Prof. PhD A.H. Maitland-van der Zee

foto

Prof. PhD A.H. Maitland-van der Zee

Position
Full Professor
Main activities
Research
Specialisation
Precision Medicine in Respiratory Disease
Focus of research

Past research of Maitland-van der Zee focused on precision medicine in among others cardiovascular medicine, airway diseases, hematology, oncology, and adverse drug reactions. Her recent research is focused on airways diseases, in particular asthma in children and adults. Precision Medicine refers to the tailoring of medical treatment to the individual characteristics of each patient. It involves the application of “omic” analysis and systems biology to analyze the cause of an individual patient's disease at the molecular level and then to utilize targeted (possibly in combination) to address that individual patient's disease process.

Key publications
  • Ahmadizar Fariba, Vijverberg Susanne J. H., Arets Hubertus G. M., de Boer Anthonius, Lang Jason E., Kattan Meyer, Palmer Colin N. A., Mukhopadhyay Somnath, Turner Steve, Maitland-van der Zee Anke H. Childhood obesity in relation to poor asthma control and exacerbation: a meta-analysis European respiratory journal 2016;48 (4):1063-1073 [PubMed]
  • Verhoef Talitha I., Ragia Georgia, de Boer Anthonius, Barallon Rita, Kolovou Genovefa, Kolovou Vana, Konstantinides Stavros, le Cessie Saskia, Maltezos Efstratios, van der Meer Felix J. M., Redekop William K., Remkes Mary, Rosendaal Frits R., van Schie Rianne M. F., Tavridou Anna, Tziakas Dimitrios, Wadelius Mia, Manolopoulos Vangelis G., Maitland-van der Zee Anke H., Daly Ann, Haschke-Becher Elisabeth, Kamali Farhad, Redekop Ken, Stingl Julia, Pirmohamed Munir, Grounidis Georgios, Kikas Petros, Mitrousi Konstantina, Kouroumichakis Ioannis, Maounis Themistocles, van der Wateren Wilma, Straasheijm-Veldhuis Brianda, Bayat Samira, Buikema Myrre, Zuurhout Miranda, Hegazy Hoda, Dorenbos Brenda, Beltman Peter, Hoeben Edwin, Vellenga Arjan, Karwar Zamiera, Hasrat Fazila, Hammoud Siham, Hagemans Inge, Berbee Jaqueline, van der Meer Simone, Verdoorn Sanne, Kraaijeveld Judith, Zwinderman Koos, Koster Ruud A Randomized Trial of Genotype-Guided Dosing of Acenocoumarol and Phenprocoumon New England journal of medicine 2013;369 (24):2304-2312 [PubMed]
  • Leusink M., Vijverberg S. J. H., Koenderman L., Raaijmakers J. A. M., de Jongste J. C., Sterk P. J., Duiverman E. J., Onland-Moret N. C., Postma D. S., de Boer A., de Bakker P. I. W., Koppelman G. H., Maitland-van der Zee A. H. Genetic variation in uncontrolled childhood asthma despite ICS treatment pharmacogenomics journal 2016;16 (2):158-163 [PubMed]
  • Vijverberg S. J. H., Koster E. S., Tavendale R., Leusink M., Koenderman L., Raaijmakers J. A. M., Postma D. S., Koppelman G. H., Turner S. W., Mukhopadhyay S., Tse S. M., Tantisira K. G., Hawcutt D. B., Francis B., Pirmohamed M., Pino-Yanes M., Eng C., Burchard E. G., Palmer C. N. A., Maitland-van der Zee A. H. ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults Clinical and experimental allergy 2015;45 (6):1051-1059 [PubMed]
  • Verhoef T. I., Redekop W. K., Buikema M. M., Schalekamp T., van der Meer F. J. M., le Cessie S., Wessels J. A. M., van Schie R. M. F., de Boer A. [=Anthonius], Teichert M., Visser L. E., Maitland-van der Zee A. H., Barallon R., Daly A., Haschke-Becher E., Kamali F., Redekop K., Stingl J., Manolopoulos V. G., Pirmohamed M., Rosendaal F. R., Wadelius M. Long-term anticoagulant effects of the CYP2C9 and VKORC1 genotypes in acenocoumarol users Journal of thrombosis and haemostasis 2012;10 (4):606-614 [PubMed]
All Publications
Curriculum Vitae

CURRICULUM VITAE

 

2016

 

 

PERSONAL DETAILS

 

Name:                                     Anke-Hilse Maitland-van der Zee, PharmD, PhD

Date and place of birth:         16-03-1975, Rotterdam, the Netherlands

Married, 3 children (Henriëtte 2002, Annelotte 2004, Dirrik 2006)

Address:                                  Dr A Scheygrondlaan 18, 2811 GN Reeuwijk, Nederland

