Prof. dr. W.J.M. Mulder publications


Publications Prof. dr. W.J.M. Mulder

Main activities
Research, Teaching
Focus of research

I established the Nanomedicine Laboratory at Mount Sinai in New York (Nano-TMII):
At Nano-TMII we develop nanomedical approaches towards molecular imaging and targeted therapy of cancer and cardiovascular disease in a preclinical setting. To that aim my lab developed libraries of nanoparticle probes based on the lipoprotein architecture to target plaque macrophages and diagnose atherosclerosis with CT, MRI and optical techniques. We also developed probes that allow apoptosis or collagen imaging of the diseased vessel wall. In parallel my lab developed complex multifunctional nanoparticles of which the size, composition and payload of drugs and diagnostic agents can be judiciously controlled. We have shown their effectiveness for targeted imaging and therapy in mouse models of cancer. I also established a research line aimed at targeted nanotherapy of atherosclerotic disease. We explored this new atherosclerosis treatment paradigm in rabbit and mouse models of atherosclerosis and show its ability to induce a rapid reduction of plaque inflammation. These studies served as the foundation of clinical trials we have initiated in September 2011 at the AMC Amsterdam where I hold a position as of January 2012. In December 2011 we contributed a seminal review paper to Nature Reviews Drug Discovery with the title “Perspectives and opportunities for nanomedicine in the management of atherosclerosis”. The goal of my research activities is to further develop state-of-the-art nanomedical approaches, develop imaging readouts and test them preclinically at Sinai, while complementary translational studies and clinical trials will be done at the AMC.


  • Duivenvoorden R, Senders ML, van Leent MMT, Pérez-Medina C, Nahrendorf M, Fayad ZA, Mulder WJM, Nanoimmunotherapy to treat ischaemic heart disease. NAT REV CARDIOL 2019;16 (1):21-32 [PubMed]


  • Braza MS, van Leent MMT, Lameijer M, Sanchez-Gaytan BL, Arts RJW, Pérez-Medina C, Conde P, Garcia MR, Gonzalez-Perez M, Brahmachary M, Fay F, Kluza E, Kossatz S, Dress RJ, Salem F, Rialdi A, Reiner T, Boros P, Strijkers GJ, Calcagno CC, Ginhoux F, Marazzi I, Lutgens E, Nicolaes GAF, Weber C, Swirski FK, Nahrendorf M, Fisher EA, Duivenvoorden R, Fayad ZA, Netea MG, Mulder WJM, Ochando J, Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance. IMMUNITY 2018;49 (5):819-+ [PubMed]
  • Duivenvoorden R, Mulder WJM, Imaging Tropoelastin in Atherosclerosis. CIRC-CARDIOVASC IMAG 2018;11 (8):e008147 [PubMed]
  • Lameijer M. Targeting macrophage dynamics to regulate the cardiovascular immune response. S.l.: s.n.; 2018. 244p. ISBN 978-94-028-0896-4 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Mulder WJM, Lutgens E; copromotor(s): Duivenvoorden R, Kluza E)
  • Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, Kroon J, Stroes ESG, Kjaer A, Ochando J, Reiner T, Perez-Medina C, Calcagno C, Fischer EA, Zhang B, Temel RE, Swirski FK, Nahrendorf M, Fayad ZA, Lutgens E, Mulder WJM, Duivenvoorden R, Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates. NAT BIOMED ENG 2018;2 (5):279-292
  • Mulder WJM, van Leent MMT, Lameijer M, Fisher EA, Fayad ZA, Pérez-Medina C, High-Density Lipoprotein Nanobiologics for Precision Medicine. ACCOUNTS CHEM RES 2018;51 (1):127-137 [PubMed]
  • Roberts S, Andreou C, Choi C, Donabedian P, Jayaraman M, Pratt EC, Tang J, Pérez-Medina C, Jason de la Cruz M, Mulder WJM, Grimm J, Kircher M, Reiner T, Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer. CHEM SCI 2018;9 (25):5646-5657 [PubMed]
  • Seijkens TTP, van Tiel CM, Kusters PJH, Atzler D, Soehnlein O, Zarzycka B, Aarts SABM, Lameijer M, Gijbels MJ, Beckers L, den Toom M, Slütter B, Kuiper J, Duchene J, Aslani M, Megens RTA, van 't Veer C, Kooij G, Schrijver R, Hoeksema MA, Boon L, Fay F, Tang J, Baxter S, Jongejan A, Moerland PD, Vriend G, Bleijlevens B, Fisher EA, Duivenvoorden R, Gerdes N, de Winther MPJ, Nicolaes GA, Mulder WJM, Weber C, Lutgens E, Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. J AM COLL CARDIOL 2018;71 (5):527-542 [PubMed]
  • Senders ML, Hernot S, Carlucci G, van de Voort JC, Fay F, Calcagno C, Tang J, Alaarg A, Zhao Y, Ishino S, Palmisano A, Boeykens G, Meerwaldt AE, Sanchez-Gaytan BL, Baxter S, Zendman L, Lobatto ME, Karakatsanis NA, Robson PM, Broisat A, Raes G, Lewis JS, Tsimikas S, Reiner T, Fayad ZA, Devoogdt N, Mulder WJM, Pérez-Medina C, Nanobody-Facilitated Multiparametric PET/MRI Phenotyping of Atherosclerosis. JACC-CARDIOVASC IMAG 2018;ahead of print [PubMed]
  • Senders ML, Lobatto ME, Soler R, Lairez O, Pérez-Medina C, Calcagno C, Fayad ZA, Mulder WJM, Fay F, Development and Multiparametric Evaluation of Experimental Atherosclerosis in Rabbits. METHODS MOL BIOL 2018;1816:385-400 [PubMed]
  • Senders ML, Mulder WJM, Targeting myeloperoxidase in inflammatory atherosclerosis. EUR HEART J 2018;39 (35):3311-3313 [PubMed]
  • Senders ML, Que X, Cho YS, Yeang C, Groenen H, Fay F, Calcagno C, Meerwaldt AE, Green S, Miu P, Lobatto ME, Reiner T, Fayad ZA, Witztum JL, Mulder WJM, Pérez-Medina C, Tsimikas S, PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis. J AM COLL CARDIOL 2018;71 (3):321-335 [PubMed]
  • Srimathveeravalli G, Abdel-Atti D, Perez-Medina C, Takaki H, Solomon SB, Mulder WJM, Reiner T, Reversible Electroporation-Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With Zr-89-Labeled Reporter Nanoparticles. MOL IMAGING 2018;ahead of print
  • Srimathveeravalli G, Abdel-Atti D, Pérez-Medina C, Takaki H, Solomon SB, Mulder WJM, Reiner T, 89Zr-Labeled Reporter Nanoparticles. MOL IMAGING 2018;17:1536012117749726 [PubMed]
  • Teunissen AJP, Pérez-Medina C, Meijerink A, Mulder WJM, Investigating supramolecular systems using Forster resonance energy transfer. CHEM SOC REV 2018;47 (18):7027-7044 [PubMed]


