J. Crezee PhD

foto

J. Crezee PhD

Position
Other Academic Staff
Main activities
Research
Specialisation
Hyperthermia
Focus of research

Hyperthermia (HT) research with main focus on:

1) The development of new hyperthermia techniques, for both superficial and locoregional hyperthermia. Goals are optimal 3-D steering and (non-invasive) thermometry. Existing techniques are often incapable of achieving the tumour goal temperature without overheating normal tissue. New 3-D steered hyperthermia systems are developed to overcome this problem. Use of treatment planning to improve and optimize the temperature distridution. Final step is commercialisation of equipment to achieve worldwide application of our equipment and to facilitate and promote high quality application of hyperthermia.

2) Clinical research to establish the clinical value of hyperthermia for different tumour sites by setting up or contributing to pilot studies and randomised phase II and phase III clinical trials comparing standard radiotherapy and/or chemotherapy to radiotherapy and/or chemotherapy plus hyperthermia. Sites include breast, cervix, bladder, pancreas. Providing high level evidence is crucial for the clinical acceptance of Hyperthermia. Example. the HyperCR study for recurrent breast cancer, comparing RT+HT+/-CDDP

3) Fundamental research into the Working Mechanisms of Hyperthermia. Includes development of small animal hyperthermia device to study various working mechanisms in an orthotopic small animal model (mouse) in collaboration with various Dutch institutes. This knowledge thus gained is utilised in topics 1-2 of this research line.
 

Projects:

 

Coordinator for:

- H2020-MSCA-ITN-2020-955625 “HYPERBOOST: Hyperthermia boosting the effect of Radiotherapy”: € 3,761,881.56

 

Project leader for a number of research projects funded by the Dutch Cancer Society KWF:

- Development of a dual modality heating technique for treatment of cancer at the esophagus (AMC 2002-2622), project leaders J Crezee, N. van Wieringen, G van Tienhoven: € 423.363,-

- Optimisation of regional hyperthermia delivery using a newly developed 3-D hyperthermia system and advanced hyperthermia treatment planning techniques (UVA 2006-3484), project leaders J Crezee, MCCM Hulshof, JB van de Kamer: € 461.914,-

- An improved temperature measurement technique to be used during hyperthermia treatment of cancer at superficial locations may improve clinical results (UVA 2007-3841), project leaders J Crezee, Nvan Wieringen, G van Tienhoven: € 262.000,-

- Improved regional hyperhtermia delivery using hyperthermia treatment planning based on MRI data to predict and suppress treatment limiting hot spots (UVA 2010-4660), project leaders J Crezee, AJ Nederveen, LJA Stalpers: € 319.600,-

- Active hot spot suppression to improve thermal dose and clinical outcome of locoregional hyperthermia (UVA 2012-5393), project leaders J Crezee, HP Kok, LJA Stalpers: € 339.300,-

- Optimization of bladder hyperthermia treatment for NMIBC by using loco-regional heating, improved thermometry and 3D hyperthermia treatment planning (UVA 2012-5539), project leaders J Crezee, MCCM Hulshof, TM de Reijke: € 417.000,-

- MRI based hyperthermia treatment planning for improved hyperthermia delivery in cervical cancer patients (UVA 2014-7197), project leaders J Crezee, ALHMW van Lier, LJA Stalpers: € 572.500,-

- Irreversible electroporation for locally advanced pancreatic cancer; optimization of clinical treatment by advanced treatment planning (UVA 2014-7244), project leaders MGH Besselink, J Crezee, TM van Gulik: € 523.100,-

- Hyperthermia induced synthetic lethality combined with PARP1 inhibition to sensitize radiotherapy and CDDP treatment of Cervical cancer (UVA 2015-7820) project leaders NAP Franken, LJA Stalpers, J Crezee: € 485.600,-

- Development of patient specific treatment planning to enhance and optimize clinical effectiveness of hyperthermic intraperitoneal chemotherapy in colorectal cancer patients (UVA 2017-10595) project leaders J Crezee, NAP Franken, HP Kok, PJ Tanis: € 563.765,-

- Clinical evaluation of the benefit of planning based steering to improve effectiveness of hyperthermia in cervical cancer patients (UVA 2017-10873) project leaders HP Kok, J Crezee, LJA Stalpers: € 326.486.-

Project leader for

- investment grant NWO-ZonMw medium “A dedicated high resolution small animal hyperthermia device to support translation of novel cancer therapies from lab to bedside” (project 40-00506-98-16015, principal applicant J. Crezee, co-applicant N.A.P. Franken): € 443.250,-

- KiKa project 253 “Radiotherapy and hyperthermia for children: from concept to breakthrough?”. Project leaders A. Bel, J. Crezee, C.R.N. Rasch, H.J. Merks: € 78.762,-.

Key publications
  • Oei A. L., Kok H. P., Oei S. B., Horsman M. R., Stalpers L. J. A., Franken N. A. P., Crezee J. Molecular and biological rationale of hyperthermia as radio- and chemosensitizer Advanced drug delivery reviews 2020 [PubMed]
  • Schooneveldt Gerben, Trefná Hana Dobšíček, Persson Mikael, de Reijke Theo, Blomgren Klas, Kok Petra, Crezee Hans Hyperthermia treatment planning including convective flow in cerebrospinal fluid for brain tumour hyperthermia treatment using a novel dedicated paediatric brain applicator Cancers 2019;11 (8) [PubMed]
  • Kok H. Petra, Korshuize-van Straten Linda, Bakker Akke, de Kroon-Oldenhof Rianne, Geijsen Elisabeth D., Stalpers Lukas J. A., Crezee Johannes Online Adaptive Hyperthermia Treatment Planning During Locoregional Heating to Suppress Treatment-Limiting Hot Spots International journal of radiation oncology, biology, physics 2017;99 (4):1039-1047 [PubMed]
  • Bakker Akke, Kolff M. Willemijn, Holman Rebecca, van Leeuwen Caspar M., Korshuize-van Straten Linda, de Kroon-Oldenhof Rianne, Rasch Coen R. N., van Tienhoven Geertjan, Crezee Hans Thermal Skin Damage During Reirradiation and Hyperthermia Is Time-Temperature Dependent International journal of radiation oncology, biology, physics 2017;98 (2):392-399 [PubMed]
  • Geijsen Elisabeth D., de Reijke Theo M., Koning Caro C., Zum Vörde Sive Vörding Paul J., de la Rosette Jean J., Rasch Coen R., van Os Rob M., Crezee Johannes Combining Mitomycin C and Regional 70 MHz Hyperthermia in Patients with Nonmuscle Invasive Bladder Cancer: A Pilot Study Journal of urology 2015;194 (5):1202-1208 [PubMed]
All Publications
Curriculum Vitae

1986: M.Sc. in experimental physics with experimental work on Medical Physics (Free University, Amsterdam).
1988-1992: Project on the representation of blood flow in thermal models used in hyperthermia treatment planning, and experimental evaluation of these models (UMC Utrecht).
1993: PhD thesis ‘verification of thermal models’ (University of Utrecht).
1992-1997: Development of a system for clinical application of interstitial hyperthermia with spatial power control for improved temperature uniformity in the target region (UMC Utrecht). Supervision of four PhD students working on projects related to the development of this hyperthermia device and on development of a clinical discrete vessel (DIVA) thermal model.
1997-1999: Clinical application of interstitial hyperthermia for brain and prostate implants (UMC Utrecht). Supervision of PhD student working on validation of thermal models.
2000-present: Hyperthermia research at the Department of Radiotherapy of the Academic Medical Center in Amsterdam, initially emphasis on system design and treatment planning. First project involved development of a new 8 antenna deep hyperthermia system for pelvic tumors.
2008-present: Principal Investigator (PI) for hyperthermia research at the Department of Radiotherapy of AMC and responsible for multidisciplinary hyperthermia research on hyperthermia system design and treatment planning, and commercialisation of resulting products developed at AMC. Treatment planning focuses on challenging locations (e.g. bladder) and on biological modelling and realtime adaptive treatment planning. Also involved in clinical trials on hyperthermia in breast cancer and bladder cancer and in basic research on working mechanisms of hyperthermia, also for inclusion in biological treatment planning. Supervision of more than10 PhD students working on different projects.A total of 161 peer reviewed publications, 136 on PubMed, a h-index of 30 (web of science) or 33 (google scolar).

