Prof. M.J. Schultz MD PhD


Prof. M.J. Schultz MD PhD

Main activities
Research, Patient care
Intensive Care
Focus of research

Dr. Schultz main research interests are in the area of acute lung injury/acute respiratory distress syndrome (ALI/ARDS), pneumonia and mechanical ventilation, specifically pre–clinical and clinical studies on the interaction between infection/inflammation and coagulation. His second interest involves implementation of new strategies in daily critical care practice. A third line of interest includes biomarkers of organ failure in the critically ill. Presently, he endorses several PhD–students towards a doctorate University of Amsterdam, Amsterdam , the Netherlands .

Dr. Schultz is presently involved in several projects in collaboration with the Netherlands Organization for Scientific Research (Zorg Onderzoek Nederland, Medische Wetenschappen, ZonMW).

Key publications
  • Hemmes SNT, Gama de Abreu M, Pelosi P, Schultz MJ [Contributors: Hemmes SNT, Gama de Abreu M, Severgnini P, Hollmann MW, Binnekade JM, Wrigge H, Canet J, Hiesmayr M, Schmid W, Jaber S, Hedenstierna G, Putensen C, Pelosi P, Schultz MJ, Sessler DI, Lachmann B, Kacmarek RM, Slutsky AS, de Baerdemaeker L, de Hert S, Heyse B, van Limmen J, Mulier JP, Velghe D, Jamaer L, Vandenbrande J, Bugedo G, Florez J, Goranović T, Mazul-Sunko B, Bluth T, Güldner A, Kiss T, Koch T, Spieth PM, Uhlig C, Yaqub J, Bastin B, Geib J, Schaefer MS, Weiss M, Treschan TA, Reske AW, Simon P, Brodhun A, Ferner M, Hartmann E, Laufenberg-Feldmann R, Strys L, de Robertis E, Perilli V, Proietti R, Amantea B, Caroleo S, Tropea F, Bacuzzi A, Vanoni M, Cinnella G, Caggianelli G, D'Antini D, La Bella D, Mollica G, Cortegiani A, Giarratano A, Montalto F, Raineri SM, Barberis B, Celentano C, Grio M, Spagnolo L, Gratarola A, Molin A, Pellerano G, Pezzato S, Rusca R, Della Rocca G, Bos LDJ, Brunelli A, Marti A, Cegarra V, Merten A, Moral MV, Parera A, Unzueta MC, Sabaté S, Sierra P, Mayoral JF, Prieto M, Gil MG, Marín CM, Mills GH, Bodger P, Vidal Melo MF, Sulemanji D, Sprung J]] , High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial. LANCET 2014;384 (9942):495-503 [PubMed]
  • Dondorp AM, Iyer SS, Schultz MJ, Critical Care in Resource-Restricted Settings. JAMA-J AM MED ASSOC 2016;315 (8):753-754 [PubMed]
  • Serpa Neto A, Cardoso SO, Manetta JA, Pereira VGM, Espósito DC, Pasqualucci MdOP, Damasceno MCT, Schultz MJ, Association Between Use of Lung-Protective Ventilation With Lower Tidal Volumes and Clinical Outcomes Among Patients Without Acute Respiratory Distress Syndrome A Meta-analysis. JAMA-J AM MED ASSOC 2012;308 (16):1651-1659 [PubMed]
  • Serpa Neto A, Hemmes SNT, Barbas CSV, Beiderlinden M, Fernandez-Bustamante A, Futier E, Hollmann MW, Jaber S, Kozian A, Licker M, Lin WQ, Moine P, Scavonetto F, Schilling T, Selmo G, Severgnini P, Sprung J, Treschan T, Unzueta C, Weingarten TN, Wolthuis EK, Wrigge H, Gama de Abreu M, Pelosi P, Schultz MJ, Incidence of mortality and morbidity related to postoperative lung injury in patients who have undergone abdominal or thoracic surgery: a systematic review and meta-analysis. LANCET RESP MED 2014;2 (12):1007-1015 [PubMed]
  • Determann RM, Royakkers A, Wolthuis EK, Vlaar AP, Choi G, Paulus F, Hofstra JJ, de Graaff MJ, Korevaar JC, Schultz MJ, Ventilation with lower tidal volumes as compared to conventional tidal volumes for patients without acute lung injury - a preventive randomized controlled trial. CRIT CARE 2010;14 (1):R1 [PubMed]
All Publications
Curriculum Vitae
Marcus J. Schultz completed his medical degree (cum laude; with honor) and residency in internal medicine at the Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands. He obtained his doctorate from the Science Division of the Royal Netherlands Academy of Arts and Sciences in Amsterdam, the Netherlands.