  • Alaarg A, Pérez-Medina C, Metselaar JM, Nahrendorf M, Fayad ZA, Storm G, Mulder WJM, Applying nanomedicine in maladaptive inflammation and angiogenesis. ADV DRUG DELIVER REV 2017;119:143-158 [PubMed]
  • Alaarg A, Senders ML, Varela-Moreira A, Pérez-Medina C, Zhao Y, Tang J, Fay F, Reiner T, Fayad ZA, Hennink WE, Metselaar JM, Mulder WJM, Storm G, A systematic comparison of clinically viable nanomedicines targeting HMG-CoA reductase in inflammatory atherosclerosis. J CONTROL RELEASE 2017;262:47-57 [PubMed]
  • Beldman TJ, Senders ML, Alaarg A, Pérez-Medina C, Tang J, Zhao Y, Fay F, Deichmöller J, Born B, Desclos E, van der Wel NN, Hoebe RA, Kohen F, Kartvelishvily E, Neeman M, Reiner T, Calcagno C, Fayad ZA, de Winther MPJ, Lutgens E, Mulder WJM, Kluza E, Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis. ACS NANO 2017;11 (6):5785-5799 [PubMed]
  • Brand C, Iacono P, Pérez-Medina C, Mulder WJM, Kircher MF, Reiner T, Specific Binding of Liposomal Nanoparticles through Inverse Electron-Demand Diels-Alder Click Chemistry. CHEMISTRYOPEN 2017;6 (5):615-619 [PubMed]
  • Fay F, Hansen L, Hectors SJCG, Sanchez-Gaytan BL, Zhao Y, Tang J, Munitz J, Alaarg A, Braza MS, Gianella A, Aaronson SA, Reiner T, Kjems J, Langer R, Hoeben FJM, Janssen HM, Calcagno C, Strijkers GJ, Fayad ZA, Perez-Medina C, Mulder WJM, Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging. BIOCONJUGATE CHEM 2017;28 (5):1413-1421 [PubMed]
  • Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJM, Weissleder R, Nahrendorf M, Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease. NAT COMMUN 2017;8:14064 [PubMed]
  • Mulder WJM, Gnjatic S, CANCER IMMUNOTHERAPY From local to global. NAT NANOTECHNOL 2017;12 (9):840-841 [PubMed]
  • Pérez-Medina C, Hak S, Reiner T, Fayad ZA, Nahrendorf M, Mulder WJM, Integrating nanomedicine and imaging. PHILOS T R SOC A 2017;375 (2107):20170110 [PubMed]
  • Sanchez-Gaytan BL, Fay F, Hak S, Alaarg A, Fayad ZA, Pérez-Medina C, Mulder WJM, Zhao Y, Real-Time Monitoring of Nanoparticle Formation by FRET Imaging. ANGEW CHEM INT EDIT 2017;56 (11):2923-2926 [PubMed]
  • Senders ML, Fayad ZA, Reiner T, Mulder WJ, Pérez-Medina C, Imaging-guided revival of nanomedicine?. NANOMEDICINE-UK 2017;12 (2):89-90 [PubMed]
  • Zhao Y, Shaffer TM, Das S, Pérez-Medina C, Mulder WJM, Grimm J, Near-Infrared Quantum Dot and (89)Zr Dual-Labeled Nanoparticles for in Vivo Cerenkov Imaging. BIOCONJUGATE CHEM 2017;28 (2):600-608 [PubMed]
  • Zupančič E, Fayad ZA, Mulder WJM, Cardiovascular Immunotherapy and the Role of Imaging. ARTERIOSCL THROM VAS 2017;37 (11):e167-e171 [PubMed]


  • Calcagno C, Mulder WJM, Nahrendorf M, Fayad ZA, Systems Biology and Noninvasive Imaging of Atherosclerosis. ARTERIOSCL THROM VAS 2016;36 (2):e1-e8 [PubMed]
  • Lobatto ME. Exploration and application of nanomedicine in atherosclerotic disease. S.l.: s.n.; 2016. 249p. ISBN 978-94-6295-424-3 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Mulder WJM, Stroes ESG; copromotor(s): Metselaar JM)
  • Mulder WJM, Combination nanotherapy penetrates atherosclerosis. CARDIOVASC RES 2016;109 (2):191-192 [PubMed]
  • Pérez-Medina C, Abdel-Atti D, Tang J, Zhao Y, Fayad ZA, Lewis JS, Mulder WJM, Reiner T, Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy. NAT COMMUN 2016;7:11838 [PubMed]
  • Pérez-Medina C, Binderup T, Lobatto ME, Tang J, Calcagno C, Giesen L, Wessel CH, Witjes J, Ishino S, Baxter S, Zhao Y, Ramachandran S, Eldib M, Sánchez-Gaytán BL, Robson PM, Bini J, Granada JF, Fish KM, Stroes ESG, Duivenvoorden R, Tsimikas S, Lewis JS, Reiner T, Fuster V, Kjær A, Fisher EA, Fayad ZA, Mulder WJM, In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models. JACC-CARDIOVASC IMAG 2016;9 (8):950-961 [PubMed]
  • Tang J, Baxter S, Menon A, Alaarg A, Sanchez-Gaytan BL, Fay F, Zhao Y, Ouimet M, Braza MS, Longo VA, Abdel-Atti D, Duivenvoorden R, Calcagno C, Storm G, Tsimikas S, Moore KJ, Swirski FK, Nahrendorf M, Fisher EA, Pérez-Medina C, Fayad ZA, Reiner T, Mulder WJM, Immune cell screening of a nanoparticle library improves atherosclerosis therapy. P NATL ACAD SCI USA 2016;113 (44):E6731-E6740 [PubMed]
  • van der Valk FM, Schulte DM, Meiler S, Tang J, Zheng KH, van den Bossche J, Seijkens T, Laudes M, de Winther M, Lutgens E, Alaarg A, Metselaar JM, Dallinga-Thie GM, Mulder WJM, Stroes ESG, Hamers AAJ, Liposomal prednisolone promotes macrophage lipotoxicity in experimental atherosclerosis. NANOMED-NANOTECHNOL 2016;12 (6):1463-1470 [PubMed]
  • Zhao Y, Fay F, Hak S, Manuel Perez-Aguilar J, Sanchez-Gaytan BL, Goode B, Duivenvoorden R, de Lange Davies C, Bjørkøy A, Weinstein H, Fayad ZA, Pérez-Medina C, Mulder WJM, Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy. NAT COMMUN 2016;7:11221 [PubMed]
  • Zheng KH, van der Valk FM, Smits LP, Sandberg M, Dasseux JL, Baron R, Barbaras R, Keyserling C, Coolen BF, Nederveen AJ, Verberne HJ, Nell TE, Vugts DJ, Duivenvoorden R, Fayad ZA, Mulder WJM, van Dongen GAMS, Stroes ESG, HDL mimetic CER-001 targets atherosclerotic plaques in patients. ATHEROSCLEROSIS 2016;251:381-388 [PubMed]


