Prof. N. Zelcer PhD


Prof. N. Zelcer PhD

Assistant Professor, Full Professor
Main activities
Transcriptional regulation of metabolism
Focus of research

* Contribution of the LXR-IDOL-LDLR axis to cholesterol metabolism

* Identification of novel metabolic genes

* Studying the contribution of the UPS system to metabolism

Key publications
  • Sorrentino Vincenzo, Fouchier Sigrid W., Motazacker Mohammad M., Nelson Jessica K., Defesche Joep C., Dallinga-Thie Geesje M., Kastelein John J. P., Kees Hovingh G., Zelcer Noam Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein European heart journal 2013;34 (17):1292-1297 [PubMed]
  • Nelson Jessica Kristine, Sorrentino Vincenzo, Avagliano Trezza Rossella, Heride Claire, Urbe Sylvie, Distel Ben, Zelcer Noam The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL Circulation research 2016;118 (3):410-419 [PubMed]
  • Lu Xifeng, Meima Marcel E., Nelson Jessica K., Sorrentino Vincenzo, Loregger Anke, Scheij Saskia, Dekkers Dick H. W., Mulder Monique T., Demmers Jeroen A. A., M-Dallinga-Thie Geesje, Zelcer Noam, Danser A. H. Jan Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism Circulation research 2016;118 (2):222-229 [PubMed]
  • Zelcer Noam, Sharpe Laura J., Loregger Anke, Kristiana Ika, Cook Emma C. L., Phan Lisa, Stevenson Julian, Brown Andrew J. The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway Molecular and cellular biology 2014;34 (7):1262-1270 [PubMed]
  • Zelcer Noam, Hong Cynthia, Boyadjian Rima, Tontonoz Peter LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor Science 2009;325 (5936):100-104 [PubMed]
All Publications
Research programmes

Prof. N. Zelcer PhD (Transcriptional regulation of metabolism)

 Research program:


A. Loregger PhD
L. Martinelli PhD
F. Mortensen PhD

M. Moeton PhD
R. Ottenhoff BEng
S. Scheij BEng
M. van den Berg BEng

Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Europese Unie
  • NWO
  • Stichting AMC Foundation (Vrijgesteld)