Prof. MD PhD C.B.L.M. Majoie

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Prof. MD PhD C.B.L.M. Majoie

Position
Full Professor
Main activities
Patient care, Research
Specialisation
Neuroradiology
Focus of research
  • Neuroradiology 
  • Interventional neuroradiology (including intracranial aneurysms and stroke)
  • CT angiography
  • CT perfusion
  • Diffusion Tensor Imaging
  • Arterial Spin Labeling
  • MR angiography
Key publications
  • Berkhemer Olvert A., Fransen Puck S. S., Beumer Debbie, van den Berg Lucie A., Lingsma Hester F., Yoo Albert J., Schonewille Wouter J., Vos Jan Albert, Nederkoorn Paul J., Wermer Marieke J. H., van Walderveen Marianne A. A., Staals Julie, Hofmeijer Jeannette, van Oostayen Jacques A., Lycklama à Nijeholt Geert J., Boiten Jelis, Brouwer Patrick A., Emmer Bart J., de Bruijn Sebastiaan F., van Dijk Lukas C., Kappelle L. Jaap, Lo Rob H., van Dijk Ewoud J., de Vries Joost, de Kort Paul L. M., van Rooij Willem Jan J., van den Berg Jan S. P., van Hasselt Boudewijn A. A. M., Aerden Leo A. M., Dallinga René J., Visser Marieke C., Bot Joseph C. J., Vroomen Patrick C., Eshghi Omid, Schreuder Tobien H. C. M. L., Heijboer Roel J. J., Keizer Koos, Tielbeek Alexander V., den Hertog Heleen M., Marquering Henk A., Sprengers Marieke E. S., Beenen Ludo F. M., van den Berg René, Roos Yvo B. W. E. M., Majoie Charles B. L. M., Santos Emilie, Borst Jordi, Jansen Ivo, Lucas Marit, Barros Renan Sales A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke New England journal of medicine 2015;372 (1):11-20 [PubMed]
  • Berkhemer Olvert A., Jansen Ivo G. H., Beumer Debbie, Fransen Puck S. S., van den Berg Lucie A., Yoo Albert J., Lingsma Hester F., Sprengers Marieke E. S., Jenniskens Sjoerd F. M., Lycklama à Nijeholt Geert J., van Walderveen Marianne A. A., van den Berg René, Bot Joseph C. J., Beenen Ludo F. M., Boers Anna M. M., Slump Cornelis H., Roos Yvo B. W. E. M., van Oostenbrugge Robert J., Dippel Diederik W. J., van der Lugt Aad, van Zwam Wim H., Marquering Henk A., Majoie Charles B. L. M., Schonewille Wouter J., Vos Jan-Albert, Nederkoorn Paul J., Wermer Marieke J. H., Staals Julie, Hofmeijer Jeannette, van Oostayen Jacques A., Boiten Jelis, Brouwer Patrick A., Emmer Bart J., de Bruijn Sebastiaan F., van Dijk Lukas C., Kappelle L. Jaap, Lo Rob H., van Dijk Ewoud J., de Vries Joost, de Kort Paul L. M., van den Berg Jan S. P., van Hassel Boudewijn A. A. M., Aerden Leo A. M., Dallinga René J., Visser Marieke C., Vroomen Patrick C., Eshghi Omid, Schreuder Tobien H. C. M. L., Heijboer Roel J. J., Keizer Koos Collateral Status on Baseline Computed Tomographic Angiography and Intra-Arterial Treatment Effect in Patients With Proximal Anterior Circulation Stroke Stroke; a journal of cerebral circulation 2016;47 (3):768-776 [PubMed]
  • Santos Emilie M. M., Marquering Henk A., den Blanken Mark D., Berkhemer Olvert A., Boers Anna M. M., Yoo Albert J., Beenen Ludo F., Treurniet Kilian M., Wismans Carrie, van Noort Kim, Lingsma Hester F., Dippel Diederik W. J., van der Lugt Aad, van Zwam Wim H., Roos Yvo B. W. E. M., van Oostenbrugge Robert J., Niessen Wiro J., Majoie Charles B., Fransen Puck S. S., Beumer Debbie, van den Berg Lucie A., Schonewille Wouter J., Vos Jan Albert, Nederkoorn Paul J., Wermer Marieke J. H., van Walderveen Marianne A. A., Staals Julie, Hofmeijer Jeannette, van Oostayen Jacques A., Lycklama à Nijeholt Geert J., Boiten Jelis, Brouwer Patrick A., Emmer Bart J., de Bruijn Sebastiaan F., van Dijk Lukas C., Kappelle L. Jaap, Lo Rob H., van Dijk Ewoud J., de Vries Joost, de Kort Paul L. M., van den Berg Jan S. P., van Hasselt Boudewijn A. A. M., Aerden Leo A. M., Bot Joseph C. J., Sprengers Marieke E. S., van den Berg René, Borst Jordi, Jansen Ivo, Lucas Marit, Barros Renan Sales Thrombus Permeability Is Associated With Improved Functional Outcome and Recanalization in Patients With Ischemic Stroke Stroke; a journal of cerebral circulation 2016;47 (3):732-741 [PubMed]
  • Borst Jordi, Berkhemer Olvert A., Roos Yvo B. W. E. M., van Bavel Ed, van Zwam Wim H., van Oostenbrugge Robert J., van Walderveen Marianne A. A., Lingsma Hester F., van der Lugt Aad, Dippel Diederik W. J., Yoo Albert J., Marquering Henk A., Majoie Charles B. L. M., Fransen Puck S. S., Beumer Debbie, van den Berg Lucie A., Schonewille Wouter J., Vos Jan Albert, Nederkoorn Paul J., Wermer Marieke J. H., Staals Julie, Hofmeijer Jeannette, van Oostayen Jacques A., Lycklama à Nijeholt Geert J., Boiten Jelis, Brouwer Patrick A., Emmer Bart J., de Bruijn Sebastiaan F., van Dijk Lukas C., Kappelle L. Jaap, Lo Rob H., van Dijk Ewoud J., de Vries Joost, de Kort Paul L. M., van den Berg Jan S. P., van Hasselt Boudewijn A. A. M., Aerden Leo A. M., Dallinga René J., Visser Marieke C., Bot Joseph C. J., Vroomen Patrick C., Eshghi Omid, Schreuder Tobien H. C. M. L., Sprengers Marieke E. S., Beenen Ludo F. M., van den Berg René, Santos Emilie, Jansen Ivo, Lucas Marit, Barros Renan Sales Value of Computed Tomographic Perfusion-Based Patient Selection for Intra-Arterial Acute Ischemic Stroke Treatment Stroke; a journal of cerebral circulation 2015;46 (12):3375-3382 [PubMed]
  • Ferns Sandra P., Sprengers Marieke E. S., van Rooij Willem Jan, van Zwam Wim H., de Kort Gérard A. P., Velthuis Birgitta K., Schaafsma Joanna D., van den Berg René, Sluzewski Menno, Brouwer Patrick A., Rinkel Gabriël J. E., Majoie Charles B. L. M. Late Reopening of Adequately Coiled Intracranial Aneurysms Frequency and Risk Factors in 400 Patients With 440 Aneurysms Stroke; a journal of cerebral circulation 2011;42 (5):1331-1337 [PubMed]
All Publications
Research programmes

