL 2010;184 (7):3656-3664 [PubMed]
  • Robertus JL, Kluiver J, Weggemans C, Harms G, Reijmers RM, Swart Y, Kok K, Rosati S, Schuuring E, van Imhoff G, Pals ST, Kluin P, van den Berg A, MiRNA profiling in B non-Hodgkin lymphoma: a MYC-related miRNA profile characterizes Burkitt lymphoma. BRIT J HAEMATOL 2010;149 (6):896-899 [PubMed]
  • van Rijssel RH, Wegman J, Oud ME, Pals ST, van Oers MHJ, A case of ATRA-induced isolated myocarditis in the absence of circulating malignant cells: Demonstration of the t(15;17) translocation in the inflammatory infiltrate by in situ hybridisation. LEUKEMIA RES 2010;34 (7):E142-E144 [PubMed]

2009

  • Iyer AM. Immunology of leprosy. Towards the search for diagnostic and prognostic biomarkers elucidating pathobiology and their utility in patient care. s.l.: s.n.; 2009. 167p. ISBN 9789064643255 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Pals ST, Das PK; copromotor(s): Faber WR)
  • Tan LP, Wang M, Robertus JL, Schakel RN, Gibcus JH, Diepstra A, Harms G, Peh SC, Reijmers RM, Pals ST, Kroesen BJ, Kluin PM, Poppema S, van den Berg A, miRNA profiling of B-cell subsets: specific miRNA profile for germinal center B cells with variation between centroblasts and centrocytes. LAB INVEST 2009;89 (6):708-716 [PubMed]

2008

  • Csikós T, Reijmers RM, Uren AG, Spaargaren M, Pals ST, Instant conditional transgenesis in the mouse hematopoietic compartment. J IMMUNOL METHODS 2008;339 (2):259-263 [PubMed]
  • de Fost M, Out TA, de Wilde FA, Tjin EPM, Pals ST, van Oers MHJ, Boot RG, Aerts JFMG, Maas M, vom Dahl S, Hollak CEM, Immunoglobulin and free light chain abnormalities in Gaucher disease type I: data from an adult cohort of 63 patients and review of the literature. ANN HEMATOL 2008;87 (6):439-449 [PubMed]
  • de Gorter DJJ. Signaling pathways involved in B cell differentiation and disease. The role of Ral, Btk and Met. s.l.: s.n.; 2008. 160p. ISBN 9789090228907 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Pals ST; copromotor(s): Spaargaren M)
  • de Gorter DJJ, Reijmers RM, Beuling EA, Naber HPH, Kuil A, Kersten MJ, Pals ST, Spaargaren M, The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells. BLOOD 2008;111 (7):3364-3372 [PubMed]
  • Groen RWJ, Oud MECM, Schilder-Tol EJM, Overdijk MB, ten Berge D, Nusse R, Spaargaren M, Pals ST, Illegitimate WNT pathway activation by beta-catenin mutation or autocrine stimulation in T-cell malignancies. CANCER RES 2008;68 (17):6969-6977 [PubMed]
  • Zeilstra J, Joosten SPJ, Dokter M, Verwiel E, Spaargaren M, Pals ST, Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. CANCER RES 2008;68 (10):3655-3661 [PubMed]

2007

  • de Gorter DJJ, Beuling EA, Kersseboom R, Middendorp S, van Gils JM, Hendriks RW, Pals ST, Spaargaren M, Bruton's tyrosine kinase and phospholipase C gamma 2 mediate chemokine-controlled B cell migration and homing. IMMUNITY 2007;26 (1):93-104 [PubMed]
  • de Gorter DJJ, Vos JCM, Pals ST, Spaargaren M, The B cell antigen receptor controls AP-1 and NFAT activity through Ras-mediated activation of Ral. J IMMUNOL 2007;178 (3):1405-1414 [PubMed]
  • Evans PAS, Pott C, Groenen PJTA, Salles G, Davi F, Berger F, Garcia JF, van Krieken JHJM, Pals S, Kluin P, Schuuring E, Spaargaren M, Boone E, González D, Martinez B, Villuendas R, Gameiro P, Diss TC, Mills K, Morgan GJ, Carter GI, Milner BJ, Pearson D, Hummel M, Jung W, Ott M, Canioni D, Beldjord K, Bastard C, Delfau-Larue MH, van Dongen JJM, Molina TJ, Cabeçadas J, Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936. LEUKEMIA 2007;21 (2):207-214 [PubMed]
  • Pals ST, de Gorter DJJ, Spaargaren M, Lymphoma dissemination: the other face of lymphocyte homing. BLOOD 2007;110 (9):3102-3111 [PubMed]

2006

  • Boon EMJ. The HGF/MET pathway in colorectal cancer. S.l.: s.n.; 2006. 120p. ISBN 9789073838666 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Pals ST; copromotor(s): van der Neut R)
  • Boon EMJ, Pouwels W, Redeker S, Joosten SPJ, Hamann J, van der Neut R, Pals ST, Activation of Wnt signaling in the intestinal mucosa of Apc +/min mice does not cause overexpression of the receptor tyrosine kinase Met. CANCER SCI 2006;97 (8):710-715 [PubMed]
  • Faridpooya K, Mulder MMS, Merks JHM, de Smet MD, Pals ST, Saeed P, Precursor B lymphoblastic lymphoma of the orbit in a child: an unusual presentation of a non-Hodgkin lymphoma. ORBIT 2006;25 (2):153-157 [PubMed]
  • Hoefnagel JJ, Mulder MMS, Dreef E, Jansen PM, Pals ST, Meijer CJLM, Willemze R, Vermeer MH, Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma. MODERN PATHOL 2006;19 (9):1270-1276 [PubMed]
  • Mulder MMS, Heddema ER, Pannekoek Y, Faridpooya K, Oud MECM, Schilder-Tol E, Saeed P, Pals ST, No evidence for an association of ocular adnexal lymphoma with Chlamydia psittaci in a cohort of patients from the Netherlands. LEUKEMIA RES 2006;30 (10):1305-1307 [PubMed]
  • Rouschop KMA. CD44 in renal disease: friend or foe?. S.l.: s.n.; 2006. 171p. ISBN 9789052910956 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Weening JJ, Pals ST; copromotor(s): Florquin S)
  • Rouschop KMA, Claessen N, Pals ST, Weening JJ, Florquin S, CD44 disruption prevents degeneration of the capillary network in obstructive nephropathy via reduction of TGF-beta1-induced apoptosis. J AM SOC NEPHROL 2006;17 (3):746-753 [PubMed]
  • Rouschop KMA, Sylva M, Teske GJD, Hoedemaeker I, Pals ST, Weening JJ, van der Poll T, Florquin S, Urothelial CD44 facilitates Escherichia coli infection of the murine urinary tract. J IMMUNOL 2006;177 (10):7225-7232 [PubMed]
  • Tjin EPM, Groen RWJ, Vogelzang I, Derksen PWB, Klok MD, Meijer HP, van Eeden S, Pals ST, Spaargaren M, Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma. BLOOD 2006;107 (2):760-768 [PubMed]