  • Calcagno C, Lobatto ME, Dyvorne H, Robson PM, Millon A, Senders ML, Lairez O, Ramachandran S, Coolen BF, Black A, Mulder WJM, Fayad ZA, Three-dimensional dynamic contrast-enhanced MRI for the accurate, extensive quantification of microvascular permeability in atherosclerotic plaques. NMR BIOMED 2015;28 (10):1304-1314 [PubMed]
  • Kootte RS, Smits LP, van der Valk FM, Dasseux JL, Keyserling CH, Barbaras R, Paolini JF, Santos RD, van Dijk TH, Dallinga-van Thie GM, Nederveen AJ, Mulder WJM, Hovingh GK, Kastelein JJP, Groen AK, Stroes ES, Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA. J LIPID RES 2015;56 (3):703-712 [PubMed]
  • Lobatto ME, Calcagno C, Millon A, Senders ML, Fay F, Robson PM, Ramachandran S, Binderup T, Paridaans MPM, Sensarn S, Rogalla S, Gordon RE, Cardoso L, Storm G, Metselaar JM, Contag CH, Stroes ESG, Fayad ZA, Mulder WJM, Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging. ACS NANO 2015;9 (2):1837-1847 [PubMed]
  • Lobatto ME, Calcagno C, Otten MJ, Millon A, Ramachandran S, Paridaans MPM, van der Valk FM, Storm G, Stroes ESG, Fayad ZA, Mulder WJM, Metselaar JM, Pharmaceutical development and preclinical evaluation of a GMP-grade anti-inflammatory nanotherapy. NANOMED-NANOTECHNOL 2015;11 (5):1133-1140 [PubMed]
  • Nahrendorf M, Frantz S, Swirski FK, Mulder WJM, Randolph G, Ertl G, Ntziachristos V, Piek JJ, Stroes ES, Schwaiger M, Mann DL, Fayad ZA, Imaging systemic inflammatory networks in ischemic heart disease. J AM COLL CARDIOL 2015;65 (15):1583-1591 [PubMed]
  • Pérez-Medina C, Tang J, Abdel-Atti D, Hogstad B, Merad M, Fisher EA, Fayad ZA, Lewis JS, Mulder WJM, Reiner T, PET Imaging of Tumor-Associated Macrophages with 89Zr-Labeled High-Density Lipoprotein Nanoparticles. J NUCL MED 2015;56 (8):1272-1277 [PubMed]
  • Priem B, Tian C, Tang J, Zhao Y, Mulder WJM, Fluorescent nanoparticles for the accurate detection of drug delivery. EXPERT OPIN DRUG DEL 2015;12 (12):1881-1894 [PubMed]
  • Sanchez-Gaytan BL, Fay F, Lobatto ME, Tang J, Ouimet M, Kim Y, van der Staay SEM, van Rijs SM, Priem B, Zhang L, Fisher EA, Moore KJ, Langer R, Fayad ZA, Mulder WJM, HDL-mimetic PLGA nanoparticle to target atherosclerosis plaque macrophages. BIOCONJUGATE CHEM 2015;26 (3):443-451 [PubMed]
  • Tang J, Lobatto ME, Hassing L, van der Staay S, van Rijs SM, Calcagno C, Braza MS, Baxter S, Fay F, Sanchez-Gaytan BL, Duivenvoorden R, Sager H, Astudillo YM, Leong W, Ramachandran S, Storm G, Pérez-Medina C, Reiner T, Cormode DP, Strijkers GJ, Stroes ESG, Swirski FK, Nahrendorf M, Fisher EA, Fayad ZA, Mulder WJM, Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation. SCI ADV 2015;1 (3):e1400223 [PubMed]
  • van der Valk FM, van Wijk DF, Lobatto ME, Verberne HJ, Storm G, Willems MCM, Legemate DA, Nederveen AJ, Calcagno C, Mani V, Ramachandran S, Paridaans MPM, Otten MJ, Dallinga-Thie GM, Fayad ZA, Nieuwdorp M, Schulte DM, Metselaar JM, Mulder WJM, Stroes ES, Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration. NANOMED-NANOTECHNOL 2015;11 (5):1039-1046 [PubMed]
  • Ye YX, Calcagno C, Binderup T, Courties G, Keliher EJ, Wojtkiewicz GR, Iwamoto Y, Tang J, Pérez-Medina C, Mani V, Ishino S, Johnbeck CB, Knigge U, Fayad ZA, Libby P, Weissleder R, Tawakol A, Dubey S, Belanger AP, Di Carli MF, Swirski FK, Kjaer A, Mulder WJM, Nahrendorf M, Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis. CIRC RES 2015;117 (10):835-845 [PubMed]


