J.J.T.H. Roelofs MD PhD


J.J.T.H. Roelofs MD PhD

Medical Specialist
Main activities
Patient care, Research
Focus of research

Reciprocal interactions between coagulation and inflammation in the context of kidney diseases.

Current research programmes:

  1. The fibrinolytic system in renal disease
  2. Active Protein C (APC) and the endothelial protein C receptor (EPCR) in acute kidney injury and renal allograft rejection
  3. APC and EPCR in antiphospholipid antibody-induced renal thrombotic microangiopathy
  4. Platelets and platelet-derived microparticles (PMP) in acute kidney injury and renal allograft rejection
Key publications
  • Jansen Marcel P. B., Emal Diba, Teske Gwendoline J. D., Dessing Mark C., Florquin Sandrine, Roelofs Joris J. T. H. Release of extracellular DNA influences renal ischemia reperfusion injury by platelet activation and formation of neutrophil extracellular traps Kidney international 2017;91 (2):352-364 [PubMed]
  • Lattenist L., Ochodnický P., Ahdi M., Claessen N., Leemans J. C., Satchell S. C., Florquin S., Gerdes V. E., Roelofs J. J. T. H. Renal endothelial protein C receptor expression and shedding during diabetic nephropathy Journal of thrombosis and haemostasis 2016;14 (6):1171-1182 [PubMed]
  • Lattenist Lionel, Kers Jesper, Claessen Nike, ten Berge Ineke J. M., Bemelman Frederike J., Florquin Sandrine, Roelofs Joris J. T. H. Renal and urinary levels of endothelial protein C receptor correlate with acute renal allograft rejection PLoS ONE 2013;8 (5):e64994 [PubMed]
  • Lattenist Lionel, Jansen Marcel P. B., Teske Gwendoline, Claessen Nike, Meijers Joost C. M., Rezaie Alireza R., Esmon Charles T., Florquin Sandrine, Roelofs Joris J. T. H. Activated protein C protects against renal ischaemia/reperfusion injury, independent of its anticoagulant properties Thrombosis and haemostasis 2016;116 (1):124-133 [PubMed]
  • Jansen Marcel P. B., Pulskens Wilco P., Butter Loes M., Florquin Sandrine, Juffermans Nicole P., Roelofs Joris J. T. H., Leemans Jaklien C. Mitochondrial DNA is Released in Urine of SIRS Patients With Acute Kidney Injury and Correlates With Severity of Renal Dysfunction Shock (Augusta, Ga.) 2018;49 (3):301-310 [PubMed]
All Publications
Curriculum Vitae

Joris Roelofs was educated at the Catholic University of Leuven (Belgium) and the VU University, Amsterdam, where he received his MD degree in 2000. He received his PhD degree from the Faculty of Medicine at the University of Amsterdam in 2007, and he was board certified in Pathology in 2008. Since then, Joris Roelofs has been a Consultant Histopathologist in the Department of Pathology at the AMC, specializing in kidney, liver and lung pathology. In 2010, he worked as a Research Fellow in the Kirkland Center for Lupus Research (Cornell University Medical College, New York City).

Research programmes

J.J.T.H. Roelofs MD PhD (Coagulation and the kidney)

My group studies reciprocal interactions between coagulation/hemostasis and mechanisms of renal disease. Currently, I focus on 2 distinct but complementary research lines:

1. The role of the Protein C and Protein S anticoagulant systems in acute kidney injury and renal transplant rejection

2. The role of blood platelets in acute and chronic renal disease, with an emphasis on diabetic nephropathy

Prof. S. Florquin PhD (Renal inflammation and repair)