PhD L.D.J. Bos


PhD L.D.J. Bos

Other Academic Staff, Research Associate
Main activities
Patient care, Research
Respiratory Medicine
Focus of research

- Prediction of individual treatment response (personalized medicine) and stratification of patients into homogeneous groups (stratified medicine) using "Omics" technologies in combination with routinely available clinical variables.

- Non-invasive diagnosis of respiratory disease, for example by exhaled breath analysis.

- Interaction of microbes within the lung. Analyses of microbes by metagenomics and of the biochemical environment by metabolomics. 

Key publications
  • Bos Lieuwe D. J., Weda Hans, Wang Yuanyue, Knobel Hugo H., Nijsen Tamara M. E., Vink Teunis J., Zwinderman Aeilko H., Sterk Peter J., Schultz Marcus J. Exhaled breath metabolomics as a noninvasive diagnostic tool for acute respiratory distress syndrome European respiratory journal 2014;44 (1):188-197 [PubMed]
  • Bos Lieuwe D J, Scicluna Brendon P, Ong David S Y, Cremer Olaf, van der Poll Tom, Schultz Marcus J Understanding Heterogeneity in Biologic Phenotypes of Acute Respiratory Distress Syndrome by Leukocyte Expression Profiles American journal of respiratory and critical care medicine 2019;200 (1):42-50 [PubMed]
  • Bos L. D., Schouten L. R., van Vught L. A., Wiewel M. A., Ong D. S. Y., Cremer O., Artigas A., Martin-Loeches I., Hoogendijk A. J., van der Poll T., Horn J., Juffermans N., Calfee C. S., Schultz M. J., Frencken Jos F., Bonten Marc, Klein Klouwenberg Peter M. C., van Hooijdonk Roosmarijn T. M., Huson Mischa A., Straat Marleen, Witteveen Esther, Glas Gerie J., Wieske Luuk, Scicluna Brendon P., Belkasim-Bohoudi H. Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis Thorax 2017;72 (10):876-883 [PubMed]
  • Zakharkina Tetyana, Martin-Loeches Ignacio, Matamoros Sébastien, Povoa Pedro, Torres Antoni, Kastelijn Janine B., Hofstra Jorrit J., de Wever B., de Jong Menno, Schultz Marcus J., Sterk Peter J., Artigas Antonio, Bos Lieuwe D. J. The dynamics of the pulmonary microbiome during mechanical ventilation in the intensive care unit and the association with occurrence of pneumonia Thorax 2017;72 (9):803-810 [PubMed]
  • van Oort Pouline M., Brinkman Paul, Slingers Gitte, Koppen Gudrun, Maas Adrie, Roelofs Joris J., Schnabel Ronny, Bergmans Dennis C., Raes M., Goodacre Royston, Fowler Stephen J., Schultz Marcus J., Bos Lieuwe D. Exhaled breath metabolomics reveals a pathogen-specific response in a rat pneumonia model for two human pathogenic bacteria: a proof-of-concept study American journal of physiology. Lung cellular and molecular physiology 2019;316 (5):L751-L756 [PubMed]
All Publications
Current research funding
  • Life Sciences Health TKI
  • Longfonds
  • Universiteit Twente