Tel.:                                         0182-396963 (home)

                                                06-51248443 (cell)

email:                                       a.h.maitland@amc.nl

           

 

CURRENT POSITION

 

2016 – now     Professor Precision Medicine in Respiratory Disease, Academic Medical Center (AMC), University of Amsterdam (UvA), Amsterdam, The Netherlands

 

 

EDUCATION

 

1998    Master’s degree Pharmaceutical Sciences – Faculty of Science / Department of Pharmaceutical Sciences, Groningen University, the Netherlands

1999    Pharmacist degree (PharmD). Faculty of Science / Department of Pharmaceutical Sciences, Groningen University, the Netherlands

2003    PhD, Title of thesis: Pharmacogenetics of HMG-CoA reductase inhibitors. Faculty of Science/ Department of Pharmaceutical Sciences, Utrecht University, the Netherlands. Supervisors: Prof. dr. A. de Boer and Prof. dr. H.G.M. Leufkens. Date of thesis defence: 17 september 2003.

2004    Registered as Epidemiologist B (SMWBO)

2010    Registered as Clinical Pharmacologist (NVKF&B)

 

 

PREVIOUS POSITIONS

 

2003 - 2005     Post-doctoral Fellow University of Texas Health Science Center, Human Genetics Center, Houston, Tx, United States of America

2005 - 2011     Assistant Professor Pharmacogenetics / Pharmacogenomics, Utrecht University, The Netherlands

2012 – 2016    Associate Professor Personalized Medicine, Utrecht University, The Netherlands          

 

 

RESEARCH ASSESSMENT

 

a. Funding of research obtained as principal investigator

 

2005:   NWO-VENI grant ' Multi-locus approach in pharmacogenetics Application in the cholesterol lowering and anti-inflammatory pathways of statins ' (budget: 270,000 Euro)

2007:   Principal Investigator of GSK–UIPS alliance project (budget 900,000 Euros)

2008:   Principal investigator of EU FP 7 collaborative project EU-PACT (budget 2.55 million euro, 10 partners).

2009    Senter Novem grant for project European Adverse Drug Reactions Biobank (budget 50,000 Euro).

2010:   Personal Grant Focus and Mass Epidemiology from Utrecht University (budget  200,000 Euro)

2010:   CBG granted project on genetic risk factors for drug induced liver injuries. (budget 250,000 Euro)

2011    GSK grant for project on pharmacogenomics of asthma therapy. (Budget 35,000 Euro)

2013    CSC-UU grant for project on Pharmacogenetics of acenocoumarol/ phenprocoumon (budget 250,000 Euro)

2013:   Work package leader for FP-7 project “PREDICTION-ADR”. (Budget 500,000 Euro).

2015:   Principal Investigator “Pharmacogenomics in Childhood Asthma” Stichting Asthma Bestrijding  (Budget 25.000 Euro)

2015:   Principal Investigator “Systems Pharmacology Approach to Pediatric Asthma (SysPharmPedia)” ERANET (total budget 1.000.000 Euro)

2016:  Principal Investigator “From genetic profile to precision medicine in children with persistent asthma. The PUFFIN trial (Pharmacogenetics Use For Further treatment Improvement in children)”Longfonds (Budget 750.000 Euro)

 

 

b. Supervisor of PhD students

 

Current supervisor of 8 PhD students and 1 post-doc

 

PhD-thesis co-promotor:

2009    Dr. B.M.A. van Wieren-de Wijer. Title PhD thesis: “Pharmacogenetics of                        antihypertensive drug treatment”.

2010    Dr. B.M.A. Peters. Title PhD thesis: “Methodological approaches to the               pharmacogenomics of statins”

2011    Dr. E. Koster Title PhD thesis: “Towards optimal drug treatment in childhood     asthma”

2013    Dr. R.M.F. van Schie Title PhD thesis: “Towards optimal dosing of coumarin      therapy”

2013    Dr. T.I. Verhoef  Title PhD thesis “Cost-effectiveness of pharmacogenetics of     anticoagulation therapy”

2014    Dr. S. Vijverberg Title thesis: “Treatment response in childhood asthma. An interplay between genes and inflammatory signals.”

2015    Dr. M. Leusink Title thesis:”Challenges and opportunities in pharmacogenomics. Studies in cardiovascular disease and asthma”.

2016    Dr. H. Mahmoudpour Title thesis: ” Adverse drug reactions of Angiotensin converting enzyme inhibitors: Towards precision medicine”.

 

PhD-thesis promotor

2016    Planned October 24th F. Ahmadizar Title thesis:”Risk factors and treatment of pediatric chronic disease – Type 1 Diabetes, Asthma and Allergy”.