Hans Crezee is project leader for several research projects granted by the Dutch Cancer Society Koningin Wilhelmina Fonds (KWF):
- Development of a dual modality hyperthermia technique for esophageal cancer (J Crezee, N van Wieringen, G van Tienhoven, AMC 2002-2622: € 423363.-).
- Optimisation of regional hyperthermia delivery using hyperthermia planning (J Crezee, MCCM Hulshof, JB van de Kamer, UVA 2006-3484: € 461914.-).
- Improved temperature reconstruction technique based on treatment planning to be used during superficial hyperthermia (J Crezee, N van Wieringen, G van Tienhoven, UVA 2007-3841: € 262000.-).
- Improved treatment delivery using treatment planning and MRI data (J Crezee, AJ Nederveen, LJA Stalpers, UVA 2010-4660: € 319600.-).
- Active hot spot suppression to improve thermal dose and clinical outcome of locoregional hyperthermia treatments (J Crezee, HP Kok, LJA Stalpers, UVA 2012-5393: € 339300.-).
- Improved bladder temperature monitoring during hyperthermia treatments (J Crezee, MCCM Hulshof, TM de Reijke, UVA 2012-5539: € 417000.-).
- MRI based hyperthermia treatment planning for improved hyperthermia delivery in cervical cancer patients (J Crezee, ALHMW van Lier, LJA Stalpers, UVA 2014-7197: € 572500.-).
- Irreversible electroporation for locally advanced pancreatic cancer; optimization of clinical treatment by advanced treatment planning (MGH Besselink, J Crezee, TM van Gulik, UVA 2014-7244: € 523100.-).
- Hyperthermia induced synthetic lethality combined with PARP1 inhibition to sensitize radiotherapy and CDDP treatment of Cervical cancer (NAP Franken, LJA Stalpers, J Crezee, UVA 2015-7820: € 485600.-).
- Development of patient specific treatment planning to enhance and optimize clinical effectiveness of hyperthermic intraperitoneal chemotherapy in colorectal cancer patients (J Crezee, NAP Franken, HP Kok, PJ Tanis project UVA 2017-10595: € 563765.-).
- Clinical evaluation of the benefit of planning based steering to improve effectiveness of hyperthermia in cervical cancer patients (HP Kok, J Crezee, LJA Stalpers project UVA 2017-10873: € 326486.-)

Other grants:
- Medium investment grant NWO-ZonMw “A dedicated high resolution small animal hyperthermia device to support translation of novel cancer therapies from lab to bedside” (project 40-00506-98-16015 (2016), principal applicant J. Crezee, co-applicant N.A.P. Franken: € 443250.-).
- Children cancer fund KiKa project 253 (2016) “Radiotherapy and hyperthermia for children: from concept to breakthrough?”. Project leaders A. Bel, J. Crezee, C.R.N. Rasch, H.J. Merks: € 78762.-.

Coordinator for EU project:
- EU H2020 European Training Network (H2020-MSCA-ITN-2020-955625) “H2020-MSCA-ITN-2020-955625 “HYPERBOOST: Hyperthermia boosting the effect of Radiotherapy” (project coordinator J. Crezee: € 3,761,881.56).

Total grant money for larger grants: € 8,978,522.-


Other activities:
- member “Treatment planning and modelling in hyperthermia” task group of the European Society for Hyperthermic Oncology in cooperation with a COMAC BME Concerted Action within the 4th Medical and Health Research Programme of the European Commission (1990-1992)
- Organisation of 2006 annual meeting Hyperthermia Working Group of the Dutch Cancer Society (Amsterdam, 21 April 2006).
- Co-Promotor for Petra Kok (PhD thesis University of Amsterdam 2007).
- Member PhD committee Judith Bergs (University of Amsterdam 2007).
- Member NWO/STW jury “vernieuwingsimpuls” VIDI for 2008.
- Secretary Hyperthermia Working Group of the Dutch Cancer Society (2008-present).
- Organisation of 2009 annual meeting Hyperthermia Working Group of the Dutch Cancer Society (Amsterdam, 8 May 2009).
- Member Quality Assurance committee of the Interdisciplinary Working Group Hyperthermia (IAH) of the German Cancer Society “Atzelsberg circle” (2010-present).
- Collaborator ISTC project 3996 “simultaneous action of radiation and heating” (2010-present)
- Member PhD committee Hana Dobsicek-Trefna (Chalmers University Göteborg, June 2010).
- Secretary Maurits and Anna de Kock Foundation (2011-present)
- Board member European Society for Hyperthermic Oncology ESHO (2011-2014)
- Member technical committee European Society for Hyperthermic Oncology ESHO (2011-present)
- Editorial Board ISRN Biomathematics (2011-present)
- Editorial Board Journal of Cancer Research and Therapeutics-JCRT (2011-present)
- Host for professor Rolf Issels (LMU, Munich), Spinoza chair at the University of Amsterdam 8-10 November 2011
- Organisation of 2011 annual meeting Hyperthermia Working Group of the Dutch Cancer Society (Amsterdam, 11 November 2011).
- Co-Promotor for Martijn de Greef (PhD thesis University of Amsterdam 9 February 2012).
- member International Scientific Committee of the 11th International Congress of Hyperthermic Oncology (Kyoto 28-31 August 2012).
- Member PhD committee Richard Canters (Erasmus University Rotterdam 2013).
- Editorial Board International Journal of Hyperthermia (2013-present)
- Guest researcher at the Department of signals and systems at Chalmers University, Göteborg, September – December 2013, August – December 2014.
- Teacher at ESHO (European Society for Hyperthermic Oncology) school, Huntsham Court, Devon, 3-6 February 2014
- Organisation of 2014 annual meeting Hyperthermia Working Group of the Dutch Cancer Society (Amsterdam, 11 December 2014).
- Organisation hyperthermia workshop during the 8th International Symposium on “Focal Therapy and Imaging in Prostate and Kidney Cancer” (Noordwijk, Netherlands, 21-23 June 2015).
- Guest Editor for special issue of Int. J Hyperthermia on hyperthermia in bladder cancer (together with Brant Inman).
- Co-Promotor for Edmond Balidemaj (PhD thesis University of Amsterdam 25 May 2016).
- Member PhD committee Tom Arends (Radboud University Nijmegen 17 June 2016).
- Member PhD committee Marianne Linthorst (Erasmus University Rotterdam 20 December 2016).
- Host for professor Mark W. Dewhirst (Duke, NC), Spinoza chair at the University of Amsterdam 21-24 March 2017
- Section Editor International Journal of Hyperthermia (2017-present)
- Co-Promotor for Caspar van Leeuwen (PhD thesis University of Amsterdam 3 July 2018)
- Secretary European Society for Hypethermic Oncology (ESHO) (2019-present)
Co-Promotor for Gerben Schooneveldt (PhD thesis University of Amsterdam 22 October 2019)
- Member PhD committee Mathias Weyland (University of Fribourg, Switzerland 2 March 2020).


