Dr. N.C. Hauck-Weber PhD

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Dr. N.C. Hauck-Weber PhD

Position
Scientific staff member (UD)
Main activities
Research
Specialisation
Organ protection, molecular mechanisms "conditioning", inflammation, endothelial research
Focus of research

 

Our research group within the L.E.I.C.A laboratory focusses primarily on protection of heart, blood vessels  (endothelium) and other organs against temporary periods of no oxygen. No oxygen conditions occur frequently in several clinical conditions (surgery, cardiac by-pass operations, shock, stroke, transplantation) and during an acute heart attack. This research therefore has a high clinical and society relevance: it can lead to improvements in clinical care and in the fight against cardiovascular diseases.

Main research focus is

Improving our understanding of underlying mechanisms of different organ protection strategies:

  • Currently we focus on the effects of the sodium glucose hydrogen exchange inhibitors like Empagliflozin on the hart and endothelium and whether these can offer protection in various damaging models. In this context different proteins are in the focus of our investigations: like Caveolins, Hexokinase II and AMPK, eNOS and others.

     

  • Another focus over the last years is ischemic conditioning, remote ischemic preconditioning, and conditioning with special anaesthetic agents as clinically-applicable interventions to protect the organ/tissue against period of no oxygen. As the translation of these intervention has broadly failed we seeks to find more clinically relevant intervention/intervention combination within our in vitro and in vivo models.

  • Organ protection by the noble gas (helium) is observed in experimental models and humans and it might be a perfect alternative as an organprotective intervention. In this project we focus on the potential of helium to affect extracellular vesicles that might be enriched in Cavelolin. In a translational approach using volunteer blood on endothelial cells we aim to find out if helium can itself induce remote conditioning.

 

Key publications
  • Weber NC, Riedemann I, Smit KF, Zitta K, van de Vondervoort D, Zuurbier CJ, Hollmann MW, Preckel B, Albrecht M, Plasma from human volunteers subjected to remote ischemic preconditioning protects human endothelial cells from hypoxia-induced cell damage. BASIC RES CARDIOL 2015;110 (2):17 [PubMed]
  • Weber NC, 'Conditioning the heart' - lessons we have learned from the past and future perspectives for new and old conditioning 'drugs'. BRIT J PHARMACOL 2015;172 (8):1909-1912 [PubMed]
  • Uthman L, Baartscheer A, Bleijlevens B, Schumacher CA, Fiolet JWT, Koeman A, Jancev M, Hollmann MW, Weber NC, Coronel R, Zuurbier CJ, + and vasodilation. DIABETOLOGIA 2018;61 (3):722-726 [PubMed]
  • Smit KF, Kerindongo RP, Böing A, Nieuwland R, Hollmann MW, Preckel B, Weber NC, Effects of helium on inflammatory and oxidative stress-induced endothelial cell damage. EXP CELL RES 2015;337 (1):37-43 [PubMed]
  • Smit KF, Konkel M, Kerindongo R, Landau MA, Zuurbier CJ, Hollman MW, Preckel B, Nieuwland R, Albrecht M, Weber NC, Helium alters the cytoskeleton and decreases permeability in endothelial cells cultured in vitro through a pathway involving Caveolin-1. SCI REP-UK 2018;8 (4768):--- [PubMed]
All Publications
Curriculum Vitae

Master's (‘doctoraal’)
University/College of Higher Education: University of Bonn, Germany
Date (dd/mm/yy): 15.07.1999
Study/main subject: Pharmacy

Doctorate
University/College of Higher Education: University of Munich, Germany
Date (dd/mm/yy): 31/08/1995
Supervisor (‘Promotor’): Prof. Dr. Angelika Vollmar
Title of thesis: (PhD thesis) “Influence of the atrial natriuretic peptide on TNF--activated human endothelial cells.-Regulation of adhesion molecule expression and cytoskeleton changes“ (summa cum laude)

Work experience

April-May 2018 Visiting scientist at the university of San Diego (UCSD), Department of Anesthesiology Professor Hemal Patel

April 2016 Visiting scientist at the university of San Diego (UCSD), Department of Anesthesiology Professor Hemal Patel

October  2015  Visiting scientist at the university of San Diego (UCSD), Department of Anesthesiology Professor Hemal Patel

September-october 2014 Visiting scientist at the university of San Diego (UCSD), Department of Anesthesiology Professor Hemal Patel

August-october 2013 Visiting scientist at the university of San Diego (UCSD), Department of Anesthesiology Professor Hemal Patel
July-august 2012 Visiting scientist at the university of San Diego (UCSD), Department of Anesthesiology Professor Hemal Patel

Since 2006/03  Head of the Laboratory of Experimental Intensive care and Anaesthesiology (L.E.I.C.A.) at the Academic Medical Center, University of Amsterdam, Department of Anesthesiology. Supervision of medical and PhD students, (ESA, SCA, IARS, ZonMW funding)


2009-2016 Editorship, Editorial board the British Journal of Pharmacology

 

Since 2014 Editor of the editorial board Frontiers in Medicine "Intensive Care Medicine and Anesthesiology”

 
2002/12-2006/02 Research pharmacist at the department of the Experimental Anaesthesiology of the Heinrich-Heine-University Düsseldorf; Supervision of medical and PhD students, grant raising (ESA funding, Else Kröner-Fresenius foundation, DFG funding GRK 1089)


2002/07 – 2002/11 Freelancer at the Centre of Drug research (Department of pharmacy and drug research, Ludwig-Maximilian-University of Munich)

International activities/boards/reviewer

2009-2016 Member of the Editorial Board of the British Journal of Pharmacology
Visiting Scientist USCD San Diego, California
Reviewer : Anesthesiology, Anesthesia Analgesia, British journal of Anesthesiology, European and British journal of Pharmacology, Circulation, Circulation research, Molecular pharmacology, Eur J Anesthesiol,

Professional Memberships

Member BPS (British Society of Pharmacology) ongoing
Member DGPKI German Society of Clinical Pharmacology)
1/1999-ongoing
Member ESA (European Society of Anaesthesiology) 1/2003-ongoing
Member SCA (Society of Cardiovascular Anesthesiology) 1/2011-ongoing
Member ASPET (The American Society for Pharmacology and Experimental Therapeutics)
1/2011-ongoing
 

Research programmes

Prof. dr. B. Preckel MA MD PhD (Patient safety, procedural sedation, cardiovascular protection, optimizing perioperative metabolism, cerebral perfusion, Wireless Monitoring)

Prof. M.J. Schultz MD PhD (Prevention and treatment of organ failure in intensive care medicine)

Dr. J. Horn MD PhD (Neurology on the Intensive Care Unit)

Prof. dr. M.W. Hollmann MD PhD (Organprotection)

Prof. N.P. Juffermans MD PhD (Pathogenesis and treatment of organ failure in the critically ill)

Dr. ir. C.J. Zuurbier PhD (Cell survival mechanisms in acute and chronic cardiovascular pathology)

Other research related activities
  • Membership of editorial board / Editorship, BRITISH JOURNAL OF PHARMACOLOGY
  • Membership of editorial board / Editorship, FRONTIERS IN MEDICINE