 

 

c. Scientific publications / citations

 

Number of publications in Scopus: 148

H-index: 22

 

d. 5 key publications in the last 5 years

 

  1. Verhoef TI, Ragia G, de Boer A, Barallon R, Kolovou G, Kolovou V, Konstantinides S, Le Cessie S, Maltezos E, van der Meer FJ, Redekop WK, Remkes M, Rosendaal FR, van Schie RM, Tavridou A, Tziakas D, Wadelius M, Manolopoulos VG, Maitland-van der Zee AH. A randomized trial of genotype-guided dosing of acenocoumarol and phenprocoumon. N Engl J Med. 2013: 12;369:2304-12.

 

  1. Pirmohamed M, Burnside G, Eriksson N, Jorgensen AL, Toh CH, Nicholson T, Kesteven P, Christersson C, Wahlström B, Stafberg C, Zhang JE, Leathart JB, Kohnke H, Maitland-van der Zee AH, Williamson PR, Daly AK, Avery P, Kamali F, Wadelius M; EU-PACT Group. A randomized trial of genotype-guided dosing of warfarin. N Engl J Med. 2013 Dec 12;369(24):2294-303.

 

  1. Swerdlow DI, Preiss D, Kuchenbaecker KB, … Maitland-van der Zee AH, Klungel OH, de Boer A, Doevendans PA, Eaton CB, et al. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet. 2015 Jan 24;385(9965):351-61.

 

  1. Leusink M, Vijverberg SJ, Koenderman L, Raaijmakers JA, de Jongste JC, Sterk PJ, Duiverman EJ, Onland-Moret NC, Postma DS, de Boer A, de Bakker PI, Koppelman  GH, Maitland-van der Zee AH. Genetic variation in uncontrolled childhood asthma despite ICS treatment. Pharmacogenomics J. 2016 Apr;16(2):158-163.

 

  1. Turner S, Francis B, Vijverberg S, Pino-Yanes M, Maitland-van der Zee AH, Basu K, Bignell L, Mukhopadhyay S, Tavendale R, Palmer C, Hawcutt D, Pirmohamed M, Burchard EG, Lipworth B; Pharmacogenomics in Childhood Asthma Consortium. Childhood asthma exacerbations and the Arg16 β(2)-receptor polymorphism: A meta-analysis stratified by treatment. J Allergy Clin Immunol. 2016 Jan 7.

 

 

CURRENT RESEARCH INTEREST

Past research of Maitland-van der Zee focused on precision medicine in among others cardiovascular medicine, airway diseases, hematology, oncology, and adverse drug reactions. Her recent research is focused on airways diseases, in particular asthma in children and adults. Precision Medicine refers to the tailoring of medical treatment to the individual characteristics of each patient. It involves the application of “omic” analysis and systems biology to analyze the cause of an individual patient's disease at the molecular level and then to utilize targeted (possibly in combination) to address that individual patient's disease process.

 

COLLABORATIONS / NETWORKS

a. international

2006 to 2016               Vice Chair of SIG Translational Research and Individualized Medicines. International Pharmacists Federation (FIP)

2009 to 2010               Co-Chair special interest group Pharmacogenomics and Molecular Epidemiology International Society PharmacoEpidemiology (ISPE)

2006 to 2015               Chair of the Steering committee of the EUFEPS European Research Network on Pharmacogenetics/genomics

2015 – present             Past-Chair and committee member of the Steering committee of the EUFEPS European Research Network on Pharmacogenetics/genomics

 

b. national

2008 – present                        Chair of the Dutch Pharmacogenetics Network

2008 – present             Member of the Working Group Pharmacogenetics of the Netherlands Royal Society for the advancement of Pharmacy (KNMP).

2014 to 2015               Secretary of the committee “Structure and Valorisation” for implementing the Strategic plan of the Department of Pharmaceutical Sciences, Utrecht University

2014 – 2016                Chair of the working group “Drug research“ of NVKF&B (Netherlands Organisation of Clincal Pharmacology and Biopharmaceutical sciences).

2015 – 2016                Chair of the working group for the development of a new focus area “Future Medicine” for Utrecht University.

2015 –2016                 Member of the Consultative group for the development of the new curriculum of the Master Pharmaceutical Sciences

2015 – present             Secretary/treasurer of the board of the NVKF& B (Netherlands Organisation of Clinical Pharmacology and Biopharmaceutical sciences)

 

 

ORGANISOR OF (INTER)NATIONAL MEETINGS

 

2006 – present             Organizer of meetings for European Research Network Pharmacogenetics (Utrecht 2006, London 2008, Leiden 2010, Utrecht 2011, Uppsala 2013)

2006 to 2009               Member of the organisational committee of the Pharmaceutical Sciences Fair (PharmSciFair) in 2009 in Nice

2007 to 2008               Member of the organizational committee of the Pharmacogenetics and Individualized medicine symposium during the AAPS (American Association of Pharmaceutical Sciences) 2008, Atlanta, GA USA.