Honors and awards:
- Recipient of 12,500.- donation awarded for KWF project UVA 2006-3484 (2007).
- Dr. B.B. Singh Award, 6th Biennial meeting of Indian Association of Hyperthermic Oncology and Medicine, Bangalore 2010.
- Annual Award of Merit at annual meeting of the Society for Cancer Research and Communication, Mumbai February 2, 2012.
- Sugahara Oration 8th Biennial meeting of Indian Association of Hyperthermic Oncology and Medicine, Bharatpur, Nepal 21-22 Feb 2014
- Life Time Achievement Award of Indian Association of Hyperthermic Oncology and Medicine, Ahmedabad, February 18, 2017
- annual ESHO pyrexar award 2018, Berlin, May 18, 2018

Peer reviewed papers

1.    Oei AL, Kok HP, Oei SB, Horsman MR, Stalpers LJA, Franken NAP, Crezee J. Molecular and Biological Rationale of Hyperthermia as Radio- and Chemosensitizer Adv Drug Deliv Rev. 2020. (early online)
2.    Kok HP, Beck M, Löke DR, Helderman RFCPA, van Tienhoven G, Ghadjar P, Wust P, Crezee J. Locoregional peritoneal hyperthermia to enhance the effectiveness of chemotherapy in patients with peritoneal carcinomatosis; a simulation study comparing different locoregional heating systems. Int J Hyperthermia. 2020;37(1):76-88.
3.    Gavazzi S, Shcherbakova Y, Bartels LW, Stalpers LJA, Lagendijk JJW, Crezee H, van den Berg CAT, Van Lier ALHMW. Transceive phase mapping using the PLANET method and its application for conductivity mapping in the brain. Magn Reson Med. 2020;83:590-607.
4.     Oei AL, Korangath P, Mulka K, Helenius M, Coulter JB, Stewart J, Velarde E, Crezee J, Simons B, Stalpers LJA, Kok HP, Gabrielson K, Franken NAP, Ivkov R. Enhancing the abscopal effect of radiation and immune checkpoint inhibitor therapies with magnetic nanoparticle hyperthermia in a model of metastatic breast cancer. Int J Hyperthermia. 2019;36(sup1):47-63.
5.     Bakker A, Van der Zee J, Van Tienhoven G, Kok HP, Rasch CRN, Crezee H. Temperature and thermal dose during radiotherapy and hyperthermia for recurrent breast cancer are related to clinical outcome and thermal toxicity: A systematic review. Int J Hyperthermia. 2019;36(1):1024-39.
6.    Schooneveldt G, Dobšiček Trefná H, Persson M, De Reijke TM, Blomgren K, Kok HP, Crezee H. Hyperthermia treatment planning including convective flow in cerebrospinal fluid for brain tumour hyperthermia treatment using a novel dedicated paediatric brain applicator. Cancers. 2019;11(8):1183.
7.    Klaver CE, Wisselink DD, Punt CJ, Snaebjornsson P, Crezee J, Aalbers AG, Brandt A, Bremers AJ, Burger JW, Fabry HF, Ferenschild F, Festen S, Grevenstein WM, Hemmer PJ, de Hingh IH, Kok NF, Musters GD, Schoonderwoerd L, Tuynman JB, van de Ven AW, van Westreenen HL, Wiezer MJ, Zimmerman DD, van Zweeden AA, Dijkgraaf MG, Tanis PJ. Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer; the COLOPEC randomized trial. Lancet Gastroenterol Hepatol. 2019;4(10):761-770.
8.    Crezee H, Kok HP, Oei AL, Franken NAP, Stalpers LJA. The Impact of the Time Interval Between Radiation and Hyperthermia on Clinical Outcome in Patients With Locally Advanced Cervical Cancer. Front Oncol. 2019;9:412.
9.    Kok HP, Crezee J. Effective Electromagnetic Coupling and Skin Cooling During RF Heating of Pelvic Tumours. In: Vrba J, Svanda M, Fiser O, Vrba D, editors. Proceedings European Microwave Conference in Central Europe; Prague: EuMA; 2019. p. 430-3.
10.    Crezee J, Zweije R, Sijbrands J, Kok HP. RF and MW Systems for Hyperthermia of Challenging Tumour Locations. In: Vrba J, Svanda M, Fiser O, Vrba D, editors. Proceedings European Microwave Conference in Central Europe; Prague: EuMA; 2019. p. 426-9.
11.    Lassche G, Crezee J, van Herpen CML. Whole-body hyperthermia in combination with systemic therapy in advanced solid malignancies. Crit Rev Oncol Hematol. 2019;139:67-74.
12.    Crezee H, Van Tienhoven G. Hyperthermie versterkt het effect van radiotherapie en/of chemotherapie bij de behandeling van meerdere vormen van kanker. Ned Tijdschr Oncol. 2019;16(2):47-53.
13.    Dobsicek Trefna H, Schmid M, Van Rhoon GC, Kok HP, Gordeyev SS, Lamprecht U, Marder D, Nadobny J, Ghadjar P, Abdel-Rahman S, Kukielka AM, Strnad V, Hurwitz MD, Vujaskovic Z, Diederich CJ, Stauffer PR, Crezee J. Quality Assurance Guidelines for Interstitial Hyperthermia. Int J Hyperthermia. 2019;36(1):277-94.
14.    Gavazzi S, Van den Berg CA, Sbrizzi A, Kok HP, Stalpers LJ, Lagendijk JJ, Crezee H, Van Lier AL. Accuracy and precision of electrical permittivity mapping at 3T: the impact of three B1+ mapping techniques. Magn Reson Med. 2019;81(6):3628-42.
15.    Helderman FCPA, Löke DR, Kok HP, Oei AL, Tanis PJ, Franken NA, Crezee J. Variation in clinical application of Hyperthermic Intraperitoneal Chemotherapy: a review Cancers. 2019;11(1):78.
16.    Elming PB, Soerensen BS, Oei AL, Franken NA, Crezee J, Overgaard J, Horsman MR. Hyperthermia: The Optimal Treatment to Overcome Radiation Resistant Hypoxia. Cancers. 2019;11(1):60.
17.    Kok HP, van Dijk IWEM, Crama KF, Franken NAP, Rasch CRN, Merks JHM, Crezee J, Balgobind BV, Bel A. Reirradiation plus hyperthermia for recurrent pediatric sarcoma; a simulation study to investigate feasibility. Int J Oncol. 2019;54(1):209-18.
18.    Schooneveldt G, Kok HP, Bakker A, Geijsen ED, Hulshof MC, De Reijke TM, Crezee J. The effect of air pockets in the urinary bladder on the temperature distribution during loco-regional hyperthermia treatment of bladder cancer patients. Int J Hyperthermia. 2018;35(1):441-9.
19.    Schooneveldt G, Kok HP, Bakker A, Geijsen ED, Rasch CR, Hulshof MC, De la Rosette JJ, De Reijke TM, Crezee J. Clinical Validation of a novel Thermophysical Bladder Model designed to improve the Accuracy of Hyperthermia Treatment Planning in the Pelvic Region. Int J Hyperthermia. 2018;35(1):383-97.
20.    Kok HP, Schooneveldt G, Bakker A, De Kroon-Oldenhof R, de Jong CE, Steggerda-Carvalho EJ, Geijsen ED, stalpers LJ, Crezee J. Predictive value of simulated SAR and temperature for changes in measured temperature after phase-amplitude steering during locoregional hyperthermia treatments. Int J Hyperthermia. 2018;35(1):330-9.
21.    Zweije R, Kok HP, Bakker A, Bel A, Crezee J. Technical and Clinical Evaluation of the ALBA-4D 70MHz Loco-Regional Hyperthermia System.  Proceedings of the 48th European Microwave Conference 2018; Madrid: 2018. p. 328-31.
22.    Kok HP, De Kroon-Oldenhof R, Korshuize-van Straten L, De Jong CE, Bakker A, Zweije R, Sijbrands J, Van Tienhoven G, Crezee J. RF Heating of Pancreatic Tumours Guided by Hyperthermia Treatment Planning and Limited Thermometry.  Proceedings of the 48th European Microwave Conference 2018; Madrid: 2018. p. 332-5.
23.    Franken NA, Stalpers LJ, Crezee J. OBITUARY Professor Gerrit Willem (Eddie) Barendsen, August 14, 1927 - June 20, 2018. int J Rad Oncol Biol Phys. 2018;102(3):483-4.
24.    IJff M, van Oorschot B, Oei AL, Krawczyk PM, Rodermond HM, stalpers LJ, Kok HP, Crezee J, Franken NA. Enhancement of radiation effectiveness in cervical cancer cells by combining ionizing radiation with hyperthermia and molecular targeting agents. Int J Mol Sci 2018;19:2420.
25.    van Leeuwen CM, Crezee J, Oei AL, Franken NAP, Stalpers LJA, Bel A, Kok HP. The effect of time interval between radiotherapy and hyperthermia on planned equivalent radiation dose. Int J Hyperthermia. 2018;34(7):901-9.
26.    van Leeuwen CM, Oei AL, Crezee J, Bel A, Franken NAP, Stalpers LJA, Kok HP. The alfa and beta of tumours: a review of parameters of the linear-quadratic model, derived from clinical radiotherapy studies. Radiat Oncol. 2018;13(1):96.
