- Vlaar Alexander P. J., Hofstra Jorrit J., Determann Rogier M., Veelo Denise P., Paulus Frederique, Kulik Wim, Korevaar Johanna, de Mol Bas A., Koopman Marianne M. W., Porcelijn Leendert, Binnekade Jan M., Vroom Margreeth B., Schultz Marcus J., Juffermans Nicole P. The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study Blood 2011;117 (16):4218-4225 [PubMed]
- Vlaar Alexander P. J., Binnekade Jan M., Prins David, van Stein Danielle, Hofstra Jorrit J., Schultz Marcus J., Juffermans Nicole P. Risk factors and outcome of transfusion-related acute lung injury in the critically ill: A nested case-control study Critical care medicine 2010;38 (3):771-778 [PubMed]
- Vlaar Alexander P. J., Hofstra Jorrit J., Kulik Wim, van Lenthe Henk, Nieuwland Rienk, Schultz Marcus J., Levi Marcel M., Roelofs Joris J. T. H., Tool Anton T. J., de Korte Dirk, Juffermans Nicole P. Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model Blood 2010;116 (8):1360-1368 [PubMed]
- Vlaar Alexander P. J., Juffermans Nicole P. Transfusion-related acute lung injury: a clinical review Lancet 2013;382 (9896):984-994 [PubMed]
- Müller M. C. A., Straat M., Meijers J. C. M., Klinkspoor J. H., de Jonge E., Arbous M. S., Schultz M. J., Vroom M. B., Juffermans N. P. Fresh frozen plasma transfusion fails to influence the hemostatic balance in critically ill patients with a coagulopathy Journal of thrombosis and haemostasis 2015;13 (6):989-997 [PubMed]
NJ has received her MD degree in 1997 from the Faculty of Medicine of the University of Amsterdam and her PhD degree in 2000 from the same Faculty. In 2005 she was board certified in Internal Medicine and in 2006 she received European board certification in Intensive Care Medicine. Since 2006, NJ is staff member of the Department of Intensive Care at the Academic Medical Center and senior researcher at the Laboratory of Experimental Intensive Care and Anesthesiology.
Prof. MD PhD N.P. Juffermans (Pathogenesis and treatment of organ failure in the critically ill)
This program focusses on the pathogenesis of organ failure and anemia occurring during critical illness.
Investigated pathways of organ failure include a dysregulated immune response which occur during excessive inflammation. Interventions are studied aimed at limiting organ injury induced by hyperinflammation or by mechanical ventilation. These interventions aim to reduce oxygen consumption during excessive inflammation.
Pathways of anemia during critical illness are studied. Efficacy of blood transfusion is studied, in particular optimizing transfusion triggers both for correction of anemia as well as for guiding therapy during bleeding. Also, risks of transfusion of blood products are studied, in particular the relation with the occurrence of organ failure. Studies seek to identify targets for interventions that aim to optimize transfusion.
The program uses a translational approach, combining observational and interventional studies in critically ill patients with fundamental studies in models of sepsis and acute lung injury.
MD PhD H. Aslami
MD PhD A.P.J. Vlaar
PhD J.M. Binnekade
A.M. Tuip-de Boer
A.Y. van der Veen
Prof. MD PhD M.J. Schultz (Prevention and treatment of organ failure in intensive care medicine)
Prof. MD PhD M.W. Hollmann (Organprotection)
MD PhD J. Horn (Neurology on the Intensive Care Unit)
MEng PhD C.J. Zuurbier (Cell survival mechanisms in acute and chronic cardiovascular pathology)
MD PhD A.P.J. Vlaar (Transfusion related morbidity and mortality)
- AMC (Vrijgesteld)
- Leids Universitair Medisch Centrum
- Sanquin Blood Supply Foundation
- Saudi Arabian Cultural Mission