Prof. G.J. Strijkers MSc PhD

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Prof. G.J. Strijkers MSc PhD

Positions
Associate Professor, Full Professor
Main activities
Education, Research
Specialisation
Preclinical and translational Magnetic Resonance Imaging
Focus of research

List of publications: scholar.google.nl/citations or pubmed

 

The Preclinical and Translational MRI group of the department of Biomedical Engineering and Physics has the ambition to develop novel quantitative and comprehensive MRI techniques with application to important healthcare problems, including cardiovascular diseases and neuromuscular disorders.

 

We have several research themes: 

 

Preclinical cardiovascular MRI
My lab is at the forefront of the development and application of cardiovascular MRI in small animal models of cardiovascular disease. Highlights include the development of (1) a preclinical first-pass contrast method for assessing myocardial perfusion of the mouse myocardium, (2) development of preclinical T1-, T2-, and T2* mapping protocols for the mouse myocardium, (3) a cardiac CINE sequence with unprecedented frame rates (1 ms) to assess mouse heart diastolic function, (4) combined PET/MRI for the assessment of mouse myocardial infarction.

 

Contrast-enhanced cardiovascular MRI
In recent years we have been interested in the development, understanding, and optimization of MRI protocols for improved detection and quantification of (targeted) contrast agents and contrast-labeled therapeutics for cardiovascular disease applications. Highlights include (1) imaging and quantification of the accumulation of Gd-labeled liposomes and micelles in infarct mouse myocardium, (2) T1-rho imaging for improved detection sensitivity of iron-oxide contrast agent, and (3) understanding of the ‘quenching’ behavior of cell-internalized Gd-based contrast agents.

 

Accelerated cardiovascular MRI
Cardiovascular MRI is seriously hampered by complicated imaging protocols that require long examination times and robust ECG triggering and respiratory gating technology. We have been working on accelerating cardiovascular MRI by the use of parallel imaging and compressed-sensing technology. Specifically, (1) we were the first to combine self-gating technology with compressed-sensing to accelerate mouse CINE cardiac MRI, (2) we have a developed a radial ultra short echo time (UTE) technique for CINE and T2* mapping, and (3) we are currently translating these types of technology for routine clinical application.

 

Multi-contrast MRI
The pre-clinical development and clinical implementation of novel cancer therapeutics benefits from imaging technology that provides early readouts of treatment effect and success. We have developed several multi-contrast approaches, combining contrast readouts such as T1, T2, T1-rho, APT, MTR, DCE, and DWI, to evaluate early effects in mouse cancer models after treatment by high-intensity focused ultrasound (HIFU) and by photodynamic therapy (PDT).

 

Diffusion imaging of muscle
We have pioneered the use of diffusion imaging of skeletal and heart muscle. Diffusion imaging provides powerful readouts of muscle tissue microstructure and architecture in health and disease. We (1) were the first to develop diffusion-tensor-imaging (DTI) for mouse skeletal muscle, (2) have translated DTI protocols for the assessment of neuromuscular disorders in humans, (3) applied ex vivo diffusion-imaging to assess microstructural and architectural changes in the mouse myocardium after myocardial infarction, and (4) are currently developing in vivo diffusion protocols for imaging of the beating human heart.



 

 

Key publications
  • Hectors Stefanie, Jacobs Igor, Lok Jasper, Peters Johannes, Bussink Johan, Hoeben Freek J. M., Keizer Henk, Janssen Henk M., Nicolay Klaas, Schabel Matthias, Strijkers Gustav Improved evaluation of antivascular cancer therapy using constrained tracer-kinetic modeling for multi-agent dynamic contrast-enhanced MRI Cancer research 2018;78 (6):1561-1570 [PubMed]
  • Braza Mounia S., van Leent Mandy M. T., Lameijer Marnix, Sanchez-Gaytan Brenda L., Arts Rob J. W., Pérez-Medina Carlos, Conde Patricia, Garcia Mercedes R., Gonzalez-Perez Maria, Brahmachary Manisha, Fay Francois, Kluza Ewelina, Kossatz Susanne, Dress Regine J., Salem Fadi, Rialdi Alexander, Reiner Thomas, Boros Peter, Strijkers Gustav J., Calcagno Claudia C., Ginhoux Florent, Marazzi Ivan, Lutgens Esther, Nicolaes Gerry A. F., Weber Christian, Swirski Filip K., Nahrendorf Matthias, Fisher Edward A., Duivenvoorden Raphaël, Fayad Zahi A., Netea Mihai G., Mulder Willem J. M., Ochando Jordi Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance Immunity 2018;49 (5):819-828.e6 [PubMed]
  • Zheng Kang H., Schoormans Jasper, Stiekema Lotte C. A., Calcagno Claudia, Cicha Iwona, Alexiou Christoph, Strijkers Gustav J., Nederveen Aart J., Stroes Erik S. G., Coolen Bram F. Plaque Permeability Assessed With DCE-MRI Associates With USPIO Uptake in Patients With Peripheral Artery Disease JACC. Cardiovascular imaging 2019;12 (10):2081-2083 [PubMed]
  • Oudeman Jos, Eftimov Filip, Strijkers Gustav J., Schneiders Joppe J., Roosendaal Stefan D., Engbersen Maurits P., Froeling Martijn, Goedee H. Stephan, van Doorn Pieter A., Caan Matthan W. A., van Schaik Ivo N., Maas Mario, Nederveen Aart J., de Visser Marianne, Verhamme Camiel Diagnostic accuracy of MRI and ultrasound in chronic immune-mediated neuropathies Neurology 2020;94 (1):e62-e74 [PubMed]
  • Senders Max L., Meerwaldt Anu E., van Leent Mandy M. T., Sanchez-Gaytan Brenda L., van de Voort Jan C., Toner Yohana C., Maier Alexander, Klein Emma D., Sullivan Nathaniel A. T., Sofias Alexandros Marios, Groenen Hannah, Faries Christopher, Oosterwijk Roderick S., van Leeuwen Esther M., Fay Francois, Chepurko Elena, Reiner Thomas, Duivenvoorden Raphael, Zangi Lior, Dijkhuizen Rick M., Hak Sjoerd, Swirski Filip K., Nahrendorf Matthias, Pérez-Medina Carlos, Teunissen Abraham J. P., Fayad Zahi A., Calcagno Claudia, Strijkers Gustav J., Mulder Willem J. M. Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging Nature nanotechnology 2020;15 (5):398-405 [PubMed]
All Publications
Curriculum Vitae

List of publications: scholar.google.nl/citations

 

Research programmes

Prof. G.J. Strijkers MSc PhD (Preclinical and Translational MRI)

  

Faculty
B.F. Coolen MEng PhD

Postdocs
M.T. Hooijmans PhD

Medewerkers buiten research programmes van afdeling Biomedical Engineering and Physics

Current research funding
  • AMC
  • Technologiestichting STW
  • Toegepaste en Technische Wetenschappen (TTW)