Prof. N.P. Juffermans MD PhD


Prof. N.P. Juffermans MD PhD

Main activities
Patient care, Research
Intensive Care Medicine
Focus of research

Focus is on two research topics:

1) efficacy of blood transfusion during critical illness

2) the effect of controlled induction of a hypo-metabolic state during critical illness

Key publications
  • Vlaar APJ, Hofstra JJ, Determann RM, Veelo DP, Paulus F, Kulik W, Korevaar J, de Mol BA, Koopman MMW, Porcelijn L, Binnekade JM, Vroom MB, Schultz MJ, Juffermans NP, The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study. BLOOD 2011;117 (16):4218-4225 [PubMed]
  • Vlaar APJ, Binnekade JM, Prins D, van Stein D, Hofstra JJ, Schultz MJ, Juffermans NP, Risk factors and outcome of transfusion-related acute lung injury in the critically ill: A nested case-control study. CRIT CARE MED 2010;38 (3):771-778 [PubMed]
  • Vlaar APJ, Hofstra JJ, Kulik W, van Lenthe H, Nieuwland R, Schultz MJ, Levi MM, Roelofs JJTH, Tool ATJ, de Korte D, Juffermans NP, Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model. BLOOD 2010;116 (8):1360-1368 [PubMed]
  • Vlaar APJ, Juffermans NP, Transfusion-related acute lung injury: a clinical review. LANCET 2013;382 (9896):984-994 [PubMed]
  • Müller MCA, Straat M, Meijers JCM, Klinkspoor JH, de Jonge E, Arbous MS, Schultz MJ, Vroom MB, Juffermans NP, Fresh frozen plasma transfusion fails to influence the hemostatic balance in critically ill patients with a coagulopathy. J THROMB HAEMOST 2015;13 (6):989-997 [PubMed]
All Publications
Curriculum Vitae

NJ has received her MD degree in 1997 from the Faculty of Medicine of the University of Amsterdam and her PhD degree in 2000 from the same Faculty. In 2005 she was board certified in Internal Medicine and in 2006 she received European board certification in Intensive Care Medicine. Since 2006, NJ is staff member of the Department of Intensive Care at the Academic Medical Center and senior researcher at the Laboratory of Experimental Intensive Care and Anesthesiology.

Research programmes

Pathogenesis and treatment of organ failure in the critically ill

This program focusses on the pathogenesis of organ failure and anemia occurring during critical illness.

Investigated pathways of organ failure  include a dysregulated immune response which occur during excessive inflammation. Interventions are studied aimed at limiting organ injury induced by hyperinflammation or by mechanical ventilation. These interventions aim to reduce oxygen consumption during excessive inflammation.

Pathways of anemia during critical illness are studied. Efficacy of blood transfusion is studied, in particular optimizing transfusion triggers both for correction of anemia as well as for guiding therapy during bleeding. Also, risks of transfusion of blood products are studied, in particular the relation with the occurrence of organ failure. Studies seek to identify targets for interventions that aim to optimize transfusion.

The program uses a translational approach, combining observational and interventional studies in critically ill patients with fundamental studies in models of sepsis and acute lung injury.

Prof. N.P. Juffermans MD PhD
Dr. N.C. Hauck-Weber PhD
Prof. dr. M.W. Hollmann MD PhD
Prof. dr. B. Preckel MA MD PhD
Dr. K.F. van der Sluijs PhD
Dr. ir. C.J. Zuurbier PhD

Dr. H. Aslami MD
Dr. A.P.J Vlaar MD PhD

PhD Students
A.J.S. Alshalani
M. Boshuizen MSc (Doctor)
D.P. van den Brink
Drs. C.A.M. Christiaans MD
Drs. M.B.A. Harmon MD
Drs. M.E. van Hezel MSc (Doctor)
Drs. C.J. Hodiamont
D.J.B. Kleinveld
L. van Manen
F. van Someren Gréve MD
M.R. Wirtz BSc
Y. Xiao PhD

Dr. J.M. Binnekade PhD
J. Buchner
A. Tuip-de Boer
A.Y. van der Veen
T. Winters

Prof. M.J. Schultz MD PhD (Prevention and treatment of organ failure in intensive care medicine)

Dr. A.P.J Vlaar MD PhD (Transfusion related morbidity and mortality)

Dr. J. Horn MD PhD (Neurology on the Intensive Care Unit)

Prof. dr. M.W. Hollmann MD PhD (Organprotection)

Dr. ir. C.J. Zuurbier PhD (Cell survival mechanisms in acute and chronic cardiovascular pathology)

Other research related activities
  • Contribution to guidelines and protocols, transfusion protocol
  • Membership of editorial board / Editorship, NETHERLANDS JOURNAL OF CRITICAL CARE
  • Membership of editorial board / Editorship, INTENSIVE CARE MEDICINE
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Europese Unie
  • Leids Universitair Medisch Centrum
  • Sanquin Blood Supply Foundation
  • Saudi Arabian Cultural Mission