2008 – present             Organiser of yearly meeting of Netherlands Network of Precision Medicine.

2009 to 2010               Member of the Core-committee for organizing the International Conference on Pharmacoepidemiology in 2010 in Brighton, UK.

2010 – present             Organiser of yearly Pre-conference course on Molecular Pharmacoepidemiology ISPE (International Society of Pharmacoepidemiology)

2010 to 2011               Member of the executive committee organizing the Pharmaceutical Sciences Fair Prague June 2011

2011                            Member of the organization committee of the BBMRI_NL-conference in Rotterdam, November 2011.

 

 

INVITED LECTURES AT INTERNATIONAL MEETINGS

 

2016

  • Canadian Society of Clinical Pharmacology “Pharmacogenomics of pediatric asthma” Vancouver, Canada

  • ERS London 2016 “Epigenetics and Transcriptome in pediatric asthma””

  • International Society of PharmacoEpidemiology (ISPE). “Methodological issues in pharmacogenetics” Dublin, Ireland

  • SAPhiRE Pharmacogenomics symposium Singapore “An overview of Statin Pharmacogenomics research and implementation of Pharmacogenomics in the Netherlands” Singapore

 

2015

  • Eurothrombosis summit 2015 (European Society of Cardiology) “Genetics and biomarkers to tailor anticoagulant strategies?” Como, Italy

  • European Society of Pharmacogenomics and Personalized Therapy (ESPT) “Pharmacogenetics of asthma medication” Boedapest, Hungary

  • 7th International Congress on Pulmonary Diseases, Intensive Care and Tuberculosis. “Precision medicine approach to childhood asthma: Fact or Fiction?” Tehran, Iran

  • International Society of PharmacoEpidemiology (ISPE). “Methodological issues in pharmacogenetics”, Boston, USA

  • American Thoracic Society (ATS) “Personalized medicine in childhood asthma”, Denver, USA

 

2014

  • German Congress of Laboratory Medicine “Pharmacogenomics in cardiovascular medicine, Is there clinical relevance?” Mannheim, Germany

  • European Society of Cardiology (ESC) “'Pharmacogenetic-guided warfarin dosing is not needed” Barcelona, Spain

  • European Association for Clinical Pharmacology and Therapeutics (EACPT)- “Role of genetics in doing of coumarins” Nijmegen, Netherlands

  • International Society for Pharmaceutical Engineering (ISPE) “Pharmacogenomics in Children”, Rotterdam, The Netherlands

  • Pharmaceutical Sciences World Conference (PSWC) “Dosing of coumarin therapy: To genotype or not to genotype”,  Melbourne,  Australia

     

 

2013

  • European Society of Cardiology (ESC) “European  Pharmacogenetics of Coumarin Therapy  trial (EU-PACT)” Amsterdam, The Netherlands

  • International Pharmaceutical Federation (FIP), “Role of racial differences in personalized therapy”  Dublin, Ireland

  • International Pharmaceutical federation (FIP),  “Pharmacogenetics of coumarins”  Dublin, Ireland

  • European Respiratory Society (ERS). “Towards personalized medicine in asthma in children” Barcelona, Spain.

  • International Society of PharmacoEpidemiology (ISPE) “Methodological issues in pharmacogenetics” Montreal, Canada 

  • Spanish Pharmacogenetics network “Pharmacogenetics of asthma in children” Bilbao, Spain

  • European Federation of Pharmeaceutical Sciences (EUFEPS) “Pharmacogenetics of coumarin therapy”  Uppsala, Sweden

  • European Society of Predictive Medicine (ESPM) conference Bologna, Italy “Pharmacogenetics of statins”

 

TEACHING EXPERIENCE

 

2005                            Basic qualification university teaching (BKO)

2005 – present             30% of working time is devoted to teaching Master students Pharmaceutical Sciences at Utrecht University

 

Research programmes

Prof. PhD A.H. Maitland-van der Zee (Precision Medicine in Respiratory Disease)

Faculty
PhD S.J.H. Vijverberg

Postdocs
PhD A.H. van Stuyvenberg-Neerincx

PhD Students
MSc Y. Zhang

Current research funding
  • BIOSCI CONSULTING VOF
  • Crediteurenadm. VUmc, p/a Profource Service Center
  • ERS Headquarters
  • Embassy of the Arab Republic of Egypt
  • Europese Unie
  • Imperial College of Science Technology and Medicine
  • Longfonds
  • NRS
  • Optimum Patient Care Global Limited
  • RIVM
  • Stichting Astma Bestrijding
  • University of Southampton
  • Vertex Pharmaceuticals Inc.
  • ZonMw