Marcus Schultz is currently professor of intensive care medicine at the Academic Medical Center of the University of Amsterdam and Principal Investigator of the Department of Intensive Care Medicine of the Academic Medical Center of the University of Amsterdam.

There is growing awareness that life-saving and organ-function replacement strategies and therapies in Intensive Care (IC) medicine may not be without risks. Life-threatening conditions often force intensivists to apply strategies and therapies that in themselves have the potential to be harmful, sometimes severely so. A typical example is mechanical ventilation. Mechanical ventilation not only increases the chance of pneumonia, it can also intensify, or even induce, sterile inflammation of the lungs. In the Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A) and in the department of IC, current translational research conducted by Schultz focuses on lung injury caused by mechanical ventilation, i.e., ventilator-induced injury to lung cells and lung tissue, to the lungs as a complete organ and also to distant organs. In this research, Schultz studies and manipulates clotting and innate immunity. In doing so, he tests new mechanical ventilation strategies - several of them developed in the laboratory - for preventing or treating mechanical ventilation-induced lung injury.

Schultz believes that new strategies and therapies could significantly improve IC medicine, but only if these are indeed applied. Many insights with respect to effective care and best practices in IC medicine are not sufficiently applied: patients do not always receive care in accordance with the latest insights. Implementation is sometimes referred to as the final step in translational research. With implementation, the aim is to introduce the full range of strategies and therapies that have been proven to contribute to improved results. Schultz is carrying out implementation research in the department of IC of the Amsterdam Medical Center (AMC) in collaboration with a number of Dutch hospitals, as well as with hospitals in Southeast Asia. In several projects, he studies the implementation of complex and often expensive strategies or therapies in the AMC and other Dutch hospitals. In the less wealthy countries in Southeast Asia (Bangladesh, India and Nepal), however, he stresses the implementation of simple, often cheaper, care.

Since 1991, Schultz has held a number of positions in the AMC, where he was trained as an internist and later as an intensivist. In recent years, he worked as Senior University Lecturer and Head of Research in the department of IC of the AMC. In 2002 he earned his PhD for research into clotting and innate immunity in the lung during pneumonia. Schultz has authored numerous publications in various international journals and is an editor of Netherlands Journal of Critical Care and Netherlands Journal of Medicine. For his research on anticoagulant strategies during pneumonia, the Netherlands Organisation for Scientific Research awarded him a Veni grant in 2004. In 2006 the same organisation awarded him an Effectiveness grant for his research into implementation of strict glycemic control in critically ill patients.

Dr. Schultz has published numerous articles in international journals and numerous chapters in scientific books, has received several research awards, and serves as a reviewer for such peer–reviewed journals as Lancet, Public Library of Science (PLOS) – Medicine, Thorax, Critical Care Medicine, Anesthesiology, Intensive Care Medicine, Critical Care, Journal of Applied Physiology, Journal of Leukocyte Biology, Journal of Antimicrobial Chemotherapy, Cellular Immunology, Blood Coagulation & Fibrinolysis, International Journal of Infectious Diseases, and Respiratory Medicine among others. He was the scientific editor in–chief of the Netherlands Journal of Intensive Care Medicine for 4 years. He was an editor/senior adviser of the Critical Care Assembly of the American Thoracic Society for 4 years.

