- Nguyen D. Tan, Geel Jurre, Schulze Martin, Raschke Michael J., Woo Savio L.-Y., van Dijk C. Niek, Blankevoort Leendert Healing of the goat anterior cruciate ligament after a new suture repair technique and bioscaffold treatment Tissue engineering. Part A 2013;19 (19-20):2292-2299 [PubMed]
- van Bergen Christiaan J. A., Kerkhoffs Gino M. M. J., Marsidi Nick, Korstjens Clara M., Everts Vincent, van Ruijven Leo J., van Dijk C. Niek, Blankevoort Leendert Osteochondral defects of the talus: a novel animal model in the goat Tissue engineering. Part C, Methods 2013;19 (6):449-457 [PubMed]
- Reilingh Mikel L., van Bergen Christiaan J. A., Gerards Rogier M., van Eekeren Inge C., de Haan Rob J., Sierevelt Inger N., Kerkhoffs Gino M. M. J., Krips Rover, Meuffels Duncan E., van Dijk C. N., Blankevoort Leendert Effects of Pulsed Electromagnetic Fields on Return to Sports After Arthroscopic Debridement and Microfracture of Osteochondral Talar Defects: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial American journal of sports medicine 2016;44 (5):1292-1300 [PubMed]
- van Bergen C. J. A., Kerkhoffs G. M. M. J., Özdemir M., Korstjens C. M., Everts V., van Ruijven L. J., van Dijk C. N., Blankevoort L. Demineralized bone matrix and platelet-rich plasma do not improve healing of osteochondral defects of the talus: an experimental goat study Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2013;21 (11):1746-1754 [PubMed]
- Buijze Geert A., Dvinskikh Natallia A., Strackee Simon D., Streekstra Geert J., Blankevoort Leendert Osseous and ligamentous scaphoid anatomy: Part II. Evaluation of ligament morphology using three-dimensional anatomical imaging Journal of hand surgery 2011;36A (12):1936-1943 [PubMed]
L. Blankevoort MEng PhD (Joint disorders)
Description of research lines (2011‑2016):
The research program of the deparment of Orthopaedic Surgery is aimed at the development and evaluation of diagnostic methods and therapeutic methods for joints disorders with a focus on minimally invasive and arthroscopic procedures. It encompasses fundamental biologic , functional anatomic and biomechanical research just like clinical trials and development of clinical guidelines. The focus is in accordance with the clinical cores of the department, i.e. the joints of the lower extremity, in particular the ankle and knee and orthopaedic sports medicine.
Within the program joint disorders the PI participates in the the research lines are focused on the ankle and the knee.
For the ankle the specific topics are the sequelae of ankle inversion injury and of impingement syndromes. For the knee the topics are total knee replacement and repair of the anterior cruciate ligament. Past projects evaluated the mechanism of biologic repair of osteochondral defects in an animal model, a theory for the development subchondral talar cysts in the ankle and the biomechanics of correction osteotomies of the hindfoot. Several aspects of anterior knee pain after total knee replacement were addressed, in a prospective clinical trial comparing a fixed-bearing and mobile bearing total knee replacement and the possible effect of malplacement. Primary repair of the torn ACL is proven to be feasible in an animal model. Proof of the healing potential was found in biopsies of the human ACL.
The current projects address biomechanical and anatomical aspects of the hindfoot related to diagnosis, treatment and prevention of pathologies of the ankle and hindfoot with particular focus on posterior ankle impingement and inversion injuries. The current knee projects aim at the development and validation of the diagnostic methods for loosening of the total and partial knee replacement, return to work and patients expectations after total knee replacement and
Research plans (2017‑2019):
The plans are to validate and valorize the technique to detect loosening of the total knee replacement and to further develop this technique for other total joint implants.
Return to work and managing patient expectations must eventually lead to more individualized care pathway for patients with disabling symptomatic osteoarthritis of the knee, not only focusing on total joint replacement but also including alternative conservative and surgical interventions. The outcomes may help to improve shared decision making.
Prognostic factors for developing chronic functionally instable ankles are to be determined, eventually designing individualized care pathways that subsequently are to be tested in clinical trials. Additionally, the mechanical, anatomical and geometrical characteristics as prognostic factors may require additional testing of cause-effect relations that help to develop the treatment guidelines, not only for the instable ankle, but also for impingement pathologies and symptomatic cartilage lesions.
G.J.M. Tuijthof MEng PhD
N. Sarkalkan MEng
Prof. C.N. van Dijk PhD (Diagnosis and treatment of joint disorders)