2005

  • Batlle E, Bacani J, Begthel H, Jonkheer S, Gregorieff A, van de Born M, Malats N, Sancho E, Boon E, Pawson T, Gallinger S, Pals S, Clevers H, EphB receptor activity suppresses colorectal cancer progression (vol 435, pg 1126, 2005). NATURE 2005;436 (7052):881
  • Batlle E, Bacani J, Begthel H, Jonkheer S, Jonkeer S, Gregorieff A, van de Born M, Malats N, Sancho E, Boon E, Pawson T, Gallinger S, Pals S, Clevers H, EphB receptor activity suppresses colorectal cancer progression. NATURE 2005;435 (7045):1126-1130 [PubMed]
  • Bende RJ, Aarts WM, Riedl RG, de Jong D, Pals ST, van Noesel CJM, Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity. J EXP MED 2005;201 (8):1229-1241 [PubMed]
  • Deloose STP, Smit LA, Pals FT, Kersten MJ, van Noesel CJM, Pals ST, High incidence of Kaposi sarcoma-associated herpesvirus infection in HIV-related solid immunoblastic/plasmablastic diffuse large B-cell lymphoma. LEUKEMIA 2005;19 (5):851-855 [PubMed]
  • Hendriks J, Planelles L, de Jong-Odding J, Hardenberg G, Pals ST, Hahne M, Spaargaren M, Medema JP, Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation. CELL DEATH DIFFER 2005;12 (6):637-648 [PubMed]
  • Rouschop KMA, Roelofs JJTH, Claessen N, da Costa Martins P, Zwaginga JJ, Pals ST, Weening JJ, Florquin S, Protection against renal ischemia reperfusion injury by CD44 disruption. J AM SOC NEPHROL 2005;16 (7):2034-2043 [PubMed]
  • Songun I, Litvinov SV, van de Velde CJH, Pals ST, Hermans J, van Krieken JHJM, Loss of Ep-CAM (CO17-1A) expression predicts survival in patients with gastric cancer. BRIT J CANCER 2005;92 (9):1767-1772 [PubMed]
  • Tjin EPM. The HFG/MET and WNT signaling pathways in B cell differentiation and neoplasia. S.l.: s.n.; 2005. 123p. ISBN 90-9019896-2 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Pals ST; copromotor(s): Spaargaren M)
  • Tjin EPM, Bende RJ, Derksen PWB, van Huijstee AP, Kataoka H, Spaargaren M, Pals ST, Follicular dendritic cells catalyze hepatocyte growth factor (HGF) activation in the germinal center microenvironment by secreting the serine protease HGF activator. J IMMUNOL 2005;175 (5):2807-2813 [PubMed]

2004

  • Boon EMJ, Keller JJ, Wormhoudt TAM, Giardiello FM, Offerhaus GJA, van der Neut R, Pals ST, Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines. BRIT J CANCER 2004;90 (1):224-229 [PubMed]
  • Derksen PWB, Tjin E, Meijer HP, Klok MD, MacGillavry HD, van Oers MHJ, Lokhorst HM, Bloem AC, Clevers H, Nusse R, van der Neut R, Spaargaren M, Pals ST, Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. P NATL ACAD SCI USA 2004;101 (16):6122-6127 [PubMed]
  • Rouschop KMA, Sewnath ME, Claessen N, Roelofs JJTH, Hoedemaeker I, van der Neut R, Aten J, Pals ST, Weening JJ, Florquin S, CD44 deficiency increases tubular damage but reduces renal fibrosis in obstructive nephropathy. J AM SOC NEPHROL 2004;15 (3):674-686 [PubMed]
  • Tjin EPM, Derksen PWB, Kataoka H, Spaargaren M, Pals ST, Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator. BLOOD 2004;104 (7):2172-2175 [PubMed]
  • van Royen N, Voskuil M, Hoefer I, Jost M, de Graaf S, Hedwig F, Andert JP, Wormhoudt TAM, Hua J, Hartmann S, Bode C, Buschmann I, Schaper W, van der Neut R, Piek JJ, Pals ST, CD44 regulates arteriogenesis in mice and is differentially expressed in patients with poor and good collateralization. CIRCULATION 2004;109 (13):1647-1652 [PubMed]

2003

  • Bende RJ, Smit LA, Bossenbroek JG, Aarts WM, Spaargaren M, de Leval L, Boeckxstaens GEE, Pals ST, van Noesel CJM, Primary follicular lymphoma of the small intestine: alpha4beta7 expression and immunoglobulin configuration suggest an origin from local antigen-experienced B cells. AM J PATHOL 2003;162 (1):105-113 [PubMed]
  • Derksen PWB. Regulation of cell growth in Multiple Myeloma: a role for the HGF/MET and WNT signaling pathways. S.l.: s.n.; 2003. 119p. ISBN 90-6464-879-4 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Pals ST; copromotor(s): )
  • Derksen PWB, de Gorter DJJ, Meijer HP, Bende RJ, van Dijk M, Lokhorst HM, Bloem AC, Spaargaren M, Pals ST, The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma. LEUKEMIA 2003;17 (4):764-774 [PubMed]
  • Kuijpers TW, Ridanpää M, Peters M, de Boer I, Vossen JMJJ, Pals ST, Kaitila I, Hennekam RCM, Short-limbed dwarfism with bowing, combined immune deficiency, and late onset aplastic anaemia caused by novel mutations in the RMPR gene. J MED GENET 2003;40 (10):761-766 [PubMed]
  • Leemans JC, Florquin S, Heikens M, Pals ST, van der Neut R, van der Poll T, CD44 is a macrophage binding site for Mycobacterium tuberculosis that mediates macrophage recruitment and protective immunity against tuberculosis. J CLIN INVEST 2003;111 (5):681-689 [PubMed]
  • Spaargaren M, Beuling EA, Rurup ML, Meijer HP, Klok MD, Middendorp S, Hendriks RW, Pals ST, The B cell antigen receptor controls integrin activity through Btk and PLCgamma2. J EXP MED 2003;198 (10):1539-1550 [PubMed]

