Dr. J. Horn MD PhD

foto

Dr. J. Horn MD PhD

Position
Scientific staff member (UD)
Main activities
Patient care, Research
Specialisation
Neurologist - intensivst
Focus of research

1) ICU acquired weakness.  

2) Brain injury after cardiac arrest

 

Key publications
  • Bouwes A, Binnekade JM, Kuiper MA, Bosch FH, Zandstra DF, Toornvliet AC, Biemond HS, Kors BM, Koelman JHTM, Verbeek MM, Weinstein HC, Hijdra A, Horn J, Prognosis of coma after therapeutic hypothermia: A prospective cohort study. ANN NEUROL 2012;71 (2):206-212 [PubMed]
  • Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Åneman A, al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Køber L, Langørgen J, Lilja G, Møller JE, Rundgren M, Rylander C, Smid O, Werer C, Winkel P, Friberg H [Contributors: Nielsen N, Cronberg T, Erlinge D, Friberg H, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Gasche Y, Pellis T, Stammet P, Wanscher M, Wetterslev J, Wise MP, Åneman A, Winkel P, Køber LV, Annane D, Wernerman J, Lange T, Lilja G, Karlsson UB, Jergle-Almqvist L, Grevstad B, Whitfield K, Micallef S, Glass P, Myburgh J, Saxena M, Stewart A, Finfer S, Bishop G, Rajbhandari D, Hammond N, Willenberg L, Miller J, Inskip D, Macken L, Eatough N, Bass F, Yarad E, O'Connor A, Bird S, Jewell T, Davies G, Ng K, Coward S, Parker S, Cortado D, Gould A, Harward M, Thompson K, Smid O, Belholavek J, Kreckova M, Kral A, Horak J, Otahal M, Rulisek J, Malik J, Prettl M, Wascher M, Boesgaard S, Moller JE, Bro-Jeppesen J, Johansen AL, Campanile V, Peratoner A, Verginella F, Leone D, Roncarati A, Franceschino E, Sanzani A, Martini A, Perlin M, Pelosi P, Brunetti I, Insorsi A, Pezzato S, de Luca G, Gazzano E, Ottonello GA, Furgani A, Telani R, Maiani S, Werer C, Kieffer J, vd Veen AL, Winters T, Juffermans NP, Bosch F, Raaijmakers MAM, Metz-Hermans SWL, Endeman H, Rijkenberg S, Bianchi A, Bugge JF, Norum H, Espinoza A, Kerans V, Brevik H, Svalebjørg M, Grindheim G, Petersen AJ, Baratt-Due A, Laake JH, Spreng U, Karlsen MMW, Langøren J, Fanebust R, Holm MS, Flinterud SI, Wickman C, Johnsson J, Ebner F, Gustavsson N, Petersson H, Petersson J, Nasiri F, Stafilidou F, Edqvist K, Uhlig S, Sköld G, Sanner J, Wallskog J, Wyon N, Golster M, Samuelsson A, Hildebrand C, Kadowaki T, Larsson-Viksten J, de Geer L, Hansson P, Appelberg H, Hellsten A, Lind S, Rundgren M, Kander T, Persson J, Annborn M, Adolfsson A, Corrigan I, Dragancea I, Undén J, Larsson M, Chew M, Unnerbäck M, Petersen P, Svedung-Rudebou A, Svensson R, Elvenes H, Bäckman C, Rylander C, Martner P, Martinell L, Biber B, Ahlqvist M, Jacobson C, Forsberg ML, Lindgren RD, Bergquist F, Thorén A, Fredholm M, Sellgren J, Segerstad LHa, Löfgren M, Gustavsson I, Henström C, Andersson B, Thiringer K, Rydholm N, Persson S, Jawad J, Östman I, Berglind I, Bergström E, Andersson A, Törnqvist C, de Mello NLM, Gardaz V, Kleger GR, Schrag C, Fässler E, Zender H, Wise M, Palmer N, Fouweather J, Cole JM, Cocks E, Frost PJ, Saayman AG, Holmes T, Hingston CD, Scholey GM, Watkins H, Fernandez S, Walden A, Atkinson J, Jacques N, Brown A, Cranshaw J, Berridge P, McCormick R, Schuster-Bruce M, Scott M, White N, Vickers E, Glover G, Ostermann M, Holmes P, Koutroumanidis M, Lei K, Sanderson B, Smith J, al-Subaie N, Moore M, Randall P, Mellinghoff J, Buratti AF, Ryan C, Ball J, Francis G]] , Targeted temperature management at 33°C versus 36°C after cardiac arrest. NEW ENGL J MED 2013;369 (23):2197-2206 [PubMed]