  • Duivenvoorden R, Tang J, Cormode DP, Mieszawska AJ, Izquierdo-Garcia D, Ozcan C, Otten MJ, Zaidi N, Lobatto ME, van Rijs SM, Priem B, Kuan EL, Martel C, Hewing B, Sager H, Nahrendorf M, Randolph GJ, Stroes ESG, Fuster V, Fisher EA, Fayad ZA, Mulder WJM, A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation. NAT COMMUN 2014;5:3065 [PubMed]
  • Duivenvoorden R, Tang J, Cormode DP, Mieszawska AJ, Izquierdo-Garcia D, Ozcan C, Otten MJ, Zaidi N, Lobatto ME, van Rijs SM, Priem B, Kuan EL, Martel C, Hewing B, Sager H, Nahrendorf M, Randolph GJ, Stroes ESG, Fuster V, Fisher EA, Fayad ZA, Mulder WJM, Erratum: A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation. NAT COMMUN 2014;5:3531 [PubMed]
  • Hak S, Cebulla J, Huuse EM, Davies CdL, Mulder WJM, Larsson HBW, Haraldseth O, Periodicity in tumor vasculature targeting kinetics of ligand-functionalized nanoparticles studied by dynamic contrast enhanced magnetic resonance imaging and intravital microscopy. ANGIOGENESIS 2014;17 (1):93-107 [PubMed]
  • Kim Y, Lobatto ME, Kawahara T, Lee Chung B, Mieszawska AJ, Sanchez-Gaytan BL, Fay F, Senders ML, Calcagno C, Becraft J, Tun Saung M, Gordon RE, Stroes ESG, Ma M, Farokhzad OC, Fayad ZA, Mulder WJM, Langer R, Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis. P NATL ACAD SCI USA 2014;111 (3):1078-1083 [PubMed]
  • Mulder WJM, Jaffer FA, Fayad ZA, Nahrendorf M, Imaging and nanomedicine in inflammatory atherosclerosis. SCI TRANSL MED 2014;6 (239):239sr1 [PubMed]
  • van der Valk FM, Kroon J, Potters WV, Thurlings RM, Bennink RJ, Verberne HJ, Nederveen AJ, Nieuwdorp M, Mulder WJM, Fayad ZA, van Buul JD, Stroes ESG, In vivo imaging of enhanced leukocyte accumulation in atherosclerotic lesions in humans. J AM COLL CARDIOL 2014;64 (10):1019-1029 [PubMed]
  • van Wijk DF, Sjouke B, Figueroa A, Emami H, van der Valk FM, MacNabb MH, Hemphill LC, Schulte DM, Koopman MG, Lobatto ME, Verberne HJ, Fayad ZA, Kastelein JJP, Mulder WJM, Hovingh GK, Tawakol A, Stroes ESG, Nonpharmacological lipoprotein apheresis reduces arterial inflammation in familial hypercholesterolemia. J AM COLL CARDIOL 2014;64 (14):1418-1426 [PubMed]
  • Zhao Y, Schapotschnikow P, Skajaa T, Vlugt TJH, Mulder WJM, de Mello Donegá C, Meijerink A, Probing Lipid Coating Dynamics of Quantum Dot Core Micelles via Forster Resonance Energy Transfer. SMALL 2014;10 (6):1163-1170 [PubMed]


  • Allijn IE, Leong W, Tang J, Gianella A, Mieszawska AJ, Fay F, Ma G, Russell S, Callo CB, Gordon RE, Korkmaz E, Post JA, Zhao Y, Gerritsen HC, Thran A, Proksa R, Daerr H, Storm G, Fuster V, Fisher EA, Fayad ZA, Mulder WJM, Cormode DP, Gold nanocrystal labeling allows low-density lipoprotein imaging from the subcellular to macroscopic level. ACS NANO 2013;7 (11):9761-9770 [PubMed]
  • Barazza A, Blachford C, Even-Or O, Joaquin VA, Briley-Saebo KC, Chen W, Jiang XC, Mulder WJM, Cormode DP, Fayad ZA, Fisher EA, The complex fate in plasma of gadolinium incorporated into high-density lipoproteins used for magnetic imaging of atherosclerotic plaques. BIOCONJUGATE CHEM 2013;24 (6):1039-1048 [PubMed]
  • Chen W, Cormode DP, Vengrenyuk Y, Herranz B, Feig JE, Klink A, Mulder WJM, Fisher EA, Fayad ZA, Collagen-specific peptide conjugated HDL nanoparticles as MRI contrast agent to evaluate compositional changes in atherosclerotic plaque regression. JACC-CARDIOVASC IMAG 2013;6 (3):373-384 [PubMed]
  • Cormode DP, Fisher EA, Stroes ESG, Mulder WJM, Fayad ZA, High-density lipoprotein is a nanoparticle, but not all nanoparticles are high-density lipoprotein. P NATL ACAD SCI USA 2013;110 (38):E3548 [PubMed]
  • Cormode DP, Sanchez-Gaytan BL, Mieszawska AJ, Fayad ZA, Mulder WJM, Inorganic nanocrystals as contrast agents in MRI: synthesis, coating and introduction of multifunctionality. NMR BIOMED 2013;26 (7):766-780 [PubMed]
  • Deddens LH, van Tilborg GAF, van der Toorn A, van der Marel K, Paulis LEM, van Bloois L, Storm G, Strijkers GJ, Mulder WJM, de Vries HE, Dijkhuizen RM, MRI of ICAM-1 upregulation after stroke: the importance of choosing the appropriate target-specific particulate contrast agent. MOL IMAGING BIOL 2013;15 (4):411-422 [PubMed]
  • Duivenvoorden R. Innovative imaging techniques for improved characterization of atherosclerosis and the assessment of novel therapies. s.l.: s.n.; 2013. 301p. ISBN 97890902777226 [UvA Dissertations Online] Proefschrift Universiteit van Amsterdam. (Promotor(s): Kastelein JJP, Stroes ESG; copromotor(s): Nederveen AJ, de Groot E, Mulder WJM)
  • Fay F, Sanchez-Gaytan BL, Cormode DP, Skajaa T, Fisher EA, Fayad ZA, Mulder WJM, Nanocrystal Core Lipoprotein Biomimetics for Imaging of Lipoproteins and Associated Diseases. CURR CARDIOVASC IMAGING REP 2013;6 (1):45-54 [PubMed]
  • Gianella A, Mieszawska AJ, Hoeben FJM, Janssen HM, Jarzyna PA, Cormode DP, Costa KD, Rao S, Farokhzad OC, Langer R, Fayad ZA, Mulder WJM, Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform. CHEM COMMUN 2013;49 (82):9392-9394 [PubMed]
  • Kim Y, Fay F, Cormode DP, Sanchez-Gaytan BL, Tang J, Hennessy EJ, Ma M, Moore K, Farokhzad OC, Fisher EA, Mulder WJM, Langer R, Fayad ZA, Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics. ACS NANO 2013;7 (11):9975-9983 [PubMed]
  • Lameijer MA, Tang J, Nahrendorf M, Beelen RHJ, Mulder WJM, Monocytes and macrophages as nanomedicinal targets for improved diagnosis and treatment of disease. EXPERT REV MOL DIAGN 2013;13 (6):567-580 [PubMed]
  • Mieszawska AJ, Kim Y, Gianella A, van Rooy I, Priem B, Labarre MP, Ozcan C, Cormode DP, Petrov A, Langer R, Farokhzad OC, Fayad ZA, Mulder WJM, Synthesis of Polymer-Lipid Nanoparticles for Image-Guided Delivery of Dual Modality Therapy. BIOCONJUGATE CHEM 2013;24 (9):1429-1434 [PubMed]
  • Mieszawska AJ, Mulder WJM, Fayad ZA, Cormode DP, Multifunctional gold nanoparticles for diagnosis and therapy of disease. MOL PHARMACEUT 2013;10 (3):831-847 [PubMed]
  • Mulder WJM, McMahon MT, Nicolay K, The evolution of MRI probes: from the initial development to state-of-the-art applications. NMR BIOMED 2013;26 (7):725-727 [PubMed]
  • Zhao Y, van Rooy I, Hak S, Fay F, Tang J, Davies CdL, Skobe M, Fisher EA, Radu A, Fayad ZA, de Mello Donegá C, Meijerink A, Mulder WJM, Near-infrared fluorescence energy transfer imaging of nanoparticle accumulation and dissociation kinetics in tumor-bearing mice. ACS NANO 2013;7 (11):10362-10370 [PubMed]