27.    Van Leeuwen CM, Oei AL, Ten Cate R, Franken NA, Bel A, Stalpers LJ, Crezee J, Kok HP. Measurement and analysis of the impact of time-interval, temperature and radiation dose on tumour cell survival and its application in thermoradiotherapy plan evaluation. Int J Hyperthermia. 2018;34(1):30-8.
28.    Bakker A, Holman R, Rodrigues DB, Dobsicek Trefna H, Stauffer PR, van Tienhoven G, Rasch CRN, Crezee H. Analysis of clinical data to determine the minimum number of sensors required for adequate skin temperature monitoring of superficial hyperthermia treatments. Int J Hyperthermia. 2018;34(7):910-7.
29.    Kok HP, Navarro F, Strigari L, Cavagnaro M, Crezee J. Locoregional hyperthermia of deep-seated tumors applied with capacitive and radiative systems: a simulation study. Int J Hyperthermia. 2018;34(6):714-30.
30.    Oldenborg S, Rasch CRN, van Os R, Kusumanto YH, Oei BS, Venselaar JL, Heymans MW, Zum Vorde Sive Vording PJ, Crezee H, van Tienhoven G. Reirradiation + hyperthermia for recurrent breast cancer en cuirasse. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft  [et al]. 2018;194(3):206-14.
31.    van der Horst A, Versteijne E, Besselink MGH, Daams JG, Bulle EB, Bijlsma MF, Wilmink JW, van Delden OM, van Hooft JE, Franken NAP, van Laarhoven HWM, Crezee J, van Tienhoven G. The clinical benefit of hyperthermia in pancreatic cancer: a systematic review. Int J Hyperthermia. 2018;34(7):969-79.
32.    Kok HP, Korshuize-van Straten L, Bakker A, de Kroon-Oldenhof R, Westerveld GH, Versteijne E, Stalpers LJA, Crezee J. Feasibility of on-line temperature-based hyperthermia treatment planning to improve tumour temperatures during locoregional hyperthermia. Int J Hyperthermia. 2018;34(7):1082-91.
33.    Oei AL, Ahire VR, Van Leeuwen CM, Ten Cate R, stalpers LJ, Crezee J, Kok HP, Franken NA. Enhancing radiosensitization on BRCA2-proficient and BRCA2-deficient cell lines with hyperthermia and PARP1-i. Int J Hyperthermia. 2018;34(1):39-48.
34.    Kok HP, Crezee J. Progress and Future Directions in Hyperthermia Treatment Planning.  Proceedings of the Microwave Bio Conference (IMBIOC), 2017 First IEEE MTT-S International; Gothenburg: 2017. p. 116-9.
35.    Crezee J, Bennis M, Gavazzi S, Stalpers LJA, Van Lier ALHMW, Kok HP. Development of Electrical Properties Tomography for Hyperthermia Treatment Planning.  Proceedings of the Microwave Bio Conference (IMBIOC), 2017 First IEEE MTT-S International; Gothenburg: 2017. p. 112-5.
36.    Kok HP, Korshuize-van Straten L, Bakker A, de Kroon-Oldenhof R, Geijsen ED, Stalpers LJA, Crezee J. Online Adaptive Hyperthermia Treatment Planning During Locoregional Heating to Suppress Treatment-Limiting Hot Spots. Int J Radiat Oncol Biol Phys. 2017;99(4):1039-47.
37.    Crezee J, Van Tienhoven G, Kolff MW, Sijbrands J, Van Stam G, Oldenborg S, Geijsen ED, Hulshof MC, Kok HP. Development of a 70 MHz unit for hyperthermia treatment of deep seated breast tumors. Int J Microw Wirel T 2017;9(6):1317-24.
38.    Crezee H, Van Stam G, Sijbrands J, Oldenborg S, Geijsen ED, Hulshof MCCM, Kok HP. Hyperthermia of deep seated pelvic tumors with a phased array of eight versus four 70 MHz waveguides.  Proceedings of the 47th European Microwave Conference 2017; Nuremberg: 2017. p. 876-9.
39.    Kok HP, Van Stam G, Sijbrands J, Bakker A, Kolff MW, Van Tienhoven G, hulshof MCCM, Crezee J. Clinical use of a waveguide hyperthermia system for superficial tumors with deep infiltration.  Proceedings of the 47th European Microwave Conference 2017; Nuremberg: 2017. p. 868-71.
40.    Van Leeuwen CM, Oei AL, Chin KW, Crezee J, Bel A, Franken NA, Stalpers LJ, Kok HP. A short time interval between radiotherapy and hyperthermia reduces in-field recurrence and mortality in women with advanced cervical cancer. Radiat Oncol. 2017;12:75.
41.    Klaver CE, Stam R, Sloothaak DA, Crezee J, Bemelman WA, Punt CJ, Tanis PJ. Colorectal cancer at high risk of peritoneal carcinomatosis; long term outcome of a pilot study on prophylactic HIPEC and future perspectives. Oncotarget. 2017;8:51200-9.
42.    van Stam G, Kok HP, Hulshof MC, Kolff MW, Van Tienhoven G, Sijbrands J, Bakker A, Schoorl J, Zum Vorde Sive Vording P, Oldenborg S, De Greef M, Rasch C, Crezee H. A flexible 70MHz phase-controlled double waveguide system for hyperthermia treatment of superficial tumours with deep infiltration. Int J Hyperthermia. 2017;33(7):796-809.
43.    Oei AL, van Leeuwen CM, Rodermond H, ten Cate R, Westermann AM, Stalpers LJ, Crezee J, Kok HP, Krawzcyk PM, Kanaar R, Franken NA. Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumor cells with hyperthermia. Oncotarget. 2017;8(17):28116-24.
44.    Dobšíček Trefná H, Crezee J, Schmidt M, Marder D, Lamprecht U, Ehmann M, Hartmann J, Gellermann J, van Holthe JM, Lomax N, Abdel-Rahman S, Bert C, Bakker A, Hurwitz M, Diedrich CJ, Stauffer PR, van Rhoon GC. Atzelsberg Research Group quality assurance guidelines for the application of superficial hyperthermia clinical trials: II. Technical requirements for heating devices. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft  [et al]. 2017;193(5):351-66.
45.    Kok HP, Kotte AN, Crezee J. Planning, optimization and evaluation of hyperthermia treatments. Int J Hyperthermia. 2017;33(6):593-607.
46.    Bakker A, Kolff MW, Holman R, van Leeuwen CM, Korshuize-van Straten L, Oldenhof-de Kroon R, Rasch CR, van Tienhoven G, Crezee J. Thermal skin damage during reirradiation and hyperthermia is time temperature dependent. Int J Rad Oncol Biol Phys. 2017;98(2):392-9.
47.    Oei AL, Vriend LE, Krawczyk PM, Horsman MR, Franken NA, Crezee J. Targeting therapy-resistant cancer stem cells by hyperthermia. Int J Hyperthermia. 2017;33(4):419-27.
48.    Dobšíček Trefná H, Crezee H, Schmidt M, Marder D, Lamprecht U, Ehmann M, Hartmann J, Nadobny J, Gellermann J, van Holthe N, Ghadjar P, Lomax N, Abdel-Rahman S, Bert C, Bakker A, Hurwitz MD, Diederich CJ, Stauffer PR, van Rhoon GC. Quality assurance guidelines for superficial hyperthermia clinical trials: I. Clinical requirements. Int J Hyperthermia. 2017;33(4):471-82.
49.    Kok HP, Crezee J. A comparison of the heating characteristics of capacitive and radiative superficial hyperthermia. Int J Hyperthermia. 2017;33(4):378-86.
50.    van Leeuwen CM, Crezee J, Oei AL, Franken NA, Stalpers LJ, Bel A, Kok HP. 3D radiobiological evaluation of combined radiotherapy and hyperthermia treatments. Int J Hyperthermia. 2017;33(2):160-9.
51.    Balidemaj E, Van den Berg CA, van Lier AL, Nederveen AJ, Stalpers LJ, Crezee H, Remis RF. B1-based SAR reconstruction using contrast source inversion-electric properties tomography (CSI-EPT). Med Biol Eng Comput. 2017;55(2):225-33.
52.    Vogel JA, van Veldhuisen E, Agnass P, Crezee J, Dijk F, Verheij J, van Gulik TM, Meijerink MR, Vroomen LG, van Lienden KP, Besselink MG. Time-Dependent Impact of Irreversible Electroporation on Pancreas, Liver, Blood Vessels and Nerves: A Systematic Review of Experimental Studies. PLoS One. 2016;11(11):e0166987.
53.    Franken NA, Kok HP, Crezee J, Barendsen GW. Analysis of enhancement at small and large radiation doses for effectiveness of inactivation in cultured cells by combining two agents with radiation. Int J Radiat Biol. 2016;92(9):521-6.
54.    Schooneveldt G, Kok HP, Balidemaj E, Geijsen ED, van Ommen F, Sijbrands J, Bakker A, de la Rosette JJ, Hulshof MC, de Reijke TM, Crezee J. Improving hyperthermia treatment planning for the pelvis by accurate fluid modelling. Med Phys. 2016;43(10):5442-52.
55.    Oei AL, Vriend LE, van Leeuwen CM, Rodermond HM, Ten Cate R, Westermann AM, Stalpers LJ, Crezee J, Kanaar R, Kok HP, Krawczyk PM, Franken NA. Sensitizing thermochemotherapy with a PARP1-inhibitor. Oncotarget. 2017;8(10):16303-12.