  • Lilja G, Nielsen N, Friberg H, Horn J, Kjaergaard J, Nilsson F, Pellis T, Wetterslev J, Wise MP, Bosch F, Bro-Jeppesen J, Brunetti I, Buratti AF, Hassager C, Hofgren C, Insorsi A, Kuiper M, Martini A, Palmer N, Rundgren M, Rylander C, van der Veen A, Wanscher M, Watkins H, Cronberg T, Cognitive function in survivors of out-of-hospital cardiac arrest after target temperature management at 33°C versus 36°C. CIRCULATION 2015;131 (15):1340-1349 [PubMed]
  • Westhall E, Rossetti AO, van Rootselaar AF, Wesenberg Kjaer T, Horn J, Ullén S, Friberg H, Nielsen N, Rosén I, Åneman A, Erlinge D, Gasche Y, Hassager C, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wetterslev J, Wise MP, Cronberg T [Contributors: Saxena M, Miller J, Inskip D, Macken L, Finfer S, Eatough N, Hammond N, Bass F, Yarad E, O'Connor A, Bird S, Jewell T, Davies G, Ng K, Coward S, Åneman A, Stewart A, Micallef S, Parker S, Cortado D, Gould A, Harward M, Thompson K, Glass P, Myburgh J, Smid O, Belholavek J, Kreckova M, Kral A, Horak J, Otahal M, Rulisek J, Malik J, Prettl M, Kjaergaard J, Hassager C, Wascher M, Boesgaard S, Moller JE, Bro-Jeppesen J, Johansen AL, Campanile V, Peratoner A, Verginella F, Leone D, Pellis T, Roncarati A, Franceschino E, Sanzani A, Martini A, Perlin M, Pelosi P, Brunetti I, Insorsi A, Pezzato S, de Luca G, Gazzano E, Ottonello GA, Furgani A, Telani R, Maiani S, Stammet P, Werer C, Kieffer J, Horn J, van der Veen AL, Winters T, Juffermans NP, Kuiper M, Egbers P, Boerma E, Gerritsen RT, Buter H, de Jager C, de Lange F, Loos M, Koetsier PM, Kingma WP, Bruins N, de Kock L, Koopmans M, Bosch F, Raaijmakers MAM, Metz-Hermans SWL, Endeman H, Rijkenberg S, Bianchi A, Hovdenes J, Bugge JF, Norum H, Espinoza A, Kerans V, Brevik H, Svalebjørg M, Grindheim G, Petersen AJ, Baratt-Due A, Laake JH, Spreng U, Wallander Karlsen MM, Langøren J, Fanebust R, Holm MS, Flinterud SI, Wickman C, Johnsson J, Ebner F, Gustavsson N, Petersson H, Petersson J, Nasiri F, Stafilidou F, Edqvist K, Uhlig S, Sköld G, Sanner J, Wallskog J, Wyon N, Golster M, Samuelsson A, Hildebrand C, Kadowaki T, Larsson-Viksten J, de Geer L, Hansson P, Appelberg H, Hellsten A, Lind S, Rundgren M, Kander T, Persson J, Annborn M, Adolfsson A, Corrigan I, Cronberg T, Friberg H, Dragancea I, Undén J, Larsson M, Chew M, Unnerbäck M, Petersen P, Svedung-Rudebou A, Svensson R, Elvenes H, Bäckman C, Rylander C, Martner P, Martinell L, Biber B, Ahlqvist M, Jacobson C, Forsberg ML, Lindgren RD, Bergquist F, Thorén A, Fredholm M, Sellgren J, Hård Af Segerstad L, Löfgren M, Gustavsson I, Henström C, Andersson B, Thiringer K, Rydholm N, Persson S, Jawad J, Östman I, Berglind I, Bergström E, Andersson A, Törnqvist C, Gasche Y, Marques de Mello NL, Gardaz V, Kleger GR, Schrag C, Fässler E, Zender H, Wise M, Palmer N, Fouweather J, Cole JM, Cocks E, Frost PJ, Saayman AG, Holmes T, Hingston CD, Scholey GM, Watkins H, Fernandez S, Walden A, Atkinson J, Jacques N, Brown A, Cranshaw J, Berridge P, McCormick R, Schuster-Bruce M, Scott M, White N, Vickers E, Glover G, Ostermann M, Holmes P, Koutroumanidis M, Lei K, Sanderson B, Smith J, al-Subaie N, Moore M, Randall P, Mellinghoff J, Buratti AF, Ryan C, Ball J, Francis G]] , Standardized EEG interpretation accurately predicts prognosis after cardiac arrest. NEUROLOGY 2016;86 (16):1482-1490 [PubMed]
  • Bouwes A, Binnekade JM, Zandstra DF, Koelman JHTM, van Schaik IN, Hijdra A, Horn J, Somatosensory evoked potentials during mild hypothermia after cardiopulmonary resuscitation. NEUROLOGY 2009;73 (18):1457-1461 [PubMed]
All Publications
Curriculum Vitae