2002

  • Aarts WM, Bende RJ, Vaandrager JW, Kluin PM, Langerak AW, Pals ST, van Noesel CJM, In situ analysis of the variable heavy chain gene of an IgM/IgG-expressing follicular lymphoma - Evidence for interfollicular trafficking of tumor cells. AM J PATHOL 2002;160 (3):883-891 [PubMed]
  • Bende RJ, Aarts WM, Pals ST, van Noesel CJM, Immunoglobulin diversification in B cell malignancies: internal splicing of heavy chain variable region as a by-product of somatic hypermutation. LEUKEMIA 2002;16 (4):636-644 [PubMed]
  • Boon EMJ, van der Neut R, van de Wetering M, Clevers H, Pals ST, Wnt signaling regulates expression of the receptor tyrosine kinase Met in colorectal cancer. CANCER RES 2002;62 (18):5126-5128 [PubMed]
  • Derksen PWB, Keehnen RMJ, Evers LM, van Oers MHJ, Spaargaren M, Pals ST, Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma. BLOOD 2002;99 (4):1405-1410 [PubMed]
  • Dingemans KP, Ramkema MD, Pals ST, CD44 is exposed to the extracellular matrix at invasive sites in basal cell carcinomas. LAB INVEST 2002;82 (3):313-322 [PubMed]
  • Florquin S, Nunziata R, Claessen N, van den Berg FM , Pals ST, Weening JJ, CD44 expression in IgA nephropathy. AM J KIDNEY DIS 2002;39 (2):407-414 [PubMed]
  • Rentenaar RJ, van Diepen FNJ, Meijer RT, Surachno S, Wilmink JM, Schellekens PTA, Pals ST, van Lier RAW, ten Berge IJM, Immune responsiveness in renal transplant recipients: mycophenolic acid severely depresses humoral immunity in vivo. KIDNEY INT 2002;62 (1):319-328 [PubMed]
  • Taher TEI. CD44 and Met: the signaling perspective. S.l.: s.n.; 2002. 202p. [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Pals ST; copromotor(s): )
  • Taher TEI, Derksen PWB, de Boer OJ, Spaargaren M, Teeling P, van der Wal AC, Pals ST, Hepatocyte growth factor triggers signaling cascades mediating vascular smooth muscle cell migration. BIOCHEM BIOPH RES CO 2002;298 (1):80-86 [PubMed]
  • Taher TEI, Tjin EPM, Beuling EA, Borst J, Spaargaren M, Pals ST, c-Cbl is involved in met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination. J IMMUNOL 2002;169 (7):3793-3800 [PubMed]
  • van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, van der Horn K, Batlle E, Coudreuse D, Haramis AP, Tjon-Pon-Fong M, Moerer P, van den Born M, Soete G, Pals S, Eilers M, Medema R, Clevers H, The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. CELL 2002;111 (2):241-250 [PubMed]

2001

  • Aarts WM, Bende RJ, Bossenbroek JG, Pals ST, van Noesel CJ, Variable heavy-chain gene analysis of follicular lymphomas: subclone selection rather than clonal evolution over time. BLOOD 2001;98 (1):238-240 [PubMed]
  • Arens R, Tesselaar K, Baars PA, van Schijndel GM, Hendriks J, Pals ST, Krimpenfort P, Borst J, van Oers MH, van Lier RA, Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion. IMMUNITY 2001;15 (5):801-812 [PubMed]
  • van den Wijngaard R, Wankowicz-Kalinska A, Pals S, Weening J, Das P, Autoimmune melanocyte destruction in vitiligo. LAB INVEST 2001;81 (8):1061-1067 [PubMed]

2000

  • Aarts WM, Bende RJ, Steenbergen EJ, Kluin PM, Ooms EC, Pals ST, van Noesel CJ, Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load. BLOOD 2000;95 (9):2922-2929 [PubMed]
  • Drillenburg P, Pals ST, Cell adhesion receptors in lymphoma dissemination. BLOOD 2000;95 (6):1900-1910 [PubMed]
  • van der Voort R, Keehnen RM, Beuling EA, Spaargaren M, Pals ST, Regulation of cytokine signaling by B cell antigen receptor and CD40-controlled expression of heparan sulfate proteoglycans. J EXP MED 2000;192 (8):1115-1124 [PubMed]
  • van der Voort R, Taher TE, Derksen PW, Spaargaren M, van der Neut R, Pals ST, The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B-cell differentiation. ADV CANCER RES 2000;79:39-90 [PubMed]
  • Wielenga VJ, van der Neut R, Offerhaus GJ, Pals ST, CD44 glycoproteins in colorectal cancer: expression, function, and prognostic value. ADV CANCER RES 2000;77:169-187 [PubMed]
  • Wielenga VJ, van der Voort R, Taher TE, Smit L, Beuling EA, van Krimpen C, Spaargaren M, Pals ST, Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer. AM J PATHOL 2000;157 (5):1563-1573 [PubMed]