56.    Balidemaj E, Kok HP, Schooneveldt G, van Lier AL, Remis RF, Stalpers LJ, Westerveld GH, Nederveen AJ, Van den Berg CA, Crezee J. Hyperthermia Treatment Planning for cervical cancer patients based on electric conductivity tissue properties acquired in vivo with EPT at 3T MRI. Int J Hyperthermia. 2016;32(5):558-68.
57.    Schooneveldt G, Kok HP, Bakker A, Geijsen ED, de Reijke TM, Crezee J. SU-F-J-05: The Effect of Air Pockets in the Urinary Bladder During Bladder Hyperthermia Treatment. Med Phys. 2016;43(6):3406.
58.    Crezee J, Van Tienhoven G, Kolff MW, Sijbrands J, Van Stam G, Oldenborg S, Geijsen ED, Hulshof MCCM, Kok HP. Development of a 70 MHz unit for hyperthermia treatment of deep seated breast tumors.  Proceedings of the 46th European Microwave Conference 2016; London; 2016. p. 906-9.
59.    Kok HP, Bakker A, Kolff MW, Van Tienhoven G, Hulshof MCCM, Van Stam G, Crezee J. 70 MHz Double Waveguide Set-up for Hyperthermia of Deep Superficial Tumors.  Proceedings of the 46th European Microwave Conference 2016; London: 2016. p. 1219-22.
60.    Crezee H, Inman B. The use of hyperthermia in the treatment of bladder cancer. Int J Hyperthermia. 2016;32(4):349-50.
61.    Liem E, Crezee J, de la Rosette JJ, de Reijke TM. Chemohyperthermia in non-muscle invasive bladder cancer: an overview of the literature and recommendations. Int J Hyperthermia. 2016;32(4):363-73.
62.    Schooneveldt G, Bakker A, Balidemaj E, Chopra R, Crezee J, Geijsen ED, Hartmann J, Hulshof MC, Kok HP, Paulides MM, Sousa-Escandon A, Stauffer PR, Maccarini PF. Thermal dosimetry for bladder cancer hyperthermia treatment. An overview. Int J Hyperthermia. 2016;32(4):417-33.
63.    Oldenborg S, Valk C, van Os R, Oei B, Venselaar J, Zum Vorde Sive Vording P, van Randen A, Crezee H, van Tienhoven G, Rasch C. Rib fractures after reirradiation plus hyperthermia for recurrent breast cancer. Strahlenther Onkol. 2016;192(4):240-7.
64.    Crezee H, van Leeuwen CM, Oei AL, Stalpers LJ, Bel A, Franken NA, Kok HP. Thermoradiotherapy planning: integration in routine clinical practice. Int J Hyperthermia. 2016;32(1):41-9.
65.    Balidemaj E, de Boer P, van Lier AL, Remis RF, Stalpers LJ, Westerveld GH, Nederveen AJ, Van den Berg CA, Crezee H. In vivo electric conductivity of cervical cancer patients based on B1+ maps at 3T MRI. Phys Med Biol. 2016;61(4):1596-607.
66.    Crezee J, van Leeuwen CM, Oei AL, van Heerden LE, Bel A, Stalpers LJ, Ghadjar P, Franken NA, Kok HP. Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer. Radiat Oncol. 2016;11:14.
67.    Oei AL, van Leeuwen CM, ten Cate R, Rodermond H, Buist MR, Stalpers LJ, Crezee J, Kok HP, Medema JP, Franken NA. Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis. Cancer Res. 2015;75(23):5120-9.
68.    Schooneveldt G, Kok HP, Geijsen ED, Van Ommen F, Bakker A, Westendarp-Zanartu MA, de la Rosette JJMCH, Hulshof MCCM, De Reijke TM, Crezee J. Improved temperature monitoring and treatment planning for loco-regional hyperthermia treatments of Non-Muscle Invasive Bladder Cancer (NMIBC). In: Jaffray DA, editor. World Congress on Medical Physics and Biomedical Engineering, June 7–12, 2015, Toronto, Canada, IFMBE Proceedings 51  Springer (Cham); 2015. p. 1691-4.
69.    Crezee J, Harms HJ, Boluijt HJ, Sijbrands J, hulshof MCCM, Kok HP. Development of a 27.12 MHz CC-LCF intraluminal applicator for hyperthermia of the oesophagus.  Proceedings of the 45th European Microwave Conference 2015; Paris: 2015. p. 769-72.
70.    Kok HP, Van Stam G, Bel A, Crezee J. A Mixed Frequency Approach to Optimize Locoregional RF Hyperthermia.  Proceedings of the 45th European Microwave Conference 2015; Paris: 2015. p. 773-6.
71.    Oldenborg S, Griesdoorn V, van Os R, Kusumanto YH, Oei BS, Venselaar JL, Zum Vorde Sive Vording PJ, Heymans MW, Kolff MW, Rasch CR, Crezee H, van Tienhoven G. Reirradiation and hyperthermia for irresectable locoregional recurrent breast cancer in previously irradiated area: Size matters. Radiother Oncol. 2015;117(2):223-8.
72.    Kok HP, Wust P, Stauffer PR, Bardati F, van Rhoon GC, Crezee J. Current state of the art of regional hyperthermia treatment planning: a review. Radiat Oncol. 2015;10:196.
73.    Oei AL, Vriend LE, Crezee J, Franken NA, Krawczyk PM. Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all. Radiat Oncol. 2015;10:165.
74.    Geijsen ED, de Reijke TM, Koning CC, Zum Vorde Sive Vording PJ, de la Rosette JJ, Rasch CR, van Os R, Crezee J. Combining Mitomycin C and regional 70 MHz hyperthermia in patients with non-muscle invasive bladder cancer: a pilot study. J Urol. 2015;194(5):1202-8.
75.    Datta NR, Gomez Ordonez S, Gaipl US, Paulides MM, Crezee H, Gellermann J, Marder D, Puric E, Bodis S. Local hyperthermia combined with radiotherapy and-/ or chemotherapy: Recent advances and promises for the future. Cancer Treat Rev. 2015;41(9):742-53.
76.    Cihoric N, Tsikkinis A, van Rhoon G, Crezee H, Aebersold DM, Bodis S, Beck M, Nadobny J, Budach V, Wust P, Ghadjar P. Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry. Int J Hyperthermia. 2015;31(6):609-14.
77.    Balidemaj E, Van den Berg CA, Trinks J, van Lier A, Nederveen AJ, Stalpers L, Crezee H, Remis RF. CSI-EPT: A Contrast Source Inversion Approach for Improved MRI-Based Electric Properties Tomography. IEEE Trans Med Imaging. 2015;34(9):1788-96.
78.    Kosterev VV, Kramer-Ageev EA, Mazokhin VN, van Rhoon GC, Crezee J. Development of a novel method to enhance the therapeutic effect on tumours by simultaneous action of radiation and heating. Int J Hyperthermia. 2015;31(4):443-52.
79.    Balidemaj E, van Lier AL, Crezee H, Nederveen AJ, Stalpers LJ, Van den Berg CA. Feasibility of Electric Property Tomography of pelvic tumors at 3T. Magn Reson Imaging. 2015;73(4):1505-13.
80.    Sloothaak DA, Gardenbroek TJ, Crezee J, Bemelman WA, Punt CJ, Buskens CJ, Tanis PJ. Feasibility of adjuvant laparoscopic hyperthermic intraperitoneal chemotherapy in a short stay setting in patients with colorectal cancer at high risk of peritoneal carcinomatosis. Eur J Surg Oncol. 2014;40(11):1453-8.
81.    Kok HP, Ciampa S, de Kroon-Oldenhof R, Steggerda-Carvalho EJ, van Stam G, Zum Vorde Sive Vording PJ, Stalpers LJ, Geijsen ED, Bardati F, Bel A, Crezee J. Towards on-line adaptive hyperthermia treatment planning: correlation between measured and simulated SAR changes caused by phase steering in patients. Int J Radiat Oncol Biol Phys. 2014;90(2):438-45.
82.    Depla AL, Scharloo-Karels CH, de Jong MA, Oldenborg S, Kolff MW, Oei SB, van Coevorden F, van Rhoon GC, Baartman EA, Scholten RJ, Crezee J, van Tienhoven G. Treatment and prognostic factors of radiation-associated angiosarcoma (RAAS) after primary breast cancer: A systematic review. Eur J Cancer. 2014;50(10):1779-88.
83.    Kok HP, Crezee J, Franken NA, Stalpers LJ, Barendsen GW, Bel A. Quantifying the Combined Effect of Radiation Therapy and Hyperthermia in Terms of Equivalent Dose Distributions. Int J Radiat Oncol Biol Phys. 2014;88(3):739-45.
84.    Cordeiro Feijoo ER, Geijsen DE, Zum Vorde Sive Vording PJ, Schooneveldt G, Sijbrands J, Hulshof MC, de la Rosette J, de Reijke TM, Crezee H. Novel multi-sensor probe for monitoring bladder temperature during loco-regional chemo-hyperthermia for non-muscle invasive bladder cancer: technical feasibility study. J Endourol. 2013;27(12):1504-9.
85.    Kok HP, Van den Berg CA, Bel A, Crezee J. Fast thermal simulations and temperature optimization for hyperthermia treatment planning, including realistic 3D vessel networks. Med Phys. 2013;40(10):103303-.
86.    Kok HP, Gellermann J, Van den Berg CA, Stauffer PR, Hand JW, Crezee J. Thermal modelling using discrete vasculature for thermal therapy: a review. Int J Hyperthermia. 2013;29(4):336-45.