Education
1994 Medical doctor, cum laude, University of Amsterdam
2001 Doctor of Philosophy, title thesis: ‘Calcium Antagonists in Stroke’
2003 Registration as consultant in neurology
2005 Registration as intensivist

Employment
Nov 1994 - Dec 1996 Research physician, dept of neurology, Academic Medical Center (AMC), Amsterdam
Dec 1996 - March 1997 Resident neurology, AMC, Amsterdam
April 1997 - May 2001 Resident neurology, MST Enschede
June 2001 – Sept 2002 Resident clinical neurophysiology, Antonius hospital, Nieuwegein
Nov 2002 - May 2003 Resident neurology, UMC Utrecht
May 2003 - Dec 2003 Consultant in neurology, West Fries Gasthuis, Hoorn.
Dec 2003 - Dec 2005 Fellow intensive care, AMC, Amsterdam
Dec 2005 - Neurologist-intensivist, intensive care, AMC, Univ of Amsterdam

Research
1994-2001 Thesis: Calcium antagonists in Stroke.
Supervisors: Prof.Dr. M. Limburg and Prof.Dr. M. Vermeulen, dept of neurology, AMC, Amsterdam. Date of PhD: March 23, 2001
2001-2002 TCD monitoring after carotid endarterectomy. Dept of Neurophysiology Nieuwegein.
2007 - 2012 Severe traumatic brain injury. Steering committee member of POCON study (prospective cohort study in five Dutch trauma centers).
2003 - Brain injury after cardiac arrest.
Principal investigator of two multicenter prospective Dutch cohort studies on prognosis and determination of outcome.
Principal investigator of single center prospective cohort study on safety and feasibility of helium ventilation.
National coordinator and member of steering group of Target Temperature Management (TTM) study
2009 - Intensive Care Unit acquired weakness.
Prinicipal investigator of prospective cohort study on intensive care unit acquired weakness in which diagnostic tests and outcome is studied (collaboration with rehabilitation medicine).
Supervisor of animal model studies on pathophysiology and treatment options.

