J.E.J. Guikema PhD

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J.E.J. Guikema PhD

Position
Research Associate
Main activities
Research
Specialisation
Molecular biology of immunoglobulin gene recombinations
Focus of research

Our research is focused on the role of DNA mutagenic processes in the adaptive immune system and in B-cell malignancies. I have a background in molecular biology and immunology, and my research includes DNA repair, immunoglobulin gene diversification mechanisms and signaling in B cells and B-cell malignancies. My laboratory addresses fundamental questions on DNA damage and repair in B cells and lymphomas, and performs translational research on novel drugs and therapeutic targets for (childhood) leukemia and multiple myeloma. My laboratory is part of the Lymphoma and Myeloma Center Amsterdam (LYMMCARE) consortium.

Key publications
  • Ochodnicka-Mackovicova Katarina, Bahjat Mahnoush, Maas Chiel, van der Veen Amélie, Bloedjes Timon A., de Bruin Alexander M., van Andel Harmen, Schrader Carol E., Hendriks Rudi W., Verhoeyen Els, Bende Richard J., van Noesel Carel J. M., Guikema Jeroen E. J. The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling Journal of immunology (Baltimore, Md. 2016;197 (7):2918-2929 [PubMed]
  • Ochodnicka-Mackovicova Katarina, Bahjat Mahnoush, Bloedjes Timon A., Maas Chiel, de Bruin Alexander M., Bende Richard J., van Noesel Carel J. M., Guikema Jeroen E. J. NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity Blood 2015;126 (11):1324-1335 [PubMed]
  • Staszewski Ori, Baker Richard E., Ucher Anna J., Martier Raygene, Stavnezer Janet, Guikema Jeroen E. J. Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells Molecular cell 2011;41 (2):232-242 [PubMed]
  • Stavnezer Janet, Guikema Jeroen E. J., Schrader Carol E. Mechanism and regulation of class switch recombination Annual review of immunology 2008;26:261-292 [PubMed]
  • Guikema Jeroen E. J., Linehan Erin K., Tsuchimoto Daisuke, Nakabeppu Yusaku, Strauss Phyllis R., Stavnezer Janet, Schrader Carol E. APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination Journal of experimental medicine 2007;204 (12):3017-3026 [PubMed]
All Publications
Curriculum Vitae

 NAME
Jeroen E.J. Guikema, Ph.D.

TITLE
Assistant Professor
Academic Medical Center, University of Amsterdam, The Netherlands

ADDRESS
Department of Pathology
Academic Medical Center, University of Amsterdam
Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Phone: +31-20-566-5708
Fax: +31-20-566-9523
E-mail: J.E.Guikema@amsterdamumc.nl

EDUCATION

  • 2004: Ph.D. Departments of Cell Biology and Hematology, University Medical Center Groningen, University of Groningen, The Netherlands. Thesis title: ‘Heterogeneity of Clonal B cells in Multiple Myeloma’
  • 1998: M.Sc. Medical and Molecular Biology, University of Groningen, The Netherlands, cum laude

POSITIONS

  • 2010–present: Assistant Professor Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
  • 2005–2010: Postdoctoral Fellow with Prof. Janet Stavnezer, Department of Microbiology and Molecular Genetics, University of Massachusetts, Worcester, MA, USA
  • 2004–2005: Postdoctoral Fellow with Prof. Philip Kluin, Department of Pathology, University Medical Center Groningen, The Netherlands

INTERNATIONAL ACTIVITIES

  • Postdoctoral fellow in the lab of Prof. Janet Stavnezer at the University of Massachusetts Medical School, Worcester, MA, USA: October 2005-March 2010.
  • Rotation project in the lab of Prof. Kris Thielemans at the Free University of Brussels, Belgium, 7 months: August 1996-March 1997.

OTHER ACADEMIC ACTIVITIES

  • 2010-2017: Member of the program committee of the 'Dutch Hematology Congress
  • 2010-present: Ad hoc member of grant reviewing committees of The Netherlands Organization for Scientific Research, the Dutch Cancer Society, the European Hematology Association
  • 2010-present: Member of the Dutch Immunology Society
  • 2017-present: Deputy Coordinator and Work Package Leader European Union Horizon-2020 Innovative Training Network COSMIC (COmbatting disorders of adaptive immunity with Systems MedICine)

NON-ACADEMIC ACTIVITIES

  • Scientific consultant and member of the scientific advisory board at ‘ImmunoQuality Therapeutics Corporation’ based in Groningen, The Netherlands.

MEMBERSHIPS

  • American Association of Immunologists (AAI)
  • Dutch Society for Immunology (NVVI)
  • Dutch Society for Hematology (NVvH)

SCHOLARSHIPS AND PRIZES

  • 2012-2017: NWO-VIDI €800,000; 1/10/2012-31/09/2017
  • 2010-2015: Amsterdam Academic Medical Center Fellowship Award €700,000; 1/04/2010-31/3/2015
  • 2007-2009: Cancer Research Institute Award $130,500; 1/01/2007-12/31/2009

 

Research programmes

Prof. C.J.M. van Noesel PhD (B cell biology and the pathogenesis of B-NHL/ The serrated neoplasia pathway to colorectal cancer)

Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Europese Unie
  • KWF Kankerbestrijding