1999

  • Aarts WM, Bende RJ, Pals ST, van Noesel CJ, Analysis of variable heavy and light chain genes in follicular lymphomas of different heavy chain isotype. CURR TOP MICROBIOL 1999;246:217-22; discussion 223-4 [PubMed]
  • Dingemans KP, Ramkema MD, Koopman G, van der Wal AC, Das PK, Pals ST, The expression of CD44 glycoprotein adhesion molecules in basal cell carcinomas is related to growth pattern and invasiveness. BRIT J DERMATOL 1999;140 (1):17-25 [PubMed]
  • Drillenburg P, Wielenga VJ, Kramer MH, van Krieken JH, Kluin-Nelemans HC, Hermans J, Heisterkamp S, Noordijk EM, Kluin PM, Pals ST, CD44 expression predicts disease outcome in localized large B cell lymphoma. LEUKEMIA 1999;13 (9):1448-1455 [PubMed]
  • Kersten MJ , Surachno S, Koopman MG, van 't Veer LJ, Pals ST, van Oers MH, Epstein-Barr-virus in een donornier als oorzaak van non-Hodgkin-lymfoom. NED TIJDSCHR GENEESKD 1999;143 (7):360-364 [PubMed]
  • Lens SM, Drillenburg P, den Drijver BF, van Schijndel G, Pals ST, van Lier RA, van Oers MH, Aberrant expression and reverse signalling of CD70 on malignant B cells. BRIT J HAEMATOL 1999;106 (2):491-503 [PubMed]
  • Taher TE, van der Voort R, Smit L, Keehnen RM, Schilder-Tol EJ, Spaargaren M, Pals ST, Cross-talk between CD44 and c-Met in B cells. CURR TOP MICROBIOL 1999;246:31-7; discussion 38 [PubMed]
  • van der Voort R, Taher TE, Wielenga VJ, Spaargaren M, Prevo R, Smit L, David G, Hartmann G, Gherardi E, Pals ST, Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met. J BIOL CHEM 1999;274 (10):6499-6506 [PubMed]
  • Wielenga VJ, Smits R, Korinek V, Smit L, Kielman M, Fodde R, Clevers H, Pals ST, Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. AM J PATHOL 1999;154 (2):515-523 [PubMed]

1998

  • Aarts WM, Willemze R, Bende RJ, Meijer CJ, Pals ST, van Noesel CJ, VH gene analysis of primary cutaneous B-cell lymphomas: evidence for ongoing somatic hypermutation and isotype switching. BLOOD 1998;92 (10):3857-3864 [PubMed]
  • Kersten MJ , van Gorp J, Pals ST, Boon F, van Oers MH, Expression of Epstein-Barr virus latent genes and adhesion molecules in AIDS-related non-Hodgkin's lymphomas: correlation with histology and CD4-cell number. LEUKEMIA LYMPHOMA 1998;30 (5-6):515-524 [PubMed]
  • Koopman G, Taher TE, Mazzucchelli I, Keehnen RM, van der Voort R, Manten-Horst E, Ricevuti G, Pals ST, Das PK, CD44 isoforms, including the CD44 V3 variant, are expressed on endothelium, suggesting a role for CD44 in the immobilization of growth factors and the regulation of the local immune response. BIOCHEM BIOPH RES CO 1998;245 (1):172-176 [PubMed]
  • Meenan J, Spaans J, Grool TA, Lammers K, Pals S, Tytgat GN, van Deventer SJ, Variation in gut-homing CD27-negative lymphocytes in inflammatory colon disease. SCAND J IMMUNOL 1998;48 (3):318-323 [PubMed]
  • Pals ST, Kraal G, Figdor CC, Cell adhesion and migration in inflammation and cancer - Preface. CELL ADHES COMMUN 1998;6 (2-3):83-84
  • Pals ST, Taher TE, van der Voort R, Smit L, Keehnen RM, Regulation of adhesion and migration in the germinal center microenvironment. CELL ADHES COMMUN 1998;6 (2-3):111-116 [PubMed]
  • van't Wout AB, Ran LJ, Kuiken CL, Kootstra NA, Pals ST, Schuitemaker H, Analysis of the temporal relationship between human immunodeficiency virus type 1 quasispecies in sequential blood samples and various organs obtained at autopsy. J VIROL 1998;72 (1):488-496 [PubMed]
  • Wielenga VJ, van der Voort R, Mulder JW, Kruyt PM, Weidema WF, Oosting J, Seldenrijk CA, van Krimpen C, Offerhaus GJ, Pals ST, CD44 splice variants as prognostic markers in colorectal cancer. SCAND J GASTROENTERO 1998;33 (1):82-87 [PubMed]
  • Wit FW, Sol CJ, Renwick N, Roos MT, Pals ST, van Leeuwen R, Goudsmit J, Reiss P, Regression of AIDS-related Kaposi's sarcoma associated with clearance of human herpesvirus-8 from peripheral blood mononuclear cells following initiation of antiretroviral therapy. AIDS 1998;12 (2):218-219 [PubMed]

1997

  • Drillenburg P, Bronkhorst CM, van der Wal AC, Noorduyn LA, Hoekzema R, Pals ST, Expression of adhesion molecules in pagetoid reticulosis (Woringer-Kolopp disease). BRIT J DERMATOL 1997;136 (4):613-616 [PubMed]
  • Drillenburg P, van der Voort R, Koopman G, Dragosics B, van Krieken JH, Kluin P, Meenan J, Lazarovits AI, Radaszkiewicz T, Pals ST, Preferential expression of the mucosal homing receptor integrin alpha 4 beta 7 in gastrointestinal non-Hodgkin's lymphomas. AM J PATHOL 1997;150 (3):919-927 [PubMed]
  • Jung K, Linse F, Pals ST, Heller R, Moths C, Neumann C, Adhesion molecules in atopic dermatitis: patch tests elicited by house dust mite. CONTACT DERMATITIS 1997;37 (4):163-172 [PubMed]
  • Kaaijk P, Pals ST, Morsink F, Bosch DA, Troost D, Differential expression of CD44 splice variants in the normal human central nervous system. J NEUROIMMUNOL 1997;73 (1-2):70-76 [PubMed]
  • Koopman G, Keehnen RM, Lindhout E, Zhou DF, de Groot C, Pals ST, Germinal center B cells rescued from apoptosis by CD40 ligation or attachment to follicular dendritic cells, but not by engagement of surface immunoglobulin or adhesion receptors, become resistant to CD95-induced apoptosis. EUR J IMMUNOL 1997;27 (1):1-7 [PubMed]
  • Koopman G, Wever PC, Ramkema MD, Bellot F, Reiss P, Keehnen RM, ten Berge IJ, Pals ST, Expression of granzyme B by cytotoxic T lymphocytes in the lymph nodes of HIV-infected patients. AIDS RES HUM RETROV 1997;13 (3):227-233 [PubMed]
  • Kuijpers TW, Etzioni A, Pollack S, Pals ST, Antigen-specific immune responsiveness and lymphocyte recruitment in leukocyte adhesion deficiency type II. INT IMMUNOL 1997;9 (4):607-613 [PubMed]
  • Lindhout E, Koopman G, Pals ST, de Groot C, Triple check for antigen specificity of B cells during germinal centre reactions. IMMUNOL TODAY 1997;18 (12):573-577 [PubMed]
  • Meenan J, Spaans J, Grool TA, Pals ST, Tytgat GN, van Deventer SJ, Altered expression of alpha 4 beta 7, a gut homing integrin, by circulating and mucosal T cells in colonic mucosal inflammation. GUT 1997;40 (2):241-246 [PubMed]
  • Mulder JW, Wielenga VJ, Pals ST, Offerhaus GJ, p53 and CD44 as clinical markers of tumour progression in colorectal carcinogenesis. HISTOCHEM J 1997;29 (6):439-452 [PubMed]
  • Pals ST, Drillenburg P, Radaszkiewicz T, Manten-Horst E, Adhesion molecules in the dissemination of non-Hodgkin's lymphomas. ACTA HAEMATOL-BASEL 1997;97 (1-2):73-80 [PubMed]
  • ten Berge RJ, Buysmann S, van Diepen FN, Surachno S, Pals ST, Increased expression of ICAM-1 and VCAM-1 in the skin after administration of the first dose of OKT3. TRANSPL P 1997;29 (1-2):325-327 [PubMed]
  • van der Voort R, Taher TE, Keehnen RM, Smit L, Groenink M, Pals ST, Paracrine regulation of germinal center B cell adhesion through the c-met-hepatocyte growth factor/scatter factor pathway. J EXP MED 1997;185 (12):2121-2131 [PubMed]