  • Hak S, Helgesen E, Hektoen HH, Huuse EM, Jarzyna PA, Mulder WJM, Haraldseth O, de Lange Davies C, The effect of nanoparticle polyethylene glycol surface density on ligand-directed tumor targeting studied in vivo by dual modality imaging. ACS NANO 2012;6 (6):5648-5658 [PubMed]
  • Jarzyna PA, Deddens LH, Kann BH, Ramachandran S, Calcagno C, Chen W, Gianella A, Dijkhuizen RM, Griffioen AW, Fayad ZA, Mulder WJM, Tumor angiogenesis phenotyping by nanoparticle-facilitated magnetic resonance and near-infrared fluorescence molecular imaging. NEOPLASIA 2012;14 (10):964-973 [PubMed]
  • Kim Y, Lee Chung B, Ma M, Mulder WJM, Fayad ZA, Farokhzad OC, Langer R, Mass Production and Size Control of Lipid-Polymer Hybrid Nanoparticles through Controlled Microvortices. NANO LETT 2012;12 (7):3587-3591 [PubMed]
  • Mieszawska AJ, Gianella A, Cormode DP, Zhao Y, Meijerink A, Langer R, Farokhzad OC, Fayad ZA, Mulder WJM, Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging. CHEM COMMUN 2012;48 (47):5835-5837 [PubMed]
  • Tang J, Lobatto ME, Read JC, Mieszawska AJ, Fayad ZA, Mulder WJM, Nanomedical Theranostics in Cardiovascular Disease. CURR CARDIOVASC IMAGING REP 2012;5 (1):19-25 [PubMed]
  • van Bochove GS, Sanders HMHF, de Smet M, Keizer HM, Mulder WJM, Krams R, Strijkers GJ, Nicolay K, Molecular MR Imaging of Collagen in Mouse Atherosclerosis by Using Paramagnetic CNA35 Micelles. EUR J INORG CHEM 2012;2012 (12):2115-2125


  • Chen W, Cormode DP, Fayad ZA, Mulder WJM, Nanoparticles as magnetic resonance imaging contrast agents for vascular and cardiac diseases. WIRES NANOMED NANOBI 2011;3 (2):146-161 [PubMed]
  • Cormode DP, Mulder WJM, Fayad ZA, Science to practice: versatile method to track transplanted encapsulated islet cells with multiple imaging modalities. RADIOLOGY 2011;258 (1):1-2 [PubMed]
  • Cormode DP, Skajaa GO, Delshad A, Parker N, Jarzyna PA, Calcagno C, Galper MW, Skajaa T, Briley-Saebo KC, Bell HM, Gordon RE, Fayad ZA, Woo SLC, Mulder WJM, A versatile and tunable coating strategy allows control of nanocrystal delivery to cell types in the liver. BIOCONJUGATE CHEM 2011;22 (3):353-361 [PubMed]
  • Gianella A, Jarzyna PA, Mani V, Ramachandran S, Calcagno C, Tang J, Kann B, Dijk WJR, Thijssen VL, Griffioen AW, Storm G, Fayad ZA, Mulder WJM, Multifunctional nanoemulsion platform for imaging guided therapy evaluated in experimental cancer. ACS NANO 2011;5 (6):4422-4433 [PubMed]
  • Klink A, Heynens J, Herranz B, Lobatto ME, Arias T, Sanders HMHF, Strijkers GJ, Merkx M, Nicolay K, Fuster V, Tedgui A, Mallat Z, Mulder WJM, Fayad ZA, In vivo characterization of a new abdominal aortic aneurysm mouse model with conventional and molecular magnetic resonance imaging. J AM COLL CARDIOL 2011;58 (24):2522-2530 [PubMed]
  • Klink A, Hyafil F, Rudd J, Faries P, Fuster V, Mallat Z, Meilhac O, Mulder WJM, Michel JB, Ramirez F, Storm G, Thompson R, Turnbull IC, Egido J, Martín-Ventura JL, Zaragoza C, Letourneur D, Fayad ZA, Diagnostic and therapeutic strategies for small abdominal aortic aneurysms. NAT REV CARDIOL 2011;8 (6):338-347 [PubMed]
  • Lobatto ME, Fuster V, Fayad ZA, Mulder WJM, Perspectives and opportunities for nanomedicine in the management of atherosclerosis. NAT REV DRUG DISCOV 2011;10 (11):835-852 [PubMed]
  • Lobatto ME, Fuster V, Fayad ZA, Mulder WJM, Perspectives and opportunities for nanomedicine in the management of atherosclerosis (vol 10, pg 835, 2011). NAT REV DRUG DISCOV 2011;10 (12):963
  • Skajaa T, Cormode DP, Jarzyna PA, Delshad A, Blachford C, Barazza A, Fisher EA, Gordon RE, Fayad ZA, Mulder WJM, The biological properties of iron oxide core high-density lipoprotein in experimental atherosclerosis. BIOMATERIALS 2011;32 (1):206-213 [PubMed]
  • Starmans LWE, Kok MB, Sanders HMHF, Zhao Y, Donegá CdM, Meijerink A, Mulder WJM, Grüll H, Strijkers GJ, Nicolay K, Influence of cell-internalization on relaxometric, optical and compositional properties of targeted paramagnetic quantum dot micelles. CONTRAST MEDIA MOL I 2011;6 (2):100-109 [PubMed]
  • van Bochove GS, Paulis LEM, Segers D, Mulder WJM, Krams R, Nicolay K, Strijkers GJ, Contrast enhancement by differently sized paramagnetic MRI contrast agents in mice with two phenotypes of atherosclerotic plaque. CONTRAST MEDIA MOL I 2011;6 (1):35-45 [PubMed]