87.    Franken NA, Oei AL, Kok HP, Rodermond HM, Sminia P, Crezee J, Stalpers LJ, Barendsen GW. Cell survival and radiosensitisation: modulation of the linear and quadratic parameters of the LQ model (Review). Int J Oncol. 2013;42(5):1501-15.
88.    de Greef M, Ipek O, Raaijmakers AJ, Crezee J, Van den Berg CA. Specific absorption rate intersubject variability in 7T parallel transmit MRI of the head. Magn Reson Med. 2013;69(5):1476-85.
89.    Sauer R, Crezee H, Hulshof M, Issels R, Ott O, van Rhoon G. The letter of the Ludwig Boltzmann Institute is unnecessarily polarizing to the discussion on whether or not hypothermia is evidence based Reply. Strahlenther Onkol. 2013;189(1):84-6.
90.    Bruggmoser G, Bauchowitz S, Canters R, Crezee H, Ehmann M, Gellermann J, Lamprecht U, Lomax N, Messmer MB, Ott O, Abdel-Rahman S, Schmidt M, Sauer R, Thrall DE, Wessalowski R, van Rhoon G, group Ar, Oncology ESfH. Guideline for the clinical application, documentation and analysis of clinical studies for regional deep hyperthermia: quality management in regional deep hyperthermia. Strahlenther Onkol. 2012;188, suppl 2:198-211.
91.    Stippel G, van Rooijen DC, Crezee J, Bel A. Automatic delineation of body contours on cone-beam CT images using a delineation booster. Phys Med Biol. 2012;57(13):N225-N36.
92.    van Rooijen DC, van Wieringen N, Stippel G, Crezee J, Koning CC, Bel A. Dose-Guided Radiotherapy: Potential Benefit of Online Dose Recalculation for Stereotactic Lung Irradiation in Patients with Non-Small-Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2012;83(4):e557-e62.
93.    Sauer R, Creeze H, Hulshof M, Issels R, Ott O, Radiooncology. obotIWGfCHACotGCSatGSo. Concerning the final report "Hyperthermia: a systematic review" of the Ludwig Boltzmann Institute for Health Technology Assessment, Vienna, March 2010. Strahlenther Onkol. 2012;188(3):209-15.
94.    Franken NA, Hovingh S, Rodermond H, Stalpers L, Barendsen GW, Crezee J. Radiosensitization with chemotherapeutic agents and hyperthermia: effects on linear-quadratic parameters of radiation cell survival curves. J Cancer Sci Ther. 2011;S5(002).
95.    Bruggmoser G, Bauchowitz S, Canters R, Crezee H, Ehmann M, Gellerman J, Lamprecht U, Lomax N, Messmer MB, Ott O, Abdel-Rahman S, Sauer R, Schmidt M, Thomsen A, Wessalowski R, van Rhoon G. Quality Assurance for Clinical Studies in Regional Deep Hyperthermia. Strahlenther Onkol. 2011;187(10):605-10.
96.    de Greef M, Kok HP, Correia D, Borsboom PP, Bel A, Crezee J. Uncertainty in hyperthermia treatment planning: the need for robust system design. Phys Med Biol. 2011;56(11):3233-50.
97.    Kok HP, de Greef M, Borsboom PP, Bel A, Crezee J. Improved power steering with double and triple ring waveguide systems: The impact of the operating frequency. Int J Hyperthermia. 2011;27(3):224-39.
98.    de Greef M, Kok HP, Bel A, Crezee J. 3D versus 2D steering in patient anatomies: a comparison using hyperthermia treatment planning. Int J Hyperthermia. 2011;27(1):74-85.
99.    Hulshof MC, van Haaren PM, Zum Vorde Sive Vording PJ, Krishnadath S, Marsman WA, van Berge Henegouwen MI, Geijsen ED, Crezee J. Radiotherapy combined with hyperthermia for primary malignant melanomas of the esophagus. Dis Esophagus. 2010;23(8):E42-E7.
100.    de Greef M, Kok HP, Correia D, Bel A, Crezee J. Optimization in hyperthermia treatment planning: The impact of tissue perfusion uncertainty. Med Phys. 2010;37:4540-50.
101.    Kok HP, de Greef M, Wiersma J, Bel A, Crezee J. The impact of the waveguide aperture size of the 3D 70 MHz AMC-8 loco-regional hyperthermia system on tumour coverage. Phys Med Biol. 2010;55:4899-916.
102.    Jansen MC, van Hillegersberg R, Schoots IG, Levi M, Beek JF, Crezee H, van Gulik TM. Cryoablation induces greater inflammatory and coagulative responses than radiofrequency ablation or laser induced thermotherapy in a rat liver model. Surgery. 2010;147(5):686-95.
103.    Kok HP, de Greef M, van Wieringen N, Correia D, Hulshof MC, Zum Vorde Sive Vording PJ, Sijbrands J, Bel A, Crezee J. Comparison of two different 70 MHz applicators for large extremity lesions: simulation and application. Int J Hyperthermia. 2010;26(4):376-88.
104.    Oldenborg S, van Os R, van Rij CM, Crezee J, van de Kamer JB, Rutgers EJ, Geijsen ED, Zum Vorde Sive Vording PJ, Koning CC, van Tienhoven G. Elective Reirradiation and Hyperthermia following Resection of Persistent Locoregional Recurrent Breast Cancer: a Retrospective Study. Int J Hyperthermia. 2010;26(2):136-44.
105.    Kok HP, Correia D, de Greef M, van Stam G, Bel A, Crezee J. SAR deposition by curved CFMA-434 applicators for superficial hyperthermia: Measurements and simulations. Int J Hyperthermia. 2010;26(2):171-84.
106.    Correia D, Kok HP, de Greef M, Bel A, van Wieringen N, Crezee J. Body conformal antennas for superficial hyperthermia: The impact of bending contact flexible microstrip applicators on their electromagnetic behavior. IEEE Trans Biomed Eng. 2009;56(12):2917-26.
107.    van Wieringen N, Wiersma J, Zum Vorde Sive Vording PJ, Oldenborg S, Gelvich EA, Mazokhin VN, van Dijk JD, Crezee H. Characteristics and performance evaluation of the capacitive Contact Flexible Microstrip Applicator operating at 70 MHz for external hyperthermia. Int J Hyperthermia. 2009;25(7):542-53.
108.    Crezee J, van Haaren PM, Westendorp H, de Greef M, Kok HP, Wiersma J, van Stam G, Sijbrands J, Zum Vorde Sive Vording PJ, van Dijk JD, Hulshof MC, Bel A. Improving locoregional hyperthermia delivery using the 3-D controlled AMC-8 phased array hyperthermia system: a preclinical study. Int J Hyperthermia. 2009;25(7):581-92.
109.    Crezee J, Barendsen GW, Westermann AM, Hulshof MC, Haveman J, Stalpers LJ, Geijsen ED, Franken NA. Quantification of the contribution of hyperthermia to results of cervical cancer trials.
in regard to Plataniotis and Dale (Int J Radiat Oncol Biol Phys 2009;73:1538-1544). Int J Radiat Oncol Biol Phys. 2009;75(2):634-.
110.    Kok HP, de Greef M, Correia D, Zum Vorde Sive Vording PJ, van Stam G, Gelvich EA, Crezee J. FDTD simulations to assess the performance of CFMA-434 applicators for superficial hyperthermia. Int J Hyperthermia. 2009;25(6):462-76.
111.    de Greef M, van Eijk JC, Pool R, Crezee J, Bel A. Accelerated ray-tracing for radiotherapy dose calculations on a GPU. Med Phys. 2009;36(9):4095-102.
112.    Kok HP, de Greef M, Bel A, Crezee J. Acceleration of high resolution temperature based optimisation for hyperthermia treatment planning using element grouping. Med Phys. 2009;36(8):3795-805.
113.    Hulshof MC, van Haaren PM, van Lanschot JJ, Richel DJ, Fockens P, Oldenborg S, Geijsen ED, van Berge Henegouwen MI, Crezee J. Preoperative chemoradiation combined with regional hyperthermia for patients with resectable esophageal cancer. Int J Hyperthermia. 2009;25(1):79-85.
114.    van Haaren PM, Hulshof MC, Kok HP, Oldenborg S, Geijsen ED, van Lanschot JJ, Crezee J. Relation between body size and temperatures during locoregional hyperthermia of oesophageal cancer patients. Int J Hyperthermia. 2008;24(8):663-74.
115.    Kok HP, Van den Berg CA, van Haaren PM, Crezee J. Artefacts in intracavitary temperature measurements during regional hyperthermia. Phys Med Biol. 2007;52(17):5157-71.
116.    Bergs JWJ, Franken NA, Haveman J, Geijsen ED, Crezee J, van Bree C. Hyperthermia, cisplatin and radiation trimodality treatment: A promising cancer treatment? A review from preclinical studies to clinical application. Int J Hyperthermia. 2007;23(4):329-41.
117.    Kok HP, van Haaren PM, van de Kamer JB, Crezee J. Theoretical comparison of intraluminal heating techniques. Int J Hyperthermia. 2007;23(4):395-411.