1996

  • Buysmann S, van Diepen FN, Surachno S, Pals ST, ten Berge RJ, Increased dermal expression of ICAM-1 and VCAM-1 after administration of OKT3 in man. CLIN NEPHROL 1996;46 (2):84-91 [PubMed]
  • Lens SM, de Jong R, Hooibrink B, Koopman G, Pals ST, van Oers MH, van Lier RA, Phenotype and function of human B cells expressing CD70 (CD27 ligand). EUR J IMMUNOL 1996;26 (12):2964-2971 [PubMed]
  • Lens SM, Keehnen RM, van Oers MH, van Lier RA, Pals ST, Koopman G, Identification of a novel subpopulation of germinal center B cells characterized by expression of IgD and CD70. EUR J IMMUNOL 1996;26 (5):1007-1011 [PubMed]
  • Songun I, van de Velde CJ, Hermans J, Pals ST, Verspaget HW, Vis AN, Menon AG, Litvinov SV, van Krieken JH, Expression of oncoproteins and the amount of eosinophilic and lymphocytic infiltrates can be used as prognostic factors in gastric cancer. Dutch Gastric Cancer Group (DGCG). BRIT J CANCER 1996;74 (11):1783-1788 [PubMed]
  • Taher TE, Smit L, Griffioen AW, Schilder-Tol EJ, Borst J, Pals ST, Signaling through CD44 is mediated by tyrosine kinases. Association with p56lck in T lymphocytes. J BIOL CHEM 1996;271 (5):2863-2867 [PubMed]
  • van den Berg H, Kroes W, van der Schoot CE, dee R, Pals ST, Bouts TH, Slater RM, A young child with acquired t(8;9)(p11;q34): additional proof that 8p11 is involved in mixed myeloid/T lymphoid malignancies. LEUKEMIA 1996;10 (7):1252-1253 [PubMed]

1995

  • Heider KH, Mulder JW, Ostermann E, Susani S, Patzelt E, Pals ST, Adolf GR, Splice variants of the cell surface glycoprotein CD44 associated with metastatic tumour cells are expressed in normal tissues of humans and cynomolgus monkeys. EUR J CANCER 1995;31A (13-14):2385-2391 [PubMed]
  • Herrlich P, Pals S, Ponta H, CD44 in colon cancer. EUR J CANCER 1995;31A (7-8):1110-1112 [PubMed]
  • Kaaijk P, Troost D, Morsink F, Keehnen RM, Leenstra S, Bosch DA, Pals ST, Expression of CD44 splice variants in human primary brain tumors. J NEURO-ONCOL 1995;26 (3):185-190 [PubMed]
  • Manten-Horst E, Danen EH, Smit L, Snoek M, Le Poole IC, van Muijen GN, Pals ST, Ruiter DJ, Expression of CD44 splice variants in human cutaneous melanoma and melanoma cell lines is related to tumor progression and metastatic potential. INT J CANCER 1995;64 (3):182-188 [PubMed]
  • Mulder JW, Kruyt PM, Sewnath M, Seldenrijk CA, Weidema WF, Pals ST, Offerhaus GJ, Difference in expression of CD44 splice variants between proximal and distal adenocarcinoma of the large bowel. BRIT J SURG 1995;82 (11):1468-1470 [PubMed]
  • Mulder JW, Wielenga VJ, Polak MM, van den Berg FM, Adolf GR, Herrlich P, Pals ST, Offerhaus GJ, Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis. GUT 1995;36 (1):76-80 [PubMed]
  • Pals ST, EFFECT OF CD44V6 ON SURVIVAL IN COLORECTAL-CARCINOMA - REPLY. LANCET 1995;345 (8945):328
  • Pals ST, Offerhaus GJ, COLORECTAL TUMORIGENESIS - REPLY. GUT 1995;36 (5):801
  • Sleeman J, Moll J, Sherman L, Dall P, Pals ST, Ponta H, Herrlich P, The role of CD44 splice variants in human metastatic cancer. CIBA FOUND SYMP 1995;189:142-51; discussion 151-6, 174-6 [PubMed]
  • van der Voort R, Manten-Horst E, Smit L, Ostermann E, van den Berg F, Pals ST, Binding of cell-surface expressed CD44 to hyaluronate is dependent on splicing and cell type. BIOCHEM BIOPH RES CO 1995;214 (1):137-144 [PubMed]