  • Chen W, Jarzyna PA, van Tilborg GAF, Nguyen VA, Cormode DP, Klink A, Griffioen AW, Randolph GJ, Fisher EA, Mulder WJM, Fayad ZA, RGD peptide functionalized and reconstituted high-density lipoprotein nanoparticles as a versatile and multimodal tumor targeting molecular imaging probe. FASEB J 2010;24 (6):1689-1699 [PubMed]
  • Cormode DP, Jarzyna PA, Mulder WJM, Fayad ZA, Modified natural nanoparticles as contrast agents for medical imaging. ADV DRUG DELIVER REV 2010;62 (3):329-338 [PubMed]
  • Cormode DP, Roessl E, Thran A, Skajaa T, Gordon RE, Schlomka JP, Fuster V, Fisher EA, Mulder WJM, Proksa R, Fayad ZA, Atherosclerotic plaque composition: analysis with multicolor CT and targeted gold nanoparticles. RADIOLOGY 2010;256 (3):774-782 [PubMed]
  • Jarzyna PA, Gianella A, Skajaa T, Knudsen G, Deddens LH, Cormode DP, Fayad ZA, Mulder WJM, Multifunctional imaging nanoprobes. WIRES NANOMED NANOBI 2010;2 (2):138-150 [PubMed]
  • Klink A, Lancelot E, Ballet S, Vucic E, Fabre JE, Gonzalez W, Medina C, Corot C, Mulder WJM, Mallat Z, Fayad ZA, Magnetic resonance molecular imaging of thrombosis in an arachidonic acid mouse model using an activated platelet targeted probe. ARTERIOSCL THROM VAS 2010;30 (3):403-410 [PubMed]
  • Kluza E, van der Schaft DWJ, Hautvast PAI, Mulder WJM, Mayo KH, Griffioen AW, Strijkers GJ, Nicolay K, Synergistic targeting of alphavbeta3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis. NANO LETT 2010;10 (1):52-58 [PubMed]
  • Lobatto ME, Fayad ZA, Silvera S, Vucic E, Calcagno C, Mani V, Dickson SD, Nicolay K, Banciu M, Schiffelers RM, Metselaar JM, van Bloois L, Wu HS, Fallon JT, Rudd JH, Fuster V, Fisher EA, Storm G, Mulder WJM, Multimodal clinical imaging to longitudinally assess a nanomedical anti-inflammatory treatment in experimental atherosclerosis. MOL PHARMACEUT 2010;7 (6):2020-2029 [PubMed]
  • Mulder WJM, Griffioen AW, Imaging of angiogenesis. ANGIOGENESIS 2010;13 (2):71-74 [PubMed]
  • Mulder WJM, Strijkers GJ, Nicolay K, Griffioen AW, Quantum dots for multimodal molecular imaging of angiogenesis. ANGIOGENESIS 2010;13 (2):131-134 [PubMed]
  • Skajaa T, Cormode DP, Falk E, Mulder WJM, Fisher EA, Fayad ZA, High-density lipoprotein-based contrast agents for multimodal imaging of atherosclerosis. ARTERIOSCL THROM VAS 2010;30 (2):169-176 [PubMed]
  • Skajaa T, Zhao Y, van den Heuvel DJ, Gerritsen HC, Cormode DP, Koole R, van Schooneveld MM, Post JA, Fisher EA, Fayad ZA, de Mello Donega C, Meijerink A, Mulder WJM, Quantum Dot and Cy5.5 Labeled Nanoparticles to Investigate Lipoprotein Biointeractions via Förster Resonance Energy Transfer. NANO LETT 2010;10 (12):5131-5138 [PubMed]
  • Strijkers GJ, Kluza E, van Tilborg GAF, van der Schaft DWJ, Griffioen AW, Mulder WJM, Nicolay K, Paramagnetic and fluorescent liposomes for target-specific imaging and therapy of tumor angiogenesis. ANGIOGENESIS 2010;13 (2):161-173 [PubMed]
  • van Schooneveld MM, Cormode DP, Koole R, van Wijngaarden JT, Calcagno C, Skajaa T, Hilhorst J, 't Hart DC, Fayad ZA, Mulder WJM, Meijerink A, A fluorescent, paramagnetic and PEGylated gold/silica nanoparticle for MRI, CT and fluorescence imaging. CONTRAST MEDIA MOL I 2010;5 (4):231-236 [PubMed]
  • van Schooneveld MM, Gloter A, Stephan O, Zagonel LF, Koole R, Meijerink A, Mulder WJM, de Groot FMF, Imaging and quantifying the morphology of an organic-inorganic nanoparticle at the sub-nanometre level. NAT NANOTECHNOL 2010;5 (7):538-544 [PubMed]
  • van Tilborg GAF, Vucic E, Strijkers GJ, Cormode DP, Mani V, Skajaa T, Reutelingsperger CPM, Fayad ZA, Mulder WJM, Nicolay K, Annexin A5-functionalized bimodal nanoparticles for MRI and fluorescence imaging of atherosclerotic plaques. BIOCONJUGATE CHEM 2010;21 (10):1794-1803 [PubMed]