Prof. MD PhD C.B.L.M. Majoie (Neuroradiology, Neurovascular diseases: imaging and endovascular treatment of acute stroke)

Research is focused on imaging and endovascular treatment of neurovascular diseases including acute ischemic and hemorhagic stroke.
A research project on Computational Fluid Dynamics of intracranial aneurysms was started in collaboration with the departments of medical physics, neurosurgery, anesthesiology of the AMC and the University of Twente. The aim of this project is to improve rupture risk assessment of aneurysms by using advanced imaging techniques, including 7T MRI. In 2010 a multicenter randomized clinical trial was started inclose cooperation with the departments of neurology and radiology of the AMC, Erasmus MC and MUMC, evaluating the safety and effectiveness of endovascular treatment of acute ischemic stroke (MRCLEAN: www.mrclean-trial.org) funded by the Dutch Heart Foundation. The trial was completed in July 2014 and showed that in patientes with acute ischemic stroke due to a large vessel occlusion intraarterial treatment leads to a siginificant higher rate of functional independence. The results were in published in the NEJM (January,1, 2015) and had a major impact of the treatment of patients with acute ischemic stroke worldwide. The long term follow-up and cost-effectiveness of this treatment is assessed in a ZonMW funded project. Advanced image analysis of ischemic stroke is performed inclose collaboration with the Department of Biomedical Engineering and Physics (AMC) and the department of interventional neuroradiology, Texas Stroke Institute, Dallas, USA. In 2016 a large grant was acquired from the Dutch Heart Foundation for CONTRAST (COnsortium for New TReatments of Acute STroke; www.contrast-consortium.nl) in collaboration with Erasmus MC and 17 other hospitals in the Netherlands with additional support from industry (unrestricetd grants) and Dutch Brain Foundation (15.000 keu). The main aims of CONTRAST are 1. to improve the process of stroke care and achieve faster optimal stroke treatment for more patients; 2. to develop and test new treatments for a broad population of patients with ischemic stroke or ICH; and 3. to broaden the indication for IAT and increase the benefit of this treatment. These aims will be reached through a united effort of basic and clinical scientists. We will perform five large acute stroke trials to test novel treatment strategies, including 1. pre-hospital augmentation of collateral blood flow and blood pressure reduction; 2. antithrombotics to prevent microvascular occlusion after IAT; 3. immediate IAT without preceding thrombolysis; 4. IAT in the 6 to 12 hour time window; and 5. microsurgical hematoma evacuation and dexamethasone in patients with ICH. We aim to identify patients who will benefit from these interventions through advanced imaging. Novel stroke treatments with animal models will be developed, in combination with data from our clinical biobank. Mathematical modelling of data from the trials will optimize stroke care. In november 2017 the H2020 project INSIST (In Silico Trials in Acute Ischemic Stroke; www.insist-h2020.eu) was startedThe main goal of INSIST is to realize in silico clinical stroke trials for biomedical products for endovascular treatment of acute ischemic stroke, consisting of generations of populations of virtual stroke patients and in silico models of treatments and of the biophysiological aspects of human response to stroke. Such trials can significantly contribute to elucidating reasons for negative outcome of treatment, improve medical device and drug development, optimize treatment and speed up implementation of novel treatments of acute stroke.  


Theme: Neurological and Psychiatric Disorders

Faculty
MEng PhD M.W.A. Caan
B.J. Emmer
PhD H.A. Marquering
MEng PhD A.J. Nederveen
PhD R. van den Berg

Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Europese Unie
  • Johnson & Johnson Medical Ltd.
  • Nederlandse Hartstichting
  • Nico-Lab B.V.
  • Siemens Healthcare Nederland B.V.
  • Stichting AMC Foundation (Vrijgesteld)
  • Stichting TWIN
  • Stichting Zorgevaluatie