1994

  • Das PK, de Boer OJ, Visser A, Verhagen CE, Bos JD, Pals ST, Differential expression of ICAM-1, E-selectin and VCAM-1 by endothelial cells in psoriasis and contact dermatitis. ACTA DERM-VENEREOL 1994;74 (Suppl 186):21-22 [PubMed]
  • de Boer OJ, Horst E, Pals ST, Bos JD, Das PK, Functional evidence that the HECA-452 antigen is involved in the adhesion of human neutrophils and lymphocytes to tumour necrosis factor-alpha-stimulated endothelial cells. IMMUNOLOGY 1994;81 (3):359-365 [PubMed]
  • de Boer OJ, Wakelkamp IM, Pals ST, Claessen N, Bos JD, Das PK, Increased expression of adhesion receptors in both lesional and non-lesional psoriatic skin. ARCH DERMATOL RES 1994;286 (6):304-311 [PubMed]
  • Griffioen AW, Horst E, Heider KH, Wielenga VJ, Adolf GR, Herrlich P, Pals ST, Expression of CD44 splice variants during lymphocyte activation and tumor progression. CELL ADHES COMMUN 1994;2 (3):195-200 [PubMed]
  • Hintzen RQ, Lens SM, Koopman G, Pals ST, Spits H, van Lier RA, CD70 represents the human ligand for CD27. INT IMMUNOL 1994;6 (3):477-480 [PubMed]
  • Koopman G, Keehnen RM, Lindhout E, Newman W, Shimizu Y, van Seventer GA, de Groot C, Pals ST, Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells. J IMMUNOL 1994;152 (8):3760-3767 [PubMed]
  • Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, van Oers MH, Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. BLOOD 1994;84 (5):1415-1420 [PubMed]
  • Mulder JW, Kruyt PM, Sewnath M, Oosting J, Seldenrijk CA, Weidema WF, Offerhaus GJ, Pals ST, Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins. LANCET 1994;344 (8935):1470-1472 [PubMed]
  • Pals ST, Drillenburg P, Dragosics B, Lazarovits AI, Radaszkiewicz T, Expression of the mucosal homing receptor alpha 4 beta 7 in malignant lymphomatous polyposis of the intestine. GASTROENTEROLOGY 1994;107 (5):1519-1523 [PubMed]

1993

  • Bos JD, de Boer OJ, Tibosch E, Das PK, Pals ST, Skin-homing T lymphocytes: detection of cutaneous lymphocyte-associated antigen (CLA) by HECA-452 in normal human skin. ARCH DERMATOL RES 1993;285 (4):179-183 [PubMed]
  • Bruynzeel I, Koopman G, van der Raaij LM, Pals ST, Willemze R, CD44 antibody stimulates adhesion of peripheral blood T cells to keratinocytes through the leukocyte function-associated antigen-1/intercellular adhesion molecule-1 pathway. J INVEST DERMATOL 1993;100 (4):424-428 [PubMed]
  • Heider KH, Hofmann M, Hors E, van den Berg F, Ponta H, Herrlich P, Pals ST, A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps. J CELL BIOL 1993;120 (1):227-233 [PubMed]
  • Herrlich P, Zöller M, Pals ST, Ponta H, CD44 splice variants: metastases meet lymphocytes. IMMUNOL TODAY 1993;14 (8):395-399 [PubMed]
  • Kersten MJ , Mertens MJ, Pals ST, Reiss P, van Oers MH, Met HIV samenhangend non-Hodgkin-lymfoom bij 45 patiënten; een retrospectieve analyse. NED TIJDSCHR GENEESKD 1993;137 (28):1396-1400 [PubMed]
  • Koopman G, Griffioen AW, Ponta H, Herrlich P, van den Berg F, Manten-Horst E, Pals ST, CD44 splice variants; expression on lymphocytes and in neoplasia. RES IMMUNOL 1993;144 (9):750-4; discussion 754-62 [PubMed]
  • Koopman G, Heider KH, Horst E, Adolf GR, van den Berg F, Ponta H, Herrlich P, Pals ST, Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44. J EXP MED 1993;177 (4):897-904 [PubMed]
  • Koopman G, Keehnen RM, Pals ST, Interaction through the LFA-1/ICAM-1 pathway prevents programmed cell death of germinal center B cells. ADV EXP MED BIOL 1993;329:387-392 [PubMed]
  • Pals ST, Koopman G, Heider KH, Griffioen A, Adolf GR, van den Berg F, Ponta H, Herrlich P, Horst E, CD44 splice variants: expression during lymphocyte activation and tumor progression. BEHRING INST MITT 1993;92 (-):273-277 [PubMed]
  • van Dinther-Janssen AC, Pals ST, Scheper RJ, Meijer CJ, Role of the CS1 adhesion motif of fibronectin in T cell adhesion to synovial membrane and peripheral lymph node endothelium. ANN RHEUM DIS 1993;52 (9):672-676 [PubMed]
  • van Oers MH, Pals ST, Evers LM, van der Schoot CE, Koopman G, Bonfrer JM, Hintzen RQ, von dem Borne AE, van Lier RA, Expression and release of CD27 in human B-cell malignancies. BLOOD 1993;82 (11):3430-3436 [PubMed]
  • Wielenga VJ, Heider KH, Offerhaus GJ, Adolf GR, van den Berg FM, Ponta H, Herrlich P, Pals ST, Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression. CANCER RES 1993;53 (20):4754-4756 [PubMed]

