Dr. A.P.J Vlaar MD PhD

foto

Dr. A.P.J Vlaar MD PhD

Position
Other
Main activities
Patient care, Research, Teaching
Specialisation
Internal Medicine, Intensive Care Medicine
Focus of research

Transfusion related morbidity and mortality in the critically ill

Key publications
  • Vlaar APJ, Juffermans NP, Transfusion-related acute lung injury: a clinical review. LANCET 2013;382 (9896):984-994 [PubMed]
  • Vlaar APJ, Hofstra JJ, Determann RM, Veelo DP, Paulus F, Kulik W, Korevaar J, de Mol BA, Koopman MMW, Porcelijn L, Binnekade JM, Vroom MB, Schultz MJ, Juffermans NP, The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study. BLOOD 2011;117 (16):4218-4225 [PubMed]
  • Vlaar APJ, Hofstra JJ, Kulik W, van Lenthe H, Nieuwland R, Schultz MJ, Levi MM, Roelofs JJTH, Tool ATJ, de Korte D, Juffermans NP, Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model. BLOOD 2010;116 (8):1360-1368 [PubMed]
  • Peters AL, van Hezel ME, Cortjens B, Tuip-de Boer AM, van Bruggen R, de Korte D, Jonkers RE, Bonta PI, Zeerleder SS, Lutter R, Juffermans NP, Vlaar APJ, Transfusion of 35-Day Stored RBCs in the Presence of Endotoxemia Does Not Result in Lung Injury in Humans. CRIT CARE MED 2016;44 (6):e412-e419 [PubMed]
  • Müller MCA , van Stein D, Binnekade JM, van Rhenen DJ, Vlaar APJ, Low-risk transfusion-related acute lung injury donor strategies and the impact on the onset of transfusion-related acute lung injury: a meta-analysis. TRANSFUSION 2015;55 (1):164-175 [PubMed]
All Publications
Research programmes

Transfusion related morbidity and mortality

Alexander Vlaar has received his MD degree in 2005 from the Faculty of Medicine of the University of Groningen and his PhD degree in 2010 from the Faculty of Medicine of the University of Amsterdam. In 2015 he was board certified in Internal Medicine and in 2016 he received European board certification in Intensive Care Medicine. Since 2016, Alexander Vlaar is consultant critical care medicine and principal investigator at the Department of Intensive Care Medicine and at the Laboratory of Experimental Intensive Care and Anesthesiology. 

Focus of Alexanders’ research is transfusion related morbidity and mortality in the critically ill. His research lines consist, among others, of pre-clinical and clinical investigation in the field of antibody and non-antibody mediated transfusion related acute lung injury (TRALI). Alexander Vlaar is currently supported by a personal grant from the Netherlands Organization for Health Research and Development (NWO-VENI grant 2013). His research has been awarded with many scientific awards. Recently he received for his work the Heineken Young Scientist Award for Medicine 2014 from the Royal Netherlands Academy of Arts and Sciences (KNAW).

Faculty
Dr. A.P.J Vlaar MD PhD
Prof. dr. M.W. Hollmann MD PhD
Prof. N.P. Juffermans MD PhD
Prof. W.S. Schlack MD PhD
Prof. M.J. Schultz MD PhD
Prof. dr. M.B. Vroom MD
Prof. dr. W.J. Wiersinga MD PhD

PhD Students
F.E.H.P. van Baarle
Drs. J. Bosboom
S. de Bruin MSc (Sanquin)
M. Karami
R.B. Klanderman MD
K.S.H. Morsing (Sanquin Research and Landsteiner Laboratory)
Drs. E.K. van de Weerdt
M. Wijnberge

Prof. dr. M.W. Hollmann MD PhD (Organprotection)

Prof. M.J. Schultz MD PhD (Prevention and treatment of organ failure in intensive care medicine)

Prof. N.P. Juffermans MD PhD (Pathogenesis and treatment of organ failure in the critically ill)

Current research funding
  • Asahi Kasai Pharma America Corp.
  • Edwards Lifesciences
  • Isala
  • Sanquin Plasma Products B.V.
  • Sanquin - Unit Transfusiegeneeskunde
  • ZonMw