Prof. P.I. Spuls PhD


Prof. P.I. Spuls PhD

Full Professor
Main activities
Education, Patient care, Research
dermatologist, methodologist
Focus of research

Psoriasis: treatments, national and international guidelines, prospective registers, outcome parameters, nail psoriasis, maintenance treatments, therapeutic drug monitoring

Atopic dermatitis: diagnostic criteria, outcomeparameters, treatments, prospective register

Off-label drug use in dermatology: systematic reviews in order to develop national guidelines

Vascular malformations: diagnostic criteria, core outcome set development

Evidence based dermatology: critical appraised topics, systematic reviews, outcome parameters (core outcome sets), guidelines, shared decision making 


Key publications
  • Schram Mandy Elvira, Roekevisch Evelien, Leeflang Mariska Maria Geertruida, Bos Jan Dositheus, Schmitt Jochen, Spuls Phyllis Ira A randomized trial of methotrexate versus azathioprine for severe atopic eczema Journal of allergy and clinical immunology 2011;128 (2):353-359 [PubMed]
  • Roekevisch Evelien, Spuls Phyllis Ira, Kuester Denise, Limpens Jacqueline, Schmitt Jochen Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: a systematic review Journal of allergy and clinical immunology 2014;133 (2):429-438 [PubMed]
  • Schmitt Jochen, Apfelbacher Christian, Spuls Phyllis I., Thomas Kim S., Simpson Eric L., Furue Masutaka, Chalmers Joanne, Williams Hywel C. The Harmonizing Outcome Measures for Eczema (HOME) roadmap: a methodological framework to develop core sets of outcome measurements in dermatology Journal of investigative dermatology 2015;135 (1):24-30 [PubMed]
  • Teulings Hansje-Eva, Limpens Jacqueline, Jansen Sophia N., Zwinderman Aeilko H., Reitsma Johannes B., Spuls Phyllis I., Luiten Rosalie M. Vitiligo-Like Depigmentation in Patients With Stage III-IV Melanoma Receiving Immunotherapy and Its Association With Survival: A Systematic Review and Meta-Analysis Journal of clinical oncology 2015;33 (7):773-781 [PubMed]
  • Spuls P. I., Gerbens L. A. A., Simpson E., Apfelbacher C. J., Chalmers J. R., Thomas K. S., Prinsen C. A. C., von Kobyletzki L. B., Singh J. A., Williams H. C., Schmitt J. Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement British journal of dermatology 2017;176 (4):979-984 [PubMed]
All Publications
Research programmes

Prof. P.I. Spuls PhD (dermato-immunology and dermato-epidemiology)

Psoriasis: biologic antibodyformation, RCT etanercept versus infliximab, methotrexate optimalisation, new developments, compliance, nail psoriasis, maintenance treatment, combination treatment, guideline development,  registries, quality of life, side-effect monitoring

Atopic dermatitis: harmonisation outcome parameters, new treatment options (azathioprine versus methotrexate (short and long term), systemic treatments, registry, fillagrin mutations, biomarkers, diagnostic criteria, topicals, side- effect monitoring, antibody formation dupilumab, skintypes, phenotypering, infections, pregnancy/lactation, astma and atopic dermatitis, 

Rosacea: quality of life, RCT doxycyckine versus minicycline, laser treatment rosacea papulopustulosa

Off-label drug use in dermatology: RCT, guideline, Regieraad project, registry

Methodology: evidence based medicine/dermatology, guideline development, critical appraised topics, core outcome set development

Psychodermatology: ehealth Beter gestemd met de huid, shared decision making, diagnostiek psychosociale problematiek, PROMs

Vascular malformations: OVAMA core outcome set development, diagnostic criteria, PROMs


M.A. Middelkamp Hup MD PhD
M.M.D. van der Linden MD

G.A.M. Appel
P.B. Eppenga-Franklin
H.M. van der Stok

Current research funding
  • AbbVie B.V.
  • Boehringer Ingelheim BV
  • Eli Lilly Cork Limited
  • Europese Unie
  • Het Nederlands Bijwerkingen Centrum Lareb
  • IQVIA RDS Switzerland Sarl
  • Janssen Cilag B.V.
  • Jubilant Clinsys, Inc.
  • PAREXEL International (IRL) Limited
  • Personeelsproject - Industrie
  • ZonMw