1992

  • Koopman G, de Graaff M, Huysmans AC, Meijer CJ, Pals ST, Induction of homotypic T cell adhesion by triggering of leukocyte function-associated antigen-1 alpha (CD11a): differential effects on resting and activated T cells. EUR J IMMUNOL 1992;22 (7):1851-1856 [PubMed]
  • Koopman G, Pals ST, Cellular interactions in the germinal center: role of adhesion receptors and significance for the pathogenesis of AIDS and malignant lymphoma. IMMUNOL REV 1992;126:21-45 [PubMed]
  • Noorduyn LA, Beljaards RC, Pals ST, van Heerde P, Radaszkiewicz T, Willemze R, Meijer CJ, Differential expression of the HECA-452 antigen (cutaneous lymphocyte associated antigen, CLA) in cutaneous and non-cutaneous T-cell lymphomas. HISTOPATHOLOGY 1992;21 (1):59-64 [PubMed]
  • Rozendaal L, Pals ST, Melief CJ, Gleichmann E, Protection from lethal graft-vs.-host disease by donor stem cell repopulation. EUR J IMMUNOL 1992;22 (2):575-579 [PubMed]
  • Spronk MH, Pals ST, Haumann TJ, Schouten-van Meeteren AY, Een kind met Wegener's granulomatosis. TIJDSCHR KINDERGENEESKD 1992;60 (2):52-56 [PubMed]
  • van Krieken JH, Medeiros LJ, Pals ST, Raffeld M, Kluin PM, Diffuse aggressive B-cell lymphomas of the gastrointestinal tract. An immunophenotypic and gene rearrangement analysis of 22 cases. AM J CLIN PATHOL 1992;97 (2):170-178 [PubMed]
  • Zweegman S, van der Meulen J , PALS SL, Oe PL, Progression of membranous glomerulopathy during cyclosporin A. CLIN NEPHROL 1992;37 (6):314 [PubMed]

1991

  • Horst E, Radaszkiewicz T, Hooftman-den Otter A, Pieters R, van Dongen JJ, Meijer CJ, Pals ST, Expression of the leucocyte integrin LFA-1 (CD11a/CD18) and its ligand ICAM-1 (CD54) in lymphoid malignancies is related to lineage derivation and stage of differentiation but not to tumor grade. LEUKEMIA 1991;5 (10):848-853 [PubMed]
  • Koopman G, Parmentier HK, Schuurman HJ, Newman W, Meijer CJ, Pals ST, Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways. J EXP MED 1991;173 (6):1297-1304 [PubMed]
  • Pals ST, Meijer CJ, Radaszkiewicz T, Expression of the human peripheral lymph node homing receptor (LECAM-1) in nodal and gastrointestinal non-Hodgkin's lymphomas. LEUKEMIA 1991;5 (7):628-631 [PubMed]
  • Pieters R, Thompson LF, Broekema GJ, Huismans DR, Peters GJ, Pals ST, Horst E, Hählen K, Veerman AJ, Expression of 5'-nucleotidase (CD73) related to other differentiation antigens in leukemias of B-cell lineage. BLOOD 1991;78 (2):488-492 [PubMed]
  • Scheeren RA, Koopman G, van der Baan S, Meijer CJ, Pals ST, Adhesion receptors involved in clustering of blood dendritic cells and T lymphocytes. EUR J IMMUNOL 1991;21 (5):1101-1105 [PubMed]
  • van Dinther-Janssen AC, Horst E, Koopman G, Newmann W, Scheper RJ, Meijer CJ, Pals ST, The VLA-4/VCAM-1 pathway is involved in lymphocyte adhesion to endothelium in rheumatoid synovium. J IMMUNOL 1991;147 (12):4207-4210 [PubMed]

1990

  • Horst E, Meijer CJ, Duijvestijn AM, Hartwig N, van der Harten HJ, Pals ST, The ontogeny of human lymphocyte recirculation: high endothelial cell antigen (HECA-452) and CD44 homing receptor expression in the development of the immune system. EUR J IMMUNOL 1990;20 (7):1483-1489 [PubMed]
  • Horst E, Meijer CJ, Radaskiewicz T, van Dongen JJ, Pieters R, Figdor CG, Hooftman A, Pals ST, Expression of a human homing receptor (CD44) in lymphoid malignancies and related stages of lymphoid development. LEUKEMIA 1990;4 (5):383-389 [PubMed]
  • Horst E, Meijer CJ, Radaszkiewicz T, Ossekoppele GJ, van Krieken JH, Pals ST, Adhesion molecules in the prognosis of diffuse large-cell lymphoma: expression of a lymphocyte homing receptor (CD44), LFA-1 (CD11a/18), and ICAM-1 (CD54). LEUKEMIA 1990;4 (8):595-599 [PubMed]
  • Koopman G, van Kooyk Y, de Graaff M, Meyer CJ, Figdor CG, Pals ST, Triggering of the CD44 antigen on T lymphocytes promotes T cell adhesion through the LFA-1 pathway. J IMMUNOL 1990;145 (11):3589-3593 [PubMed]
  • Pals ST, Radaszkiewicz T, Willemze R, Meijer CJ, Expression of cell adhesion molecules in lymphoid malignancies. CURR PROBL DERMATOL 1990;19:29-34 [PubMed]
  • Rozendaal L, Pals ST, Gleichmann E, Melief CJ, Persistence of allospecific helper T cells is required for maintaining autoantibody formation in lupus-like graft-versus-host disease. CLIN EXP IMMUNOL 1990;82 (3):527-532 [PubMed]
  • van Dinther-Janssen AC, Pals ST, Scheper R, Breedveld F, Meijer CJ, Dendritic cells and high endothelial venules in the rheumatoid synovial membrane. J RHEUMATOL 1990;17 (1):11-17 [PubMed]

1989

  • Facchetti F, de Wolf-Peeters C, van den Oord JJ, Meijer CJ, Pals ST, Desmet VJ, Anti-high endothelial venule monoclonal antibody HECA-452 recognizes plasmacytoid T cells and delineates an "extranodular" compartment in the reactive lymph node. IMMUNOL LETT 1989;20 (4):277-281 [PubMed]
  • Kabel PJ, Voorbij HA, de Haan-Meulman M, Pals ST, Drexhage HA, High endothelial venules present in lymphoid cell accumulations in thyroids affected by autoimmune disease: a study in men and BB rats of functional activity and development. J CLIN ENDOCR METAB 1989;68 (4):744-751 [PubMed]
  • Pals ST, Hogervorst F, Keizer GD, Thepen T, Horst E, Figdor CC, Identification of a widely distributed 90-kDa glycoprotein that is homologous to the Hermes-1 human lymphocyte homing receptor. J IMMUNOL 1989;143 (3):851-857 [PubMed]
  • Pals ST, Horst E, Ossekoppele GJ, Figdor CG, Scheper RJ, Meijer CJ, Expression of lymphocyte homing receptor as a mechanism of dissemination in non-Hodgkin's lymphoma. BLOOD 1989;73 (4):885-888 [PubMed]
  • Pals ST, Horst E, Scheper RJ, Meijer CJ, Mechanisms of human lymphocyte migration and their role in the pathogenesis of disease. IMMUNOL REV 1989;108:111-133 [PubMed]
  • Rozemuller JM, Eikelenboom P, Pals ST, Stam FC, Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family. NEUROSCI LETT 1989;101 (3):288-292 [PubMed]
  • Rozendaal L, Pals ST, Schilham M, Melief CJ, Gleichmann E, Allosuppression of B cells in vitro by graft-vs.-host reaction-derived T cells is caused by cytotoxic T lymphocytes. EUR J IMMUNOL 1989;19 (9):1669-1675 [PubMed]
  • Seldenrijk CA, Drexhage HA, Meuwissen SG, Pals ST, Meijer CJ, Dendritic cells and scavenger macrophages in chronic inflammatory bowel disease. GUT 1989;30 (4):484-491 [PubMed]