118.    van Haaren PM, Kok HP, Van den Berg CA, Zum Vorde Sive Vording PJ, Oldenborg S, Stalpers LJ, Schilthuis MS, de Leeuw AA, Crezee J. On verification of hyperthermia treatment planning for cervical carcinoma patients. Int J Hyperthermia. 2007;23(3):303-14.
119.    Wiersma J, van Wieringen N, Crezee H, van Dijk JD. Delineation of potential hot spots for hyperthermia treatment planning optimisation. Int J Hyperthermia. 2007;23(3):287-301.
120.    van Haaren PM, Kok HP, Zum Vorde Sive Vording PJ, van Dijk JD, Hulshof MC, Fockens P, van Lanschot JJ, Crezee J. Reliability of temperature and SAR measurements at oesophageal tumour locations. Int J Hyperthermia. 2006;22(7):545-61.
121.    Westerterp M, Omloo JM, Sloof GW, Hulshof MC, Hoekstra OS, Crezee H, Boellaard R, Vervenne WL, ten Kate FJ, van Lanschot JJ. Monitoring of response to preoperative chemoradiation in combination with hyperthermia in oesophageal cancer by FDG-PET. J Clin Gastroenterol. 2006;40(8 Suppl 4):S180-S.
122.    Kok HP, van Haaren PM, van de Kamer JB, Zum Vorde Sive Vording PJ, Wiersma J, Hulshof MC, Geijsen ED, van Lanschot JJ, Crezee J. Prospective treatment planning to improve locoregional hyperthermia for oesophageal cancer. Int J Hyperthermia. 2006;22(5):375-89.
123.    Westerterp M, Omloo JM, Sloof GW, Hulshof MC, Hoekstra OS, Crezee H, Boellaard R, Vervenne WL, ten Kate FJ, van Lanschot JJ. Monitoring of response to pre-operative chemoradiation in combination with hyperthermia in oesophageal cancer by FDG-PET. Int J Hyperthermia. 2006;22(2):149-60.
124.    Kok HP, van Haaren PM, van de Kamer JB, Wiersma J, van Dijk JD, Crezee J. High resolution temperature based optimisation for hyperthermia treatment planning. Phys Med Biol. 2005;50(13):3127-41.
125.    Kok HP, van Haaren PM, van Dijk J, Crezee J. On estimation of the temperature maximum in intraluminal or intracavitary hyperthermia. Int J Hyperthermia. 2005;21(4):287-304.
126.    Albregts M, Hulshof MC, PJ ZVSV, van Lanschot JJ, Richel DJ, Crezee H, Fockens P, van Dijk JD, Gonzalez GD. A feasibility study in oesophageal carcinoma using deep loco-regional hyperthermia combined with concurrent chemotherapy followed by surgery. Int J Hyperthermia. 2004;20(6):647-59.
127.    Hulshof MC, Raaymakers BW, Lagendijk JJ, Koot RW, Crezee H, Stalpers LJ, Gonzalez GD. A feasibility study of interstitial hyperthermia plus external beam radiotherapy in glioblastoma multiforme using the Multi ELectrode Current Source (MECS) system. Int J Hyperthermia. 2004;20(5):451-63.
128.    van Vulpen M, Raaymakers BW, Lagendijk JJ, Crezee J, de Leeuw AA, van Moorselaar JR, Ligtvoet CM, Battermann JJ. Three-dimensional controlled interstitial hyperthermia combined with radiotherapy for locally advanced prostate carcinoma--a feasibility study. Int J Radiat Oncol Biol Phys. 2002;53(1):116-26.
129.    Raaymakers BW, van Vulpen M, Lagendijk JJ, de Leeuw AA, Crezee J, Battermann JJ. Determination and validation of the actual 3D temperature distribution during interstitial hyperthermia of prostate carcinoma. Phys Med Biol. 2001;46(12):3115-31.
130.    Kaatee RS, Nowak PC, van der Zee J, de Bree J, Kanis BP, Crezee H, Levendag PC, Visser AG. Clinical thermometry, using the 27 MHz multi-electrode current-source interstitial hyperthermia system in brain tumours. Radiother Oncol. 2001;59(2):227-31.
131.    Raaymakers BW, Crezee J, Lagendijk JJ. Modelling individual temperature profiles from an isolated perfused bovine tongue. Phys Med Biol. 2000;45(3):765-80.
132.    Kaatee RS, Crezee H, Visser AG. Temperature measurement errors with thermocouples inside 27 MHz current source interstitial hyperthermia applicators. Phys Med Biol. 1999;44(6):1499-511.
133.    Crezee J, Kaatee RS, van der Koijk JF, Lagendijk JJ. Spatial steering with quadruple electrodes in 27 MHz capacitively coupled interstitial hyperthermia. Int J Hyperthermia. 1999;15(2):145-56.
134.    van der Koijk JF, Crezee J, Lagendijk JJ. Thermal properties of capacitively coupled electrodes in interstitial hyperthermia. Phys Med Biol. 1998;43(1):139-53.
135.    Raaymakers BW, Crezee J, Lagendijk JJ. Comparison of temperature distributions in interstitial hyperthermia: experiments in bovine tongues versus generic simulations. Phys Med Biol. 1998;43(5):1199-214.
136.    van der Koijk JF, de Bree J, Crezee J, Lagendijk JJ. Numerical analysis of capacitively coupled electrodes for interstitial hyperthermia. Int J Hyperthermia. 1997;13(6):607-19.
137.    van Leeuwen GM, Kotte AN, Crezee J, Lagendijk JJ. Tests of the geometrical description of blood vessels in a thermal model using counter-current geometries. Phys Med Biol. 1997;42(8):1515-32.
138.    van der Koijk JF, Lagendijk JJ, Crezee J, de Bree J, Kotte AN, van Leeuwen GM, Battermann JJ. The influence of vasculature on temperature distributions in MECS interstitial hyperthermia: importance of longitudinal control. Int J Hyperthermia. 1997;13(4):365-85.
139.    van Leeuwen GM, Kotte AN, de Bree J, van der Koijk JF, Crezee J, Lagendijk JJ. Accuracy of geometrical modelling of heat transfer from tissue to blood vessels. Phys Med Biol. 1997;42(7):1451-60.
140.    Kaatee RS, Crezee J, Kanis AP, Lagendijk JJ, Levendag PC, Visser AG. Design of applicators for a 27 MHz multielectrode current source interstitial hyperthermia system; impedance matching and effective power. Phys Med Biol. 1997;42(6):1087-108.
141.    Crezee J, van der Koijk JF, Kaatee RS, Lagendijk JJ. Implications of using thermocouple thermometry in 27 MHz capacitively coupled interstitial hyperthermia. Phys Med Biol. 1997;42(4):637-50.
142.    Kaatee RS, Crezee H, Kanis BP, Lagendijk JJ, Levendag PC, Visser AG. Spatial temperature control with a 27 MHz current source interstitial hyperthermia system. Int J Radiat Oncol Biol Phys. 1997;37(1):189-97.
143.    Kotte A, van Leeuwen G, de Bree J, van der KJ, Crezee H, Lagendijk J. A description of discrete vessel segments in thermal modelling of tissues. Phys Med Biol. 1996;41(5):865-84.
144.    van der Koijk JF, Crezee J, van Leeuwen GM, Battermann JJ, Lagendijk JJ. Dose uniformity in MECS interstitial hyperthermia: the impact of longitudinal control in model anatomies. Phys Med Biol. 1996;41(3):429-44.
145.    Lagendijk JJ, Crezee J, Hand JW. Dose uniformity in scanned focused ultrasound hyperthermia. Int J Hyperthermia. 1994;10(6):775-84.
146.    Crezee J, Mooibroek J, Lagendijk JJ, van Leeuwen GM. The theoretical and experimental evaluation of the heat balance in perfused tissue. Phys Med Biol. 1994;39(5):813-32.
147.    de Leeuw AA, Crezee J, Lagendijk JJ. Temperature and SAR measurements in deep-body hyperthermia with thermocouple thermometry. Int J Hyperthermia. 1993;9(5):685-97.
148.    Crezee J, Lagendijk JJ. Temperature uniformity during hyperthermia: the impact of large vessels. Phys Med Biol. 1992;37(6):1321-37.
149.    Bos CK, Crezee J, Mooibroek J, Lagendijk JJ. A perfusion technique for tongues to be used in bioheat transfer studies. Phys Med Biol. 1991;36(6):843-6.
150.    Crezee J, Mooibroek J, Bos CK, Lagendijk JJ. Interstitial heating: experiments in artificially perfused bovine tongues. Phys Med Biol. 1991;36(6):823-33.
151.    Crezee J, Lagendijk JJ. Experimental verification of bioheat transfer theories: measurement of temperature profiles around large artificial vessels in perfused tissue. Phys Med Biol. 1990;35(7):905-23.
152.    Metselaar JW, Goovaerts HG, Crezee J. Generation of a fast and homogeneous temperature step. J Biochem Biophys Methods. 1987;14(4):233-42.
153.    Metselaar JW, Crezee J, Goovaerts HG. Generation of a rapid step in the temperature of a papillary muscle. Med Biol Eng Comput. 1986;24(5):475-81.