Marcus Schultz was supported by a personal grant from the Netherlands Organization for Health Research and Development (NWO–VENI grant 2004 [project number 016.056.001]).
Research programmes

Prevention and treatment of organ failure in intensive care medicine

Anticoagulant agents were tested systemically in pre–clinical models of acute lung injury (ALI) (thesis G. Choi, collaboration with the Univ. of Toronto; VENI (ZonMW)–grant);  these agents were additionally tested locally (i.e., by means of nebulization) in similar models (thesis J–J. Hofstra, VENI–grant); a mouse–ventilation model was set–up, and successfully used for a first series of studies in which anticoagulants were tested for the prevention of ventilator–induced lung injury (thesis E. Wolthuis); a clinical study on the prevalence and pathophysiology of transfusion–related ALI (thesis A. Vlaar, collaboration with Sanguin, Amsterdam) and a clinical study on the effects of a natural anticoagulant in single–organ ALI were started (thesis J–J. Hofstra, collaboration with the Free University, Amsterdam; industry–sponsored); a study on lower versus conventional tidal volumes in patients not suffering from ALI in the ICU was continued (thesis R. Determann); a similar study was finished in the OR (thesis G. Choi and E. Wolthuis); an automatic mode of mechanical ventilation was tested in cardiothoracic surgery patients (thesis D. Dongelmans; industry–sponsored) and patients after tracheotomy (thesis D. Veelo); manual hyperinflation was tested and improved in a skills–laboratory (thesis F. Paulus).

This research group participates in CINIMA

Prof. M.J. Schultz MD PhD
Dr. J.M. Binnekade PhD
A.M. Dondorp MD PhD (Mahidol-Oxford Research Unit, Bangkok, Thailand)
Dr. D.A. Dongelmans MD MSc PhD
S. Eberl MD
Dr. N.C. Hauck-Weber PhD
Prof. dr. M.W. Hollmann MD PhD
Dr. J. Horn MD PhD
Prof. N.P. Juffermans MD PhD
Dr. W.K. Lagrand MD PhD
Dr. P.B. Lirk MSc
Dr. F. Paulus MSc
Prof. dr. B. Preckel MA MD PhD
Dr. M.F. Stevens MD PhD
Prof. dr. M.B. Vroom MD
Dr. ir. C.J. Zuurbier PhD

R.M. Determann MD PhD
R. Tepaske MD PhD
Dr. D.P. Veelo MD PhD
Dr. A.P.J Vlaar MD PhD

PhD Students
M.M. Admiraal
A. Akkermans
A.G. Algera
Drs. F.M. de Beer
M. Boshuizen MSc (Doctor)
Drs. G.J. Glas
L.A. Hagens MSc
Drs. M.B.A. Harmon MD
Drs. M.E. van Hezel MSc (Doctor)
Drs. S.M. van der Hoeven
L. Hol
Drs. J. Juschten
Drs. I.M. Lok (The Hospital for Sick Children (SickKids), Toronto, Canada)
Drs. D.M.P. van Meenen MD
S.G.L.H. Nijbroek
P.M.P. van Oort
Dr. L. Pisani MD
Drs. L.R.A. Schouten
F.D. Simonis MD
M.R. Smit
A. Smorenberg
F. van Someren Gréve MD
W. Stilma
M.C.E. van der Woude

J.F. Buchner-Doeven
A. Tuip-de Boer
A.L.I.P. van der Veen
T. Winters

Dr. A.P.J Vlaar MD PhD (Transfusion related morbidity and mortality)

Dr. J. Horn MD PhD (Neurology on the Intensive Care Unit)

Prof. dr. M.W. Hollmann MD PhD (Organprotection)

Other research related activities
  • Membership of editorial board / Editorship, INTENSIVE CARE MEDICINE
  • Membership of editorial board / Editorship, ANNALS OF INTENSIVE CARE
  • Membership of editorial board / Editorship, CRITICAL CARE
  • Membership of editorial board / Editorship, CRITICAL CARE RESEARCH AND PRACTICE
  • Membership of editorial board / Editorship, NETHERLANDS JOURNAL OF CRITICAL CARE
  • Membership of advisory board / Consultant, Other
  • Membership of advisory board / Consultant, NovaLung
  • Membership of advisory board / Consultant, Roche
  • Speakers bureau / Lectures, NovaLung
  • Speakers bureau / Lectures, Hamilton
  • Contribution to guidelines and protocols, iCERTAIN: guidelines for resource-poor settings
  • Contribution to guidelines and protocols, Global Working Group of the European Society of Intensive Care Medicine: guidelines for resource-restricted settings
Current research funding
  • Life Sciences Health TKI
  • National University of Ireland Galway
  • ZonMw