1988

  • Duijvestijn AM, Horst E, Pals ST, Rouse BN, Steere AC, Picker LJ, Meijer CJ, Butcher EC, High endothelial differentiation in human lymphoid and inflammatory tissues defined by monoclonal antibody HECA-452. AM J PATHOL 1988;130 (1):147-155 [PubMed]
  • Horst E, Pals ST, Duijvestijn AM, von Mourik J, Kraal G, Butcher EC, Meijer CJ, Expression and regulation of an antigen specific for endothelium involved in human lymphocyte homing. ADV EXP MED BIOL 1988;237:477-484 [PubMed]
  • Pals ST, den Otter A, Miedema F, Kabel P, Keizer GD, Scheper RJ, Meijer CJ, Evidence that leukocyte function-associated antigen-1 is involved in recirculation and homing of human lymphocytes via high endothelial venules. J IMMUNOL 1988;140 (6):1851-1853 [PubMed]
  • Pals ST, den Otter A, Miedema F, Kabel P, Keizer GD, Scheper RJ, Meijer CJ, MEL-14 and LFA-1, organ specific and non-specific adhesion molecules involved in homing of human lymphocytes. ADV EXP MED BIOL 1988;237:505-509 [PubMed]

1986

  • Pals ST, Kraal G, Horst E, de Groot A, Scheper RJ, Meijer CJ, Human lymphocyte-high endothelial venule interaction: organ-selective binding of T and B lymphocyte populations to high endothelium. J IMMUNOL 1986;137 (3):760-763 [PubMed]
  • Pals ST, Zijstra M, Radaszkiewicz T, Quint W, Cuypers HT, Schoenmakers HJ, Melief CJ, Berns A, Gleichmann E, Immunologic induction of malignant lymphoma: graft-vs-host reaction-induced B cell lymphomas contain integrations of predominantly ecotropic murine leukemia proviruses. J IMMUNOL 1986;136 (1):331-339 [PubMed]

1985

  • Pals ST, Radaszkiewicz T, Roozendaal L, Gleichmann E, Chronic progressive polyarthritis and other symptoms of collagen vascular disease induced by graft-vs-host reaction. J IMMUNOL 1985;134 (3):1475-1482 [PubMed]

1984

  • Gleichmann E, Pals ST, Rolink AG, Radaszkiewicz T, Gleichmann H, Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases. IMMUNOL TODAY 1984;5 (11):324-332 [PubMed]
  • Pals ST, Gleichmann H, Gleichmann E, Allosuppressor and allohelper T cells in acute and chronic graft-vs-host disease. V. F1 mice with secondary chronic GVHD contain F1-reactive allohelper but no allosuppressor T cells. J EXP MED 1984;159 (2):508-523 [PubMed]
  • Pals ST, Radaszkiewicz T, Gleichmann E, Allosuppressor- and allohelper-T cells in acute and chronic graft-vs-host disease. IV. Activation of donor allosuppressor cells is confined to acute GVHD. J IMMUNOL 1984;132 (4):1669-1678 [PubMed]

1983

  • Gleichmann E, Rolink AG, Pals ST, Gleichmann H, GRAFT-VERSUS-HOST REACTIONS (GVHRS) - CLUES TO THE PATHOGENESIS OF A BROAD-SPECTRUM OF IMMUNOLOGICAL DISEASES. TRANSPL P 1983;15 (1):1436-1440
  • Gleichmann HI, Pals ST, Radaszkiewicz T, T cell-dependent B-cell proliferation and activation induced by administration of the drug diphenylhydantoin to mice. HEMATOL ONCOL 1983;1 (2):165-176 [PubMed]
  • Pals ST, Gleichmann E, A SEQUENTIAL ALLOACTIVATION OF SUBSETS OF DONOR T-CELLS UNDERLIES THE TRANSITION FROM ACUTE GRAFT-VERSUS-HOST DISEASE (GVHD) TO CHRONIC GVHD. TRANSPL P 1983;15 (1):1480-1483
  • Rolink AG, Pals ST, Gleichmann E, Allosuppressor and allohelper T cells in acute and chronic graft-vs.-host disease. II. F1 recipients carrying mutations at H-2K and/or I-A. J EXP MED 1983;157 (2):755-771 [PubMed]

1982

  • Gleichmann H, Pals S, Radaszkiewicz T, WASSER M, T cell-dependent B cell lymphoproliferation and activation induced by the drug diphenylhydantoin. ADV EXP MED BIOL 1982;149:617-622 [PubMed]
  • Pals ST, Radaszkiewicz T, Gleichmann E, Induction of either acute or chronic graft-versus-host disease due to genetic differences among donor T cells. ADV EXP MED BIOL 1982;149:537-544 [PubMed]
  • Rolink AG, Radaszkiewicz T, Pals ST, van der Meer WG, Gleichmann E, Allosuppressor and allohelper T cells in acute and chronic graft-vs-host disease. I. Alloreactive suppressor cells rather than killer T cells appear to be the decisive effector cells in lethal graft-vs.-host disease. J EXP MED 1982;155 (5):1501-1522 [PubMed]

1977

  • Klein B, Pals S, MASSE R, LAFUMA J, MORIN M, BINART N, JASMIN JR, JASMIN C, Studies of bone and soft-tissue tumours induced in rats with radioactive cerium chloride. INT J CANCER 1977;20 (1):112-119 [PubMed]