Book chapters
1. Crezee H, Kaidar–Person O, Poortmans P. Locally Recurrent Disease. In “Breast Cancer: Essentials for Clinicians”(editors Fatima Cardoso, Vesa Kataja, Vivianne Tjan-Heijnen), ISBN: 978-88-941795-3-8, ESMO Press, 2017, pp 86-89
2. Franken N, Hovingh S, Oei A, Cobussen P, Rodermond H, Bergs J, Van Bree C, Stalpers L, Kok P, Barendsen GW, Crezee J. Radiosensitization with hyperthermia and chemotherapeutic agents: Effects on linear-quadratic parameters of radiation cell survival curves. In Ionizing Radiation / Book 1, ISBN 979-953-307-345-2, InTech, Editor M. Nenoi.
3. Mooibroek J, Crezee J, Lagendijk JJW. Basics of thermal models. Chapter 19 in `Thermoradiotherapy ad Thermochemotherapy, vol !. Biology, Physiology and Physics. Seegenschmiedt MH, Fessenden P, Vernon CC (eds), Berlin± Springer-Verlag, 1995, pp 425-37.
4. Crezee J, Mooibroek J, Lagendijk JJW. Thermal model verification in interstitial hyperthermia. In ´interstitial and intracavitary thermoradiotherapy´, Seegenschmiedt MH, Sauer R (eds), Berlin Springer, 1993, pp 147-53.

 

Research programmes

J. Crezee PhD (Hyperthermia)

1) The development of new hyperthermia techniques

2) The development and application of hyperthermia treatment planning

3) Clinical hyperthermia research

4) Working mechanisms of hyperthermia

Postdocs
O.J. Gurney-Champion PhD
H.P. Kok PhD
A. van der Horst PhD

PhD Students
S. Gavazzi MSc

Others
G. van Stam

A. Bel PhD (Innovative image guided radiotherapy)

Prof. C.R.N. Rasch PhD (Image guided and physics application in the clinic)

Current research funding
  • KWF Kankerbestrijding
  • Med-Logix Srl
  • UMCG
  • ZonMw