  • Beilvert A, Cormode DP, Chaubet F, Briley-Saebo KC, Mani V, Mulder WJM, Vucic E, Toussaint JF, Letourneur D, Fayad ZA, Tyrosine polyethylene glycol (PEG)-micelle magnetic resonance contrast agent for the detection of lipid rich areas in atherosclerotic plaque. MAGN RESON MED 2009;62 (5):1195-1201 [PubMed]
  • Briley-Saebo KC, Geninatti-Crich S, Cormode DP, Barazza A, Mulder WJM, Chen W, Giovenzana GB, Fisher EA, Aime S, Fayad ZA, High-relaxivity gadolinium-modified high-density lipoproteins as magnetic resonance imaging contrast agents. J PHYS CHEM B 2009;113 (18):6283-6289 [PubMed]
  • Cormode DP, Chandrasekar R, Delshad A, Briley-Saebo KC, Calcagno C, Barazza A, Mulder WJM, Fisher EA, Fayad ZA, Comparison of synthetic high density lipoprotein (HDL) contrast agents for MR imaging of atherosclerosis. BIOCONJUGATE CHEM 2009;20 (5):937-943 [PubMed]
  • Cormode DP, Frias JC, Ma Y, Chen W, Skajaa T, Briley-Saebo K, Barazza A, Williams KJ, Mulder WJ, Fayad ZA, Fisher EA, HDL as a contrast agent for medical imaging. CLIN LIPIDOL 2009;4 (4):493-500 [PubMed]
  • Cormode DP, Skajaa T, Fayad ZA, Mulder WJM, Nanotechnology in medical imaging: probe design and applications. ARTERIOSCL THROM VAS 2009;29 (7):992-1000 [PubMed]
  • Jarzyna PA, Skajaa T, Gianella A, Cormode DP, Samber DD, Dickson SD, Chen W, Griffioen AW, Fayad ZA, Mulder WJM, Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging. BIOMATERIALS 2009;30 (36):6947-6954 [PubMed]
  • Kok MB, Hak S, Mulder WJM, van der Schaft DWJ, Strijkers GJ, Nicolay K, Cellular compartmentalization of internalized paramagnetic liposomes strongly influences both T1 and T2 relaxivity. MAGN RESON MED 2009;61 (5):1022-1032 [PubMed]
  • Koole R, Mulder WJM, van Schooneveld MM, Strijkers GJ, Meijerink A, Nicolay K, Magnetic quantum dots for multimodal imaging. WIRES NANOMED NANOBI 2009;1 (5):475-491 [PubMed]
  • Mulder WJM, Castermans K, van Beijnum JR, Oude Egbrink MGA, Chin PTK, Fayad ZA, Löwik CWGM, Kaijzel EL, Que I, Storm G, Strijkers GJ, Griffioen AW, Nicolay K, Molecular imaging of tumor angiogenesis using alphavbeta3-integrin targeted multimodal quantum dots. ANGIOGENESIS 2009;12 (1):17-24 [PubMed]
  • Mulder WJM, Strijkers GJ, van Tilborg GAF, Cormode DP, Fayad ZA, Nicolay K, Nanoparticulate assemblies of amphiphiles and diagnostically active materials for multimodality imaging. ACCOUNTS CHEM RES 2009;42 (7):904-914 [PubMed]
  • Sanders HMHF, Strijkers GJ, Mulder WJM, Huinink HP, Erich SJF, Adan OCG, Sommerdijk NAJM, Merkx M, Nicolay K, Morphology, binding behavior and MR-properties of paramagnetic collagen-binding liposomes. CONTRAST MEDIA MOL I 2009;4 (2):81-88 [PubMed]
  • Vucic E, Sanders HMHF, Arena F, Terreno E, Aime S, Nicolay K, Leupold E, Dathe M, Sommerdijk NAJM, Fayad ZA, Mulder WJM, Well-defined, multifunctional nanostructures of a paramagnetic lipid and a lipopeptide for macrophage imaging. J AM CHEM SOC 2009;131 (2):406-407 [PubMed]


  • Briley-Saebo KC, Shaw PX, Mulder WJM, Choi SH, Vucic E, Aguinaldo JGS, Witztum JL, Fuster V, Tsimikas S, Fayad ZA, Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. CIRCULATION 2008;117 (25):3206-3215 [PubMed]
  • Chen W, Vucic E, Leupold E, Mulder WJM, Cormode DP, Briley-Saebo KC, Barazza A, Fisher EA, Dathe M, Fayad ZA, Incorporation of an apoE-derived lipopeptide in high-density lipoprotein MRI contrast agents for enhanced imaging of macrophages in atherosclerosis. CONTRAST MEDIA MOL I 2008;3 (6):233-242 [PubMed]
  • Cormode DP, Briley-Saebo KC, Mulder WJM, Aguinaldo JGS, Barazza A, Ma Y, Fisher EA, Fayad ZA, An ApoA-I mimetic peptide high-density-lipoprotein-based MRI contrast agent for atherosclerotic plaque composition detection. SMALL 2008;4 (9):1437-1444 [PubMed]
  • Cormode DP, Skajaa T, van Schooneveld MM, Koole R, Jarzyna P, Lobatto ME, Calcagno C, Barazza A, Gordon RE, Zanzonico P, Fisher EA, Fayad ZA, Mulder WJM, Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform. NANO LETT 2008;8 (11):3715-3723 [PubMed]
  • Koole R, van Schooneveld MM, Hilhorst J, Castermans K, Cormode DP, Strijkers GJ, de Mello Donegá C, Vanmaekelbergh D, Griffioen AW, Nicolay K, Fayad ZA, Meijerink A, Mulder WJM, Paramagnetic lipid-coated silica nanoparticles with a fluorescent quantum dot core: a new contrast agent platform for multimodality imaging. BIOCONJUGATE CHEM 2008;19 (12):2471-2479 [PubMed]
  • Mulder WJM, Cormode DP, Hak S, Lobatto ME, Silvera S, Fayad ZA, Multimodality nanotracers for cardiovascular applications. NAT CLIN PRACT CARD 2008;5 (Suppl. 2):S103-S111 [PubMed]
  • Mulder WJM, Fayad ZA, Nanomedicine captures cardiovascular disease. ARTERIOSCL THROM VAS 2008;28 (5):801-802 [PubMed]
  • van Schooneveld MM, Vucic E, Koole R, Zhou Y, Stocks J, Cormode DP, Tang CY, Gordon RE, Nicolay K, Meijerink A, Fayad ZA, Mulder WJM, Improved biocompatibility and pharmacokinetics of silica nanoparticles by means of a lipid coating: a multimodality investigation. NANO LETT 2008;8 (8):2517-2525 [PubMed]
  • van Tilborg GAF, Mulder WJM, van der Schaft DWJ, Reutelingsperger CPM, Griffioen AW, Strijkers GJ, Nicolay K, Improved magnetic resonance molecular imaging of tumor angiogenesis by avidin-induced clearance of nonbound bimodal liposomes. NEOPLASIA 2008;10 (12):1459-1469 [PubMed]
  • van Tilborg GAF, Strijkers GJ, Pouget EM, Reutelingsperger CPM, Sommerdijk NAJM, Nicolay K, Mulder WJM, Kinetics of avidin-induced clearance of biotinylated bimodal liposomes for improved MR molecular imaging. MAGN RESON MED 2008;60 (6):1444-1456 [PubMed]