Grants
2006 Hersenstichting Prediction of poor outcome with somatosensory evoked potentials (SSEP) during hypothermia in patients after cardiac arrest
2007 Hartstichting Prognosis of postanoxic coma (PROPACII)
2012 ZonMw Agiko stipendium Complement activation in critical illness neuromyopathy
2013 Nationaal Epilepsie Fonds Electroencephalografic status epilepticus in postanoxic coma: to treat or not to treat
 

Research programmes

Neurology on the Intensive Care Unit

Two fields at the interface of intensive care medicine and neurology are my research topics: ICU acquired weakness (ICU-AW) and brain injury after cardiac arrest.
ICU-AW is a major problem which leads to increased mortality and disability. We investigated methods to establish the diagnosis early, autonomic nervous system problems and long-term disability. Despite the research of Luuk Wieske (PhD student), early diagnosis is still difficult. A model for a risk score was developed. This is currently validated in a new large cohort of ICU patients (by Esther Witteveen (PhD student)). She also investigates the use of ultrasound as a diagnostic test. As pathophysiology of ICU-AW is unclear we are developing an animal model in the LEICA laboratory. In this model we will investigate the inflammatory mechanisms involved in ICU-AW and the role of complement activation. Finally, the diaphragm seems to be especially sensitive to the harmful effects of mechanical ventilation. Ventilation induced diaphragm dysfunction is a recently recognized entity on the ICU. With the already available knowledge on ICU-AW we will further develop our research into this topic. Monitoring of the electrical activity of the diaphragm will become a major topic of research. Collaboration exists with the department of neurology and rehabilitation of the AMC and the department of physiology of the VUMC (C. Ottenheim). A Doelmatigheidsgrant has been applied for.
In brain injury after cardiac arrest both treatment and optimal prognostication have been studied and will be the topics for the years to come. By optimizing treatment, brain injury can probably be diminished leading to an improved outcome. Both temperature strategies and neuroprotective drugs will be studied. In postanoxic coma, reliable tools to determine the prognosis of the patient have been developed. However, many questions remain. A large (intern)national collaboration exists for this research topic.

Faculty
Dr. J. Horn MD PhD
Prof. dr. R.H.H. Engelbert PhD PT
Dr. N.C. Hauck-Weber PhD
J. Hofmeijer MD PhD (Technical University of Twente)
Prof. dr. M.W. Hollmann MD PhD
Prof. N.P. Juffermans MD PhD
Dr. W.K. Lagrand MD PhD
Dr. P.B. Lirk MSc
Prof. F. Nollet MD PhD
Prof. dr. B. Preckel MA MD PhD
Prof. dr. ir. M.J.A.M. van Putten (Technical Medicine, University of Twente)
Dr. M. van der Schaaf
Prof. dr. I.N. van Schaik
Prof. M.J. Schultz MD PhD
Dr. M.F. Stevens MD PhD
Dr. C. Verhamme MD
Dr. ir. C.J. Zuurbier PhD

PhD Students
M.M. Admiraal
Drs. D. Brevoord MD
Drs. G.J. Glas
Drs. J. Sommers MD
Drs. F.M. de Beer
Drs. W. ten Hoope

Others
R.P. Kerindongo
A.J. van der Veen
T. Winters

Prof. M.J. Schultz MD PhD (Prevention and treatment of organ failure in intensive care medicine)

Prof. dr. B. Preckel MA MD PhD (Patient safety, procedural sedation, cardiovascular protection, optimizing perioperative metabolism, cerebral perfusion, Wireless Monitoring)

Prof. dr. M.W. Hollmann MD PhD (Organprotection)

Other research related activities
  • Contribution to guidelines and protocols, CBO guideline SEDATIE EN/OF ANALGESIE (PSA) OP
  • Contribution to guidelines and protocols, Prognostication in comatose survivors of cardiac arrest: an advisory statement from the European Resuscitation Council and the European Society of Intensive Care Medicine.
  • Membership of editorial board / Editorship, NETHERLANDS JOURNAL OF CRITICAL CARE
  • Speakers bureau / Lectures, Nederlandse Vereniging voor neurologie
  • Speakers bureau / Lectures, European Society of Intensive Care Medicin
  • Speakers bureau / Lectures, European Society of Anesthesiology
Current research funding
  • Neurophyxia B.V.
  • ZonMw