  • Brandwijk RJMGE, Mulder WJM, Nicolay K, Mayo KH, Thijssen VLJL, Griffioen AW, Anginex-conjugated liposomes for targeting of angiogenic endothelial cells. BIOCONJUGATE CHEM 2007;18 (3):785-790 [PubMed]
  • Briley-Saebo KC, Mulder WJM, Mani V, Hyafil F, Amirbekian V, Aguinaldo JGS, Fisher EA, Fayad ZA, Magnetic resonance imaging of vulnerable atherosclerotic plaques: current imaging strategies and molecular imaging probes. J MAGN RESON IMAGING 2007;26 (3):460-479 [PubMed]
  • Cormode DP, Mulder WJM, Fisher EA, Fayad ZA, Modified lipoproteins as contrast agents for molecular imaging. FUTURE LIPIDOL 2007;2 (6):587-590
  • Mulder WJM, Griffioen AW, Strijkers GJ, Cormode DP, Nicolay K, Fayad ZA, Magnetic and fluorescent nanoparticles for multimodality imaging. NANOMEDICINE-UK 2007;2 (3):307-324 [PubMed]
  • Mulder WJM, Strijkers GJ, Briley-Saboe KC, Frias JC, Aguinaldo JGS, Vucic E, Amirbekian V, Tang C, Chin PTK, Nicolay K, Fayad ZA, Molecular imaging of macrophages in atherosclerotic plaques using bimodal PEG-micelles. MAGN RESON MED 2007;58 (6):1164-1170 [PubMed]
  • Mulder WJM, Strijkers GJ, Vucic E, Cormode DP, Nicolay K, Fayad ZA, Magnetic resonance molecular imaging contrast agents and their application in atherosclerosis. TOP MAGN RESON IMAGING 2007;18 (5):409-417 [PubMed]
  • Mulder WJM, van der Schaft DWJ, Hautvast PAI, Strijkers GJ, Koning GA, Storm G, Mayo KH, Griffioen AW, Nicolay K, Early in vivo assessment of angiostatic therapy efficacy by molecular MRI. FASEB J 2007;21 (2):378-383 [PubMed]
  • Reulen SWA, Brusselaars WWT, Langereis S, Mulder WJM, Breurken M, Merkx M, Protein-liposome conjugates using cysteine-lipids and native chemical ligation. BIOCONJUGATE CHEM 2007;18 (2):590-596 [PubMed]
  • Strijkers GJ, Mulder WJM, van Tilborg GAF, Nicolay K, MRI contrast agents: current status and future perspectives. ANTI-CANCER AGENT ME 2007;7 (3):291-305 [PubMed]


  • Mulder WJM, Douma K, Koning GA, van Zandvoort MA, Lutgens E, Daemen MJ, Nicolay K, Strijkers GJ, Liposome-enhanced MRI of neointimal lesions in the ApoE-KO mouse. MAGN RESON MED 2006;55 (5):1170-1174 [PubMed]
  • Mulder WJM, Koole R, Brandwijk RJ, Storm G, Chin PTK, Strijkers GJ, de Mello Donegá C, Nicolay K, Griffioen AW, Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe. NANO LETT 2006;6 (1):1-6 [PubMed]
  • Mulder WJM, Strijkers GJ, van Tilborg GAF, Griffioen AW, Nicolay K, Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging. NMR BIOMED 2006;19 (1):142-164 [PubMed]
  • van Tilborg GAF, Mulder WJM, Chin PTK, Storm G, Reutelingsperger CP, Nicolay K, Strijkers GJ, Annexin A5-conjugated quantum dots with a paramagnetic lipidic coating for the multimodal detection of apoptotic cells. BIOCONJUGATE CHEM 2006;17 (4):865-868 [PubMed]
  • van Tilborg GAF, Mulder WJM, Deckers N, Storm G, Reutelingsperger CPM, Strijkers GJ, Nicolay K, Annexin A5-functionalized bimodal lipid-based contrast agents for the detection of apoptosis. BIOCONJUGATE CHEM 2006;17 (3):741-749 [PubMed]


  • Mulder WJM, Strijkers GJ, Habets JW, Bleeker EJW, van der Schaft DWJ, Storm G, Koning GA, Griffioen AW, Nicolay K, MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle. FASEB J 2005;19 (14):2008-2010 [PubMed]
  • Strijkers GJ, Mulder WJM, van Heeswijk RB, Frederik PM, Bomans P, Magusin PCMM, Nicolay K, Relaxivity of liposomal paramagnetic MRI contrast agents. MAGN RESON MATER PHY 2005;18 (4):186-192 [PubMed]


  • Mulder WJM, Strijkers GJ, Griffioen AW, van Bloois L, Molema G, Storm G, Koning GA, Nicolay K, A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets. BIOCONJUGATE CHEM 2004;15 (4):799-806 [PubMed]
  • Velinova MJ, Staffhorst RWHM, Mulder WJM, Dries AS, Jansen BAJ, de Kruijff B, de Kroon AIPM, Preparation and stability of lipid-coated nanocapsules of cisplatin: anionic phospholipid specificity. BBA-BIOMEMBRANES 2004;1663 (1-2):135-142 [PubMed]


  • Bruin T, Tuzgöl S, Mulder WJ, van den Ende AE, Jansen H, Hayden MR, Kastelein JJ, A compound heterozygote for lipoprotein lipase deficiency, Val69-->Leu and Gly188-->Glu: correlation between in vitro LPL activity and clinical expression. J LIPID RES 1994;35 (3):438-445 [PubMed]
  • Knipscheer HC, Nurmohamed MT, van den Ende A, Plaat B, Pruijs HJ, Mulder WJ, Kastelein JJ, Gemfibrozil treatment of the high triglyceride-low high-density lipoprotein cholesterol trait in men with established atherosclerosis. J INTERN MED 1994;236 (4):377-384 [PubMed]


  • Mulder WJ, Berghout A, Wiersinga WM, Cushing's syndrome during pregnancy. NETH J MED 1990;36 (5-6):234-241 [PubMed]